Q6LDS4 (Q6LDS4_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Superoxide dismutase [Cu-Zn] RuleBase RU000393
EC=1.15.1.1 RuleBase RU000393

Gene names

Name:

Sod1 RGD 3731

Organism

Rattus norvegicus (Rat) EMBL AAA40996.1

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	152 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Destroys radicals which are normally produced within the cells and which are toxic to biological systems By similarity. RuleBase RU000393
Catalytic activity	2 superoxide + 2 H+ = O2 + H2O2. RuleBase RU000393
Cofactor	Binds 1 copper ion per subunit By similarity. RuleBase RU000393 Binds 1 zinc ion per subunit By similarity. RuleBase RU000393
Sequence similarities	Belongs to the Cu-Zn superoxide dismutase family. RuleBase RU000393

Ontologies

Keywords
Ligand	Copper RuleBase RU000393 Metal-binding RuleBase RU000393 Zinc RuleBase RU000393
Molecular function	Oxidoreductase RuleBase RU000393
Gene Ontology (GO)
Biological_process	activation of MAPK activity Inferred from electronic annotation. Source: Compara anterograde axon cargo transport Inferred from electronic annotation. Source: Compara apoptotic DNA fragmentation Inferred from electronic annotation. Source: Compara auditory receptor cell stereocilium organization Inferred from electronic annotation. Source: Compara cell aging Inferred from electronic annotation. Source: Compara cellular iron ion homeostasis Inferred from electronic annotation. Source: Compara double-strand break repair Inferred from electronic annotation. Source: Compara embryo implantation Inferred from electronic annotation. Source: Compara glutathione metabolic process Inferred from electronic annotation. Source: Compara heart contraction Inferred from electronic annotation. Source: Compara hydrogen peroxide biosynthetic process Inferred from electronic annotation. Source: Compara locomotory behavior Inferred from electronic annotation. Source: Compara muscle cell homeostasis Inferred from electronic annotation. Source: Compara myeloid cell homeostasis Inferred from electronic annotation. Source: Compara negative regulation of cholesterol biosynthetic process Inferred from electronic annotation. Source: Compara negative regulation of neuron apoptotic process Inferred from electronic annotation. Source: Compara neurofilament cytoskeleton organization Inferred from electronic annotation. Source: Compara ovarian follicle development Inferred from electronic annotation. Source: Compara peripheral nervous system myelin maintenance Inferred from electronic annotation. Source: Compara positive regulation of cytokine production Inferred from electronic annotation. Source: Compara regulation of blood pressure Inferred from electronic annotation. Source: Compara regulation of mitochondrial membrane potential Inferred from electronic annotation. Source: Compara regulation of multicellular organism growth Inferred from electronic annotation. Source: Compara relaxation of vascular smooth muscle Inferred from electronic annotation. Source: Compara removal of superoxide radicals Inferred from electronic annotation. Source: Compara response to axon injury Inferred from electronic annotation. Source: Compara response to drug Inferred from electronic annotation. Source: Compara response to ethanol Inferred from electronic annotation. Source: Compara response to heat Inferred from electronic annotation. Source: Compara response to hydrogen peroxide Inferred from electronic annotation. Source: Compara retina homeostasis Inferred from electronic annotation. Source: Compara retrograde axon cargo transport Inferred from electronic annotation. Source: Compara sensory perception of sound Inferred from electronic annotation. Source: Compara spermatogenesis Inferred from electronic annotation. Source: Compara superoxide anion generation Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasmic vesicle Inferred from electronic annotation. Source: Compara cytosol Inferred from electronic annotation. Source: Compara dendrite cytoplasm Inferred from electronic annotation. Source: Compara extracellular matrix Inferred from electronic annotation. Source: Compara extracellular space Inferred from electronic annotation. Source: Compara mitochondrion Inferred from electronic annotation. Source: Compara neuronal cell body Inferred from electronic annotation. Source: Compara nucleus Inferred from electronic annotation. Source: Compara plasma membrane Inferred from electronic annotation. Source: Compara protein complex Inferred from electronic annotation. Source: Compara
Molecular_function	copper ion binding Inferred from electronic annotation. Source: Compara superoxide dismutase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q6LDS4 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 4630256A2B0F3CB4	FASTA	152	15,709
	10 20 30 40 50 60 MKAVCVLKGD GPVQGVIHFE QKASGEPVVV SGQITGLTEG EHGFHVHQYG DNTQGCTTAG 70 80 90 100 110 120 PHFNPHSKKH GGPADEERHV GDLGNVAAGK DGVANVSIED RVISLSGEHS IIGRTMVVHE 130 140 150 KQDDLGKGGN EESTKTGNAG SRLACGVIGI AQ

References

[1]	"Isolation and nucleotide sequence of rat Cu/Zn superoxide dismutase cDNA clones." Puga A., Oates E.L. Free Radic. Res. Commun. 3:337-346(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M21060 mRNA. Translation: AAA40996.1.
IPI	IPI00231643.
UniGene	Rn.6059.
3D structure databases
HSSP	HSSP built from PDB template 1AZV based on UniProtKB P00441.
ProteinModelPortal	Q6LDS4.
SMR	Q6LDS4. Positions 2-152.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6LDS4.
Proteomic databases
PRIDE	Q6LDS4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
RGD	3731. Sod1.
Phylogenomic databases
HOVERGEN	HBG000062.
Gene expression databases
ArrayExpress	Q6LDS4.
Genevestigator	Q6LDS4.
Family and domain databases
Gene3D	2.60.40.200. 1 hit.
InterPro	IPR024134. SOD_Cu/Zn_/chaperones. IPR018152. SOD_Cu/Zn_BS. IPR001424. SOD_Cu_Zn_dom. [Graphical view]
PANTHER	PTHR10003. PTHR10003. 1 hit.
Pfam	PF00080. Sod_Cu. 1 hit. [Graphical view]
PRINTS	PR00068. CUZNDISMTASE.
SUPFAM	SSF49329. SOD_Cu_Zn. 1 hit.
PROSITE	PS00087. SOD_CU_ZN_1. 1 hit. PS00332. SOD_CU_ZN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q6LDS4_RAT

Accession

Primary (citable) accession number: Q6LDS4

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	April 3, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)