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Q6LDH7

- Q6LDH7_HUMAN

UniProt

Q6LDH7 - Q6LDH7_HUMAN

Protein
Submitted name:

D(2) dopamine receptor

Gene

DRD2

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. dopamine binding Source: Ensembl
    2. dopamine neurotransmitter receptor activity, coupled via Gi/Go Source: Ensembl
    3. drug binding Source: Ensembl

    GO - Biological processi

    1. acid secretion Source: Ensembl
    2. activation of protein kinase activity Source: Ensembl
    3. adenohypophysis development Source: Ensembl
    4. adenylate cyclase-inhibiting dopamine receptor signaling pathway Source: Ensembl
    5. adult walking behavior Source: Ensembl
    6. auditory behavior Source: Ensembl
    7. axonogenesis Source: Ensembl
    8. behavioral response to cocaine Source: Ensembl
    9. behavioral response to ethanol Source: Ensembl
    10. branching morphogenesis of a nerve Source: Ensembl
    11. cerebral cortex GABAergic interneuron migration Source: Ensembl
    12. circadian regulation of gene expression Source: Ensembl
    13. dopamine metabolic process Source: Ensembl
    14. feeding behavior Source: Ensembl
    15. G-protein coupled receptor internalization Source: Ensembl
    16. grooming behavior Source: Ensembl
    17. long-term memory Source: Ensembl
    18. negative regulation of adenylate cyclase activity Source: Ensembl
    19. negative regulation of blood pressure Source: Ensembl
    20. negative regulation of cell migration Source: Ensembl
    21. negative regulation of cell proliferation Source: Ensembl
    22. negative regulation of circadian sleep/wake cycle, sleep Source: Ensembl
    23. negative regulation of cytosolic calcium ion concentration Source: Ensembl
    24. negative regulation of dopamine receptor signaling pathway Source: Ensembl
    25. negative regulation of dopamine secretion Source: Ensembl
    26. negative regulation of insulin secretion Source: Ensembl
    27. negative regulation of protein kinase B signaling Source: Ensembl
    28. negative regulation of synaptic transmission, glutamatergic Source: Ensembl
    29. negative regulation of voltage-gated calcium channel activity Source: Ensembl
    30. neurological system process involved in regulation of systemic arterial blood pressure Source: Ensembl
    31. orbitofrontal cortex development Source: Ensembl
    32. peristalsis Source: Ensembl
    33. phosphatidylinositol metabolic process Source: Ensembl
    34. phospholipase C-activating dopamine receptor signaling pathway Source: Ensembl
    35. pigmentation Source: Ensembl
    36. positive regulation of dopamine uptake involved in synaptic transmission Source: Ensembl
    37. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
    38. positive regulation of G-protein coupled receptor protein signaling pathway Source: Ensembl
    39. positive regulation of growth hormone secretion Source: Ensembl
    40. positive regulation of long-term synaptic potentiation Source: Ensembl
    41. positive regulation of multicellular organism growth Source: Ensembl
    42. positive regulation of neuroblast proliferation Source: Ensembl
    43. positive regulation of receptor internalization Source: Ensembl
    44. positive regulation of renal sodium excretion Source: Ensembl
    45. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    46. positive regulation of urine volume Source: Ensembl
    47. prepulse inhibition Source: Ensembl
    48. protein localization Source: Ensembl
    49. regulation of heart rate Source: Ensembl
    50. regulation of locomotion involved in locomotory behavior Source: Ensembl
    51. regulation of long-term neuronal synaptic plasticity Source: Ensembl
    52. regulation of phosphoprotein phosphatase activity Source: Ensembl
    53. regulation of potassium ion transport Source: Ensembl
    54. regulation of sodium ion transport Source: Ensembl
    55. regulation of synapse structural plasticity Source: Ensembl
    56. regulation of synaptic transmission, GABAergic Source: Ensembl
    57. release of sequestered calcium ion into cytosol Source: Ensembl
    58. response to amphetamine Source: Ensembl
    59. response to axon injury Source: Ensembl
    60. response to drug Source: Ensembl
    61. response to hypoxia Source: Ensembl
    62. response to inactivity Source: Ensembl
    63. response to iron ion Source: Ensembl
    64. response to morphine Source: Ensembl
    65. response to nicotine Source: Ensembl
    66. response to toxic substance Source: Ensembl
    67. sensory perception of smell Source: Ensembl
    68. striatum development Source: Ensembl
    69. synapse assembly Source: Ensembl
    70. synaptic transmission, dopaminergic Source: Ensembl
    71. temperature homeostasis Source: Ensembl
    72. visual learning Source: Ensembl
    73. Wnt signaling pathway Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptorUniRule annotation, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    D(2) dopamine receptorImported
    Submitted name:
    Dopamine D2 receptorImported
    Gene namesi
    Name:DRD2Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:3023. DRD2.

    Subcellular locationi

    GO - Cellular componenti

    1. acrosomal vesicle Source: Ensembl
    2. axon terminus Source: Ensembl
    3. dendritic spine Source: Ensembl
    4. endocytic vesicle Source: Ensembl
    5. integral component of plasma membrane Source: InterPro
    6. lateral plasma membrane Source: Ensembl
    7. perikaryon Source: Ensembl
    8. postsynaptic density Source: Ensembl
    9. sperm flagellum Source: Ensembl
    10. synaptic vesicle membrane Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    Structurei

    3D structure databases

    ProteinModelPortaliQ6LDH7.
    SMRiQ6LDH7. Positions 37-175.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.UniRule annotation

    Keywords - Domaini

    TransmembraneUniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000239242.
    HOVERGENiHBG100412.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000929. Dopamine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00242. DOPAMINER.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q6LDH7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDPLNLSWYD DDLERQNWSR PFNGSDGKAD RPHYNYYATL LTLLIAVIVF    50
    GNVLVCMAVS REKALQTTTN YLIVSLAVAD LLVATLVMPW VVYLEVVGEW 100
    KFSRIHCDIF VTLDVMMCTA SILNLCAISI DRYTAVAMPM LYNTRYSSKR 150
    RVTVMISIVW VLSFTISCPL LFGLNNA 177
    Length:177
    Mass (Da):20,091
    Last modified:July 5, 2004 - v1
    Checksum:i4CF4CD4B8328000D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei177 – 1771Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP002840 Genomic DNA. No translation available.
    M77249, M77247, M77248 Genomic DNA. Translation: AAA52328.1.
    UniGeneiHs.73893.

    Genome annotation databases

    EnsembliENST00000543292; ENSP00000438419; ENSG00000149295.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP002840 Genomic DNA. No translation available.
    M77249 , M77247 , M77248 Genomic DNA. Translation: AAA52328.1 .
    UniGenei Hs.73893.

    3D structure databases

    ProteinModelPortali Q6LDH7.
    SMRi Q6LDH7. Positions 37-175.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000543292 ; ENSP00000438419 ; ENSG00000149295 .

    Organism-specific databases

    HGNCi HGNC:3023. DRD2.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000239242.
    HOVERGENi HBG100412.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000929. Dopamine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00242. DOPAMINER.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.
    2. "Direct sequencing of the dopamine D2 receptor (DRD2) in schizophrenics reveals three polymorphisms but no structural change in the receptor."
      Sarkar G., Kapelner S., Grandy D.K., Marchionni M., Civelli O., Sobell J., Heston L., Sommer S.S.
      Genomics 11:8-14(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiQ6LDH7_HUMAN
    AccessioniPrimary (citable) accession number: Q6LDH7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3