Q6L8H4 (KRA51_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Keratin-associated protein 5-1

Alternative name(s):
Keratin, cuticle, ultrahigh sulphur 1-like
Keratin-associated protein 5.1
Ultrahigh sulfur keratin-associated protein 5.1

Gene names

Name:	KRTAP5-1
Synonyms:	KAP5.1, KRN1L, KRTAP5.1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	278 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Subunit structure	Interacts with hair keratins.
Tissue specificity	Expressed in hair root but not in skin. Expressed also in lung, pancreas, ovary, testis. Ref.1
Sequence similarities	Belongs to the KRTAP type 5 family.

Ontologies

Keywords
Cellular component	Keratin
Domain	Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	keratin filament Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 278	278	Keratin-associated protein 5-1		PRO_0000184099
Regions
	Repeat	42 – 45	4	1
	Repeat	48 – 51	4	2
	Repeat	130 – 133	4	3
	Repeat	136 – 139	4	4
	Repeat	142 – 145	4	5
	Repeat	239 – 242	4	6
	Repeat	258 – 261	4	7
	Repeat	268 – 271	4	8
	Region	42 – 271	230	8 X 4 AA repeats of C-C-X-P

Sequences

	Sequence		Length	Mass (Da)
	Q6L8H4 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 75E235FDB8AD66F5	FASTA	278	24,194
	10 20 30 40 50 60 MGCCGCSGGC GSSCGGCGSG CGGCGSGCGG CGSGCGGSGS SCCVPVCCCK PVCCRVPTCS 70 80 90 100 110 120 CSSCGKGGCG SSGGSKGGCG SCGGCKGGCG SCGGSKGGCG SCGGSKGGCG SCGGSKGGCG 130 140 150 160 170 180 SGCGGCGSSC CVPVCCCKPM CCCVPACSCS SCGKGGCGSC GCSKGACGSC GGSKGGCGSC 190 200 210 220 230 240 GGCKGGCGSC GGSKGGCGSG CGGCGSGCGV PVCCCSCSSC GSCAGSKGGC GSSCSQCSCC 250 260 270 KPCCCSSGCG SSCCQSSCCK PCCSQSSCCV PVCCQCKI

References

[1]	"Identification of two novel clusters of ultrahigh-sulfur keratin-associated protein genes on human chromosome 11." Yahagi S., Shibuya K., Obayashi I., Masaki H., Kurata Y., Kudoh J., Shimizu N. Biochem. Biophys. Res. Commun. 318:655-664(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Hair root.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB126070 mRNA. Translation: BAD20197.1.
IPI	IPI00418171.
RefSeq	NP_001005922.1. NM_001005922.1.
UniGene	Hs.632147.
3D structure databases
ProteinModelPortal	Q6L8H4.
ModBase	Search...
Polymorphism databases
DMDM	56749060.
Proteomic databases
PaxDb	Q6L8H4.
PRIDE	Q6L8H4.
Protocols and materials databases
DNASU	387264.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000382171; ENSP00000371606; ENSG00000205869.
GeneID	387264.
KEGG	hsa:387264.
UCSC	uc001ltu.1. human.
Organism-specific databases
CTD	387264.
GeneCards	GC11M001605.
H-InvDB	HIX0035832.
HGNC	HGNC:23596. KRTAP5-1.
MIM	148022. gene.
neXtProt	NX_Q6L8H4.
PharmGKB	PA134874098.
GenAtlas	Search...
Phylogenomic databases
OMA	GVCKGGC.
Gene expression databases
Bgee	Q6L8H4.
CleanEx	HS_KRTAP5-1.
Genevestigator	Q6L8H4.
Family and domain databases
InterPro	IPR002494. Keratin-assoc. [Graphical view]
PANTHER	PTHR23262. PTHR23262. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	387264.
NextBio	101248.
SOURCE	Search...

Entry information

Entry name

KRA51_HUMAN

Accession

Primary (citable) accession number: Q6L8H4

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 21, 2004
Last sequence update:	July 5, 2004
Last modified:	April 3, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.