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Q6LDS4

- Q6LDS4_RAT

UniProt

Q6LDS4 - Q6LDS4_RAT

Protein

Superoxide dismutase [Cu-Zn]

Gene

Sod1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation

    Catalytic activityi

    2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

    Cofactori

    Binds 1 copper ion per subunit.UniRule annotation
    Binds 1 zinc ion per subunit.UniRule annotation

    GO - Molecular functioni

    1. copper ion binding Source: Ensembl
    2. superoxide dismutase activity Source: UniProtKB-EC
    3. zinc ion binding Source: Ensembl

    GO - Biological processi

    1. activation of MAPK activity Source: Ensembl
    2. anterograde axon cargo transport Source: Ensembl
    3. auditory receptor cell stereocilium organization Source: Ensembl
    4. cell aging Source: Ensembl
    5. cellular iron ion homeostasis Source: Ensembl
    6. embryo implantation Source: Ensembl
    7. glutathione metabolic process Source: Ensembl
    8. heart contraction Source: Ensembl
    9. hydrogen peroxide biosynthetic process Source: Ensembl
    10. locomotory behavior Source: Ensembl
    11. muscle cell cellular homeostasis Source: Ensembl
    12. myeloid cell homeostasis Source: Ensembl
    13. negative regulation of cholesterol biosynthetic process Source: Ensembl
    14. negative regulation of neuron apoptotic process Source: Ensembl
    15. neurofilament cytoskeleton organization Source: Ensembl
    16. ovarian follicle development Source: Ensembl
    17. peripheral nervous system myelin maintenance Source: Ensembl
    18. positive regulation of cytokine production Source: Ensembl
    19. positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Source: Ensembl
    20. positive regulation of superoxide anion generation Source: Ensembl
    21. regulation of blood pressure Source: Ensembl
    22. regulation of mitochondrial membrane potential Source: Ensembl
    23. regulation of multicellular organism growth Source: Ensembl
    24. regulation of Rac GTPase activity Source: Ensembl
    25. relaxation of vascular smooth muscle Source: Ensembl
    26. response to axon injury Source: Ensembl
    27. response to drug Source: Ensembl
    28. response to ethanol Source: Ensembl
    29. response to heat Source: Ensembl
    30. response to hydrogen peroxide Source: Ensembl
    31. retina homeostasis Source: Ensembl
    32. retrograde axon cargo transport Source: Ensembl
    33. sensory perception of sound Source: Ensembl
    34. spermatogenesis Source: Ensembl
    35. superoxide anion generation Source: Ensembl
    36. transmission of nerve impulse Source: Ensembl

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Ligandi

    CopperUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Superoxide dismutase [Cu-Zn]UniRule annotation (EC:1.15.1.1UniRule annotation)
    Gene namesi
    Name:Sod1Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

    Organism-specific databases

    RGDi3731. Sod1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasmic vesicle Source: Ensembl
    2. cytosol Source: Ensembl
    3. dendrite cytoplasm Source: Ensembl
    4. extracellular matrix Source: Ensembl
    5. extracellular space Source: Ensembl
    6. mitochondrion Source: Ensembl
    7. neuronal cell body Source: Ensembl
    8. nucleus Source: Ensembl
    9. plasma membrane Source: Ensembl
    10. protein complex Source: Ensembl

    PTM / Processingi

    Proteomic databases

    PRIDEiQ6LDS4.

    Expressioni

    Gene expression databases

    GenevestigatoriQ6LDS4.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6LDS4.
    SMRiQ6LDS4. Positions 2-152.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Cu-Zn superoxide dismutase family.UniRule annotation

    Phylogenomic databases

    HOVERGENiHBG000062.

    Family and domain databases

    Gene3Di2.60.40.200. 1 hit.
    InterProiIPR018152. SOD_Cu/Zn_BS.
    IPR001424. SOD_Cu_Zn_dom.
    [Graphical view]
    PfamiPF00080. Sod_Cu. 1 hit.
    [Graphical view]
    PRINTSiPR00068. CUZNDISMTASE.
    SUPFAMiSSF49329. SSF49329. 1 hit.
    PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
    PS00332. SOD_CU_ZN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6LDS4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKAVCVLKGD GPVQGVIHFE QKASGEPVVV SGQITGLTEG EHGFHVHQYG    50
    DNTQGCTTAG PHFNPHSKKH GGPADEERHV GDLGNVAAGK DGVANVSIED 100
    RVISLSGEHS IIGRTMVVHE KQDDLGKGGN EESTKTGNAG SRLACGVIGI 150
    AQ 152
    Length:152
    Mass (Da):15,709
    Last modified:July 5, 2004 - v1
    Checksum:i4630256A2B0F3CB4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M21060 mRNA. Translation: AAA40996.1.
    UniGeneiRn.6059.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M21060 mRNA. Translation: AAA40996.1 .
    UniGenei Rn.6059.

    3D structure databases

    ProteinModelPortali Q6LDS4.
    SMRi Q6LDS4. Positions 2-152.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q6LDS4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    RGDi 3731. Sod1.

    Phylogenomic databases

    HOVERGENi HBG000062.

    Gene expression databases

    Genevestigatori Q6LDS4.

    Family and domain databases

    Gene3Di 2.60.40.200. 1 hit.
    InterProi IPR018152. SOD_Cu/Zn_BS.
    IPR001424. SOD_Cu_Zn_dom.
    [Graphical view ]
    Pfami PF00080. Sod_Cu. 1 hit.
    [Graphical view ]
    PRINTSi PR00068. CUZNDISMTASE.
    SUPFAMi SSF49329. SSF49329. 1 hit.
    PROSITEi PS00087. SOD_CU_ZN_1. 1 hit.
    PS00332. SOD_CU_ZN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and nucleotide sequence of rat Cu/Zn superoxide dismutase cDNA clones."
      Puga A., Oates E.L.
      Free Radic. Res. Commun. 3:337-346(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ6LDS4_RAT
    AccessioniPrimary (citable) accession number: Q6LDS4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)