Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q6LEB3 (Q6LEB3_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Pdx1 MGI 102851
Synonyms:Ipf1 MGI 102851
OrganismMus musculus (Mouse) EMBL AAA53037.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length27 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

Ontologies

Keywords
   DomainHomeobox EMBL AAA53037.1
Gene Ontology (GO)
   Biological_processcell differentiation

Inferred from mutant phenotype PubMed 16418487. Source: MGI

central nervous system development

Inferred from electronic annotation. Source: Ensembl

detection of glucose

Inferred from electronic annotation. Source: Ensembl

digestive tract development

Inferred from mutant phenotype PubMed 19619492. Source: MGI

endocrine pancreas development

Inferred from mutant phenotype PubMed 18155690. Source: MGI

exocrine pancreas development

Inferred from mutant phenotype PubMed 16126192. Source: MGI

glucose homeostasis

Inferred from mutant phenotype PubMed 18155690. Source: MGI

glucose metabolic process

Inferred from direct assay PubMed 12904469. Source: MGI

insulin secretion

Inferred from electronic annotation. Source: Ensembl

liver development

Inferred from mutant phenotype PubMed 19619492. Source: MGI

morphogenesis of embryonic epithelium

Inferred from mutant phenotype PubMed 8625829. Source: MGI

negative regulation of cell proliferation

Inferred from mutant phenotype PubMed 18155690. Source: MGI

negative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

Inferred from mutant phenotype PubMed 20811152. Source: MGI

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 17056599. Source: MGI

negative regulation of type B pancreatic cell apoptotic process

Inferred from mutant phenotype PubMed 20811152. Source: MGI

nitric oxide mediated signal transduction

Inferred from electronic annotation. Source: Ensembl

organ regeneration

Inferred from electronic annotation. Source: Ensembl

organ senescence

Inferred from electronic annotation. Source: Ensembl

pancreas development

Inferred from mutant phenotype PubMed 16418487PubMed 8625829. Source: MGI

positive regulation of DNA binding

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell death

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell proliferation

Inferred from mutant phenotype PubMed 18155690. Source: MGI

positive regulation of insulin secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 14701942PubMed 15486225. Source: MGI

positive regulation of transcription, DNA-templated

Inferred from direct assay PubMed 12368292. Source: MGI

regulation of cell proliferation

Inferred from direct assay PubMed 12488434. Source: MGI

regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 14701942. Source: MGI

response to chlorate

Inferred from electronic annotation. Source: Ensembl

response to cytokine

Inferred from electronic annotation. Source: Ensembl

response to drug

Inferred from electronic annotation. Source: Ensembl

response to fatty acid

Inferred from electronic annotation. Source: Ensembl

response to glucocorticoid

Inferred from electronic annotation. Source: Ensembl

response to iron(II) ion

Inferred from electronic annotation. Source: Ensembl

response to leucine

Inferred from electronic annotation. Source: Ensembl

response to nicotine

Inferred from electronic annotation. Source: Ensembl

response to vitamin

Inferred from electronic annotation. Source: Ensembl

response to wounding

Inferred from electronic annotation. Source: Ensembl

smoothened signaling pathway

Inferred from electronic annotation. Source: Ensembl

stem cell differentiation

Inferred from electronic annotation. Source: Ensembl

transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

transdifferentiation

Inferred from electronic annotation. Source: Ensembl

type B pancreatic cell differentiation

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

intracellular

Inferred from direct assay PubMed 10868931PubMed 15793245. Source: MGI

nucleus

Inferred from direct assay PubMed 12488434PubMed 14702043PubMed 15486225PubMed 15888377PubMed 18155690. Source: MGI

   Molecular_functionDNA binding

Inferred from direct assay PubMed 12368292PubMed 12972592PubMed 15486225PubMed 17056599. Source: MGI

chromatin binding

Inferred from direct assay PubMed 19651901. Source: MGI

core promoter sequence-specific DNA binding

Inferred from electronic annotation. Source: Ensembl

protein binding

Inferred from physical interaction PubMed 17056599. Source: MGI

sequence-specific DNA binding

Inferred from direct assay PubMed 14701942. Source: MGI

sequence-specific DNA binding transcription factor activity

Inferred from direct assay PubMed 15486225. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue11 EMBL AAA53037.1
Non-terminal residue271 EMBL AAA53037.1

Sequences

Sequence LengthMass (Da)Tools
Q6LEB3 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 6F33C72B12CF0015

FASTA273,311
        10         20 
LFNKYISRPR RVELAVMLNL TERHIKI 

« Hide

References

[1]"Unpublished."
Palis J.
Submitted (NOV-1993) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: CD-1 EMBL AAA53037.1.
Tissue: Early somite stage visceral yolk sac EMBL AAA53037.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L26239 mRNA. Translation: AAA53037.1.
UniGeneMm.389714.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:102851. Pdx1.

Phylogenomic databases

InParanoidQ6LEB3.

Gene expression databases

ArrayExpressQ6LEB3.
BgeeQ6LEB3.
GenevestigatorQ6LEB3.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry nameQ6LEB3_MOUSE
AccessionPrimary (citable) accession number: Q6LEB3
Entry history
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: June 11, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)