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Protein

Acetyl-CoA acetyltransferase

Gene

PAT1

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Essential for n-decane utilization.

Catalytic activityi

2 acetyl-CoA = CoA + acetoacetyl-CoA.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei95 – 951Acyl-thioester intermediateBy similarity
Metal bindingi187 – 1871PotassiumBy similarity
Binding sitei187 – 1871Coenzyme ABy similarity
Binding sitei230 – 2301Coenzyme ABy similarity
Metal bindingi246 – 2461Potassium; via carbonyl oxygenBy similarity
Metal bindingi247 – 2471Potassium; via carbonyl oxygenBy similarity
Metal bindingi249 – 2491Potassium; via carbonyl oxygenBy similarity
Binding sitei250 – 2501Coenzyme ABy similarity
Metal bindingi347 – 3471Potassium; via carbonyl oxygenBy similarity
Active sitei351 – 3511Proton acceptorBy similarity
Active sitei379 – 3791Proton acceptorBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Ligandi

Metal-binding, Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-CoA acetyltransferase (EC:2.3.1.9)
Alternative name(s):
Peroxisomal acetoacetyl-CoA thiolase
Short name:
Thiolase
Gene namesi
Name:PAT1
Ordered Locus Names:YALI0E11099g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
Proteomesi
  • UP000001300 Componenti: Chromosome E

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 397397Acetyl-CoA acetyltransferasePRO_0000206415Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6L8K7.
SMRiQ6L8K7. Positions 6-393.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thiolase family.Curated

Phylogenomic databases

HOGENOMiHOG000012238.
InParanoidiQ6L8K7.
KOiK00626.
OMAiYGGACAQ.
OrthoDBiEOG092C2K2G.

Family and domain databases

Gene3Di3.40.47.10. 4 hits.
InterProiIPR002155. Thiolase.
IPR016039. Thiolase-like.
IPR020615. Thiolase_acyl_enz_int_AS.
IPR020617. Thiolase_C.
IPR020613. Thiolase_CS.
IPR020616. Thiolase_N.
[Graphical view]
PfamiPF02803. Thiolase_C. 1 hit.
PF00108. Thiolase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000429. Ac-CoA_Ac_transf. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
TIGRFAMsiTIGR01930. AcCoA-C-Actrans. 1 hit.
PROSITEiPS00098. THIOLASE_1. 1 hit.
PS00737. THIOLASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6L8K7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLTLPRLNA AYIVGAARTP VGKFNGALKS VSAIDLGITA AKAAVQRSKV
60 70 80 90 100
PADQIDEFLF GQVLTANSGQ APARQVVIKG GFPESVEATT INKVCSSGLK
110 120 130 140 150
TVALAAQAIK AGDRNVIVAG GMESMSNTPY YSGRGLVFGN QKLEDSIVKD
160 170 180 190 200
GLWDPYNNIH MGNCCENTNK RDGITREQQD EYAIESYRRA NESIKNGAFK
210 220 230 240 250
DEIVPVEIKT RKGTVTVSED EEPKGANAEK LKGLKPVFDK QGSVTAGNAS
260 270 280 290 300
PINDGASAVV VASGTKAKEL GTPVLAKIVS YADAATAPID FTIAPSLAIP
310 320 330 340 350
AALKKAGLTK DDIALWEINE AFSGVALANL MRLGIDKSKV NVKGGAVALG
360 370 380 390
HPIGASGNRI FVTLVNALKE GEYGVAAICN GGGASTAIVI KKVSSVE
Length:397
Mass (Da):41,357
Last modified:July 5, 2004 - v1
Checksum:i84CFBCE9D5A29EE0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB120846 Genomic DNA. Translation: BAD20191.1.
CR382131 Genomic DNA. Translation: CAG79399.1.
PIRiJC7675.
RefSeqiXP_503808.1. XM_503808.1.

Genome annotation databases

EnsemblFungiiCAG79399; CAG79399; YALI0_E11099g.
GeneIDi2911520.
KEGGiyli:YALI0E11099g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB120846 Genomic DNA. Translation: BAD20191.1.
CR382131 Genomic DNA. Translation: CAG79399.1.
PIRiJC7675.
RefSeqiXP_503808.1. XM_503808.1.

3D structure databases

ProteinModelPortaliQ6L8K7.
SMRiQ6L8K7. Positions 6-393.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAG79399; CAG79399; YALI0_E11099g.
GeneIDi2911520.
KEGGiyli:YALI0E11099g.

Phylogenomic databases

HOGENOMiHOG000012238.
InParanoidiQ6L8K7.
KOiK00626.
OMAiYGGACAQ.
OrthoDBiEOG092C2K2G.

Family and domain databases

Gene3Di3.40.47.10. 4 hits.
InterProiIPR002155. Thiolase.
IPR016039. Thiolase-like.
IPR020615. Thiolase_acyl_enz_int_AS.
IPR020617. Thiolase_C.
IPR020613. Thiolase_CS.
IPR020616. Thiolase_N.
[Graphical view]
PfamiPF02803. Thiolase_C. 1 hit.
PF00108. Thiolase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000429. Ac-CoA_Ac_transf. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
TIGRFAMsiTIGR01930. AcCoA-C-Actrans. 1 hit.
PROSITEiPS00098. THIOLASE_1. 1 hit.
PS00737. THIOLASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTHIL_YARLI
AccessioniPrimary (citable) accession number: Q6L8K7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.