Q6LDH7 (Q6LDH7_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
D(2) dopamine receptor Ensembl ENSP00000438419

Submitted name:
Dopamine D2 receptor EMBL AAA52328.1

Gene names

Name:

DRD2 EMBL AAA52328.1 Ensembl ENSP00000438419

Organism

Homo sapiens (Human) [Reference proteome] EMBL AAA52328.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	177 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. RuleBase RU000688

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane RuleBase RU000688
Molecular function	G-protein coupled receptor RuleBase RU000688 Receptor Transducer
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor internalization Inferred from electronic annotation. Source: Compara Wnt receptor signaling pathway Inferred from electronic annotation. Source: Compara acid secretion Inferred from electronic annotation. Source: Compara activation of protein kinase activity Inferred from electronic annotation. Source: Compara adenohypophysis development Inferred from electronic annotation. Source: Compara adenylate cyclase-inhibiting dopamine receptor signaling pathway Inferred from electronic annotation. Source: Compara adult walking behavior Inferred from electronic annotation. Source: Compara auditory behavior Inferred from electronic annotation. Source: Compara axonogenesis Inferred from electronic annotation. Source: Compara behavioral response to cocaine Inferred from electronic annotation. Source: Compara behavioral response to ethanol Inferred from electronic annotation. Source: Compara branching morphogenesis of a nerve Inferred from electronic annotation. Source: Compara cerebral cortex GABAergic interneuron migration Inferred from electronic annotation. Source: Compara circadian regulation of gene expression Inferred from electronic annotation. Source: Compara dopamine metabolic process Inferred from electronic annotation. Source: Compara feeding behavior Inferred from electronic annotation. Source: Compara grooming behavior Inferred from electronic annotation. Source: Compara long-term memory Inferred from electronic annotation. Source: Compara negative regulation of adenylate cyclase activity Inferred from electronic annotation. Source: Compara negative regulation of blood pressure Inferred from electronic annotation. Source: Compara negative regulation of cell migration Inferred from electronic annotation. Source: Compara negative regulation of cell proliferation Inferred from electronic annotation. Source: Compara negative regulation of circadian sleep/wake cycle, sleep Inferred from electronic annotation. Source: Compara negative regulation of dopamine receptor signaling pathway Inferred from electronic annotation. Source: Compara negative regulation of insulin secretion Inferred from electronic annotation. Source: Compara negative regulation of protein kinase B signaling cascade Inferred from electronic annotation. Source: Compara negative regulation of synaptic transmission, glutamatergic Inferred from electronic annotation. Source: Compara negative regulation of voltage-gated calcium channel activity Inferred from electronic annotation. Source: Compara neurological system process involved in regulation of systemic arterial blood pressure Inferred from electronic annotation. Source: Compara peristalsis Inferred from electronic annotation. Source: Compara phosphatidylinositol metabolic process Inferred from electronic annotation. Source: Compara phospholipase C-activating dopamine receptor signaling pathway Inferred from electronic annotation. Source: Compara pigmentation Inferred from electronic annotation. Source: Compara positive regulation of ERK1 and ERK2 cascade Inferred from electronic annotation. Source: Compara positive regulation of G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: Compara positive regulation of dopamine uptake involved in synaptic transmission Inferred from electronic annotation. Source: Compara positive regulation of growth hormone secretion Inferred from electronic annotation. Source: Compara positive regulation of multicellular organism growth Inferred from electronic annotation. Source: Compara positive regulation of neuroblast proliferation Inferred from electronic annotation. Source: Compara positive regulation of receptor internalization Inferred from electronic annotation. Source: Compara positive regulation of renal sodium excretion Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara positive regulation of urine volume Inferred from electronic annotation. Source: Compara prepulse inhibition Inferred from electronic annotation. Source: Compara protein localization Inferred from electronic annotation. Source: Compara reduction of cytosolic calcium ion concentration Inferred from electronic annotation. Source: Compara regulation of dopamine secretion Inferred from electronic annotation. Source: Compara regulation of heart rate Inferred from electronic annotation. Source: Compara regulation of long-term neuronal synaptic plasticity Inferred from electronic annotation. Source: Compara regulation of phosphoprotein phosphatase activity Inferred from electronic annotation. Source: Compara regulation of potassium ion transport Inferred from electronic annotation. Source: Compara regulation of sodium ion transport Inferred from electronic annotation. Source: Compara regulation of synaptic transmission, GABAergic Inferred from electronic annotation. Source: Compara release of sequestered calcium ion into cytosol Inferred from electronic annotation. Source: Compara response to amphetamine Inferred from electronic annotation. Source: Compara response to axon injury Inferred from electronic annotation. Source: Compara response to drug Inferred from electronic annotation. Source: Compara response to hypoxia Inferred from electronic annotation. Source: Compara response to inactivity Inferred from electronic annotation. Source: Compara response to iron ion Inferred from electronic annotation. Source: Compara response to morphine Inferred from electronic annotation. Source: Compara response to nicotine Inferred from electronic annotation. Source: Compara response to toxin Inferred from electronic annotation. Source: Compara sensory perception of smell Inferred from electronic annotation. Source: Compara synapse assembly Inferred from electronic annotation. Source: Compara synaptic transmission, dopaminergic Inferred from electronic annotation. Source: Compara temperature homeostasis Inferred from electronic annotation. Source: Compara visual learning Inferred from electronic annotation. Source: Compara
Cellular_component	acrosomal vesicle Inferred from electronic annotation. Source: Compara axon terminus Inferred from electronic annotation. Source: Compara endocytic vesicle Inferred from electronic annotation. Source: Compara integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW lateral plasma membrane Inferred from electronic annotation. Source: Compara perikaryon Inferred from electronic annotation. Source: Compara postsynaptic density Inferred from electronic annotation. Source: Compara synaptic vesicle membrane Inferred from electronic annotation. Source: Compara
Molecular_function	dopamine binding Inferred from electronic annotation. Source: Compara dopamine neurotransmitter receptor activity, coupled via Gi/Go Inferred from electronic annotation. Source: Compara drug binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL AAA52328.1
	Non-terminal residue	177	1	Ensembl ENSP00000438419

