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Protein

Interleukin-21

Gene

IL21

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG1 and IgG3 in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

ReactomeiR-CFA-9020958 Interleukin-21 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-21
Short name:
IL-21
Gene namesi
Name:IL21
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi

Organism-specific databases

VGNCiVGNC:41967 IL21

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000001550418 – 146Interleukin-21Add BLAST129

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi64 ↔ 115Sequence analysis
Disulfide bondi71 ↔ 118Sequence analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ6L7I9

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000005939

Structurei

3D structure databases

ProteinModelPortaliQ6L7I9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-15/IL-21 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWTD Eukaryota
ENOG411198G LUCA
GeneTreeiENSGT00390000010494
HOGENOMiHOG000113039
HOVERGENiHBG052106
InParanoidiQ6L7I9
KOiK05434
OMAiIQKMIHQ
OrthoDBiEOG091G0OEJ
TreeFamiTF336380

Family and domain databases

Gene3Di1.20.1250.70, 1 hit
InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR003443 IL-15/IL-21_fam
IPR038327 IL-15/IL-21_sf
IPR028151 IL-21
PANTHERiPTHR14356 PTHR14356, 1 hit
PfamiView protein in Pfam
PF02372 IL15, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6L7I9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKIVICLMV IFLGTVAHKS SFQEQDLLLI RMRQLIDIVD QLKNYVNDLD
60 70 80 90 100
PESLPAPEDV KRHCERSAFS CFQKVQLKAA NTGGNEQIIN VLTKQLKRKL
110 120 130 140
PPTNAGRRQK HRPACPSCDS YEKAPPKEFL ERLKSLIQKM IHQHLS
Length:146
Mass (Da):16,776
Last modified:July 5, 2004 - v1
Checksum:iFFE8DF836AF219AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB127975 mRNA Translation: BAD22569.1
RefSeqiNP_001003347.1, NM_001003347.1
UniGeneiCfa.4569

Genome annotation databases

EnsembliENSCAFT00000006415; ENSCAFP00000005939; ENSCAFG00000004004
GeneIDi442935
KEGGicfa:442935

Entry informationi

Entry nameiIL21_CANLF
AccessioniPrimary (citable) accession number: Q6L7I9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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