SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q6LDH7

- Q6LDH7_HUMAN

UniProt

Q6LDH7 - Q6LDH7_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name:

D(2) dopamine receptor

Gene
DRD2
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5 - Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. dopamine binding Source: Ensembl
  2. dopamine neurotransmitter receptor activity, coupled via Gi/Go Source: Ensembl
  3. drug binding Source: Ensembl

GO - Biological processi

  1. acid secretion Source: Ensembl
  2. activation of protein kinase activity Source: Ensembl
  3. adenohypophysis development Source: Ensembl
  4. adenylate cyclase-inhibiting dopamine receptor signaling pathway Source: Ensembl
  5. adult walking behavior Source: Ensembl
  6. auditory behavior Source: Ensembl
  7. axonogenesis Source: Ensembl
  8. behavioral response to cocaine Source: Ensembl
  9. behavioral response to ethanol Source: Ensembl
  10. branching morphogenesis of a nerve Source: Ensembl
  11. cerebral cortex GABAergic interneuron migration Source: Ensembl
  12. circadian regulation of gene expression Source: Ensembl
  13. dopamine metabolic process Source: Ensembl
  14. feeding behavior Source: Ensembl
  15. G-protein coupled receptor internalization Source: Ensembl
  16. grooming behavior Source: Ensembl
  17. long-term memory Source: Ensembl
  18. negative regulation of adenylate cyclase activity Source: Ensembl
  19. negative regulation of blood pressure Source: Ensembl
  20. negative regulation of cell migration Source: Ensembl
  21. negative regulation of cell proliferation Source: Ensembl
  22. negative regulation of circadian sleep/wake cycle, sleep Source: Ensembl
  23. negative regulation of cytosolic calcium ion concentration Source: Ensembl
  24. negative regulation of dopamine receptor signaling pathway Source: Ensembl
  25. negative regulation of dopamine secretion Source: Ensembl
  26. negative regulation of insulin secretion Source: Ensembl
  27. negative regulation of protein kinase B signaling Source: Ensembl
  28. negative regulation of synaptic transmission, glutamatergic Source: Ensembl
  29. negative regulation of voltage-gated calcium channel activity Source: Ensembl
  30. neurological system process involved in regulation of systemic arterial blood pressure Source: Ensembl
  31. orbitofrontal cortex development Source: Ensembl
  32. peristalsis Source: Ensembl
  33. phosphatidylinositol metabolic process Source: Ensembl
  34. phospholipase C-activating dopamine receptor signaling pathway Source: Ensembl
  35. pigmentation Source: Ensembl
  36. positive regulation of dopamine uptake involved in synaptic transmission Source: Ensembl
  37. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  38. positive regulation of G-protein coupled receptor protein signaling pathway Source: Ensembl
  39. positive regulation of growth hormone secretion Source: Ensembl
  40. positive regulation of long-term synaptic potentiation Source: Ensembl
  41. positive regulation of multicellular organism growth Source: Ensembl
  42. positive regulation of neuroblast proliferation Source: Ensembl
  43. positive regulation of receptor internalization Source: Ensembl
  44. positive regulation of renal sodium excretion Source: Ensembl
  45. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  46. positive regulation of urine volume Source: Ensembl
  47. prepulse inhibition Source: Ensembl
  48. protein localization Source: Ensembl
  49. regulation of heart rate Source: Ensembl
  50. regulation of locomotion involved in locomotory behavior Source: Ensembl
  51. regulation of long-term neuronal synaptic plasticity Source: Ensembl
  52. regulation of phosphoprotein phosphatase activity Source: Ensembl
  53. regulation of potassium ion transport Source: Ensembl
  54. regulation of sodium ion transport Source: Ensembl
  55. regulation of synapse structural plasticity Source: Ensembl
  56. regulation of synaptic transmission, GABAergic Source: Ensembl
  57. release of sequestered calcium ion into cytosol Source: Ensembl
  58. response to amphetamine Source: Ensembl
  59. response to axon injury Source: Ensembl
  60. response to drug Source: Ensembl
  61. response to hypoxia Source: Ensembl
  62. response to inactivity Source: Ensembl
  63. response to iron ion Source: Ensembl
  64. response to morphine Source: Ensembl
  65. response to nicotine Source: Ensembl
  66. response to toxic substance Source: Ensembl
  67. sensory perception of smell Source: Ensembl
  68. striatum development Source: Ensembl
  69. synapse assembly Source: Ensembl
  70. synaptic transmission, dopaminergic Source: Ensembl
  71. temperature homeostasis Source: Ensembl
  72. visual learning Source: Ensembl
  73. Wnt signaling pathway Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorUniRule annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
D(2) dopamine receptorImported
Submitted name:
Dopamine D2 receptorImported
Gene namesi
Name:DRD2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:3023. DRD2.

Subcellular locationi

GO - Cellular componenti

  1. acrosomal vesicle Source: Ensembl
  2. axon terminus Source: Ensembl
  3. dendritic spine Source: Ensembl
  4. endocytic vesicle Source: Ensembl
  5. integral component of plasma membrane Source: InterPro
  6. lateral plasma membrane Source: Ensembl
  7. perikaryon Source: Ensembl
  8. postsynaptic density Source: Ensembl
  9. sperm flagellum Source: Ensembl
  10. synaptic vesicle membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Structurei

3D structure databases

ProteinModelPortaliQ6LDH7.
SMRiQ6LDH7. Positions 37-175.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

TransmembraneUniRule annotation

Phylogenomic databases

HOGENOMiHOG000239242.
HOVERGENiHBG100412.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q6LDH7-1 [UniParc]FASTAAdd to Basket

« Hide

MDPLNLSWYD DDLERQNWSR PFNGSDGKAD RPHYNYYATL LTLLIAVIVF    50
GNVLVCMAVS REKALQTTTN YLIVSLAVAD LLVATLVMPW VVYLEVVGEW 100
KFSRIHCDIF VTLDVMMCTA SILNLCAISI DRYTAVAMPM LYNTRYSSKR 150
RVTVMISIVW VLSFTISCPL LFGLNNA 177
Length:177
Mass (Da):20,091
Last modified:July 5, 2004 - v1
Checksum:i4CF4CD4B8328000D
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei177 – 1771Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP002840 Genomic DNA. No translation available.
M77249, M77247, M77248 Genomic DNA. Translation: AAA52328.1.
UniGeneiHs.73893.

Genome annotation databases

EnsembliENST00000543292; ENSP00000438419; ENSG00000149295.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP002840 Genomic DNA. No translation available.
M77249 , M77247 , M77248 Genomic DNA. Translation: AAA52328.1 .
UniGenei Hs.73893.

3D structure databases

ProteinModelPortali Q6LDH7.
SMRi Q6LDH7. Positions 37-175.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000543292 ; ENSP00000438419 ; ENSG00000149295 .

Organism-specific databases

HGNCi HGNC:3023. DRD2.
GenAtlasi Search...

Phylogenomic databases

HOGENOMi HOG000239242.
HOVERGENi HBG100412.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
  2. "Direct sequencing of the dopamine D2 receptor (DRD2) in schizophrenics reveals three polymorphisms but no structural change in the receptor."
    Sarkar G., Kapelner S., Grandy D.K., Marchionni M., Civelli O., Sobell J., Heston L., Sommer S.S.
    Genomics 11:8-14(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiQ6LDH7_HUMAN
AccessioniPrimary (citable) accession number: Q6LDH7
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi