Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q6L8H2

- KRA53_HUMAN

UniProt

Q6L8H2 - KRA53_HUMAN

Protein

Keratin-associated protein 5-3

Gene

KRTAP5-3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Keratin-associated protein 5-3
    Alternative name(s):
    Keratin-associated protein 5-9
    Keratin-associated protein 5.3
    Keratin-associated protein 5.9
    UHS KerB-like
    Ultrahigh sulfur keratin-associated protein 5.3
    Gene namesi
    Name:KRTAP5-3
    Synonyms:KAP5-9, KAP5.3, KRTAP5-9, KRTAP5.3, KRTAP5.9
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:23598. KRTAP5-3.

    Subcellular locationi

    GO - Cellular componenti

    1. keratin filament Source: InterPro

    Keywords - Cellular componenti

    Keratin

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134865306.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 238238Keratin-associated protein 5-3PRO_0000184101Add
    BLAST

    Proteomic databases

    PaxDbiQ6L8H2.
    PRIDEiQ6L8H2.

    Expressioni

    Tissue specificityi

    Restricted to hair root, not detected in any other tissues.1 Publication

    Gene expression databases

    CleanExiHS_KRTAP5-3.
    HS_KRTAP5-9.
    GenevestigatoriQ6L8H2.

    Interactioni

    Subunit structurei

    Interacts with hair keratins.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6L8H2.
    SMRiQ6L8H2. Positions 141-216.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati35 – 3841
    Repeati41 – 4442
    Repeati47 – 5043
    Repeati91 – 9444
    Repeati150 – 15345
    Repeati160 – 16346
    Repeati170 – 17347
    Repeati189 – 19248
    Repeati199 – 20249
    Repeati218 – 221410
    Repeati228 – 231411

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni35 – 23119711 X 4 AA repeats of C-C-X-PAdd
    BLAST

    Sequence similaritiesi

    Belongs to the KRTAP type 5 family.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    OMAiCGGSKGV.

    Family and domain databases

    InterProiIPR002494. KAP.
    [Graphical view]
    PANTHERiPTHR23262. PTHR23262. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6L8H2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGCSGCSGGC GSSCGGCGSS CGGCGSGYGG CGSGCCVPVC CCKPVCCCVP    50
    ACSCSSCGSC GGSKGVCGSC GGCKGGCGSC GGSKGGCGSS CCVPVCCSSS 100
    CGSCGGSKGV CGFRGGSKGG CGSCGCSQCS CYKPCCCSSG CGSSCCQSSC 150
    CKPSCSQSSC CKPCCSQSSC CKPCCCSSGC GSSCCQSSCC KPCCSQSSCC 200
    KPCCCSSGCG SSCCQSSCCK PCSSQSSCCV PICCQCKI 238
    Length:238
    Mass (Da):22,106
    Last modified:July 5, 2004 - v1
    Checksum:iE3D415F060B6DC4B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti4 – 41S → C in AAT09005. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti27 – 271G → S.
    Corresponds to variant rs7129002 [ dbSNP | Ensembl ].
    VAR_060115
    Natural varianti28 – 281Y → C.
    Corresponds to variant rs7108370 [ dbSNP | Ensembl ].
    VAR_060116
    Natural varianti73 – 731C → S.
    Corresponds to variant rs7125831 [ dbSNP | Ensembl ].
    VAR_060117
    Natural varianti76 – 761G → V.
    Corresponds to variant rs7125826 [ dbSNP | Ensembl ].
    VAR_060118
    Natural varianti83 – 831S → C.
    Corresponds to variant rs7113784 [ dbSNP | Ensembl ].
    VAR_060119

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB126072 mRNA. Translation: BAD20199.1.
    AJ628246 mRNA. Translation: CAF31638.1.
    AY597812 mRNA. Translation: AAT09005.1.
    CCDSiCCDS41591.1.
    RefSeqiNP_001012726.1. NM_001012708.2.
    UniGeneiHs.532471.

    Genome annotation databases

    EnsembliENST00000399685; ENSP00000382592; ENSG00000196224.
    GeneIDi387266.
    KEGGihsa:387266.
    UCSCiuc001ltw.1. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB126072 mRNA. Translation: BAD20199.1 .
    AJ628246 mRNA. Translation: CAF31638.1 .
    AY597812 mRNA. Translation: AAT09005.1 .
    CCDSi CCDS41591.1.
    RefSeqi NP_001012726.1. NM_001012708.2.
    UniGenei Hs.532471.

    3D structure databases

    ProteinModelPortali Q6L8H2.
    SMRi Q6L8H2. Positions 141-216.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q6L8H2.
    PRIDEi Q6L8H2.

    Protocols and materials databases

    DNASUi 387266.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000399685 ; ENSP00000382592 ; ENSG00000196224 .
    GeneIDi 387266.
    KEGGi hsa:387266.
    UCSCi uc001ltw.1. human.

    Organism-specific databases

    CTDi 387266.
    GeneCardsi GC11M001628.
    HGNCi HGNC:23598. KRTAP5-3.
    neXtProti NX_Q6L8H2.
    PharmGKBi PA134865306.
    GenAtlasi Search...

    Phylogenomic databases

    OMAi CGGSKGV.

    Miscellaneous databases

    GenomeRNAii 387266.
    NextBioi 101252.
    PROi Q6L8H2.

    Gene expression databases

    CleanExi HS_KRTAP5-3.
    HS_KRTAP5-9.
    Genevestigatori Q6L8H2.

    Family and domain databases

    InterProi IPR002494. KAP.
    [Graphical view ]
    PANTHERi PTHR23262. PTHR23262. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of two novel clusters of ultrahigh-sulfur keratin-associated protein genes on human chromosome 11."
      Yahagi S., Shibuya K., Obayashi I., Masaki H., Kurata Y., Kudoh J., Shimizu N.
      Biochem. Biophys. Res. Commun. 318:655-664(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Hair root.
    2. "Characterization of two domains of keratin associated protein (KAP) family members on human chromosome 11."
      Rogers M.A., Langbein L., Winter H., Praetzel S., Schweizer J.
      Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 72-238.
      Tissue: Scalp.
    3. Li H., Zhong G., Zhou G., Shen C., Ke R., Lin L., Yang S.
      Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiKRA53_HUMAN
    AccessioniPrimary (citable) accession number: Q6L8H2
    Secondary accession number(s): Q6PL44, Q701N3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 21, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3