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Protein

Keratin-associated protein 5-11

Gene

KRTAP5-11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6805567. Keratinization.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 5-11
Alternative name(s):
Keratin-associated protein 5.11
Ultrahigh sulfur keratin-associated protein 5.11
Gene namesi
Name:KRTAP5-11
Synonyms:KAP5.11, KRTAP5.11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000204571.5.
HGNCiHGNC:23606. KRTAP5-11.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000204571.
PharmGKBiPA134989436.

Polymorphism and mutation databases

BioMutaiKRTAP5-11.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001841091 – 156Keratin-associated protein 5-11Add BLAST156

Proteomic databases

PaxDbiQ6L8G4.
PRIDEiQ6L8G4.

PTM databases

iPTMnetiQ6L8G4.
PhosphoSitePlusiQ6L8G4.

Expressioni

Tissue specificityi

Restricted to hair root, not detected in any other tissues.1 Publication

Gene expression databases

BgeeiENSG00000204571.
CleanExiHS_KRTAP5-11.
ExpressionAtlasiQ6L8G4. baseline and differential.

Interactioni

Subunit structurei

Interacts with hair keratins.

Binary interactionsi

Show more details

Protein-protein interaction databases

IntActiQ6L8G4. 50 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ6L8G4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati35 – 3814
Repeati41 – 4424
Repeati47 – 5034
Repeati87 – 9044
Repeati121 – 12454
Repeati146 – 14964

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni35 – 1496 X 4 AA repeats of C-C-X-PAdd BLAST115

Sequence similaritiesi

Belongs to the KRTAP type 5 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00810000126946.

Family and domain databases

InterProiView protein in InterPro
IPR002494. KAP.
PANTHERiPTHR23262. PTHR23262. 1 hit.
PfamiView protein in Pfam
PF13885. Keratin_B2_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6L8G4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCCGCSGGC GSGCGGCGSG SGGCGSGCGG CGSSCCVPIC CCKPVCCCVP
60 70 80 90 100
ACSCSSCGSC GGSKGGCGSC GSSKGGCGSC GCSQSNCCKP CCSSSGCGSF
110 120 130 140 150
CCQSSCSKPC CCQSSCCQSS CCKPCCCQSS CCQSSCFKPC CCQSSCCVPV

CCQCKI
Length:156
Mass (Da):14,610
Last modified:July 5, 2004 - v1
Checksum:i42BEF951559C0A50
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB126080 mRNA. Translation: BAD20207.1.
CCDSiCCDS41685.1.
RefSeqiNP_001005405.1. NM_001005405.2.
UniGeneiHs.679617.

Genome annotation databases

EnsembliENST00000398530; ENSP00000381541; ENSG00000204571.
GeneIDi440051.
KEGGihsa:440051.
UCSCiuc001oqu.3. human.

Similar proteinsi

Entry informationi

Entry nameiKR511_HUMAN
AccessioniPrimary (citable) accession number: Q6L8G4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: July 5, 2004
Last modified: September 27, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families