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Q6LBZ1

- Q6LBZ1_HUMAN

UniProt

Q6LBZ1 - Q6LBZ1_HUMAN

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Protein
Submitted name:

MRNA for apolipoprotein E (apo E)

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. cholesterol transporter activity Source: Ensembl
  2. hydroxyapatite binding Source: Ensembl
  3. lipoprotein particle binding Source: Ensembl
  4. phospholipid binding Source: Ensembl

GO - Biological processi

  1. aging Source: Ensembl
  2. artery morphogenesis Source: Ensembl
  3. cellular calcium ion homeostasis Source: Ensembl
  4. cellular response to cholesterol Source: Ensembl
  5. cellular response to growth factor stimulus Source: Ensembl
  6. cellular response to interleukin-1 Source: Ensembl
  7. cholesterol catabolic process Source: Ensembl
  8. cholesterol efflux Source: Ensembl
  9. cholesterol homeostasis Source: Ensembl
  10. lipoprotein biosynthetic process Source: Ensembl
  11. lipoprotein catabolic process Source: Ensembl
  12. low-density lipoprotein particle remodeling Source: Ensembl
  13. maintenance of location in cell Source: Ensembl
  14. negative regulation of inflammatory response Source: Ensembl
  15. negative regulation of neuron apoptotic process Source: Ensembl
  16. oligodendrocyte differentiation Source: Ensembl
  17. peripheral nervous system axon regeneration Source: Ensembl
  18. positive regulation of axon extension Source: Ensembl
  19. regulation of gene expression Source: Ensembl
  20. response to dietary excess Source: Ensembl
  21. response to ethanol Source: Ensembl
  22. response to insulin Source: Ensembl
  23. response to oxidative stress Source: Ensembl
  24. response to retinoic acid Source: Ensembl
  25. vasodilation Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Lipid transportSAAS annotation, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
MRNA for apolipoprotein E (apo E)Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Secreted SAAS annotation

GO - Cellular componenti

  1. dendrite Source: Ensembl
  2. discoidal high-density lipoprotein particle Source: Ensembl
  3. early endosome Source: Ensembl
  4. endoplasmic reticulum Source: Ensembl
  5. extrinsic component of external side of plasma membrane Source: Ensembl
  6. Golgi apparatus Source: Ensembl
  7. late endosome Source: Ensembl
  8. lysosome Source: Ensembl
  9. microtubule Source: Ensembl
  10. neuronal cell body Source: Ensembl
  11. nuclear envelope Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

SecretedSAAS annotation

PTM / Processingi

Keywords - PTMi

LipoproteinImported

Proteomic databases

PRIDEiQ6LBZ1.

Expressioni

Gene expression databases

BgeeiQ6LBZ1.
ExpressionAtlasiQ6LBZ1. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ6LBZ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000034006.
HOVERGENiHBG010582.

Family and domain databases

InterProiIPR000074. ApoA1_A4_E.
[Graphical view]
PfamiPF01442. Apolipoprotein. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q6LBZ1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
QVQEELLSSQ VTQELRALMD ETMKELKAYK SELEEQLTPV AEETRARLSK
60 70 80 90 100
ELQAAQARLG ADMEDVCGRL VQYRGEVQAM LGQSTEELRV RLASHLRKLR
110 120 130 140 150
KRLLRDADDL QKRLAVYQAG AREGAERGLS AIRERLGPLV EQGRVRAATV
160 170
GSLAGQPLQE RAQAWGERLR ARMEEM
Length:176
Mass (Da):19,910
Last modified:July 5, 2004 - v1
Checksum:iFD7312DD136F055E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei176 – 1761Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00199 mRNA. Translation: CAA25017.1.
UniGeneiHs.654439.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00199 mRNA. Translation: CAA25017.1 .
UniGenei Hs.654439.

3D structure databases

ProteinModelPortali Q6LBZ1.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q6LBZ1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOGENOMi HOG000034006.
HOVERGENi HBG010582.

Gene expression databases

Bgeei Q6LBZ1.
ExpressionAtlasi Q6LBZ1. baseline and differential.

Family and domain databases

InterProi IPR000074. ApoA1_A4_E.
[Graphical view ]
Pfami PF01442. Apolipoprotein. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The isolation of cDNA clones for human apolipoprotein E and the detection of apoE RNA in hepatic and extra-hepatic tissues."
    Wallis S.C., Rogne S., Gill L., Markham A., Edge M., Woods D., Williamson R., Humphries S.
    EMBO J. 2:2369-2373(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ6LBZ1_HUMAN
AccessioniPrimary (citable) accession number: Q6LBZ1
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: November 26, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.