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Q6LDS4

- Q6LDS4_RAT

UniProt

Q6LDS4 - Q6LDS4_RAT

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Protein
Superoxide dismutase [Cu-Zn]
Gene
Sod1
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems By similarity.UniRule annotation

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

Cofactori

Binds 1 copper ion per subunit By similarity.UniRule annotation
Binds 1 zinc ion per subunit By similarity.UniRule annotation

GO - Molecular functioni

  1. copper ion binding Source: Ensembl
  2. superoxide dismutase activity Source: UniProtKB-EC
  3. zinc ion binding Source: Ensembl
Complete GO annotation...

GO - Biological processi

  1. activation of MAPK activity Source: Ensembl
  2. anterograde axon cargo transport Source: Ensembl
  3. auditory receptor cell stereocilium organization Source: Ensembl
  4. cell aging Source: Ensembl
  5. cellular iron ion homeostasis Source: Ensembl
  6. embryo implantation Source: Ensembl
  7. glutathione metabolic process Source: Ensembl
  8. heart contraction Source: Ensembl
  9. hydrogen peroxide biosynthetic process Source: Ensembl
  10. locomotory behavior Source: Ensembl
  11. muscle cell cellular homeostasis Source: Ensembl
  12. myeloid cell homeostasis Source: Ensembl
  13. negative regulation of cholesterol biosynthetic process Source: Ensembl
  14. negative regulation of neuron apoptotic process Source: Ensembl
  15. neurofilament cytoskeleton organization Source: Ensembl
  16. ovarian follicle development Source: Ensembl
  17. peripheral nervous system myelin maintenance Source: Ensembl
  18. positive regulation of cytokine production Source: Ensembl
  19. positive regulation of intrinsic apoptotic signaling pathway in response to oxidative stress Source: Ensembl
  20. positive regulation of superoxide anion generation Source: Ensembl
  21. regulation of Rac GTPase activity Source: Ensembl
  22. regulation of blood pressure Source: Ensembl
  23. regulation of mitochondrial membrane potential Source: Ensembl
  24. regulation of multicellular organism growth Source: Ensembl
  25. relaxation of vascular smooth muscle Source: Ensembl
  26. response to axon injury Source: Ensembl
  27. response to drug Source: Ensembl
  28. response to ethanol Source: Ensembl
  29. response to heat Source: Ensembl
  30. response to hydrogen peroxide Source: Ensembl
  31. retina homeostasis Source: Ensembl
  32. retrograde axon cargo transport Source: Ensembl
  33. sensory perception of sound Source: Ensembl
  34. spermatogenesis Source: Ensembl
  35. superoxide anion generation Source: Ensembl
  36. transmission of nerve impulse Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Ligandi

CopperUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn]UniRule annotation (EC:1.15.1.1UniRule annotation)
Gene namesi
Name:Sod1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi3731. Sod1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasmic vesicle Source: Ensembl
  2. cytosol Source: Ensembl
  3. dendrite cytoplasm Source: Ensembl
  4. extracellular matrix Source: Ensembl
  5. extracellular space Source: Ensembl
  6. mitochondrion Source: Ensembl
  7. neuronal cell body Source: Ensembl
  8. nucleus Source: Ensembl
  9. plasma membrane Source: Ensembl
  10. protein complex Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ6LDS4.

Expressioni

Gene expression databases

GenevestigatoriQ6LDS4.

Structurei

3D structure databases

ProteinModelPortaliQ6LDS4.
SMRiQ6LDS4. Positions 2-152.

Family & Domainsi

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG000062.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
PRINTSiPR00068. CUZNDISMTASE.
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6LDS4-1 [UniParc]FASTAAdd to Basket

« Hide

MKAVCVLKGD GPVQGVIHFE QKASGEPVVV SGQITGLTEG EHGFHVHQYG    50
DNTQGCTTAG PHFNPHSKKH GGPADEERHV GDLGNVAAGK DGVANVSIED 100
RVISLSGEHS IIGRTMVVHE KQDDLGKGGN EESTKTGNAG SRLACGVIGI 150
AQ 152
Length:152
Mass (Da):15,709
Last modified:July 5, 2004 - v1
Checksum:i4630256A2B0F3CB4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M21060 mRNA. Translation: AAA40996.1.
UniGeneiRn.6059.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M21060 mRNA. Translation: AAA40996.1 .
UniGenei Rn.6059.

3D structure databases

ProteinModelPortali Q6LDS4.
SMRi Q6LDS4. Positions 2-152.
ModBasei Search...

Proteomic databases

PRIDEi Q6LDS4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

RGDi 3731. Sod1.

Phylogenomic databases

HOVERGENi HBG000062.

Gene expression databases

Genevestigatori Q6LDS4.

Family and domain databases

Gene3Di 2.60.40.200. 1 hit.
InterProi IPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view ]
Pfami PF00080. Sod_Cu. 1 hit.
[Graphical view ]
PRINTSi PR00068. CUZNDISMTASE.
SUPFAMi SSF49329. SSF49329. 1 hit.
PROSITEi PS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and nucleotide sequence of rat Cu/Zn superoxide dismutase cDNA clones."
    Puga A., Oates E.L.
    Free Radic. Res. Commun. 3:337-346(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ6LDS4_RAT
AccessioniPrimary (citable) accession number: Q6LDS4
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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