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Q6L8H4

- KRA51_HUMAN

UniProt

Q6L8H4 - KRA51_HUMAN

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Protein

Keratin-associated protein 5-1

Gene

KRTAP5-1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 5-1
Alternative name(s):
Keratin, cuticle, ultrahigh sulphur 1-like
Keratin-associated protein 5.1
Ultrahigh sulfur keratin-associated protein 5.1
Gene namesi
Name:KRTAP5-1
Synonyms:KAP5.1, KRN1L, KRTAP5.1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:23596. KRTAP5-1.

Subcellular locationi

GO - Cellular componenti

  1. keratin filament Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134874098.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278Keratin-associated protein 5-1PRO_0000184099Add
BLAST

Proteomic databases

PaxDbiQ6L8H4.
PRIDEiQ6L8H4.

Expressioni

Tissue specificityi

Expressed in hair root but not in skin. Expressed also in lung, pancreas, ovary, testis.1 Publication

Gene expression databases

BgeeiQ6L8H4.
CleanExiHS_KRTAP5-1.
GenevestigatoriQ6L8H4.

Interactioni

Subunit structurei

Interacts with hair keratins.

Structurei

3D structure databases

ProteinModelPortaliQ6L8H4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati42 – 4541
Repeati48 – 5142
Repeati130 – 13343
Repeati136 – 13944
Repeati142 – 14545
Repeati239 – 24246
Repeati258 – 26147
Repeati268 – 27148

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni42 – 2712308 X 4 AA repeats of C-C-X-PAdd
BLAST

Sequence similaritiesi

Belongs to the KRTAP type 5 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

OMAiNCGACGH.

Family and domain databases

InterProiIPR002494. KAP.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6L8H4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGCCGCSGGC GSSCGGCGSG CGGCGSGCGG CGSGCGGSGS SCCVPVCCCK
60 70 80 90 100
PVCCRVPTCS CSSCGKGGCG SSGGSKGGCG SCGGCKGGCG SCGGSKGGCG
110 120 130 140 150
SCGGSKGGCG SCGGSKGGCG SGCGGCGSSC CVPVCCCKPM CCCVPACSCS
160 170 180 190 200
SCGKGGCGSC GCSKGACGSC GGSKGGCGSC GGCKGGCGSC GGSKGGCGSG
210 220 230 240 250
CGGCGSGCGV PVCCCSCSSC GSCAGSKGGC GSSCSQCSCC KPCCCSSGCG
260 270
SSCCQSSCCK PCCSQSSCCV PVCCQCKI
Length:278
Mass (Da):24,194
Last modified:July 5, 2004 - v1
Checksum:i75E235FDB8AD66F5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB126070 mRNA. Translation: BAD20197.1.
CCDSiCCDS31330.1.
RefSeqiNP_001005922.1. NM_001005922.1.
UniGeneiHs.632147.

Genome annotation databases

EnsembliENST00000382171; ENSP00000371606; ENSG00000205869.
GeneIDi387264.
KEGGihsa:387264.
UCSCiuc001ltu.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB126070 mRNA. Translation: BAD20197.1 .
CCDSi CCDS31330.1.
RefSeqi NP_001005922.1. NM_001005922.1.
UniGenei Hs.632147.

3D structure databases

ProteinModelPortali Q6L8H4.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q6L8H4.
PRIDEi Q6L8H4.

Protocols and materials databases

DNASUi 387264.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000382171 ; ENSP00000371606 ; ENSG00000205869 .
GeneIDi 387264.
KEGGi hsa:387264.
UCSCi uc001ltu.1. human.

Organism-specific databases

CTDi 387264.
GeneCardsi GC11M001605.
H-InvDB HIX0035832.
HGNCi HGNC:23596. KRTAP5-1.
MIMi 148022. gene.
neXtProti NX_Q6L8H4.
PharmGKBi PA134874098.
GenAtlasi Search...

Phylogenomic databases

OMAi NCGACGH.

Miscellaneous databases

GenomeRNAii 387264.
NextBioi 101248.
PROi Q6L8H4.
SOURCEi Search...

Gene expression databases

Bgeei Q6L8H4.
CleanExi HS_KRTAP5-1.
Genevestigatori Q6L8H4.

Family and domain databases

InterProi IPR002494. KAP.
[Graphical view ]
PANTHERi PTHR23262. PTHR23262. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Identification of two novel clusters of ultrahigh-sulfur keratin-associated protein genes on human chromosome 11."
    Yahagi S., Shibuya K., Obayashi I., Masaki H., Kurata Y., Kudoh J., Shimizu N.
    Biochem. Biophys. Res. Commun. 318:655-664(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Hair root.

Entry informationi

Entry nameiKRA51_HUMAN
AccessioniPrimary (citable) accession number: Q6L8H4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: July 5, 2004
Last modified: October 1, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3