Q6L8G8 (KRA57_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Keratin-associated protein 5-7

Alternative name(s):
Keratin-associated protein 5-3
Keratin-associated protein 5.3
Keratin-associated protein 5.7
Ultrahigh sulfur keratin-associated protein 5.7

Gene names

Name:	KRTAP5-7
Synonyms:	KAP5-7, KAP5.3, KRTAP5.3, KRTAP5.7

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	165 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Subunit structure	Interacts with hair keratins.
Tissue specificity	Expressed in hair root but not in skin. Ref.1
Sequence similarities	Belongs to the KRTAP type 5 family.

Ontologies

Keywords
Cellular component	Keratin
Domain	Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	keratin filament Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 165	165	Keratin-associated protein 5-7		PRO_0000184105
Regions
	Repeat	35 – 38	4	1
	Repeat	41 – 44	4	2
	Repeat	47 – 50	4	3
	Repeat	116 – 119	4	4
	Repeat	126 – 129	4	5
	Repeat	145 – 148	4	6
	Repeat	155 – 158	4	7
	Region	35 – 158	124	7 X 4 AA repeats of C-C-X-P

Sequences

	Sequence		Length	Mass (Da)
	Q6L8G8 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 717A45732B1431C5	FASTA	165	15,150
	10 20 30 40 50 60 MGCCGCSEGC GSGCGGCGSG CGGCGSGCGG CGSSCCVPVC CCKPVCCCVP ACSCSSCGSC 70 80 90 100 110 120 GGSKGGCGSC GGSKGGCGSC GGSKGGCGSC GCSQCSCYKP CCCSSGCGSS CCQSSCCKPC 130 140 150 160 CCQSSCCKPC CCSSGCGSSC CQSSCCNPCC SQSSCCVPVC CQCKI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of two novel clusters of ultrahigh-sulfur keratin-associated protein genes on human chromosome 11." Yahagi S., Shibuya K., Obayashi I., Masaki H., Kurata Y., Kudoh J., Shimizu N. Biochem. Biophys. Res. Commun. 318:655-664(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Hair root.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"Characterization of two domains of keratin associated protein (KAP) family members on human chromosome 11." Rogers M.A., Langbein L., Winter H., Praetzel S., Schweizer J. Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 128-165. Tissue: Scalp.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB126076 mRNA. Translation: BAD20203.1. BC136967 mRNA. Translation: AAI36968.1. BC136968 mRNA. Translation: AAI36969.1. AJ628243 mRNA. Translation: CAF31636.1.
IPI	IPI00437999.
RefSeq	NP_001012521.1. NM_001012503.1.
UniGene	Hs.710675.
3D structure databases
ProteinModelPortal	Q6L8G8.
SMR	Q6L8G8. Positions 128-165.
ModBase	Search...
Polymorphism databases
DMDM	56749056.
Proteomic databases
PaxDb	Q6L8G8.
PRIDE	Q6L8G8.
Protocols and materials databases
DNASU	440050.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000398536; ENSP00000417330; ENSG00000244411.
GeneID	440050.
KEGG	hsa:440050.
UCSC	uc001oqq.1. human.
Organism-specific databases
CTD	440050.
GeneCards	GC11P071238.
HGNC	HGNC:23602. KRTAP5-7.
neXtProt	NX_Q6L8G8.
PharmGKB	PA134880610.
GenAtlas	Search...
Phylogenomic databases
OMA	CQSSSCK.
Gene expression databases
CleanEx	HS_KRTAP5-7.
Genevestigator	Q6L8G8.
GermOnline	ENSG00000172886. Homo sapiens.
Family and domain databases
InterPro	IPR002494. Keratin-assoc. [Graphical view]
PANTHER	PTHR23262. PTHR23262. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	440050.
NextBio	108875.

Entry information

Entry name

KRA57_HUMAN

Accession

Primary (citable) accession number: Q6L8G8
Secondary accession number(s): B2RNM3, Q701N5

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 21, 2004
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.