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Q6L7I9 (IL21_CANFA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-21

Short name=IL-21
Gene names
Name:IL21
OrganismCanis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]
Taxonomic identifier9615 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Protein attributes

Sequence length146 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG1 and IgG3 in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells By similarity. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the IL-15/IL-21 family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell maturation

Inferred from electronic annotation. Source: Ensembl

immune response

Inferred from electronic annotation. Source: InterPro

positive regulation of B cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of T cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of interferon-gamma biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-10 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-17 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of natural killer cell cytokine production

Inferred from electronic annotation. Source: Ensembl

positive regulation of natural killer cell differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of natural killer cell mediated cytotoxicity

Inferred from electronic annotation. Source: Ensembl

positive regulation of tyrosine phosphorylation of Stat1 protein

Inferred from electronic annotation. Source: Ensembl

positive regulation of tyrosine phosphorylation of Stat3 protein

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 146129Interleukin-21
PRO_0000015504

Amino acid modifications

Disulfide bond64 ↔ 115 Potential
Disulfide bond71 ↔ 118 Potential

Sequences

Sequence LengthMass (Da)Tools
Q6L7I9 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: FFE8DF836AF219AA

FASTA14616,776
        10         20         30         40         50         60 
MEKIVICLMV IFLGTVAHKS SFQEQDLLLI RMRQLIDIVD QLKNYVNDLD PESLPAPEDV 

        70         80         90        100        110        120 
KRHCERSAFS CFQKVQLKAA NTGGNEQIIN VLTKQLKRKL PPTNAGRRQK HRPACPSCDS 

       130        140 
YEKAPPKEFL ERLKSLIQKM IHQHLS 

« Hide

References

[1]"Molecular cloning of canine interleukin-21 cDNA."
Miyake M., Saze K., Haga Y., Yamamoto Y., Iwabuchi S.
Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Spleen.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB127975 mRNA. Translation: BAD22569.1.
RefSeqNP_001003347.1. NM_001003347.1.
UniGeneCfa.4569.

3D structure databases

ProteinModelPortalQ6L7I9.
SMRQ6L7I9. Positions 23-146.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9615.ENSCAFP00000005939.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSCAFT00000006415; ENSCAFP00000005939; ENSCAFG00000004004.
GeneID442935.
KEGGcfa:442935.

Organism-specific databases

CTD59067.

Phylogenomic databases

eggNOGNOG40525.
GeneTreeENSGT00390000010494.
HOGENOMHOG000113039.
HOVERGENHBG052106.
InParanoidQ6L7I9.
KOK05434.
OMAEQSAFSC.
OrthoDBEOG7M98JN.
TreeFamTF336380.

Family and domain databases

InterProIPR009079. 4_helix_cytokine-like_core.
IPR003443. IL-15/IL-21_fam.
IPR028151. IL-21.
[Graphical view]
PANTHERPTHR14356. PTHR14356. 1 hit.
PfamPF02372. IL15. 1 hit.
[Graphical view]
SUPFAMSSF47266. SSF47266. 1 hit.
ProtoNetSearch...

Other

NextBio20831604.

Entry information

Entry nameIL21_CANFA
AccessionPrimary (citable) accession number: Q6L7I9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: July 5, 2004
Last modified: June 11, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families