Q6LBZ1 (Q6LBZ1_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: MRNA for apolipoprotein E (apo E) EMBL CAA25017.1
Organism	Homo sapiens (Human) EMBL CAA25017.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	176 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Biological process	Lipid transport SAAS SAAS000074 Transport
Cellular component	Secreted SAAS SAAS000074
PTM	Lipoprotein EMBL CAA25017.1
Gene Ontology (GO)
Biological_process	aging Inferred from electronic annotation. Source: Compara artery morphogenesis Inferred from electronic annotation. Source: Compara cellular calcium ion homeostasis Inferred from electronic annotation. Source: Compara cellular response to cholesterol Inferred from electronic annotation. Source: Compara cellular response to growth factor stimulus Inferred from electronic annotation. Source: Compara cellular response to interleukin-1 Inferred from electronic annotation. Source: Compara cholesterol catabolic process Inferred from electronic annotation. Source: Compara cholesterol efflux Inferred from electronic annotation. Source: Compara cholesterol homeostasis Inferred from electronic annotation. Source: Compara lipoprotein biosynthetic process Inferred from electronic annotation. Source: Compara lipoprotein catabolic process Inferred from electronic annotation. Source: Compara low-density lipoprotein particle remodeling Inferred from electronic annotation. Source: Compara maintenance of location in cell Inferred from electronic annotation. Source: Compara negative regulation of inflammatory response Inferred from electronic annotation. Source: Compara negative regulation of neuron apoptotic process Inferred from electronic annotation. Source: Compara oligodendrocyte differentiation Inferred from electronic annotation. Source: Compara peripheral nervous system axon regeneration Inferred from electronic annotation. Source: Compara positive regulation of axon extension Inferred from electronic annotation. Source: Compara positive regulation of cholesterol esterification Inferred from electronic annotation. Source: Compara regulation of gene expression Inferred from electronic annotation. Source: Compara response to dietary excess Inferred from electronic annotation. Source: Compara response to ethanol Inferred from electronic annotation. Source: Compara response to insulin stimulus Inferred from electronic annotation. Source: Compara response to oxidative stress Inferred from electronic annotation. Source: Compara response to retinoic acid Inferred from electronic annotation. Source: Compara vasodilation Inferred from electronic annotation. Source: Compara very-low-density lipoprotein particle remodeling Inferred from electronic annotation. Source: Compara
Cellular_component	Golgi apparatus Inferred from electronic annotation. Source: Compara dendrite Inferred from electronic annotation. Source: Compara extrinsic to external side of plasma membrane Inferred from electronic annotation. Source: Compara late endosome Inferred from electronic annotation. Source: Compara low-density lipoprotein particle Inferred from electronic annotation. Source: Compara neuronal cell body Inferred from electronic annotation. Source: Compara
Molecular_function	cholesterol transporter activity Inferred from electronic annotation. Source: Compara hydroxyapatite binding Inferred from electronic annotation. Source: Compara lipoprotein particle binding Inferred from electronic annotation. Source: Compara phosphatidylcholine-sterol O-acyltransferase activator activity Inferred from electronic annotation. Source: Compara phospholipid binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL CAA25017.1
	Non-terminal residue	176	1	EMBL CAA25017.1

Sequences

	Sequence		Length	Mass (Da)
	Q6LBZ1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: FD7312DD136F055E	FASTA	176	19,910
	10 20 30 40 50 60 QVQEELLSSQ VTQELRALMD ETMKELKAYK SELEEQLTPV AEETRARLSK ELQAAQARLG 70 80 90 100 110 120 ADMEDVCGRL VQYRGEVQAM LGQSTEELRV RLASHLRKLR KRLLRDADDL QKRLAVYQAG 130 140 150 160 170 AREGAERGLS AIRERLGPLV EQGRVRAATV GSLAGQPLQE RAQAWGERLR ARMEEM

References

[1]	"The isolation of cDNA clones for human apolipoprotein E and the detection of apoE RNA in hepatic and extra-hepatic tissues." Wallis S.C., Rogne S., Gill L., Markham A., Edge M., Woods D., Williamson R., Humphries S. EMBO J. 2:2369-2373(1983) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X00199 mRNA. Translation: CAA25017.1.
IPI	IPI00878953.
UniGene	Hs.654439.
3D structure databases
ProteinModelPortal	Q6LBZ1.
ModBase	Search...
Proteomic databases
PRIDE	Q6LBZ1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOGENOM	HOG000034006.
HOVERGEN	HBG010582.
Gene expression databases
ArrayExpress	Q6LBZ1.
Bgee	Q6LBZ1.
Family and domain databases
InterPro	IPR013326. ApoA. IPR000074. ApoA1_A4_E. [Graphical view]
Pfam	PF01442. Apolipoprotein. 1 hit. [Graphical view]
SUPFAM	SSF47162. SSF47162. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q6LBZ1_HUMAN

Accession

Primary (citable) accession number: Q6LBZ1

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	May 29, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.