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Q6L8G8

- KRA57_HUMAN

UniProt

Q6L8G8 - KRA57_HUMAN

Protein

Keratin-associated protein 5-7

Gene

KRTAP5-7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Keratin-associated protein 5-7
    Alternative name(s):
    Keratin-associated protein 5-3
    Keratin-associated protein 5.3
    Keratin-associated protein 5.7
    Ultrahigh sulfur keratin-associated protein 5.7
    Gene namesi
    Name:KRTAP5-7
    Synonyms:KAP5-7, KAP5.3, KRTAP5.3, KRTAP5.7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:23602. KRTAP5-7.

    Subcellular locationi

    GO - Cellular componenti

    1. keratin filament Source: InterPro

    Keywords - Cellular componenti

    Keratin

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134880610.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 165165Keratin-associated protein 5-7PRO_0000184105Add
    BLAST

    Proteomic databases

    PaxDbiQ6L8G8.
    PRIDEiQ6L8G8.

    Expressioni

    Tissue specificityi

    Expressed in hair root but not in skin.1 Publication

    Gene expression databases

    CleanExiHS_KRTAP5-7.
    GenevestigatoriQ6L8G8.

    Interactioni

    Subunit structurei

    Interacts with hair keratins.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6L8G8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati35 – 3841
    Repeati41 – 4442
    Repeati47 – 5043
    Repeati116 – 11944
    Repeati126 – 12945
    Repeati145 – 14846
    Repeati155 – 15847

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni35 – 1581247 X 4 AA repeats of C-C-X-PAdd
    BLAST

    Sequence similaritiesi

    Belongs to the KRTAP type 5 family.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    OMAiVCCSQSS.

    Family and domain databases

    InterProiIPR002494. KAP.
    [Graphical view]
    PANTHERiPTHR23262. PTHR23262. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6L8G8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGCCGCSEGC GSGCGGCGSG CGGCGSGCGG CGSSCCVPVC CCKPVCCCVP    50
    ACSCSSCGSC GGSKGGCGSC GGSKGGCGSC GGSKGGCGSC GCSQCSCYKP 100
    CCCSSGCGSS CCQSSCCKPC CCQSSCCKPC CCSSGCGSSC CQSSCCNPCC 150
    SQSSCCVPVC CQCKI 165
    Length:165
    Mass (Da):15,150
    Last modified:July 5, 2004 - v1
    Checksum:i717A45732B1431C5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB126076 mRNA. Translation: BAD20203.1.
    BC136967 mRNA. Translation: AAI36968.1.
    BC136968 mRNA. Translation: AAI36969.1.
    AJ628243 mRNA. Translation: CAF31636.1.
    CCDSiCCDS41682.1.
    RefSeqiNP_001012521.1. NM_001012503.1.
    UniGeneiHs.710675.

    Genome annotation databases

    EnsembliENST00000398536; ENSP00000417330; ENSG00000244411.
    GeneIDi440050.
    KEGGihsa:440050.
    UCSCiuc001oqq.1. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB126076 mRNA. Translation: BAD20203.1 .
    BC136967 mRNA. Translation: AAI36968.1 .
    BC136968 mRNA. Translation: AAI36969.1 .
    AJ628243 mRNA. Translation: CAF31636.1 .
    CCDSi CCDS41682.1.
    RefSeqi NP_001012521.1. NM_001012503.1.
    UniGenei Hs.710675.

    3D structure databases

    ProteinModelPortali Q6L8G8.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q6L8G8.
    PRIDEi Q6L8G8.

    Protocols and materials databases

    DNASUi 440050.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000398536 ; ENSP00000417330 ; ENSG00000244411 .
    GeneIDi 440050.
    KEGGi hsa:440050.
    UCSCi uc001oqq.1. human.

    Organism-specific databases

    CTDi 440050.
    GeneCardsi GC11P071238.
    HGNCi HGNC:23602. KRTAP5-7.
    neXtProti NX_Q6L8G8.
    PharmGKBi PA134880610.
    GenAtlasi Search...

    Phylogenomic databases

    OMAi VCCSQSS.

    Miscellaneous databases

    GenomeRNAii 440050.
    NextBioi 108875.
    PROi Q6L8G8.

    Gene expression databases

    CleanExi HS_KRTAP5-7.
    Genevestigatori Q6L8G8.

    Family and domain databases

    InterProi IPR002494. KAP.
    [Graphical view ]
    PANTHERi PTHR23262. PTHR23262. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of two novel clusters of ultrahigh-sulfur keratin-associated protein genes on human chromosome 11."
      Yahagi S., Shibuya K., Obayashi I., Masaki H., Kurata Y., Kudoh J., Shimizu N.
      Biochem. Biophys. Res. Commun. 318:655-664(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Hair root.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Characterization of two domains of keratin associated protein (KAP) family members on human chromosome 11."
      Rogers M.A., Langbein L., Winter H., Praetzel S., Schweizer J.
      Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 128-165.
      Tissue: Scalp.

    Entry informationi

    Entry nameiKRA57_HUMAN
    AccessioniPrimary (citable) accession number: Q6L8G8
    Secondary accession number(s): B2RNM3, Q701N5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 21, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3