Q6L6Q5 (LYS_OSTED) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lysozyme
EC=3.2.1.17

Alternative name(s):
1,4-beta-N-acetylmuramidase

Gene names

Name:

lysoz

Organism

Ostrea edulis (Native oyster) (European flat oyster)

Taxonomic identifier

37623 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Lophotrochozoa › Mollusca › Bivalvia › Pteriomorphia › Ostreoida › Ostreoidea › Ostreidae › Ostrea

Protein attributes

Sequence length	137 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play a role in digestion and in the host defense mechanisms against invading microbes.
Catalytic activity	Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.
Subcellular location	Secreted.
Sequence similarities	Belongs to the lysozyme type I family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Antibiotic Antimicrobial Bacteriolytic enzyme Glycosidase Hydrolase
Gene Ontology (GO)
Biological_process	cytolysis Inferred from electronic annotation. Source: UniProtKB-KW defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	lysozyme activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 137	117	Lysozyme		PRO_0000280512

Sequences

	Sequence		Length	Mass (Da)
	Q6L6Q5 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 5E267529DE695722	FASTA	137	14,918
	10 20 30 40 50 60 MSAVLVLALV LLSLTCVTDA ISDACLTCIC KQESYGCTQI GCRMDGRSLS CGYFQIKKSY 70 80 90 100 110 120 WIDCGRLGSS WEACADDYNC AVRCVRAYMK KYIGKSGCTA NCKNYARLHN GGPKGCTKPS 130 TLTYWNAVKN QGCSINS

References

[1]	"Cloning of cDNAs and hybridization analysis of lysozymes from two oyster species, Crassostrea gigas and Ostrea edulis." Matsumoto T., Nakamura A.M., Takahashi K.G. Comp. Biochem. Physiol. 145B:325-330(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB179776 mRNA. Translation: BAD19060.1.
3D structure databases
HSSP	HSSP built from PDB template 3LHM based on UniProtKB P61626.
ProteinModelPortal	Q6L6Q5.
SMR	Q6L6Q5. Positions 18-130.
ModBase	Search...
Protein family/group databases
CAZy	GH22. Glycoside Hydrolase Family 22.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR008597. Destabilase. IPR023346. Lysozyme-like_dom. [Graphical view]
PANTHER	PTHR11195. PTHR11195. 1 hit.
Pfam	PF05497. Destabilase. 1 hit. [Graphical view]
SUPFAM	SSF53955. SSF53955. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LYS_OSTED

Accession

Primary (citable) accession number: Q6L6Q5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	July 5, 2004
Last modified:	October 3, 2012
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)