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Unreviewed, UniProtKB/TrEMBL Q6LDZ3 (Q6LDZ3_RAT)

Last modified February 9, 2010. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · Ontologies · Sequences · References · Cross-references · Entry information

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Names and origin

Protein namesSubmitted name:
    Leukocyte common antigen EMBL AAA41513.1
Gene names
Name: Ptprc RGD 3451
Synonyms: L-CA EMBL AAA41513.1
OrganismRattus norvegicus (Rat) EMBL AAA41513.1
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

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Protein attributes

Sequence length962 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

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Ontologies

Keywords
   Molecular functionHydrolase RuleBase RU000691V2
Gene Ontology (GO)
   Biological processT cell proliferation

Inferred from electronic annotation. Source: Compara

T cell receptor signaling pathway

Inferred from electronic annotation. Source: Compara

activation of MAPK activity

Inferred from electronic annotation. Source: Compara

heterotypic cell-cell adhesion

Inferred from electronic annotation. Source: Compara

immunoglobulin biosynthetic process

Inferred from electronic annotation. Source: Compara

leukocyte adhesion

Inferred from electronic annotation. Source: Compara

negative regulation of peptidyl-tyrosine phosphorylation

Inferred from electronic annotation. Source: Compara

negative regulation of protein amino acid autophosphorylation

Inferred from electronic annotation. Source: Compara

negative thymic T cell selection

Inferred from electronic annotation. Source: Compara

positive regulation of B cell proliferation

Inferred from electronic annotation. Source: Compara

positive regulation of MAPKKK cascade

Inferred from electronic annotation. Source: Compara

positive regulation of T cell mediated cytotoxicity

Inferred from electronic annotation. Source: Compara

positive regulation of alpha-beta T cell proliferation

Inferred from electronic annotation. Source: Compara

positive regulation of apoptosis

Inferred from electronic annotation. Source: Compara

positive regulation of gamma-delta T cell differentiation

Inferred from electronic annotation. Source: Compara

positive regulation of humoral immune response mediated by circulating immunoglobulin

Inferred from electronic annotation. Source: Compara

positive regulation of isotype switching to IgG isotypes

Inferred from electronic annotation. Source: Compara

positive thymic T cell selection

Inferred from electronic annotation. Source: Compara

protein amino acid dephosphorylation

Traceable author statement. Source: RGD

regulation of B cell differentiation

Inferred from electronic annotation. Source: Compara

regulation of B cell receptor signaling pathway

Inferred from electronic annotation. Source: Compara

regulation of S phase

Inferred from electronic annotation. Source: Compara

response to gamma radiation

Inferred from direct assay. Source: RGD

   Cellular componentexternal side of plasma membrane

Inferred from electronic annotation. Source: Compara

integral to membrane

Inferred from direct assay. Source: RGD

internal side of plasma membrane

Traceable author statement. Source: RGD

   Molecular functionheparan sulfate proteoglycan binding

Inferred from electronic annotation. Source: Compara

heparin binding

Inferred from electronic annotation. Source: Compara

protein kinase binding

Inferred from electronic annotation. Source: Compara

protein kinase regulator activity

Traceable author statement. Source: RGD

transmembrane receptor protein tyrosine phosphatase activity

Traceable author statement. Source: RGD

Complete GO annotation...

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Sequences

Sequence LengthMass (Da)Tools
Q6LDZ3-1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: D2E6B7F23D29CC92

FASTA962109,934
        10         20         30         40         50         60 
MKTFALDKHG TLWLHNLTVR TNYTCAAEVL YNNVILLKQD RRVQTDFGTP EMLPHVQCKN 

        70         80         90        100        110        120 
STNSTTLVSW AEPASKHHGY ILCYKKTPSE KCENLANDVN SFEVKNLRPY TEYTVSLFAY 

       130        140        150        160        170        180 
VIGRVQRNGP AKDCNFRTKA ARPGKVNGMK TSRASDNSIN VTCNSPYEIN GPEARYILEV 

       190        200        210        220        230        240 
KSGGSLVKTF NQSTCKFVVD NLYYSTDYEF LVYFYNGEYL GDPEIKPQST SYNSKALIIF 

       250        260        270        280        290        300 
LVFLIIVTSI ALLVVLYKIY DLRKKRSSNL DEQQELVERD EEKQLINVDP IHSDLLLETY 

       310        320        330        340        350        360 
KRKIADEGRL FLAEFQSIPR VFSKFPIKDA RKSQNQNKNR YVDILPYDYN RVELSEINGD 

       370        380        390        400        410        420 
AGSTYINASY IDGFKEPRKY IAAQGPRDET VDDFWKMIWE QKATVIVMVT RCEEGNRNKC 

       430        440        450        460        470        480 
AEYWPCMEEG TRTFRDVVVT INDHKRCPDY IIQKLSIAHK KEKATGREVT HIQFTSWPDH 

       490        500        510        520        530        540 
GVPEDPHLLL KLRRRVNAFS NFFSGPIVVH CSAGVGRTGT YIGIDAMLES LEAEGKVDVY 

       550        560        570        580        590        600 
GYVVNLRRQR CLMVQVEAQY ILIHQALVEY NQFGETEVNL SELHSCLQNL KKRDPPSDPS 

       610        620        630        640        650        660 
PLEAEYQRLP SYRSWRTQHI GNQEENKKKN RSSNVVPYDF NRVPLKHELE MSKESEAESD 

       670        680        690        700        710        720 
ESSDEDSDSE ETSKYINASF VMSYWKPEMM IAAQGPLKET IGDFWQMIFQ RKVKVIVMLT 

       730        740        750        760        770        780 
ELMSGDQEVC AQYWGEGKQT YGDMEVMLKD TNKSSAYILR AFELRHSKRK EPRTVYQYQC 

       790        800        810        820        830        840 
TTWKGEELPA EPKDLVTLIQ NIKQKLPKSG SEGMKYHKHA SILVHCRDGS QQTGLFCALF 

       850        860        870        880        890        900 
NLLESAETED VVDVFQVVKS LRKARPGMVG SFEQYQFLYD IMASIYPTQN GQVKKANSQD 

       910        920        930        940        950        960 
KIEFHNEVDG AKQDANCVQP ADPLNKAQED SKEVGASEPA SGSEEPEHSA NGPMSPALTP 


SS

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References

[1]"Evidence from cDNA clones that the rat leukocyte-common antigen (T200) spans the lipid bilayer and contains a cytoplasmic domain of 80,000 Mr."
Thomas M.L., Barclay A.N., Gagnon J., Williams A.F.
Cell 41:83-93(1985) [PubMed: 3158393] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Sprague-Dawley EMBL AAA41513.1.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M10072 mRNA. Translation: AAA41513.1.
IPIIPI00777870.
RefSeqNP_001103357.1.
NP_001103358.1.
NP_001103359.1.
NP_001103360.1.
NP_612516.2.
UniGeneRn.90166

3D structure databases

HSSPHSSP built from PDB template 1A5Y based on UniProtKB P18031.
SMRQ6LDZ3. Positions 46-221, 257-571, 283-887.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ6LDZ3.

Genome annotation databases

EnsemblENSRNOT00000000814; ENSRNOP00000000814; ENSRNOG00000000655; Rattus norvegicus. [Genome view]
ENSRNOT00000029865; ENSRNOP00000029889; ENSRNOG00000000655; Rattus norvegicus. [Genome view]
ENSRNOT00000029878; ENSRNOP00000030503; ENSRNOG00000000655; Rattus norvegicus. [Genome view]
ENSRNOT00000060292; ENSRNOP00000057042; ENSRNOG00000000655; Rattus norvegicus. [Genome view]
ENSRNOT00000064785; ENSRNOP00000063859; ENSRNOG00000000655; Rattus norvegicus. [Genome view]
GeneID24699.
KEGGrno:24699.
UCSCNM_138507. rat.

Organism-specific databases

CTD24699.

Phylogenomic databases

HOVERGENQ6LDZ3.
InParanoidQ6LDZ3.
OrthoDBEOG9SJ80D.
PhylomeDBQ6LDZ3.

Gene expression databases

ArrayExpressQ6LDZ3.
GenevestigatorQ6LDZ3.

Family and domain databases

InterProIPR000387. Dual-sp/Tyr_phosphatase.
IPR008957. Fibronectin_typ-III-like_fold.
IPR003961. FN_III.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
Gene3DG3DSA:2.60.40.30. FN_III-like. 1 hit.
PfamPF00041. fn3. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSPR00700. PRTYPHPHTASE.
SMARTSM00060. FN3. 2 hits.
SM00194. PTPc. 2 hits.
[Graphical view]
PROSITEPS50853. FN3. 2 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio604155.

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Entry information

Entry nameQ6LDZ3_RAT
AccessionPrimary (citable) accession number: Q6LDZ3
Entry history
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: February 9, 2010
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
Names and origin · Protein attributes · Ontologies · Sequences · References · Cross-references · Entry information