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Protein

Alcohol dehydrogenase

Gene

Adh

Organism
Drosophila pseudoobscura pseudoobscura (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei138SubstrateBy similarity1
Active sitei151Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 33NADBy similarityAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase (EC:1.1.1.1)
Gene namesi
Name:Adh
ORF Names:GA17214
OrganismiDrosophila pseudoobscura pseudoobscura (Fruit fly)
Taxonomic identifieri46245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000001819 Componenti: Partially assembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0243561. Dpse\Adh.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000544912 – 254Alcohol dehydrogenaseAdd BLAST253

Proteomic databases

PRIDEiQ6LCE4.

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliQ6LCE4.
SMRiQ6LCE4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

InParanoidiQ6LCE4.
KOiK00001.
OMAiWSKHWDS.
PhylomeDBiQ6LCE4.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiView protein in InterPro
IPR002425. ADH_Drosophila-type.
IPR002424. ADH_insect.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
PfamiView protein in Pfam
PF00106. adh_short. 1 hit.
PRINTSiPR01168. ALCDHDRGNASE.
PR01167. INSADHFAMILY.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00061. ADH_SHORT. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6LCE4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLTNKNVVF VAGLGGIGLD TSRELVKRNL KNLVILDRID NPAAIAELKA
60 70 80 90 100
INPKVTITFY PYDVTVPVAE TTKLLKTIFA QVKTIDVLIN GAGILDDHQI
110 120 130 140 150
ERTIAVNYTG LVNTTTAILD FWDKRKGGPG GIICNIGSVT GFNAIYQVPV
160 170 180 190 200
YSGSKAAVVN FTSSLAKLAP ITGVTAYTVN PGITKTTLVH KFNSWLDVEP
210 220 230 240 250
RVAEKLLEHP TQTSQQCAEN FVKAIELNKN GAIWKLDLGT LEPITWTQHW

DSGI
Length:254
Mass (Da):27,617
Last modified:January 23, 2007 - v3
Checksum:iD8484F252366D786
GO

Sequence cautioni

The sequence EAL34444 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti34V → F in strain: PS246. 1
Natural varianti68V → I in strain: PS230. 1
Natural varianti185K → R in strain: PS295. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00602 Genomic DNA. Translation: CAA68645.1.
M60979 Genomic DNA. Translation: AAA99022.1.
M60980 Genomic DNA. Translation: AAA99023.1.
M60981 Genomic DNA. Translation: AAA99025.1.
M60982, M60981 Genomic DNA. Translation: AAA99016.1.
M60983 Genomic DNA. Translation: AAA99017.1.
M60984 Genomic DNA. Translation: AAA99018.1.
M60985 Genomic DNA. Translation: AAA99020.1.
M60986 Genomic DNA. Translation: AAA99019.1.
M60987 Genomic DNA. Translation: AAA99021.1.
M60988 Genomic DNA. Translation: AAA99024.1.
X64468 Genomic DNA. Translation: CAA45797.1.
X64469 Genomic DNA. Translation: CAA45798.1.
X64470 Genomic DNA. Translation: CAA45799.1.
X64471 Genomic DNA. Translation: CAA45800.1.
X64472 Genomic DNA. Translation: CAA45801.1.
X64473 Genomic DNA. Translation: CAA45802.1.
X64474 Genomic DNA. Translation: CAA45803.1.
X64475 Genomic DNA. Translation: CAA45804.1.
X64476 Genomic DNA. Translation: CAA45805.1.
X64477 Genomic DNA. Translation: CAA45806.1.
X64478 Genomic DNA. Translation: CAA45807.1.
X64479 Genomic DNA. Translation: CAA45808.1.
X64480 Genomic DNA. Translation: CAA45809.1.
X64481 Genomic DNA. Translation: CAA45810.1.
X64482 Genomic DNA. Translation: CAA45811.1.
X64483 Genomic DNA. Translation: CAA45812.1.
X64484 Genomic DNA. Translation: CAA45813.1.
X64485 Genomic DNA. Translation: CAA45814.1.
X64486 Genomic DNA. Translation: CAA45815.1.
X64487 Genomic DNA. Translation: CAA45816.1.
X64488 Genomic DNA. Translation: CAA45817.1.
X64489 Genomic DNA. Translation: CAA45818.1.
X62181 Genomic DNA. Translation: CAA44102.1.
X62182 Genomic DNA. Translation: CAA44103.1.
X62183 Genomic DNA. Translation: CAA44104.1.
X62184 Genomic DNA. Translation: CAA44105.1.
X62185 Genomic DNA. Translation: CAA44106.1.
X62186 Genomic DNA. Translation: CAA44107.1.
X62187 Genomic DNA. Translation: CAA44108.1.
X62188 Genomic DNA. Translation: CAA44109.1.
X62189 Genomic DNA. Translation: CAA44110.1.
X62190 Genomic DNA. Translation: CAA44111.1.
X62191 Genomic DNA. Translation: CAA44112.1.
X62192 Genomic DNA. Translation: CAA44113.1.
X62193 Genomic DNA. Translation: CAA44114.1.
X62194 Genomic DNA. Translation: CAA44115.1.
X62195 Genomic DNA. Translation: CAA44116.1.
X62196 Genomic DNA. Translation: CAA44117.1.
X62197 Genomic DNA. Translation: CAA44118.1.
X62198 Genomic DNA. Translation: CAA44119.1.
X62199 Genomic DNA. Translation: CAA44120.1.
X62200 Genomic DNA. Translation: CAA44121.1.
X62201 Genomic DNA. Translation: CAA44122.1.
X62202 Genomic DNA. Translation: CAA44123.1.
X62203 Genomic DNA. Translation: CAA44124.1.
X62204 Genomic DNA. Translation: CAA44125.1.
X62205 Genomic DNA. Translation: CAA44126.1.
X62206 Genomic DNA. Translation: CAA44127.1.
X62207 Genomic DNA. Translation: CAA44128.1.
X62208 Genomic DNA. Translation: CAA44129.1.
X62209 Genomic DNA. Translation: CAA44130.1.
X62210 Genomic DNA. Translation: CAA44131.1.
X62211 Genomic DNA. Translation: CAA44132.1.
X62212 Genomic DNA. Translation: CAA44133.1.
X62213 Genomic DNA. Translation: CAA44134.1.
X62214 Genomic DNA. Translation: CAA44135.1.
X62215 Genomic DNA. Translation: CAA44136.1.
