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Protein

Superoxide dismutase [Cu-Zn]

Gene

Sod1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Cu cationUniRule annotationNote: Binds 1 copper ion per subunit.UniRule annotation
  • Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandCopperUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn]UniRule annotation (EC:1.15.1.1UniRule annotation)
Gene namesi
Name:Sod1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi3731. Sod1.

PTM / Processingi

Proteomic databases

PaxDbiQ6LDS4.
PRIDEiQ6LDS4.

Structurei

3D structure databases

ProteinModelPortaliQ6LDS4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 148Sod_CuInterPro annotationAdd BLAST139

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0441. Eukaryota.
COG2032. LUCA.
HOVERGENiHBG000062.

Family and domain databases

CDDicd00305. Cu-Zn_Superoxide_Dismutase. 1 hit.
Gene3Di2.60.40.200. 1 hit.
InterProiView protein in InterPro
IPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
PfamiView protein in Pfam
PF00080. Sod_Cu. 1 hit.
PRINTSiPR00068. CUZNDISMTASE.
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiView protein in PROSITE
PS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6LDS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAVCVLKGD GPVQGVIHFE QKASGEPVVV SGQITGLTEG EHGFHVHQYG
60 70 80 90 100
DNTQGCTTAG PHFNPHSKKH GGPADEERHV GDLGNVAAGK DGVANVSIED
110 120 130 140 150
RVISLSGEHS IIGRTMVVHE KQDDLGKGGN EESTKTGNAG SRLACGVIGI

AQ
Length:152
Mass (Da):15,709
Last modified:July 5, 2004 - v1
Checksum:i4630256A2B0F3CB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21060 mRNA. Translation: AAA40996.1.
UniGeneiRn.6059.

Similar proteinsi

Entry informationi

Entry nameiQ6LDS4_RAT
AccessioniPrimary (citable) accession number: Q6LDS4
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: August 30, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)