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Protein

Acetyl-CoA acetyltransferase

Gene

PAT1

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential for n-decane utilization.

Catalytic activityi

2 acetyl-CoA = CoA + acetoacetyl-CoA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei95Acyl-thioester intermediateBy similarity1
Metal bindingi187PotassiumBy similarity1
Binding sitei187Coenzyme ABy similarity1
Binding sitei230Coenzyme ABy similarity1
Metal bindingi246Potassium; via carbonyl oxygenBy similarity1
Metal bindingi247Potassium; via carbonyl oxygenBy similarity1
Metal bindingi249Potassium; via carbonyl oxygenBy similarity1
Binding sitei250Coenzyme ABy similarity1
Metal bindingi347Potassium; via carbonyl oxygenBy similarity1
Active sitei351Proton acceptorBy similarity1
Active sitei379Proton acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
LigandMetal-binding, Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-CoA acetyltransferase (EC:2.3.1.9)
Alternative name(s):
Peroxisomal acetoacetyl-CoA thiolase
Short name:
Thiolase
Gene namesi
Name:PAT1
Ordered Locus Names:YALI0E11099g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
Proteomesi
  • UP000001300 Componenti: Chromosome E

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002064151 – 397Acetyl-CoA acetyltransferaseAdd BLAST397

Interactioni

Protein-protein interaction databases

STRINGi4952.XP_503808.1

Structurei

3D structure databases

ProteinModelPortaliQ6L8K7
SMRiQ6L8K7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thiolase family.Curated

Phylogenomic databases

HOGENOMiHOG000012238
InParanoidiQ6L8K7
KOiK00626
OMAiWDVYNKF
OrthoDBiEOG092C2K2G

Family and domain databases

CDDicd00751 thiolase, 1 hit
Gene3Di3.40.47.104 hits
InterProiView protein in InterPro
IPR002155 Thiolase
IPR016039 Thiolase-like
IPR020615 Thiolase_acyl_enz_int_AS
IPR020617 Thiolase_C
IPR020613 Thiolase_CS
IPR020616 Thiolase_N
PfamiView protein in Pfam
PF02803 Thiolase_C, 1 hit
PF00108 Thiolase_N, 1 hit
PIRSFiPIRSF000429 Ac-CoA_Ac_transf, 1 hit
SUPFAMiSSF53901 SSF53901, 2 hits
TIGRFAMsiTIGR01930 AcCoA-C-Actrans, 1 hit
PROSITEiView protein in PROSITE
PS00098 THIOLASE_1, 1 hit
PS00737 THIOLASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6L8K7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLTLPRLNA AYIVGAARTP VGKFNGALKS VSAIDLGITA AKAAVQRSKV
60 70 80 90 100
PADQIDEFLF GQVLTANSGQ APARQVVIKG GFPESVEATT INKVCSSGLK
110 120 130 140 150
TVALAAQAIK AGDRNVIVAG GMESMSNTPY YSGRGLVFGN QKLEDSIVKD
160 170 180 190 200
GLWDPYNNIH MGNCCENTNK RDGITREQQD EYAIESYRRA NESIKNGAFK
210 220 230 240 250
DEIVPVEIKT RKGTVTVSED EEPKGANAEK LKGLKPVFDK QGSVTAGNAS
260 270 280 290 300
PINDGASAVV VASGTKAKEL GTPVLAKIVS YADAATAPID FTIAPSLAIP
310 320 330 340 350
AALKKAGLTK DDIALWEINE AFSGVALANL MRLGIDKSKV NVKGGAVALG
360 370 380 390
HPIGASGNRI FVTLVNALKE GEYGVAAICN GGGASTAIVI KKVSSVE
Length:397
Mass (Da):41,357
Last modified:July 5, 2004 - v1
Checksum:i84CFBCE9D5A29EE0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB120846 Genomic DNA Translation: BAD20191.1
CR382131 Genomic DNA Translation: CAG79399.1
PIRiJC7675
RefSeqiXP_503808.1, XM_503808.1

Genome annotation databases

EnsemblFungiiCAG79399; CAG79399; YALI0_E11099g
GeneIDi2911520
KEGGiyli:YALI0E11099g

Similar proteinsi

Entry informationi

Entry nameiTHIL_YARLI
AccessioniPrimary (citable) accession number: Q6L8K7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 5, 2004
Last modified: February 28, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome