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Q6LBZ1

- Q6LBZ1_HUMAN

UniProt

Q6LBZ1 - Q6LBZ1_HUMAN

Protein
Submitted name:

MRNA for apolipoprotein E (apo E)

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. cholesterol transporter activity Source: Ensembl
    2. hydroxyapatite binding Source: Ensembl
    3. lipoprotein particle binding Source: Ensembl
    4. phosphatidylcholine-sterol O-acyltransferase activator activity Source: Ensembl
    5. phospholipid binding Source: Ensembl

    GO - Biological processi

    1. aging Source: Ensembl
    2. artery morphogenesis Source: Ensembl
    3. cellular calcium ion homeostasis Source: Ensembl
    4. cellular response to cholesterol Source: Ensembl
    5. cellular response to growth factor stimulus Source: Ensembl
    6. cellular response to interleukin-1 Source: Ensembl
    7. cholesterol catabolic process Source: Ensembl
    8. cholesterol efflux Source: Ensembl
    9. cholesterol homeostasis Source: Ensembl
    10. lipoprotein biosynthetic process Source: Ensembl
    11. lipoprotein catabolic process Source: Ensembl
    12. low-density lipoprotein particle remodeling Source: Ensembl
    13. maintenance of location in cell Source: Ensembl
    14. negative regulation of inflammatory response Source: Ensembl
    15. negative regulation of neuron apoptotic process Source: Ensembl
    16. oligodendrocyte differentiation Source: Ensembl
    17. peripheral nervous system axon regeneration Source: Ensembl
    18. positive regulation of axon extension Source: Ensembl
    19. positive regulation of cholesterol esterification Source: Ensembl
    20. regulation of gene expression Source: Ensembl
    21. response to dietary excess Source: Ensembl
    22. response to ethanol Source: Ensembl
    23. response to insulin Source: Ensembl
    24. response to oxidative stress Source: Ensembl
    25. response to retinoic acid Source: Ensembl
    26. vasodilation Source: Ensembl
    27. very-low-density lipoprotein particle remodeling Source: Ensembl

    Keywords - Biological processi

    Lipid transportSAAS annotation, Transport

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    MRNA for apolipoprotein E (apo E)Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    Secreted SAAS annotation

    GO - Cellular componenti

    1. dendrite Source: Ensembl
    2. extrinsic component of external side of plasma membrane Source: Ensembl
    3. Golgi apparatus Source: Ensembl
    4. late endosome Source: Ensembl
    5. low-density lipoprotein particle Source: Ensembl
    6. neuronal cell body Source: Ensembl

    Keywords - Cellular componenti

    SecretedSAAS annotation

    PTM / Processingi

    Keywords - PTMi

    LipoproteinImported

    Proteomic databases

    PRIDEiQ6LBZ1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6LBZ1.
    BgeeiQ6LBZ1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6LBZ1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOGENOMiHOG000034006.
    HOVERGENiHBG010582.

    Family and domain databases

    InterProiIPR000074. ApoA1_A4_E.
    [Graphical view]
    PfamiPF01442. Apolipoprotein. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q6LBZ1-1 [UniParc]FASTAAdd to Basket

    « Hide

    QVQEELLSSQ VTQELRALMD ETMKELKAYK SELEEQLTPV AEETRARLSK    50
    ELQAAQARLG ADMEDVCGRL VQYRGEVQAM LGQSTEELRV RLASHLRKLR 100
    KRLLRDADDL QKRLAVYQAG AREGAERGLS AIRERLGPLV EQGRVRAATV 150
    GSLAGQPLQE RAQAWGERLR ARMEEM 176
    Length:176
    Mass (Da):19,910
    Last modified:July 5, 2004 - v1
    Checksum:iFD7312DD136F055E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei176 – 1761Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X00199 mRNA. Translation: CAA25017.1.
    UniGeneiHs.654439.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X00199 mRNA. Translation: CAA25017.1 .
    UniGenei Hs.654439.

    3D structure databases

    ProteinModelPortali Q6LBZ1.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q6LBZ1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOGENOMi HOG000034006.
    HOVERGENi HBG010582.

    Gene expression databases

    ArrayExpressi Q6LBZ1.
    Bgeei Q6LBZ1.

    Family and domain databases

    InterProi IPR000074. ApoA1_A4_E.
    [Graphical view ]
    Pfami PF01442. Apolipoprotein. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The isolation of cDNA clones for human apolipoprotein E and the detection of apoE RNA in hepatic and extra-hepatic tissues."
      Wallis S.C., Rogne S., Gill L., Markham A., Edge M., Woods D., Williamson R., Humphries S.
      EMBO J. 2:2369-2373(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ6LBZ1_HUMAN
    AccessioniPrimary (citable) accession number: Q6LBZ1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.