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Protein

Lysozyme

Gene

lysoz

Organism
Crassostrea gigas (Pacific oyster) (Crassostrea angulata)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in digestion and in the host defense mechanisms against invading microbes.

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

GO - Molecular functioni

  1. lysozyme activity Source: UniProtKB-EC

GO - Biological processi

  1. cytolysis Source: UniProtKB-KW
  2. defense response to bacterium Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH22. Glycoside Hydrolase Family 22.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme (EC:3.2.1.17)
Alternative name(s):
1,4-beta-N-acetylmuramidase
Gene namesi
Name:lysoz
OrganismiCrassostrea gigas (Pacific oyster) (Crassostrea angulata)
Taxonomic identifieri29159 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaBivalviaPteriomorphiaOstreoidaOstreoideaOstreidaeCrassostrea

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 137117LysozymePRO_0000280511Add
BLAST

Expressioni

Tissue specificityi

Expressed in the basophil cells of the oyster digestive gland.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ6L6Q6.
SMRiQ6L6Q6. Positions 17-130.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lysozyme type I family.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR008597. Destabilase.
IPR023346. Lysozyme-like_dom.
[Graphical view]
PANTHERiPTHR11195. PTHR11195. 1 hit.
PfamiPF05497. Destabilase. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6L6Q6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRLLGSIVI LATVFTFCEA TISSACLRCI CNVESGCRPI GCHYDVYSYS
60 70 80 90 100
CGYFQIKENY WEDCGKPGTS FKACANDYTC ASNCVRAYMK RYIGSSGCPA
110 120 130
NCESYARIHN GGPRGCRHPS TLRYWEKVHQ QGCNVNS
Length:137
Mass (Da):15,274
Last modified:July 5, 2004 - v1
Checksum:i1E2A8F1AF5403CE5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB179775 mRNA. Translation: BAD19059.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB179775 mRNA. Translation: BAD19059.1.

3D structure databases

ProteinModelPortaliQ6L6Q6.
SMRiQ6L6Q6. Positions 17-130.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH22. Glycoside Hydrolase Family 22.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR008597. Destabilase.
IPR023346. Lysozyme-like_dom.
[Graphical view]
PANTHERiPTHR11195. PTHR11195. 1 hit.
PfamiPF05497. Destabilase. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Cloning of cDNAs and hybridization analysis of lysozymes from two oyster species, Crassostrea gigas and Ostrea edulis."
    Matsumoto T., Nakamura A.M., Takahashi K.G.
    Comp. Biochem. Physiol. 145B:325-330(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.

Entry informationi

Entry nameiLYS_CRAGI
AccessioniPrimary (citable) accession number: Q6L6Q6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: July 5, 2004
Last modified: January 7, 2015
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.