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Q6LDS4

- Q6LDS4_RAT

UniProt

Q6LDS4 - Q6LDS4_RAT

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Protein

Superoxide dismutase [Cu-Zn]

Gene

Sod1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Note: Binds 1 copper ion per subunit.UniRule annotation
  • Note: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

  1. copper ion binding Source: Ensembl
  2. superoxide dismutase activity Source: UniProtKB-EC
  3. zinc ion binding Source: Ensembl

GO - Biological processi

  1. activation of MAPK activity Source: Ensembl
  2. anterograde axon cargo transport Source: Ensembl
  3. auditory receptor cell stereocilium organization Source: Ensembl
  4. cell aging Source: Ensembl
  5. cellular iron ion homeostasis Source: Ensembl
  6. embryo implantation Source: Ensembl
  7. glutathione metabolic process Source: Ensembl
  8. heart contraction Source: Ensembl
  9. hydrogen peroxide biosynthetic process Source: Ensembl
  10. locomotory behavior Source: Ensembl
  11. muscle cell cellular homeostasis Source: Ensembl
  12. myeloid cell homeostasis Source: Ensembl
  13. negative regulation of cholesterol biosynthetic process Source: Ensembl
  14. negative regulation of neuron apoptotic process Source: Ensembl
  15. neurofilament cytoskeleton organization Source: Ensembl
  16. ovarian follicle development Source: Ensembl
  17. peripheral nervous system myelin maintenance Source: Ensembl
  18. positive regulation of cytokine production Source: Ensembl
  19. positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Source: Ensembl
  20. positive regulation of superoxide anion generation Source: Ensembl
  21. regulation of blood pressure Source: Ensembl
  22. regulation of mitochondrial membrane potential Source: Ensembl
  23. regulation of multicellular organism growth Source: Ensembl
  24. regulation of Rac GTPase activity Source: Ensembl
  25. relaxation of vascular smooth muscle Source: Ensembl
  26. response to axon injury Source: Ensembl
  27. response to drug Source: Ensembl
  28. response to ethanol Source: Ensembl
  29. response to heat Source: Ensembl
  30. response to hydrogen peroxide Source: Ensembl
  31. retina homeostasis Source: Ensembl
  32. retrograde axon cargo transport Source: Ensembl
  33. sensory perception of sound Source: Ensembl
  34. spermatogenesis Source: Ensembl
  35. superoxide anion generation Source: Ensembl
  36. transmission of nerve impulse Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Ligandi

CopperUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn]UniRule annotation (EC:1.15.1.1UniRule annotation)
Gene namesi
Name:Sod1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi3731. Sod1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasmic vesicle Source: Ensembl
  2. cytosol Source: Ensembl
  3. dendrite cytoplasm Source: Ensembl
  4. extracellular matrix Source: Ensembl
  5. extracellular space Source: Ensembl
  6. extracellular vesicular exosome Source: Ensembl
  7. mitochondrion Source: Ensembl
  8. neuronal cell body Source: Ensembl
  9. nucleus Source: Ensembl
  10. plasma membrane Source: Ensembl
  11. protein complex Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ6LDS4.

Expressioni

Gene expression databases

ExpressionAtlasiQ6LDS4. baseline.
GenevestigatoriQ6LDS4.

Structurei

3D structure databases

ProteinModelPortaliQ6LDS4.
SMRiQ6LDS4. Positions 2-152.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG000062.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
PRINTSiPR00068. CUZNDISMTASE.
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6LDS4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKAVCVLKGD GPVQGVIHFE QKASGEPVVV SGQITGLTEG EHGFHVHQYG
60 70 80 90 100
DNTQGCTTAG PHFNPHSKKH GGPADEERHV GDLGNVAAGK DGVANVSIED
110 120 130 140 150
RVISLSGEHS IIGRTMVVHE KQDDLGKGGN EESTKTGNAG SRLACGVIGI

AQ
Length:152
Mass (Da):15,709
Last modified:July 5, 2004 - v1
Checksum:i4630256A2B0F3CB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21060 mRNA. Translation: AAA40996.1.
UniGeneiRn.6059.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21060 mRNA. Translation: AAA40996.1 .
UniGenei Rn.6059.

3D structure databases

ProteinModelPortali Q6LDS4.
SMRi Q6LDS4. Positions 2-152.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q6LDS4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

RGDi 3731. Sod1.

Phylogenomic databases

HOVERGENi HBG000062.

Gene expression databases

ExpressionAtlasi Q6LDS4. baseline.
Genevestigatori Q6LDS4.

Family and domain databases

Gene3Di 2.60.40.200. 1 hit.
InterProi IPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view ]
Pfami PF00080. Sod_Cu. 1 hit.
[Graphical view ]
PRINTSi PR00068. CUZNDISMTASE.
SUPFAMi SSF49329. SSF49329. 1 hit.
PROSITEi PS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and nucleotide sequence of rat Cu/Zn superoxide dismutase cDNA clones."
    Puga A., Oates E.L.
    Free Radic. Res. Commun. 3:337-346(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ6LDS4_RAT
AccessioniPrimary (citable) accession number: Q6LDS4
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: November 26, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)