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Q6LDS4 (Q6LDS4_RAT) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Superoxide dismutase [Cu-Zn] RuleBase RU000393

EC=1.15.1.1 RuleBase RU000393
Gene names
Name:Sod1 RGD 3731
OrganismRattus norvegicus (Rat) EMBL AAA40996.1
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length152 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Destroys radicals which are normally produced within the cells and which are toxic to biological systems By similarity. RuleBase RU000393

Catalytic activity

2 superoxide + 2 H+ = O2 + H2O2. RuleBase RU000393

Cofactor

Binds 1 copper ion per subunit By similarity. RuleBase RU000393

Binds 1 zinc ion per subunit By similarity. RuleBase RU000393

Sequence similarities

Belongs to the Cu-Zn superoxide dismutase family. RuleBase RU000393

Ontologies

Keywords
   LigandCopper RuleBase RU000393 SAAS SAAS024134
Metal-binding RuleBase RU000393 SAAS SAAS024134
Zinc RuleBase RU000393 SAAS SAAS024134
   Molecular functionOxidoreductase RuleBase RU000393
Gene Ontology (GO)
   Biological_processactivation of MAPK activity

Inferred from electronic annotation. Source: Ensembl

anterograde axon cargo transport

Inferred from electronic annotation. Source: Ensembl

auditory receptor cell stereocilium organization

Inferred from electronic annotation. Source: Ensembl

cell aging

Inferred from electronic annotation. Source: Ensembl

cellular iron ion homeostasis

Inferred from electronic annotation. Source: Ensembl

embryo implantation

Inferred from electronic annotation. Source: Ensembl

glutathione metabolic process

Inferred from electronic annotation. Source: Ensembl

heart contraction

Inferred from electronic annotation. Source: Ensembl

hydrogen peroxide biosynthetic process

Inferred from electronic annotation. Source: Ensembl

locomotory behavior

Inferred from electronic annotation. Source: Ensembl

muscle cell cellular homeostasis

Inferred from electronic annotation. Source: Ensembl

myeloid cell homeostasis

Inferred from electronic annotation. Source: Ensembl

negative regulation of cholesterol biosynthetic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of neuron apoptotic process

Inferred from electronic annotation. Source: Ensembl

neurofilament cytoskeleton organization

Inferred from electronic annotation. Source: Ensembl

ovarian follicle development

Inferred from electronic annotation. Source: Ensembl

peripheral nervous system myelin maintenance

Inferred from electronic annotation. Source: Ensembl

positive regulation of cytokine production

Inferred from electronic annotation. Source: Ensembl

positive regulation of intrinsic apoptotic signaling pathway in response to oxidative stress

Inferred from electronic annotation. Source: Ensembl

positive regulation of superoxide anion generation

Inferred from electronic annotation. Source: Ensembl

regulation of Rac GTPase activity

Inferred from electronic annotation. Source: Ensembl

regulation of blood pressure

Inferred from electronic annotation. Source: Ensembl

regulation of mitochondrial membrane potential

Inferred from electronic annotation. Source: Ensembl

regulation of multicellular organism growth

Inferred from electronic annotation. Source: Ensembl

relaxation of vascular smooth muscle

Inferred from electronic annotation. Source: Ensembl

removal of superoxide radicals

Inferred from electronic annotation. Source: Ensembl

response to axon injury

Inferred from electronic annotation. Source: Ensembl

response to drug

Inferred from electronic annotation. Source: Ensembl

response to ethanol

Inferred from electronic annotation. Source: Ensembl

response to heat

Inferred from electronic annotation. Source: Ensembl

response to hydrogen peroxide

Inferred from electronic annotation. Source: Ensembl

retina homeostasis

Inferred from electronic annotation. Source: Ensembl

retrograde axon cargo transport

Inferred from electronic annotation. Source: Ensembl

sensory perception of sound

Inferred from electronic annotation. Source: Ensembl

spermatogenesis

Inferred from electronic annotation. Source: Ensembl

superoxide anion generation

Inferred from electronic annotation. Source: Ensembl

transmission of nerve impulse

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasmic vesicle

Inferred from electronic annotation. Source: Ensembl

cytosol

Inferred from electronic annotation. Source: Ensembl

dendrite cytoplasm

Inferred from electronic annotation. Source: Ensembl

extracellular matrix

Inferred from electronic annotation. Source: Ensembl

extracellular space

Inferred from electronic annotation. Source: Ensembl

mitochondrion

Inferred from electronic annotation. Source: Ensembl

neuronal cell body

Inferred from electronic annotation. Source: Ensembl

nucleus

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Inferred from electronic annotation. Source: Ensembl

protein complex

Inferred from electronic annotation. Source: Ensembl

   Molecular_functioncopper ion binding

Inferred from electronic annotation. Source: Ensembl

superoxide dismutase activity

Inferred from electronic annotation. Source: UniProtKB-EC

zinc ion binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q6LDS4 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 4630256A2B0F3CB4

FASTA15215,709
        10         20         30         40         50         60 
MKAVCVLKGD GPVQGVIHFE QKASGEPVVV SGQITGLTEG EHGFHVHQYG DNTQGCTTAG 

        70         80         90        100        110        120 
PHFNPHSKKH GGPADEERHV GDLGNVAAGK DGVANVSIED RVISLSGEHS IIGRTMVVHE 

       130        140        150 
KQDDLGKGGN EESTKTGNAG SRLACGVIGI AQ 

« Hide

References

[1]"Isolation and nucleotide sequence of rat Cu/Zn superoxide dismutase cDNA clones."
Puga A., Oates E.L.
Free Radic. Res. Commun. 3:337-346(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M21060 mRNA. Translation: AAA40996.1.
UniGeneRn.6059.

3D structure databases

ProteinModelPortalQ6LDS4.
SMRQ6LDS4. Positions 2-152.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ6LDS4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

RGD3731. Sod1.

Phylogenomic databases

HOVERGENHBG000062.

Gene expression databases

GenevestigatorQ6LDS4.

Family and domain databases

Gene3D2.60.40.200. 1 hit.
InterProIPR024134. SOD_Cu/Zn_/chaperone.
IPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PANTHERPTHR10003. PTHR10003. 1 hit.
PfamPF00080. Sod_Cu. 1 hit.
[Graphical view]
PRINTSPR00068. CUZNDISMTASE.
SUPFAMSSF49329. SSF49329. 1 hit.
PROSITEPS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ6LDS4_RAT
AccessionPrimary (citable) accession number: Q6LDS4
Entry history
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)