Reviewed, UniProtKB/Swiss-Prot Q6L6Q6 (LYS_CRAGI)

Names and origin

Protein names

Recommended name:
    Lysozyme
    EC=3.2.1.17
Alternative name(s):
    1,4-beta-N-acetylmuramidase

Gene names

Name:

lysoz

Organism

Crassostrea gigas (Pacific oyster) (Crassostrea angulata)

Taxonomic identifier

29159 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Mollusca › Bivalvia › Pteriomorphia › Ostreoida › Ostreoidea › Ostreidae › Crassostrea

Protein attributes

Sequence length	137 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May play a role in digestion and in the host defense mechanisms against invading microbes.
Catalytic activity	Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.
Subcellular location	Secreted.
Tissue specificity	Expressed in the basophil cells of the oyster digestive gland. Ref.1
Sequence similarities	Belongs to the lysozyme type I family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Antibiotic Antimicrobial Bacteriolytic enzyme Glycosidase Hydrolase
Gene Ontology (GO)
Biological process	cytolysis Inferred from electronic annotation. Source: UniProtKB-KW defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	lysozyme activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 137	117	Lysozyme		PRO_0000280511

Sequences

	Sequence		Length	Mass (Da)
	Q6L6Q6-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 1E2A8F1AF5403CE5	FASTA	137	15,274
	10 20 30 40 50 60 MQRLLGSIVI LATVFTFCEA TISSACLRCI CNVESGCRPI GCHYDVYSYS CGYFQIKENY 70 80 90 100 110 120 WEDCGKPGTS FKACANDYTC ASNCVRAYMK RYIGSSGCPA NCESYARIHN GGPRGCRHPS 130 TLRYWEKVHQ QGCNVNS

References

[1]	"Cloning of cDNAs and hybridization analysis of lysozymes from two oyster species, Crassostrea gigas and Ostrea edulis." Matsumoto T., Nakamura A.M., Takahashi K.G. Comp. Biochem. Physiol. 145B:325-330(2006) [PubMed: 16996284] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB179775 mRNA. Translation: BAD19059.1.
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GH22. Glycoside Hydrolase Family 22.
Enzyme and pathway databases
BRENDA	3.2.1.17. 8516.
Family and domain databases
InterPro	IPR008597. Destabilase. [Graphical view]
PANTHER	PTHR11195. Destabilase. 1 hit.
Pfam	PF05497. Destabilase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LYS_CRAGI

Accession

Primary (citable) accession number: Q6L6Q6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	July 5, 2004
Last modified:	June 16, 2009
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)