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Protein
Submitted name:

Homeodomain

Gene

Pdx1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. core promoter sequence-specific DNA binding Source: Ensembl
  3. DNA binding Source: MGI
  4. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: Ensembl
  5. sequence-specific DNA binding Source: MGI
  6. sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  1. cell differentiation Source: MGI
  2. central nervous system development Source: Ensembl
  3. detection of glucose Source: Ensembl
  4. digestive tract development Source: MGI
  5. endocrine pancreas development Source: MGI
  6. exocrine pancreas development Source: MGI
  7. glucose homeostasis Source: MGI
  8. glucose metabolic process Source: MGI
  9. insulin secretion Source: MGI
  10. liver development Source: MGI
  11. morphogenesis of embryonic epithelium Source: MGI
  12. negative regulation of cell proliferation Source: MGI
  13. negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Source: MGI
  14. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  15. negative regulation of type B pancreatic cell apoptotic process Source: MGI
  16. nitric oxide mediated signal transduction Source: MGI
  17. organ regeneration Source: Ensembl
  18. organ senescence Source: Ensembl
  19. pancreas development Source: MGI
  20. positive regulation of cell death Source: Ensembl
  21. positive regulation of cell proliferation Source: MGI
  22. positive regulation of DNA binding Source: Ensembl
  23. positive regulation of insulin secretion involved in cellular response to glucose stimulus Source: MGI
  24. positive regulation of transcription, DNA-templated Source: MGI
  25. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  26. regulation of cell proliferation Source: MGI
  27. regulation of transcription from RNA polymerase II promoter Source: MGI
  28. response to chlorate Source: Ensembl
  29. response to cytokine Source: Ensembl
  30. response to drug Source: Ensembl
  31. response to fatty acid Source: Ensembl
  32. response to glucocorticoid Source: Ensembl
  33. response to iron(II) ion Source: Ensembl
  34. response to leucine Source: Ensembl
  35. response to nicotine Source: Ensembl
  36. response to vitamin Source: Ensembl
  37. response to wounding Source: Ensembl
  38. smoothened signaling pathway Source: Ensembl
  39. stem cell differentiation Source: Ensembl
  40. transdifferentiation Source: Ensembl
  41. type B pancreatic cell differentiation Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
HomeodomainImported
Gene namesi
Name:Pdx1Imported
Synonyms:Ipf1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:102851. Pdx1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. intracellular Source: MGI
  3. nuclear speck Source: MGI
  4. nucleus Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ6LEB3.
ExpressionAtlasiQ6LEB3. baseline and differential.
GenevestigatoriQ6LEB3.

Family & Domainsi

Keywords - Domaini

HomeoboxImported

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q6LEB3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20 
LFNKYISRPR RVELAVMLNL TERHIKI
Length:27
Mass (Da):3,311
Last modified:July 5, 2004 - v1
Checksum:i6F33C72B12CF0015
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei27 – 271Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26239 mRNA. Translation: AAA53037.1.
UniGeneiMm.389714.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26239 mRNA. Translation: AAA53037.1.
UniGeneiMm.389714.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:102851. Pdx1.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiQ6LEB3.
ExpressionAtlasiQ6LEB3. baseline and differential.
GenevestigatoriQ6LEB3.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Unpublished."
    Palis J.
    Submitted (NOV-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CD-1Imported.
    Tissue: Early somite stage visceral yolk sacImported.

Entry informationi

Entry nameiQ6LEB3_MOUSE
AccessioniPrimary (citable) accession number: Q6LEB3
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: February 4, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.