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Q6L8H4 (KRA51_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Keratin-associated protein 5-1
Alternative name(s):
Keratin, cuticle, ultrahigh sulphur 1-like
Keratin-associated protein 5.1
Ultrahigh sulfur keratin-associated protein 5.1
Gene names
Name:KRTAP5-1
Synonyms:KAP5.1, KRN1L, KRTAP5.1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length278 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Subunit structure

Interacts with hair keratins.

Tissue specificity

Expressed in hair root but not in skin. Expressed also in lung, pancreas, ovary, testis. Ref.1

Sequence similarities

Belongs to the KRTAP type 5 family.

Ontologies

Keywords
   Cellular componentKeratin
   DomainRepeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentkeratin filament

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 278278Keratin-associated protein 5-1
PRO_0000184099

Regions

Repeat42 – 4541
Repeat48 – 5142
Repeat130 – 13343
Repeat136 – 13944
Repeat142 – 14545
Repeat239 – 24246
Repeat258 – 26147
Repeat268 – 27148
Region42 – 2712308 X 4 AA repeats of C-C-X-P

Sequences

Sequence LengthMass (Da)Tools
Q6L8H4 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 75E235FDB8AD66F5

FASTA27824,194
        10         20         30         40         50         60 
MGCCGCSGGC GSSCGGCGSG CGGCGSGCGG CGSGCGGSGS SCCVPVCCCK PVCCRVPTCS 

        70         80         90        100        110        120 
CSSCGKGGCG SSGGSKGGCG SCGGCKGGCG SCGGSKGGCG SCGGSKGGCG SCGGSKGGCG 

       130        140        150        160        170        180 
SGCGGCGSSC CVPVCCCKPM CCCVPACSCS SCGKGGCGSC GCSKGACGSC GGSKGGCGSC 

       190        200        210        220        230        240 
GGCKGGCGSC GGSKGGCGSG CGGCGSGCGV PVCCCSCSSC GSCAGSKGGC GSSCSQCSCC 

       250        260        270 
KPCCCSSGCG SSCCQSSCCK PCCSQSSCCV PVCCQCKI 

« Hide

References

[1]"Identification of two novel clusters of ultrahigh-sulfur keratin-associated protein genes on human chromosome 11."
Yahagi S., Shibuya K., Obayashi I., Masaki H., Kurata Y., Kudoh J., Shimizu N.
Biochem. Biophys. Res. Commun. 318:655-664(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Hair root.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB126070 mRNA. Translation: BAD20197.1.
RefSeqNP_001005922.1. NM_001005922.1.
UniGeneHs.632147.

3D structure databases

ProteinModelPortalQ6L8H4.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbQ6L8H4.
PRIDEQ6L8H4.

Protocols and materials databases

DNASU387264.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000382171; ENSP00000371606; ENSG00000205869.
GeneID387264.
KEGGhsa:387264.
UCSCuc001ltu.1. human.

Organism-specific databases

CTD387264.
GeneCardsGC11M001605.
H-InvDBHIX0035832.
HGNCHGNC:23596. KRTAP5-1.
MIM148022. gene.
neXtProtNX_Q6L8H4.
PharmGKBPA134874098.
GenAtlasSearch...

Phylogenomic databases

OMAAGYKCES.

Gene expression databases

BgeeQ6L8H4.
CleanExHS_KRTAP5-1.
GenevestigatorQ6L8H4.

Family and domain databases

InterProIPR002494. Keratin-assoc.
[Graphical view]
PANTHERPTHR23262. PTHR23262. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi387264.
NextBio101248.
PROQ6L8H4.
SOURCESearch...

Entry information

Entry nameKRA51_HUMAN
AccessionPrimary (citable) accession number: Q6L8H4
Entry history
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM