Q6LE81 (Q6LE81_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
RB1 protein EMBL AAA65744.1

Gene names

Name:

RB1 EMBL AAA65744.1

Organism

Homo sapiens (Human) EMBL AAA65744.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	35 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

Ontologies

Gene Ontology (GO)
Biological_process	cell cycle arrest Inferred from electronic annotation. Source: Compara cell division Inferred from electronic annotation. Source: Compara cell morphogenesis involved in neuron differentiation Inferred from electronic annotation. Source: Compara digestive tract development Inferred from electronic annotation. Source: Compara enucleate erythrocyte differentiation Inferred from electronic annotation. Source: Compara negative regulation of epithelial cell proliferation Inferred from electronic annotation. Source: Compara negative regulation of smoothened signaling pathway Inferred from electronic annotation. Source: Compara negative regulation of transcription involved in G1/S phase of mitotic cell cycle Inferred from electronic annotation. Source: Compara neuron apoptotic process Inferred from electronic annotation. Source: Compara neuron maturation Inferred from electronic annotation. Source: Compara neuron projection development Inferred from electronic annotation. Source: Compara positive regulation of macrophage differentiation Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara regulation of S phase of mitotic cell cycle Inferred from electronic annotation. Source: Compara striated muscle cell differentiation Inferred from electronic annotation. Source: Compara
Cellular_component	Rb-E2F complex Inferred from electronic annotation. Source: Compara spindle Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL AAA65744.1
	Non-terminal residue	35	1	EMBL AAA65744.1

Sequences

	Sequence		Length	Mass (Da)
	Q6LE81 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: ADED7EEB7D980D15	FASTA	35	4,045
	10 20 30 IMMCSMYGIC KVKNIDLKFK IIVTAYKDLP HAVQE

References

[1]	"Detection of heterozygous mutations in the RB1 gene in retinoblastoma patients using single-strand conformation polymorphism analysis and polymerase chain reaction sequencing." Hogg A., Onadim Z., Baird P.N., Cowell J.K. Oncogene 7:1445-1451(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L41908 Genomic DNA. Translation: AAA65744.1.
IPI	IPI01010522.
UniGene	Hs.408528.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q6LE81.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Gene expression databases
ArrayExpress	Q6LE81.
Bgee	Q6LE81.
Family and domain databases
Gene3D	1.10.472.10. 1 hit.
InterPro	IPR013763. Cyclin-like. IPR002719. RB_B. [Graphical view]
Pfam	PF01857. RB_B. 1 hit. [Graphical view]
SUPFAM	SSF47954. Cyclin_like. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	RB1. human.

Entry information

Entry name

Q6LE81_HUMAN

Accession

Primary (citable) accession number: Q6LE81

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	April 3, 2013
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.