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Q6L8G8

- KRA57_HUMAN

UniProt

Q6L8G8 - KRA57_HUMAN

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Protein

Keratin-associated protein 5-7

Gene

KRTAP5-7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 5-7
Alternative name(s):
Keratin-associated protein 5-3
Keratin-associated protein 5.3
Keratin-associated protein 5.7
Ultrahigh sulfur keratin-associated protein 5.7
Gene namesi
Name:KRTAP5-7
Synonyms:KAP5-7, KAP5.3, KRTAP5.3, KRTAP5.7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:23602. KRTAP5-7.

Subcellular locationi

GO - Cellular componenti

  1. keratin filament Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134880610.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 165165Keratin-associated protein 5-7PRO_0000184105Add
BLAST

Proteomic databases

PaxDbiQ6L8G8.
PRIDEiQ6L8G8.

Expressioni

Tissue specificityi

Expressed in hair root but not in skin.1 Publication

Gene expression databases

CleanExiHS_KRTAP5-7.
GenevestigatoriQ6L8G8.

Interactioni

Subunit structurei

Interacts with hair keratins.

Structurei

3D structure databases

ProteinModelPortaliQ6L8G8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati35 – 3841
Repeati41 – 4442
Repeati47 – 5043
Repeati116 – 11944
Repeati126 – 12945
Repeati145 – 14846
Repeati155 – 15847

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni35 – 1581247 X 4 AA repeats of C-C-X-PAdd
BLAST

Sequence similaritiesi

Belongs to the KRTAP type 5 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00730000114070.
OMAiVCCSQSS.

Family and domain databases

InterProiIPR002494. KAP.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6L8G8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGCCGCSEGC GSGCGGCGSG CGGCGSGCGG CGSSCCVPVC CCKPVCCCVP
60 70 80 90 100
ACSCSSCGSC GGSKGGCGSC GGSKGGCGSC GGSKGGCGSC GCSQCSCYKP
110 120 130 140 150
CCCSSGCGSS CCQSSCCKPC CCQSSCCKPC CCSSGCGSSC CQSSCCNPCC
160
SQSSCCVPVC CQCKI
Length:165
Mass (Da):15,150
Last modified:July 5, 2004 - v1
Checksum:i717A45732B1431C5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB126076 mRNA. Translation: BAD20203.1.
BC136967 mRNA. Translation: AAI36968.1.
BC136968 mRNA. Translation: AAI36969.1.
AJ628243 mRNA. Translation: CAF31636.1.
CCDSiCCDS41682.1.
RefSeqiNP_001012521.1. NM_001012503.1.
UniGeneiHs.710675.

Genome annotation databases

EnsembliENST00000398536; ENSP00000417330; ENSG00000244411.
GeneIDi440050.
KEGGihsa:440050.
UCSCiuc001oqq.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB126076 mRNA. Translation: BAD20203.1 .
BC136967 mRNA. Translation: AAI36968.1 .
BC136968 mRNA. Translation: AAI36969.1 .
AJ628243 mRNA. Translation: CAF31636.1 .
CCDSi CCDS41682.1.
RefSeqi NP_001012521.1. NM_001012503.1.
UniGenei Hs.710675.

3D structure databases

ProteinModelPortali Q6L8G8.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q6L8G8.
PRIDEi Q6L8G8.

Protocols and materials databases

DNASUi 440050.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000398536 ; ENSP00000417330 ; ENSG00000244411 .
GeneIDi 440050.
KEGGi hsa:440050.
UCSCi uc001oqq.1. human.

Organism-specific databases

CTDi 440050.
GeneCardsi GC11P071238.
HGNCi HGNC:23602. KRTAP5-7.
neXtProti NX_Q6L8G8.
PharmGKBi PA134880610.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00730000114070.
OMAi VCCSQSS.

Miscellaneous databases

GenomeRNAii 440050.
NextBioi 108875.
PROi Q6L8G8.

Gene expression databases

CleanExi HS_KRTAP5-7.
Genevestigatori Q6L8G8.

Family and domain databases

InterProi IPR002494. KAP.
[Graphical view ]
PANTHERi PTHR23262. PTHR23262. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of two novel clusters of ultrahigh-sulfur keratin-associated protein genes on human chromosome 11."
    Yahagi S., Shibuya K., Obayashi I., Masaki H., Kurata Y., Kudoh J., Shimizu N.
    Biochem. Biophys. Res. Commun. 318:655-664(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Hair root.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Characterization of two domains of keratin associated protein (KAP) family members on human chromosome 11."
    Rogers M.A., Langbein L., Winter H., Praetzel S., Schweizer J.
    Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 128-165.
    Tissue: Scalp.

Entry informationi

Entry nameiKRA57_HUMAN
AccessioniPrimary (citable) accession number: Q6L8G8
Secondary accession number(s): B2RNM3, Q701N5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3