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Protein

Keratin-associated protein 5-7

Gene

KRTAP5-7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 5-7
Alternative name(s):
Keratin-associated protein 5-3
Keratin-associated protein 5.3
Keratin-associated protein 5.7
Ultrahigh sulfur keratin-associated protein 5.7
Gene namesi
Name:KRTAP5-7
Synonyms:KAP5-7, KAP5.3, KRTAP5.3, KRTAP5.7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:23602. KRTAP5-7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134880610.

Polymorphism and mutation databases

BioMutaiKRTAP5-7.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 165165Keratin-associated protein 5-7PRO_0000184105Add
BLAST

Proteomic databases

PaxDbiQ6L8G8.
PRIDEiQ6L8G8.

Expressioni

Tissue specificityi

Expressed in hair root but not in skin.1 Publication

Gene expression databases

CleanExiHS_KRTAP5-7.

Interactioni

Subunit structurei

Interacts with hair keratins.

Protein-protein interaction databases

STRINGi9606.ENSP00000417330.

Structurei

3D structure databases

ProteinModelPortaliQ6L8G8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati35 – 3841
Repeati41 – 4442
Repeati47 – 5043
Repeati116 – 11944
Repeati126 – 12945
Repeati145 – 14846
Repeati155 – 15847

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni35 – 1581247 X 4 AA repeats of C-C-X-PAdd
BLAST

Sequence similaritiesi

Belongs to the KRTAP type 5 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00730000114070.
OMAiCSSPGCQ.

Family and domain databases

InterProiIPR002494. KAP.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6L8G8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCCGCSEGC GSGCGGCGSG CGGCGSGCGG CGSSCCVPVC CCKPVCCCVP
60 70 80 90 100
ACSCSSCGSC GGSKGGCGSC GGSKGGCGSC GGSKGGCGSC GCSQCSCYKP
110 120 130 140 150
CCCSSGCGSS CCQSSCCKPC CCQSSCCKPC CCSSGCGSSC CQSSCCNPCC
160
SQSSCCVPVC CQCKI
Length:165
Mass (Da):15,150
Last modified:July 5, 2004 - v1
Checksum:i717A45732B1431C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB126076 mRNA. Translation: BAD20203.1.
BC136967 mRNA. Translation: AAI36968.1.
BC136968 mRNA. Translation: AAI36969.1.
AJ628243 mRNA. Translation: CAF31636.1.
CCDSiCCDS41682.1.
RefSeqiNP_001012521.1. NM_001012503.1.
UniGeneiHs.710675.

Genome annotation databases

EnsembliENST00000398536; ENSP00000417330; ENSG00000244411.
GeneIDi440050.
KEGGihsa:440050.
UCSCiuc001oqq.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB126076 mRNA. Translation: BAD20203.1.
BC136967 mRNA. Translation: AAI36968.1.
BC136968 mRNA. Translation: AAI36969.1.
AJ628243 mRNA. Translation: CAF31636.1.
CCDSiCCDS41682.1.
RefSeqiNP_001012521.1. NM_001012503.1.
UniGeneiHs.710675.

3D structure databases

ProteinModelPortaliQ6L8G8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000417330.

Polymorphism and mutation databases

BioMutaiKRTAP5-7.

Proteomic databases

PaxDbiQ6L8G8.
PRIDEiQ6L8G8.

Protocols and materials databases

DNASUi440050.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398536; ENSP00000417330; ENSG00000244411.
GeneIDi440050.
KEGGihsa:440050.
UCSCiuc001oqq.1. human.

Organism-specific databases

CTDi440050.
GeneCardsiGC11P071238.
HGNCiHGNC:23602. KRTAP5-7.
neXtProtiNX_Q6L8G8.
PharmGKBiPA134880610.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00730000114070.
OMAiCSSPGCQ.

Miscellaneous databases

GenomeRNAii440050.
NextBioi108875.
PROiQ6L8G8.

Gene expression databases

CleanExiHS_KRTAP5-7.

Family and domain databases

InterProiIPR002494. KAP.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of two novel clusters of ultrahigh-sulfur keratin-associated protein genes on human chromosome 11."
    Yahagi S., Shibuya K., Obayashi I., Masaki H., Kurata Y., Kudoh J., Shimizu N.
    Biochem. Biophys. Res. Commun. 318:655-664(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Hair root.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Characterization of two domains of keratin associated protein (KAP) family members on human chromosome 11."
    Rogers M.A., Langbein L., Winter H., Praetzel S., Schweizer J.
    Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 128-165.
    Tissue: Scalp.

Entry informationi

Entry nameiKRA57_HUMAN
AccessioniPrimary (citable) accession number: Q6L8G8
Secondary accession number(s): B2RNM3, Q701N5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: July 5, 2004
Last modified: June 24, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.