X62216 Genomic DNA. Translation: CAA44137.1.
X62217 Genomic DNA. Translation: CAA44138.1.
X62218 Genomic DNA. Translation: CAA44139.1.
X62219 Genomic DNA. Translation: CAA44140.1.
X62220 Genomic DNA. Translation: CAA44141.1.
X62221 Genomic DNA. Translation: CAA44142.1.
X62222 Genomic DNA. Translation: CAA44143.1.
X62223 Genomic DNA. Translation: CAA44144.1.
X62224 Genomic DNA. Translation: CAA44145.1.
X62225 Genomic DNA. Translation: CAA44146.1.
X62226 Genomic DNA. Translation: CAA44147.1.
X62227 Genomic DNA. Translation: CAA44148.1.
X62228 Genomic DNA. Translation: CAA44149.1.
X62229 Genomic DNA. Translation: CAA44150.1.
X62230 Genomic DNA. Translation: CAA44151.1.
X62231 Genomic DNA. Translation: CAA44152.1.
X62232 Genomic DNA. Translation: CAA44153.1.
X62233 Genomic DNA. Translation: CAA44154.1.
X62234 Genomic DNA. Translation: CAA44155.1.
X62235 Genomic DNA. Translation: CAA44156.1.
X62236 Genomic DNA. Translation: CAA44157.1.
X62237 Genomic DNA. Translation: CAA44158.1.
X62238 Genomic DNA. Translation: CAA44159.1.
X68159 Genomic DNA. Translation: CAA48262.1.
X68160 Genomic DNA. Translation: CAA48263.1.
X68161 Genomic DNA. Translation: CAA48264.1.
X68162 Genomic DNA. Translation: CAA48265.1.
X68163 Genomic DNA. Translation: CAA48266.1.
X68164 Genomic DNA. Translation: CAA48267.1.
X68165 Genomic DNA. Translation: CAA48268.1.
X68166 Genomic DNA. Translation: CAA48269.1.
U64521 Genomic DNA. Translation: AAB06136.1.
U64522 Genomic DNA. Translation: AAB06137.1.
U64523 Genomic DNA. Translation: AAB06138.1.
U64524 Genomic DNA. Translation: AAB06139.1.
U64525 Genomic DNA. Translation: AAB06140.1.
U64526 Genomic DNA. Translation: AAB06141.1.
U64527 Genomic DNA. Translation: AAB06142.1.
U64528 Genomic DNA. Translation: AAB06143.1.
U64529 Genomic DNA. Translation: AAB06144.1.
U64530 Genomic DNA. Translation: AAB06145.1.
U64531 Genomic DNA. Translation: AAB06146.1.
U64532 Genomic DNA. Translation: AAB06147.1.
U64533 Genomic DNA. Translation: AAB06148.1.
U64534 Genomic DNA. Translation: AAB06149.1.
U64535 Genomic DNA. Translation: AAB06150.1.
U64536 Genomic DNA. Translation: AAB06151.1.
U64537 Genomic DNA. Translation: AAB06152.1.
U64538 Genomic DNA. Translation: AAB06153.1.
U64539 Genomic DNA. Translation: AAB06154.1.
U64540 Genomic DNA. Translation: AAB06155.1.
U64541 Genomic DNA. Translation: AAB06156.1.
U64542 Genomic DNA. Translation: AAB06157.1.
U64543 Genomic DNA. Translation: AAB06158.1.
U64544 Genomic DNA. Translation: AAB06159.1.
U64545 Genomic DNA. Translation: AAB06160.1.
U64546 Genomic DNA. Translation: AAB06161.1.
U64547 Genomic DNA. Translation: AAB06162.1.
U64548 Genomic DNA. Translation: AAB06163.1.
U64549 Genomic DNA. Translation: AAB06164.1.
U64550 Genomic DNA. Translation: AAB06165.1.
U64551 Genomic DNA. Translation: AAB06166.1.
U64552 Genomic DNA. Translation: AAB06167.1.
U64553 Genomic DNA. Translation: AAB06168.1.
U64554 Genomic DNA. Translation: AAB06169.1.
U64555 Genomic DNA. Translation: AAB06170.1.
U64556 Genomic DNA. Translation: AAB06171.1.
U64557 Genomic DNA. Translation: AAB06172.1.
U64558 Genomic DNA. Translation: AAB06173.1.
U64559 Genomic DNA. Translation: AAB06174.1.
U64560 Genomic DNA. Translation: AAB06175.1.
CH379058 Genomic DNA. Translation: EAL34444.1. Sequence problems.
PIRiS06292.
S26769.
S26770.
S26779.
RefSeqiXP_001357375.2. XM_001357339.3.

