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Protein

Keratin-associated protein 5-7

Gene

KRTAP5-7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 5-7
Alternative name(s):
Keratin-associated protein 5-3
Keratin-associated protein 5.3
Keratin-associated protein 5.7
Ultrahigh sulfur keratin-associated protein 5.7
Gene namesi
Name:KRTAP5-7
Synonyms:KAP5-7, KAP5.3, KRTAP5.3, KRTAP5.7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000244411.3
HGNCiHGNC:23602 KRTAP5-7
neXtProtiNX_Q6L8G8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000244411
PharmGKBiPA134880610

Polymorphism and mutation databases

BioMutaiKRTAP5-7

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001841051 – 165Keratin-associated protein 5-7Add BLAST165

Proteomic databases

PaxDbiQ6L8G8
PeptideAtlasiQ6L8G8
PRIDEiQ6L8G8

PTM databases

iPTMnetiQ6L8G8
PhosphoSitePlusiQ6L8G8

Expressioni

Tissue specificityi

Expressed in hair root but not in skin.1 Publication

Gene expression databases

BgeeiENSG00000244411
CleanExiHS_KRTAP5-7

Interactioni

Subunit structurei

Interacts with hair keratins.

Binary interactionsi

Show more details

Protein-protein interaction databases

IntActiQ6L8G8 62 interactors.
STRINGi9606.ENSP00000417330

Structurei

3D structure databases

ProteinModelPortaliQ6L8G8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati35 – 3814
Repeati41 – 4424
Repeati47 – 5034
Repeati116 – 11944
Repeati126 – 12954
Repeati145 – 14864
Repeati155 – 15874

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni35 – 1587 X 4 AA repeats of C-C-X-PAdd BLAST124

Sequence similaritiesi

Belongs to the KRTAP type 5 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410KC6R Eukaryota
ENOG4110P9Z LUCA
GeneTreeiENSGT00910000146727
OMAiSCKGGCC

Family and domain databases

InterProiView protein in InterPro
IPR002494 KAP
PANTHERiPTHR23262 PTHR23262, 3 hits

Sequencei

Sequence statusi: Complete.

Q6L8G8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCCGCSEGC GSGCGGCGSG CGGCGSGCGG CGSSCCVPVC CCKPVCCCVP
60 70 80 90 100
ACSCSSCGSC GGSKGGCGSC GGSKGGCGSC GGSKGGCGSC GCSQCSCYKP
110 120 130 140 150
CCCSSGCGSS CCQSSCCKPC CCQSSCCKPC CCSSGCGSSC CQSSCCNPCC
160
SQSSCCVPVC CQCKI
Length:165
Mass (Da):15,150
Last modified:July 5, 2004 - v1
Checksum:i717A45732B1431C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB126076 mRNA Translation: BAD20203.1
BC136967 mRNA Translation: AAI36968.1
BC136968 mRNA Translation: AAI36969.1
AJ628243 mRNA Translation: CAF31636.1
CCDSiCCDS41682.1
RefSeqiNP_001012521.1, NM_001012503.1
UniGeneiHs.710675

Genome annotation databases

EnsembliENST00000398536; ENSP00000417330; ENSG00000244411
GeneIDi440050
KEGGihsa:440050
UCSCiuc001oqq.2 human

Similar proteinsi

Entry informationi

Entry nameiKRA57_HUMAN
AccessioniPrimary (citable) accession number: Q6L8G8
Secondary accession number(s): B2RNM3, Q701N5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome