Skip Header

Contribute Send feedback
Read comments (0) or add your own

Unreviewed, UniProtKB/TrEMBL Q6LDN6 (Q6LDN6_HUMAN)

Last modified January 19, 2010. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information

Names and origin

Protein namesSubmitted name:
    CD45 EMBL AAS46930.1
Submitted name:
    Leukocyte common antigen EMBL AAA59497.1
Gene names
Name: PTPRC EMBL AAA59497.1
OrganismHomo sapiens (Human) EMBL AAA59497.1
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length47 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level.

Ontologies

Gene Ontology (GO)
   Biological processT cell proliferation

Inferred from electronic annotation. Source: Compara

activation of MAPK activity

Inferred from electronic annotation. Source: Compara

heterotypic cell-cell adhesion

Inferred from electronic annotation. Source: Compara

leukocyte adhesion

Inferred from electronic annotation. Source: Compara

negative regulation of peptidyl-tyrosine phosphorylation

Inferred from electronic annotation. Source: Compara

negative regulation of protein amino acid autophosphorylation

Inferred from electronic annotation. Source: Compara

negative thymic T cell selection

Inferred from electronic annotation. Source: Compara

positive regulation of B cell proliferation

Inferred from electronic annotation. Source: Compara

positive regulation of MAPKKK cascade

Inferred from electronic annotation. Source: Compara

positive regulation of T cell mediated cytotoxicity

Inferred from electronic annotation. Source: Compara

positive regulation of alpha-beta T cell proliferation

Inferred from electronic annotation. Source: Compara

positive regulation of apoptosis

Inferred from electronic annotation. Source: Compara

positive regulation of gamma-delta T cell differentiation

Inferred from electronic annotation. Source: Compara

positive regulation of humoral immune response mediated by circulating immunoglobulin

Inferred from electronic annotation. Source: Compara

positive regulation of isotype switching to IgG isotypes

Inferred from electronic annotation. Source: Compara

positive thymic T cell selection

Inferred from electronic annotation. Source: Compara

regulation of B cell differentiation

Inferred from electronic annotation. Source: Compara

regulation of B cell receptor signaling pathway

Inferred from electronic annotation. Source: Compara

response to gamma radiation

Inferred from electronic annotation. Source: Compara

   Cellular componentexternal side of plasma membrane

Inferred from electronic annotation. Source: Compara

integral to plasma membrane

Inferred from electronic annotation. Source: Compara

   Molecular functionheparan sulfate proteoglycan binding

Inferred from electronic annotation. Source: Compara

heparin binding

Inferred from electronic annotation. Source: Compara

protein tyrosine phosphatase activity

Inferred from electronic annotation. Source: Compara

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue11 EMBL AAA59497.1
Non-terminal residue471 EMBL AAA59497.1

Sequences

Sequence LengthMass (Da)Tools
Q6LDN6-1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: EFB587A5EE90EE69

FASTA474,766
        10         20         30         40 
VPGERSTAST FPTDPVSPLT TTLSLAHHSS AALPARTSNT TITANTS 

« Hide

References

[1]"Integrity of the exon 6 sequence is essential for tissue-specific alternative splicing of human leukocyte common antigen pre-mRNA."
Tsai A.Y.M., Streuli M., Saito H.
Mol. Cell. Biol. 9:4550-4555(1989) [PubMed: 2531281] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]"Rapid evolution by positive Darwinian selection in the extracellular domain of the abundant lymphocyte protein CD45 in primates."
Filip L.C., Mundy N.I.
Mol. Biol. Evol. 21:1504-1511(2004) [PubMed: 15014144] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M29253 Genomic DNA. Translation: AAA59497.1.
AY539675 Genomic DNA. Translation: AAS46930.1.
IPIIPI00640906.
UniGeneHs.654514

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ6LDN6.

Genome annotation databases

EnsemblENST00000271610; ENSP00000271610; ENSG00000081237; Homo sapiens. [Genome view]
ENST00000367366; ENSP00000356336; ENSG00000081237; Homo sapiens. [Genome view]
ENST00000367376; ENSP00000356346; ENSG00000081237; Homo sapiens. [Genome view]
ENST00000391970; ENSP00000375831; ENSG00000081237; Homo sapiens. [Genome view]
ENST00000442510; ENSP00000411355; ENSG00000081237; Homo sapiens. [Genome view]

Organism-specific databases

HGNCHGNC:9666. PTPRC.
GenAtlasSearch...

Phylogenomic databases

HOVERGENQ6LDN6.

Gene expression databases

ArrayExpressQ6LDN6.
BgeeQ6LDN6.

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameQ6LDN6_HUMAN
AccessionPrimary (citable) accession number: Q6LDN6
Entry history
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: January 19, 2010
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
Names and origin · Protein attributes · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information