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Q6L8H4

- KRA51_HUMAN

UniProt

Q6L8H4 - KRA51_HUMAN

Protein

Keratin-associated protein 5-1

Gene

KRTAP5-1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Keratin-associated protein 5-1
    Alternative name(s):
    Keratin, cuticle, ultrahigh sulphur 1-like
    Keratin-associated protein 5.1
    Ultrahigh sulfur keratin-associated protein 5.1
    Gene namesi
    Name:KRTAP5-1
    Synonyms:KAP5.1, KRN1L, KRTAP5.1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:23596. KRTAP5-1.

    Subcellular locationi

    GO - Cellular componenti

    1. keratin filament Source: InterPro

    Keywords - Cellular componenti

    Keratin

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134874098.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 278278Keratin-associated protein 5-1PRO_0000184099Add
    BLAST

    Proteomic databases

    PaxDbiQ6L8H4.
    PRIDEiQ6L8H4.

    Expressioni

    Tissue specificityi

    Expressed in hair root but not in skin. Expressed also in lung, pancreas, ovary, testis.1 Publication

    Gene expression databases

    BgeeiQ6L8H4.
    CleanExiHS_KRTAP5-1.
    GenevestigatoriQ6L8H4.

    Interactioni

    Subunit structurei

    Interacts with hair keratins.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6L8H4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati42 – 4541
    Repeati48 – 5142
    Repeati130 – 13343
    Repeati136 – 13944
    Repeati142 – 14545
    Repeati239 – 24246
    Repeati258 – 26147
    Repeati268 – 27148

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni42 – 2712308 X 4 AA repeats of C-C-X-PAdd
    BLAST

    Sequence similaritiesi

    Belongs to the KRTAP type 5 family.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    OMAiNCGACGH.

    Family and domain databases

    InterProiIPR002494. KAP.
    [Graphical view]
    PANTHERiPTHR23262. PTHR23262. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6L8H4-1 [UniParc]FASTAAdd to Basket

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    MGCCGCSGGC GSSCGGCGSG CGGCGSGCGG CGSGCGGSGS SCCVPVCCCK    50
    PVCCRVPTCS CSSCGKGGCG SSGGSKGGCG SCGGCKGGCG SCGGSKGGCG 100
    SCGGSKGGCG SCGGSKGGCG SGCGGCGSSC CVPVCCCKPM CCCVPACSCS 150
    SCGKGGCGSC GCSKGACGSC GGSKGGCGSC GGCKGGCGSC GGSKGGCGSG 200
    CGGCGSGCGV PVCCCSCSSC GSCAGSKGGC GSSCSQCSCC KPCCCSSGCG 250
    SSCCQSSCCK PCCSQSSCCV PVCCQCKI 278
    Length:278
    Mass (Da):24,194
    Last modified:July 5, 2004 - v1
    Checksum:i75E235FDB8AD66F5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB126070 mRNA. Translation: BAD20197.1.
    CCDSiCCDS31330.1.
    RefSeqiNP_001005922.1. NM_001005922.1.
    UniGeneiHs.632147.

    Genome annotation databases

    EnsembliENST00000382171; ENSP00000371606; ENSG00000205869.
    GeneIDi387264.
    KEGGihsa:387264.
    UCSCiuc001ltu.1. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB126070 mRNA. Translation: BAD20197.1 .
    CCDSi CCDS31330.1.
    RefSeqi NP_001005922.1. NM_001005922.1.
    UniGenei Hs.632147.

    3D structure databases

    ProteinModelPortali Q6L8H4.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q6L8H4.
    PRIDEi Q6L8H4.

    Protocols and materials databases

    DNASUi 387264.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000382171 ; ENSP00000371606 ; ENSG00000205869 .
    GeneIDi 387264.
    KEGGi hsa:387264.
    UCSCi uc001ltu.1. human.

    Organism-specific databases

    CTDi 387264.
    GeneCardsi GC11M001605.
    H-InvDB HIX0035832.
    HGNCi HGNC:23596. KRTAP5-1.
    MIMi 148022. gene.
    neXtProti NX_Q6L8H4.
    PharmGKBi PA134874098.
    GenAtlasi Search...

    Phylogenomic databases

    OMAi NCGACGH.

    Miscellaneous databases

    GenomeRNAii 387264.
    NextBioi 101248.
    PROi Q6L8H4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6L8H4.
    CleanExi HS_KRTAP5-1.
    Genevestigatori Q6L8H4.

    Family and domain databases

    InterProi IPR002494. KAP.
    [Graphical view ]
    PANTHERi PTHR23262. PTHR23262. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of two novel clusters of ultrahigh-sulfur keratin-associated protein genes on human chromosome 11."
      Yahagi S., Shibuya K., Obayashi I., Masaki H., Kurata Y., Kudoh J., Shimizu N.
      Biochem. Biophys. Res. Commun. 318:655-664(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Hair root.

    Entry informationi

    Entry nameiKRA51_HUMAN
    AccessioniPrimary (citable) accession number: Q6L8H4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 21, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3