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Q6LEB3

- Q6LEB3_MOUSE

UniProt

Q6LEB3 - Q6LEB3_MOUSE

Protein
Submitted name:

Homeodomain

Gene

Pdx1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. core promoter sequence-specific DNA binding Source: Ensembl
    3. DNA binding Source: MGI
    4. protein binding Source: MGI
    5. sequence-specific DNA binding Source: MGI
    6. sequence-specific DNA binding transcription factor activity Source: MGI

    GO - Biological processi

    1. cell differentiation Source: MGI
    2. central nervous system development Source: Ensembl
    3. detection of glucose Source: Ensembl
    4. digestive tract development Source: MGI
    5. endocrine pancreas development Source: MGI
    6. exocrine pancreas development Source: MGI
    7. glucose homeostasis Source: MGI
    8. glucose metabolic process Source: MGI
    9. insulin secretion Source: Ensembl
    10. liver development Source: MGI
    11. morphogenesis of embryonic epithelium Source: MGI
    12. negative regulation of cell proliferation Source: MGI
    13. negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Source: MGI
    14. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    15. negative regulation of type B pancreatic cell apoptotic process Source: MGI
    16. nitric oxide mediated signal transduction Source: Ensembl
    17. organ regeneration Source: Ensembl
    18. organ senescence Source: Ensembl
    19. pancreas development Source: MGI
    20. positive regulation of cell death Source: Ensembl
    21. positive regulation of cell proliferation Source: MGI
    22. positive regulation of DNA binding Source: Ensembl
    23. positive regulation of insulin secretion Source: Ensembl
    24. positive regulation of transcription, DNA-templated Source: MGI
    25. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    26. regulation of cell proliferation Source: MGI
    27. regulation of transcription from RNA polymerase II promoter Source: MGI
    28. response to chlorate Source: Ensembl
    29. response to cytokine Source: Ensembl
    30. response to drug Source: Ensembl
    31. response to fatty acid Source: Ensembl
    32. response to glucocorticoid Source: Ensembl
    33. response to iron(II) ion Source: Ensembl
    34. response to leucine Source: Ensembl
    35. response to nicotine Source: Ensembl
    36. response to vitamin Source: Ensembl
    37. response to wounding Source: Ensembl
    38. smoothened signaling pathway Source: Ensembl
    39. stem cell differentiation Source: Ensembl
    40. transcription from RNA polymerase II promoter Source: Ensembl
    41. transdifferentiation Source: Ensembl
    42. type B pancreatic cell differentiation Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    HomeodomainImported
    Gene namesi
    Name:Pdx1Imported
    Synonyms:Ipf1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:102851. Pdx1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. intracellular Source: MGI
    3. nucleus Source: MGI

    Expressioni

    Gene expression databases

    ArrayExpressiQ6LEB3.
    BgeeiQ6LEB3.
    GenevestigatoriQ6LEB3.

    Family & Domainsi

    Keywords - Domaini

    HomeoboxImported

    Phylogenomic databases

    InParanoidiQ6LEB3.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.

    Sequencei

    Sequence statusi: Fragment.

    Q6LEB3-1 [UniParc]FASTAAdd to Basket

    « Hide

    LFNKYISRPR RVELAVMLNL TERHIKI                            27
    Length:27
    Mass (Da):3,311
    Last modified:July 5, 2004 - v1
    Checksum:i6F33C72B12CF0015
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei27 – 271Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L26239 mRNA. Translation: AAA53037.1.
    UniGeneiMm.389714.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L26239 mRNA. Translation: AAA53037.1 .
    UniGenei Mm.389714.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:102851. Pdx1.

    Phylogenomic databases

    InParanoidi Q6LEB3.

    Miscellaneous databases

    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6LEB3.
    Bgeei Q6LEB3.
    Genevestigatori Q6LEB3.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Unpublished."
      Palis J.
      Submitted (NOV-1993) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: CD-1Imported.
      Tissue: Early somite stage visceral yolk sacImported.

    Entry informationi

    Entry nameiQ6LEB3_MOUSE
    AccessioniPrimary (citable) accession number: Q6LEB3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)