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Q6L6Q6 (LYS_CRAGI) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysozyme

EC=3.2.1.17
Alternative name(s):
1,4-beta-N-acetylmuramidase
Gene names
Name:lysoz
OrganismCrassostrea gigas (Pacific oyster) (Crassostrea angulata)
Taxonomic identifier29159 [NCBI]
Taxonomic lineageEukaryotaMetazoaLophotrochozoaMolluscaBivalviaPteriomorphiaOstreoidaOstreoideaOstreidaeCrassostrea

Protein attributes

Sequence length137 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in digestion and in the host defense mechanisms against invading microbes.

Catalytic activity

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Subcellular location

Secreted.

Tissue specificity

Expressed in the basophil cells of the oyster digestive gland. Ref.1

Sequence similarities

Belongs to the lysozyme type I family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionAntibiotic
Antimicrobial
Bacteriolytic enzyme
Glycosidase
Hydrolase
Gene Ontology (GO)
   Biological_processcytolysis

Inferred from electronic annotation. Source: UniProtKB-KW

defense response to bacterium

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionlysozyme activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 137117Lysozyme
PRO_0000280511

Sequences

Sequence LengthMass (Da)Tools
Q6L6Q6 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 1E2A8F1AF5403CE5

FASTA13715,274
        10         20         30         40         50         60 
MQRLLGSIVI LATVFTFCEA TISSACLRCI CNVESGCRPI GCHYDVYSYS CGYFQIKENY 

        70         80         90        100        110        120 
WEDCGKPGTS FKACANDYTC ASNCVRAYMK RYIGSSGCPA NCESYARIHN GGPRGCRHPS 

       130 
TLRYWEKVHQ QGCNVNS 

« Hide

References

[1]"Cloning of cDNAs and hybridization analysis of lysozymes from two oyster species, Crassostrea gigas and Ostrea edulis."
Matsumoto T., Nakamura A.M., Takahashi K.G.
Comp. Biochem. Physiol. 145B:325-330(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB179775 mRNA. Translation: BAD19059.1.

3D structure databases

ProteinModelPortalQ6L6Q6.
SMRQ6L6Q6. Positions 17-130.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGH22. Glycoside Hydrolase Family 22.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR008597. Destabilase.
IPR023346. Lysozyme-like_dom.
[Graphical view]
PANTHERPTHR11195. PTHR11195. 1 hit.
PfamPF05497. Destabilase. 1 hit.
[Graphical view]
SUPFAMSSF53955. SSF53955. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLYS_CRAGI
AccessionPrimary (citable) accession number: Q6L6Q6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: July 5, 2004
Last modified: October 16, 2013
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries