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Protein

Keratin-associated protein 5-6

Gene

KRTAP5-6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 5-6
Alternative name(s):
Keratin-associated protein 5.6
Ultrahigh sulfur keratin-associated protein 5.6
Gene namesi
Name:KRTAP5-6
Synonyms:KAP5.6, KRTAP5.6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:23600. KRTAP5-6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134922071.

Polymorphism and mutation databases

BioMutaiKRTAP5-6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 129129Keratin-associated protein 5-6PRO_0000184104Add
BLAST

Proteomic databases

PaxDbiQ6L8G9.
PRIDEiQ6L8G9.

PTM databases

iPTMnetiQ6L8G9.
PhosphoSiteiQ6L8G9.

Expressioni

Tissue specificityi

Expressed in hair root and not in skin. Expressed also in liver and skeletal muscle.1 Publication

Gene expression databases

CleanExiHS_KRTAP5-6.

Interactioni

Subunit structurei

Interacts with hair keratins.

Binary interactionsi

WithEntry#Exp.IntActNotes
ADAMTSL4Q6UY14-33EBI-10250562,EBI-10173507
CATSPER1Q8NEC53EBI-10250562,EBI-744545
CREB5Q02930-33EBI-10250562,EBI-10192698
GLRX3O760033EBI-10250562,EBI-374781
HOXA1P496393EBI-10250562,EBI-740785
KRTAP10-5P603703EBI-10250562,EBI-10172150
KRTAP10-7P604093EBI-10250562,EBI-10172290
KRTAP10-8P604103EBI-10250562,EBI-10171774
KRTAP10-9P604113EBI-10250562,EBI-10172052
KRTAP26-1Q6PEX33EBI-10250562,EBI-3957672
KRTAP4-12Q9BQ663EBI-10250562,EBI-739863
KRTAP4-2Q9BYR53EBI-10250562,EBI-10172511
KRTAP5-9P263713EBI-10250562,EBI-3958099
KRTAP9-2Q9BYQ43EBI-10250562,EBI-1044640
KRTAP9-4Q9BYQ23EBI-10250562,EBI-10185730
MEOX2A4D1273EBI-10250562,EBI-10172134
NLKQ9UBE83EBI-10250562,EBI-366978
NOTCH2NLQ7Z3S93EBI-10250562,EBI-945833
NUFIP2A1L3A73EBI-10250562,EBI-10172018
OTX1P322423EBI-10250562,EBI-740446
PLSCR1O151623EBI-10250562,EBI-740019
RGS20O76081-63EBI-10250562,EBI-10178530
SMCPP499013EBI-10250562,EBI-750494
SPRY2O435973EBI-10250562,EBI-742487

Protein-protein interaction databases

BioGridi136221. 26 interactions.
IntActiQ6L8G9. 24 interactions.
STRINGi9606.ENSP00000371595.

Structurei

3D structure databases

ProteinModelPortaliQ6L8G9.
SMRiQ6L8G9. Positions 91-129.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati28 – 3141
Repeati34 – 3742
Repeati40 – 4343
Repeati90 – 9344
Repeati109 – 11245
Repeati119 – 12246

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni28 – 112856 X 4 AA repeats of C-C-X-PAdd
BLAST

Sequence similaritiesi

Belongs to the KRTAP type 5 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

OMAiADATHKG.

Sequencei

Sequence statusi: Complete.

Q6L8G9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCCGCSGGC GSGCGGCGSG CGGCGSSCCV PICCCKPVCC CVPACSCTSC
60 70 80 90 100
GSCGGSKGCC GSCGGSKGGC GSCGGSKGGC GSCGCSQCSC CKPCYCSSGC
110 120
GSSCCQSSCC KPCCSQASCC VPICCQCKI
Length:129
Mass (Da):11,784
Last modified:July 5, 2004 - v1
Checksum:i3C19C560119E2C3F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti6 – 61C → F.
Corresponds to variant rs58645950 [ dbSNP | Ensembl ].
VAR_062155

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB126075 mRNA. Translation: BAD20202.1.
BC130399 mRNA. Translation: AAI30400.1.
BC133035 mRNA. Translation: AAI33036.1.
CCDSiCCDS31332.1.
RefSeqiNP_001012416.1. NM_001012416.1.
UniGeneiHs.534863.

Genome annotation databases

EnsembliENST00000382160; ENSP00000371595; ENSG00000205864.
ENST00000611731; ENSP00000479098; ENSG00000277389.
GeneIDi440023.
KEGGihsa:440023.
UCSCiuc001lua.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB126075 mRNA. Translation: BAD20202.1.
BC130399 mRNA. Translation: AAI30400.1.
BC133035 mRNA. Translation: AAI33036.1.
CCDSiCCDS31332.1.
RefSeqiNP_001012416.1. NM_001012416.1.
UniGeneiHs.534863.

3D structure databases

ProteinModelPortaliQ6L8G9.
SMRiQ6L8G9. Positions 91-129.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi136221. 26 interactions.
IntActiQ6L8G9. 24 interactions.
STRINGi9606.ENSP00000371595.

PTM databases

iPTMnetiQ6L8G9.
PhosphoSiteiQ6L8G9.

Polymorphism and mutation databases

BioMutaiKRTAP5-6.

Proteomic databases

PaxDbiQ6L8G9.
PRIDEiQ6L8G9.

Protocols and materials databases

DNASUi440023.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382160; ENSP00000371595; ENSG00000205864.
ENST00000611731; ENSP00000479098; ENSG00000277389.
GeneIDi440023.
KEGGihsa:440023.
UCSCiuc001lua.3. human.

Organism-specific databases

CTDi440023.
GeneCardsiKRTAP5-6.
HGNCiHGNC:23600. KRTAP5-6.
neXtProtiNX_Q6L8G9.
PharmGKBiPA134922071.
GenAtlasiSearch...

Phylogenomic databases

OMAiADATHKG.

Miscellaneous databases

GenomeRNAii440023.
PROiQ6L8G9.

Gene expression databases

CleanExiHS_KRTAP5-6.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiKRA56_HUMAN
AccessioniPrimary (citable) accession number: Q6L8G9
Secondary accession number(s): A1L452
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.