Reviewed, UniProtKB/Swiss-Prot Q6LCE4 (ADH_DROPS)

Names and origin

Protein names

Recommended name:
    Alcohol dehydrogenase
    EC=1.1.1.1

Gene names

Name:	Adh
ORF Names:	GA17214

Organism

Drosophila pseudoobscura pseudoobscura (Fruit fly) [Complete proteome]

Taxonomic identifier

46245 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	254 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	An alcohol + NAD+ = an aldehyde or ketone + NADH.
Subunit structure	Homodimer.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Sequence caution	The sequence EAL34444.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular alcohol metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alcohol dehydrogenase activity Inferred from electronic annotation. Source: EC binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 254	253	Alcohol dehydrogenase		PRO_0000054491
Regions
	Nucleotide binding	10 – 33	24	NAD By similarity
Sites
	Active site	151	1	Proton acceptor By similarity
	Binding site	138	1	Substrate By similarity
Natural variations
	Natural variant	34	1	V → F in strain: PS246.
	Natural variant	68	1	V → I in strain: PS230.
	Natural variant	185	1	K → R in strain: PS295.

Sequences

	Sequence		Length	Mass (Da)
	Q6LCE4-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: D8484F252366D786	FASTA	254	27,617
	10 20 30 40 50 60 MSLTNKNVVF VAGLGGIGLD TSRELVKRNL KNLVILDRID NPAAIAELKA INPKVTITFY 70 80 90 100 110 120 PYDVTVPVAE TTKLLKTIFA QVKTIDVLIN GAGILDDHQI ERTIAVNYTG LVNTTTAILD 130 140 150 160 170 180 FWDKRKGGPG GIICNIGSVT GFNAIYQVPV YSGSKAAVVN FTSSLAKLAP ITGVTAYTVN 190 200 210 220 230 240 PGITKTTLVH KFNSWLDVEP RVAEKLLEHP TQTSQQCAEN FVKAIELNKN GAIWKLDLGT 250 LEPITWTQHW DSGI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence of the Adh gene region of Drosophila pseudoobscura: evolutionary change and evidence for an ancient gene duplication." Schaeffer S.W., Aquadro C.F. Genetics 117:61-73(1987) [PubMed: 3666441] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Nucleotide sequence analysis of Adh genes estimates the time of geographic isolation of the Bogota population of Drosophila pseudoobscura." Schaeffer S.W., Miller E.L. Proc. Natl. Acad. Sci. U.S.A. 88:6097-6101(1991) [PubMed: 2068088] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Molecular population genetics of an electrophoretically monomorphic protein in the alcohol dehydrogenase region of Drosophila pseudoobscura." Schaeffer S.W., Miller E.L. Genetics 132:163-178(1992) [PubMed: 1398051] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: PS163, PS164, PS170, PS192, PS214, PS219, PS220, PS224, PS230, PS243, PS245, PS261, PS262, PS265, PS274, PS279, PS281, PS282, PS283, PS287, PS289 and PS297.
[4]	"Estimates of gene flow in Drosophila pseudoobscura determined from nucleotide sequence analysis of the alcohol dehydrogenase region." Schaeffer S.W., Miller E.L. Genetics 132:471-480(1992) [PubMed: 1427038] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: BC414, BC86, BC93, BJ855, BN16, BR10F, BR3F, BR5F, BR7F, BR8F, GB103, GB104, GB109, GB112, GB114, GB116, GB118, GB119, GB12, GB13, GB24, GB26, GB27, GB32, GB33, GB41, GB54, GB59, GB66, GB68, GB69, GB78, GB82, GB91, GB92, GB96, GC4, MT228, MT350, MV21, MV27, MV28, MV36, MV43, MXA31, MXA64, MXZ26, OREG3, OREG4, PS101, PS102, PS108, PS126, PS139, SB14, SB18, SB2 and SB6.
[5]	"Estimates of linkage disequilibrium and the recombination parameter determined from segregating nucleotide sites in the alcohol dehydrogenase region of Drosophila pseudoobscura." Schaeffer S.W., Miller E.L. Genetics 135:541-552(1993) [PubMed: 8244013] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: PS298, PS299, PS302, PS306, PS309, PS314, PS315 and PS316.
[6]	"Molecular population genetics of sequence length diversity in the Adh region of Drosophila pseudoobscura." Schaeffer S.W. Genet. Res. 80:163-175(2002) [PubMed: 12688655] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: GB48, PS228, PS231, PS232, PS236, PS242, PS246, PS248, PS251, PS254, PS256, PS260, PS267, PS268, PS271, PS273, PS277, PS280, PS295, PS296, PS301, PS308, PS311, PS317, PS320, PS322, PS323, PS329, PS331, PS333, PS334, PS336, PS342, PS343, PS348, PS350, PS352, PS353, PS356 and PS367.
[7]	"Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution." Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., Howells S.L. , Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F., Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M., Weinstock G.M., Gibbs R.A. Genome Res. 15:1-18(2005) [PubMed: 15632085] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MV2-25.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Y00602 Genomic DNA. Translation: CAA68645.1. M60979 Genomic DNA. Translation: AAA99022.1. M60980 Genomic DNA. Translation: AAA99023.1. M60981 Genomic DNA. Translation: AAA99025.1. M60982, M60981 Genomic DNA. Translation: AAA99016.1. M60983 Genomic DNA. Translation: AAA99017.1. M60984 Genomic DNA. Translation: AAA99018.1. M60985 Genomic DNA. Translation: AAA99020.1. M60986 Genomic DNA. Translation: AAA99019.1. M60987 Genomic DNA. Translation: AAA99021.1. M60988 Genomic DNA. Translation: AAA99024.1. X64468 Genomic DNA. Translation: CAA45797.1. X64469 Genomic DNA. Translation: CAA45798.1. X64470 Genomic DNA. Translation: CAA45799.1. X64471 Genomic DNA. Translation: CAA45800.1. X64472 Genomic DNA. Translation: CAA45801.1. X64473 Genomic DNA. Translation: CAA45802.1. X64474 Genomic DNA. Translation: CAA45803.1. X64475 Genomic DNA. Translation: CAA45804.1. X64476 Genomic DNA. Translation: CAA45805.1. X64477 Genomic DNA. Translation: CAA45806.1. X64478 Genomic DNA. Translation: CAA45807.1. X64479 Genomic DNA. Translation: CAA45808.1. X64480 Genomic DNA. Translation: CAA45809.1. X64481 Genomic DNA. Translation: CAA45810.1. X64482 Genomic DNA. Translation: CAA45811.1. X64483 Genomic DNA. Translation: CAA45812.1. X64484 Genomic DNA. Translation: CAA45813.1. X64485 Genomic DNA. Translation: CAA45814.1. X64486 Genomic DNA. Translation: CAA45815.1. X64487 Genomic DNA. Translation: CAA45816.1. X64488 Genomic DNA. Translation: CAA45817.1. X64489 Genomic DNA. Translation: CAA45818.1. X62181 Genomic DNA. Translation: CAA44102.1. X62182 Genomic DNA. Translation: CAA44103.1. X62183 Genomic DNA. Translation: CAA44104.1. X62184 Genomic DNA. Translation: CAA44105.1. X62185 Genomic DNA. Translation: CAA44106.1. X62186 Genomic DNA. Translation: CAA44107.1. X62187 Genomic DNA. Translation: CAA44108.1. X62188 Genomic DNA. Translation: CAA44109.1. X62189 Genomic DNA. Translation: CAA44110.1. X62190 Genomic DNA. Translation: CAA44111.1. X62191 Genomic DNA. Translation: CAA44112.1. X62192 Genomic DNA. Translation: CAA44113.1. X62193 Genomic DNA. Translation: CAA44114.1. X62194 Genomic DNA. Translation: CAA44115.1. X62195 Genomic DNA. Translation: CAA44116.1. X62196 Genomic DNA. Translation: CAA44117.1. X62197 Genomic DNA. Translation: CAA44118.1. X62198 Genomic DNA. Translation: CAA44119.1. X62199 Genomic DNA. Translation: CAA44120.1. X62200 Genomic DNA. Translation: CAA44121.1. X62201 Genomic DNA. Translation: CAA44122.1. X62202 Genomic DNA. Translation: CAA44123.1. X62203 Genomic DNA. Translation: CAA44124.1. X62204 Genomic DNA. Translation: CAA44125.1. X62205 Genomic DNA. Translation: CAA44126.1. X62206 Genomic DNA. Translation: CAA44127.1. X62207 Genomic DNA. Translation: CAA44128.1. X62208 Genomic DNA. Translation: CAA44129.1. X62209 Genomic DNA. Translation: CAA44130.1. X62210 Genomic DNA. Translation: CAA44131.1. X62211 Genomic DNA. Translation: CAA44132.1. X62212 Genomic DNA. Translation: CAA44133.1. X62213 Genomic DNA. Translation: CAA44134.1. X62214 Genomic DNA. Translation: CAA44135.1. X62215 Genomic DNA. Translation: CAA44136.1. X62216 Genomic DNA. Translation: CAA44137.1. X62217 Genomic DNA. Translation: CAA44138.1. X62218 Genomic DNA. Translation: CAA44139.1. X62219 Genomic DNA. Translation: CAA44140.1. X62220 Genomic DNA. Translation: CAA44141.1. X62221 Genomic DNA. Translation: CAA44142.1. X62222 Genomic DNA. Translation: CAA44143.1. X62223 Genomic DNA. Translation: CAA44144.1. X62224 Genomic DNA. Translation: CAA44145.1. X62225 Genomic DNA. Translation: CAA44146.1. X62226 Genomic DNA. Translation: CAA44147.1. X62227 Genomic DNA. Translation: CAA44148.1. X62228 Genomic DNA. Translation: CAA44149.1. X62229 Genomic DNA. Translation: CAA44150.1. X62230 Genomic DNA. Translation: CAA44151.1. X62231 Genomic DNA. Translation: CAA44152.1. X62232 Genomic DNA. Translation: CAA44153.1. X62233 Genomic DNA. Translation: CAA44154.1. X62234 Genomic DNA. Translation: CAA44155.1. X62235 Genomic DNA. Translation: CAA44156.1. X62236 Genomic DNA. Translation: CAA44157.1. X62237 Genomic DNA. Translation: CAA44158.1. X62238 Genomic DNA. Translation: CAA44159.1. X68159 Genomic DNA. Translation: CAA48262.1. X68160 Genomic DNA. Translation: CAA48263.1. X68161 Genomic DNA. Translation: CAA48264.1. X68162 Genomic DNA. Translation: CAA48265.1. X68163 Genomic DNA. Translation: CAA48266.1. X68164 Genomic DNA. Translation: CAA48267.1. X68165 Genomic DNA. Translation: CAA48268.1. X68166 Genomic DNA. Translation: CAA48269.1. U64521 Genomic DNA. Translation: AAB06136.1. U64522 Genomic DNA. Translation: AAB06137.1. U64523 Genomic DNA. Translation: AAB06138.1. U64524 Genomic DNA. Translation: AAB06139.1. U64525 Genomic DNA. Translation: AAB06140.1. U64526 Genomic DNA. Translation: AAB06141.1. U64527 Genomic DNA. Translation: AAB06142.1. U64528 Genomic DNA. Translation: AAB06143.1. U64529 Genomic DNA. Translation: AAB06144.1. U64530 Genomic DNA. Translation: AAB06145.1. U64531 Genomic DNA. Translation: AAB06146.1. U64532 Genomic DNA. Translation: AAB06147.1. U64533 Genomic DNA. Translation: AAB06148.1. U64534 Genomic DNA. Translation: AAB06149.1. U64535 Genomic DNA. Translation: AAB06150.1. U64536 Genomic DNA. Translation: AAB06151.1. U64537 Genomic DNA. Translation: AAB06152.1. U64538 Genomic DNA. Translation: AAB06153.1. U64539 Genomic DNA. Translation: AAB06154.1. U64540 Genomic DNA. Translation: AAB06155.1. U64541 Genomic DNA. Translation: AAB06156.1. U64542 Genomic DNA. Translation: AAB06157.1. U64543 Genomic DNA. Translation: AAB06158.1. U64544 Genomic DNA. Translation: AAB06159.1. U64545 Genomic DNA. Translation: AAB06160.1. U64546 Genomic DNA. Translation: AAB06161.1. U64547 Genomic DNA. Translation: AAB06162.1. U64548 Genomic DNA. Translation: AAB06163.1. U64549 Genomic DNA. Translation: AAB06164.1. U64550 Genomic DNA. Translation: AAB06165.1. U64551 Genomic DNA. Translation: AAB06166.1. U64552 Genomic DNA. Translation: AAB06167.1. U64553 Genomic DNA. Translation: AAB06168.1. U64554 Genomic DNA. Translation: AAB06169.1. U64555 Genomic DNA. Translation: AAB06170.1. U64556 Genomic DNA. Translation: AAB06171.1. U64557 Genomic DNA. Translation: AAB06172.1. U64558 Genomic DNA. Translation: AAB06173.1. U64559 Genomic DNA. Translation: AAB06174.1. U64560 Genomic DNA. Translation: AAB06175.1. CH379058 Genomic DNA. Translation: EAL34444.1. Sequence problems.
PIR	S06292. S26769. S26770. S26779.
RefSeq	XP_001357375.1.
3D structure databases
HSSP	HSSP built from PDB template 1B16 based on UniProtKB P10807.
SMR	Q6LCE4. Positions 2-254.
ModBase	Search...
Genome annotation databases
GeneID	4818070.
KEGG	dpo:Dpse_GA17214.
Organism-specific databases
FlyBase	FBgn0243561. Dpse\Adh.
Phylogenomic databases
OMA	Q6LCE4. HQIERTI.
Enzyme and pathway databases
BRENDA	1.1.1.1. 190795.
Family and domain databases
InterPro	IPR002198. DH_sc/Rdtase_SDR. IPR002425. Insect_ADH. IPR002424. Insect_AlcDH_fam. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR19410. ADH_short_C2. 1 hit.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR01168. ALCDHDRGNASE. PR01167. INSADHFAMILY. PR00080. SDRFAMILY.
ProDom	PD000819. SRP54. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADH_DROPS

Accession

Primary (citable) accession number: Q6LCE4
Secondary accession number(s): P07158 , Q27613, Q29P49, Q95092

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1988
Last sequence update:	January 23, 2007
Last modified:	June 16, 2009
This is version 37 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project