Sequences

	Sequence		Length	Mass (Da)
	Q6LDH7 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 4CF4CD4B8328000D	FASTA	177	20,091
	10 20 30 40 50 60 MDPLNLSWYD DDLERQNWSR PFNGSDGKAD RPHYNYYATL LTLLIAVIVF GNVLVCMAVS 70 80 90 100 110 120 REKALQTTTN YLIVSLAVAD LLVATLVMPW VVYLEVVGEW KFSRIHCDIF VTLDVMMCTA 130 140 150 160 170 SILNLCAISI DRYTAVAMPM LYNTRYSSKR RVTVMISIVW VLSFTISCPL LFGLNNA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of the cDNA and gene for a human D2 dopamine receptor." Grandy D.K., Marchionni M.A., Makam H., Stofko R.E., Alfano M., Frothingham L., Fischer J.B., Burke-Howie K.J., Bunzow J.R., Server A.C., Civelli O. Proc. Natl. Acad. Sci. U.S.A. 86:9762-9766(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Direct sequencing of the dopamine D2 receptor (DRD2) in schizophrenics reveals three polymorphisms but no structural change in the receptor." Sarkar G., Kapelner S., Grandy D.K., Marchionni M., Civelli O., Sobell J., Heston L., Sommer S.S. Genomics 11:8-14(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[3]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP002840 Genomic DNA. No translation available. M77249, M77247, M77248 Genomic DNA. Translation: AAA52328.1.
IPI	IPI01015728.
UniGene	Hs.73893.
3D structure databases
SMR	Q6LDH7. Positions 37-175.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000543292; ENSP00000438419; ENSG00000149295.
Organism-specific databases
HGNC	HGNC:3023. DRD2.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HOG000239242.
HOVERGEN	HBG100412.
OrthoDB	EOG4MW865.
Gene expression databases
ArrayExpress	Q6LDH7.
Family and domain databases
InterPro	IPR000929. Dopamine_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00242. DOPAMINER. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q6LDH7_HUMAN

Accession

Primary (citable) accession number: Q6LDH7

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.