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Q6L7I9

- IL21_CANFA

UniProt

Q6L7I9 - IL21_CANFA

Protein

Interleukin-21

Gene

IL21

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG1 and IgG3 in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells By similarity. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation By similarity.By similarity

    GO - Biological processi

    1. cell maturation Source: Ensembl
    2. immune response Source: InterPro
    3. positive regulation of B cell proliferation Source: Ensembl
    4. positive regulation of interferon-gamma biosynthetic process Source: Ensembl
    5. positive regulation of interleukin-10 production Source: Ensembl
    6. positive regulation of interleukin-17 production Source: Ensembl
    7. positive regulation of natural killer cell cytokine production Source: Ensembl
    8. positive regulation of natural killer cell differentiation Source: Ensembl
    9. positive regulation of natural killer cell mediated cytotoxicity Source: Ensembl
    10. positive regulation of T cell proliferation Source: Ensembl
    11. positive regulation of tyrosine phosphorylation of Stat1 protein Source: Ensembl
    12. positive regulation of tyrosine phosphorylation of Stat3 protein Source: Ensembl

    Keywords - Molecular functioni

    Cytokine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-21
    Short name:
    IL-21
    Gene namesi
    Name:IL21
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Chromosome 19

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 146129Interleukin-21PRO_0000015504Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi64 ↔ 115Sequence Analysis
    Disulfide bondi71 ↔ 118Sequence Analysis

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Protein-protein interaction databases

    STRINGi9615.ENSCAFP00000005939.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6L7I9.
    SMRiQ6L7I9. Positions 23-146.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IL-15/IL-21 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG40525.
    GeneTreeiENSGT00390000010494.
    HOGENOMiHOG000113039.
    HOVERGENiHBG052106.
    InParanoidiQ6L7I9.
    KOiK05434.
    OMAiEQSAFSC.
    OrthoDBiEOG7M98JN.
    TreeFamiTF336380.

    Family and domain databases

    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR003443. IL-15/IL-21_fam.
    IPR028151. IL-21.
    [Graphical view]
    PANTHERiPTHR14356. PTHR14356. 1 hit.
    PfamiPF02372. IL15. 1 hit.
    [Graphical view]
    SUPFAMiSSF47266. SSF47266. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6L7I9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKIVICLMV IFLGTVAHKS SFQEQDLLLI RMRQLIDIVD QLKNYVNDLD    50
    PESLPAPEDV KRHCERSAFS CFQKVQLKAA NTGGNEQIIN VLTKQLKRKL 100
    PPTNAGRRQK HRPACPSCDS YEKAPPKEFL ERLKSLIQKM IHQHLS 146
    Length:146
    Mass (Da):16,776
    Last modified:July 5, 2004 - v1
    Checksum:iFFE8DF836AF219AA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB127975 mRNA. Translation: BAD22569.1.
    RefSeqiNP_001003347.1. NM_001003347.1.
    UniGeneiCfa.4569.

    Genome annotation databases

    EnsembliENSCAFT00000006415; ENSCAFP00000005939; ENSCAFG00000004004.
    GeneIDi442935.
    KEGGicfa:442935.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB127975 mRNA. Translation: BAD22569.1 .
    RefSeqi NP_001003347.1. NM_001003347.1.
    UniGenei Cfa.4569.

    3D structure databases

    ProteinModelPortali Q6L7I9.
    SMRi Q6L7I9. Positions 23-146.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9615.ENSCAFP00000005939.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCAFT00000006415 ; ENSCAFP00000005939 ; ENSCAFG00000004004 .
    GeneIDi 442935.
    KEGGi cfa:442935.

    Organism-specific databases

    CTDi 59067.

    Phylogenomic databases

    eggNOGi NOG40525.
    GeneTreei ENSGT00390000010494.
    HOGENOMi HOG000113039.
    HOVERGENi HBG052106.
    InParanoidi Q6L7I9.
    KOi K05434.
    OMAi EQSAFSC.
    OrthoDBi EOG7M98JN.
    TreeFami TF336380.

    Miscellaneous databases

    NextBioi 20831604.

    Family and domain databases

    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR003443. IL-15/IL-21_fam.
    IPR028151. IL-21.
    [Graphical view ]
    PANTHERi PTHR14356. PTHR14356. 1 hit.
    Pfami PF02372. IL15. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of canine interleukin-21 cDNA."
      Miyake M., Saze K., Haga Y., Yamamoto Y., Iwabuchi S.
      Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Spleen.

    Entry informationi

    Entry nameiIL21_CANFA
    AccessioniPrimary (citable) accession number: Q6L7I9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 23, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3