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Q6L6Q6

- LYS_CRAGI

UniProt

Q6L6Q6 - LYS_CRAGI

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Protein

Lysozyme

Gene

lysoz

Organism
Crassostrea gigas (Pacific oyster) (Crassostrea angulata)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May play a role in digestion and in the host defense mechanisms against invading microbes.

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

GO - Molecular functioni

  1. lysozyme activity Source: UniProtKB-EC

GO - Biological processi

  1. cytolysis Source: UniProtKB-KW
  2. defense response to bacterium Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH22. Glycoside Hydrolase Family 22.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme (EC:3.2.1.17)
Alternative name(s):
1,4-beta-N-acetylmuramidase
Gene namesi
Name:lysoz
OrganismiCrassostrea gigas (Pacific oyster) (Crassostrea angulata)
Taxonomic identifieri29159 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaBivalviaPteriomorphiaOstreoidaOstreoideaOstreidaeCrassostrea

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 137117LysozymePRO_0000280511Add
BLAST

Expressioni

Tissue specificityi

Expressed in the basophil cells of the oyster digestive gland.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ6L6Q6.
SMRiQ6L6Q6. Positions 17-130.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lysozyme type I family.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR008597. Destabilase.
IPR023346. Lysozyme-like_dom.
[Graphical view]
PANTHERiPTHR11195. PTHR11195. 1 hit.
PfamiPF05497. Destabilase. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6L6Q6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQRLLGSIVI LATVFTFCEA TISSACLRCI CNVESGCRPI GCHYDVYSYS
60 70 80 90 100
CGYFQIKENY WEDCGKPGTS FKACANDYTC ASNCVRAYMK RYIGSSGCPA
110 120 130
NCESYARIHN GGPRGCRHPS TLRYWEKVHQ QGCNVNS
Length:137
Mass (Da):15,274
Last modified:July 5, 2004 - v1
Checksum:i1E2A8F1AF5403CE5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB179775 mRNA. Translation: BAD19059.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB179775 mRNA. Translation: BAD19059.1 .

3D structure databases

ProteinModelPortali Q6L6Q6.
SMRi Q6L6Q6. Positions 17-130.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH22. Glycoside Hydrolase Family 22.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR008597. Destabilase.
IPR023346. Lysozyme-like_dom.
[Graphical view ]
PANTHERi PTHR11195. PTHR11195. 1 hit.
Pfami PF05497. Destabilase. 1 hit.
[Graphical view ]
SUPFAMi SSF53955. SSF53955. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Cloning of cDNAs and hybridization analysis of lysozymes from two oyster species, Crassostrea gigas and Ostrea edulis."
    Matsumoto T., Nakamura A.M., Takahashi K.G.
    Comp. Biochem. Physiol. 145B:325-330(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.

Entry informationi

Entry nameiLYS_CRAGI
AccessioniPrimary (citable) accession number: Q6L6Q6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3