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Q6L7I9

- IL21_CANFA

UniProt

Q6L7I9 - IL21_CANFA

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Protein

Interleukin-21

Gene
IL21
Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG1 and IgG3 in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells By similarity. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation By similarity.

GO - Biological processi

  1. cell maturation Source: Ensembl
  2. immune response Source: InterPro
  3. positive regulation of B cell proliferation Source: Ensembl
  4. positive regulation of interferon-gamma biosynthetic process Source: Ensembl
  5. positive regulation of interleukin-10 production Source: Ensembl
  6. positive regulation of interleukin-17 production Source: Ensembl
  7. positive regulation of natural killer cell cytokine production Source: Ensembl
  8. positive regulation of natural killer cell differentiation Source: Ensembl
  9. positive regulation of natural killer cell mediated cytotoxicity Source: Ensembl
  10. positive regulation of T cell proliferation Source: Ensembl
  11. positive regulation of tyrosine phosphorylation of Stat1 protein Source: Ensembl
  12. positive regulation of tyrosine phosphorylation of Stat3 protein Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-21
Short name:
IL-21
Gene namesi
Name:IL21
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Chromosome 19

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed predictionAdd
BLAST
Chaini18 – 146129Interleukin-21PRO_0000015504Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi64 ↔ 115 Reviewed prediction
Disulfide bondi71 ↔ 118 Reviewed prediction

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000005939.

Structurei

3D structure databases

ProteinModelPortaliQ6L7I9.
SMRiQ6L7I9. Positions 23-146.

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-15/IL-21 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG40525.
GeneTreeiENSGT00390000010494.
HOGENOMiHOG000113039.
HOVERGENiHBG052106.
InParanoidiQ6L7I9.
KOiK05434.
OMAiEQSAFSC.
OrthoDBiEOG7M98JN.
TreeFamiTF336380.

Family and domain databases

InterProiIPR009079. 4_helix_cytokine-like_core.
IPR003443. IL-15/IL-21_fam.
IPR028151. IL-21.
[Graphical view]
PANTHERiPTHR14356. PTHR14356. 1 hit.
PfamiPF02372. IL15. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6L7I9-1 [UniParc]FASTAAdd to Basket

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MEKIVICLMV IFLGTVAHKS SFQEQDLLLI RMRQLIDIVD QLKNYVNDLD    50
PESLPAPEDV KRHCERSAFS CFQKVQLKAA NTGGNEQIIN VLTKQLKRKL 100
PPTNAGRRQK HRPACPSCDS YEKAPPKEFL ERLKSLIQKM IHQHLS 146
Length:146
Mass (Da):16,776
Last modified:July 5, 2004 - v1
Checksum:iFFE8DF836AF219AA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB127975 mRNA. Translation: BAD22569.1.
RefSeqiNP_001003347.1. NM_001003347.1.
UniGeneiCfa.4569.

Genome annotation databases

EnsembliENSCAFT00000006415; ENSCAFP00000005939; ENSCAFG00000004004.
GeneIDi442935.
KEGGicfa:442935.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB127975 mRNA. Translation: BAD22569.1 .
RefSeqi NP_001003347.1. NM_001003347.1.
UniGenei Cfa.4569.

3D structure databases

ProteinModelPortali Q6L7I9.
SMRi Q6L7I9. Positions 23-146.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9615.ENSCAFP00000005939.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCAFT00000006415 ; ENSCAFP00000005939 ; ENSCAFG00000004004 .
GeneIDi 442935.
KEGGi cfa:442935.

Organism-specific databases

CTDi 59067.

Phylogenomic databases

eggNOGi NOG40525.
GeneTreei ENSGT00390000010494.
HOGENOMi HOG000113039.
HOVERGENi HBG052106.
InParanoidi Q6L7I9.
KOi K05434.
OMAi EQSAFSC.
OrthoDBi EOG7M98JN.
TreeFami TF336380.

Miscellaneous databases

NextBioi 20831604.

Family and domain databases

InterProi IPR009079. 4_helix_cytokine-like_core.
IPR003443. IL-15/IL-21_fam.
IPR028151. IL-21.
[Graphical view ]
PANTHERi PTHR14356. PTHR14356. 1 hit.
Pfami PF02372. IL15. 1 hit.
[Graphical view ]
SUPFAMi SSF47266. SSF47266. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of canine interleukin-21 cDNA."
    Miyake M., Saze K., Haga Y., Yamamoto Y., Iwabuchi S.
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Spleen.

Entry informationi

Entry nameiIL21_CANFA
AccessioniPrimary (citable) accession number: Q6L7I9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: July 5, 2004
Last modified: June 11, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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