Genome annotation databases

EnsemblMetazoaiFBtr0280541; FBpp0278979; FBgn0243561.
GeneIDi4818070.
KEGGidpo:Dpse_GA17214.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00602 Genomic DNA. Translation: CAA68645.1.
M60979 Genomic DNA. Translation: AAA99022.1.
M60980 Genomic DNA. Translation: AAA99023.1.
M60981 Genomic DNA. Translation: AAA99025.1.
M60982, M60981 Genomic DNA. Translation: AAA99016.1.
M60983 Genomic DNA. Translation: AAA99017.1.
M60984 Genomic DNA. Translation: AAA99018.1.
M60985 Genomic DNA. Translation: AAA99020.1.
M60986 Genomic DNA. Translation: AAA99019.1.
M60987 Genomic DNA. Translation: AAA99021.1.
M60988 Genomic DNA. Translation: AAA99024.1.
X64468 Genomic DNA. Translation: CAA45797.1.
X64469 Genomic DNA. Translation: CAA45798.1.
X64470 Genomic DNA. Translation: CAA45799.1.
X64471 Genomic DNA. Translation: CAA45800.1.
X64472 Genomic DNA. Translation: CAA45801.1.
X64473 Genomic DNA. Translation: CAA45802.1.
X64474 Genomic DNA. Translation: CAA45803.1.
X64475 Genomic DNA. Translation: CAA45804.1.
X64476 Genomic DNA. Translation: CAA45805.1.
X64477 Genomic DNA. Translation: CAA45806.1.
X64478 Genomic DNA. Translation: CAA45807.1.
X64479 Genomic DNA. Translation: CAA45808.1.
X64480 Genomic DNA. Translation: CAA45809.1.
X64481 Genomic DNA. Translation: CAA45810.1.
X64482 Genomic DNA. Translation: CAA45811.1.
X64483 Genomic DNA. Translation: CAA45812.1.
X64484 Genomic DNA. Translation: CAA45813.1.
X64485 Genomic DNA. Translation: CAA45814.1.
X64486 Genomic DNA. Translation: CAA45815.1.
X64487 Genomic DNA. Translation: CAA45816.1.
X64488 Genomic DNA. Translation: CAA45817.1.
X64489 Genomic DNA. Translation: CAA45818.1.
X62181 Genomic DNA. Translation: CAA44102.1.
X62182 Genomic DNA. Translation: CAA44103.1.
X62183 Genomic DNA. Translation: CAA44104.1.
X62184 Genomic DNA. Translation: CAA44105.1.
X62185 Genomic DNA. Translation: CAA44106.1.
X62186 Genomic DNA. Translation: CAA44107.1.
X62187 Genomic DNA. Translation: CAA44108.1.
X62188 Genomic DNA. Translation: CAA44109.1.
X62189 Genomic DNA. Translation: CAA44110.1.
X62190 Genomic DNA. Translation: CAA44111.1.
X62191 Genomic DNA. Translation: CAA44112.1.
X62192 Genomic DNA. Translation: CAA44113.1.
X62193 Genomic DNA. Translation: CAA44114.1.
X62194 Genomic DNA. Translation: CAA44115.1.
X62195 Genomic DNA. Translation: CAA44116.1.
X62196 Genomic DNA. Translation: CAA44117.1.
X62197 Genomic DNA. Translation: CAA44118.1.
X62198 Genomic DNA. Translation: CAA44119.1.
X62199 Genomic DNA. Translation: CAA44120.1.
X62200 Genomic DNA. Translation: CAA44121.1.
X62201 Genomic DNA. Translation: CAA44122.1.
X62202 Genomic DNA. Translation: CAA44123.1.
X62203 Genomic DNA. Translation: CAA44124.1.
X62204 Genomic DNA. Translation: CAA44125.1.
X62205 Genomic DNA. Translation: CAA44126.1.
X62206 Genomic DNA. Translation: CAA44127.1.
X62207 Genomic DNA. Translation: CAA44128.1.
X62208 Genomic DNA. Translation: CAA44129.1.
X62209 Genomic DNA. Translation: CAA44130.1.
X62210 Genomic DNA. Translation: CAA44131.1.
X62211 Genomic DNA. Translation: CAA44132.1.
X62212 Genomic DNA. Translation: CAA44133.1.
X62213 Genomic DNA. Translation: CAA44134.1.
X62214 Genomic DNA. Translation: CAA44135.1.
X62215 Genomic DNA. Translation: CAA44136.1.
X62216 Genomic DNA. Translation: CAA44137.1.
X62217 Genomic DNA. Translation: CAA44138.1.
X62218 Genomic DNA. Translation: CAA44139.1.
X62219 Genomic DNA. Translation: CAA44140.1.
X62220 Genomic DNA. Translation: CAA44141.1.
X62221 Genomic DNA. Translation: CAA44142.1.
X62222 Genomic DNA. Translation: CAA44143.1.
X62223 Genomic DNA. Translation: CAA44144.1.
X62224 Genomic DNA. Translation: CAA44145.1.
X62225 Genomic DNA. Translation: CAA44146.1.
X62226 Genomic DNA. Translation: CAA44147.1.
X62227 Genomic DNA. Translation: CAA44148.1.
X62228 Genomic DNA. Translation: CAA44149.1.
X62229 Genomic DNA. Translation: CAA44150.1.
X62230 Genomic DNA. Translation: CAA44151.1.
X62231 Genomic DNA. Translation: CAA44152.1.
X62232 Genomic DNA. Translation: CAA44153.1.
X62233 Genomic DNA. Translation: CAA44154.1.
X62234 Genomic DNA. Translation: CAA44155.1.
X62235 Genomic DNA. Translation: CAA44156.1.
X62236 Genomic DNA. Translation: CAA44157.1.
X62237 Genomic DNA. Translation: CAA44158.1.
X62238 Genomic DNA. Translation: CAA44159.1.
X68159 Genomic DNA. Translation: CAA48262.1.
X68160 Genomic DNA. Translation: CAA48263.1.
X68161 Genomic DNA. Translation: CAA48264.1.
X68162 Genomic DNA. Translation: CAA48265.1.
X68163 Genomic DNA. Translation: CAA48266.1.
X68164 Genomic DNA. Translation: CAA48267.1.
X68165 Genomic DNA. Translation: CAA48268.1.
X68166 Genomic DNA. Translation: CAA48269.1.
U64521 Genomic DNA. Translation: AAB06136.1.
U64522 Genomic DNA. Translation: AAB06137.1.
U64523 Genomic DNA. Translation: AAB06138.1.
U64524 Genomic DNA. Translation: AAB06139.1.
U64525 Genomic DNA. Translation: AAB06140.1.
U64526 Genomic DNA. Translation: AAB06141.1.
U64527 Genomic DNA. Translation: AAB06142.1.
U64528 Genomic DNA. Translation: AAB06143.1.
U64529 Genomic DNA. Translation: AAB06144.1.
U64530 Genomic DNA. Translation: AAB06145.1.
U64531 Genomic DNA. Translation: AAB06146.1.
U64532 Genomic DNA. Translation: AAB06147.1.
U64533 Genomic DNA. Translation: AAB06148.1.
U64534 Genomic DNA. Translation: AAB06149.1.
U64535 Genomic DNA. Translation: AAB06150.1.
U64536 Genomic DNA. Translation: AAB06151.1.
U64537 Genomic DNA. Translation: AAB06152.1.
U64538 Genomic DNA. Translation: AAB06153.1.
U64539 Genomic DNA. Translation: AAB06154.1.
U64540 Genomic DNA. Translation: AAB06155.1.
U64541 Genomic DNA. Translation: AAB06156.1.
U64542 Genomic DNA. Translation: AAB06157.1.
U64543 Genomic DNA. Translation: AAB06158.1.
U64544 Genomic DNA. Translation: AAB06159.1.
U64545 Genomic DNA. Translation: AAB06160.1.
U64546 Genomic DNA. Translation: AAB06161.1.
U64547 Genomic DNA. Translation: AAB06162.1.
U64548 Genomic DNA. Translation: AAB06163.1.
U64549 Genomic DNA. Translation: AAB06164.1.
U64550 Genomic DNA. Translation: AAB06165.1.
U64551 Genomic DNA. Translation: AAB06166.1.
U64552 Genomic DNA. Translation: AAB06167.1.
U64553 Genomic DNA. Translation: AAB06168.1.
U64554 Genomic DNA. Translation: AAB06169.1.
U64555 Genomic DNA. Translation: AAB06170.1.
U64556 Genomic DNA. Translation: AAB06171.1.
U64557 Genomic DNA. Translation: AAB06172.1.
U64558 Genomic DNA. Translation: AAB06173.1.
U64559 Genomic DNA. Translation: AAB06174.1.
U64560 Genomic DNA. Translation: AAB06175.1.
CH379058 Genomic DNA. Translation: EAL34444.1. Sequence problems.
PIRiS06292.
S26769.
S26770.
S26779.
RefSeqiXP_001357375.2. XM_001357339.3.

3D structure databases

ProteinModelPortaliQ6LCE4.
SMRiQ6LCE4.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ6LCE4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0280541; FBpp0278979; FBgn0243561.
GeneIDi4818070.
KEGGidpo:Dpse_GA17214.

Organism-specific databases

FlyBaseiFBgn0243561. Dpse\Adh.

Phylogenomic databases

InParanoidiQ6LCE4.
KOiK00001.
OMAiWSKHWDS.
PhylomeDBiQ6LCE4.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiView protein in InterPro
IPR002425. ADH_Drosophila-type.
IPR002424. ADH_insect.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
PfamiView protein in Pfam
PF00106. adh_short. 1 hit.
PRINTSiPR01168. ALCDHDRGNASE.
PR01167. INSADHFAMILY.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00061. ADH_SHORT. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADH_DROPS
AccessioniPrimary (citable) accession number: Q6LCE4
Secondary accession number(s): P07158
, Q27613, Q29P49, Q95092
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: January 23, 2007
Last modified: March 15, 2017
This is version 79 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.