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Q6L5H6

- P2C50_ORYSJ

UniProt

Q6L5H6 - P2C50_ORYSJ

Protein

Probable protein phosphatase 2C 50

Gene

Os05g0537400

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi118 – 1181Manganese 1By similarity
    Metal bindingi118 – 1181Manganese 2By similarity
    Metal bindingi119 – 1191Manganese 1; via carbonyl oxygenBy similarity
    Metal bindingi306 – 3061Manganese 2By similarity
    Metal bindingi368 – 3681Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein serine/threonine phosphatase activity Source: InterPro

    GO - Biological processi

    1. protein dephosphorylation Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable protein phosphatase 2C 50 (EC:3.1.3.16)
    Short name:
    OsPP2C50
    Gene namesi
    Ordered Locus Names:Os05g0537400, LOC_Os05g46040
    ORF Names:OJ1741_B01.18, OSJNBa0052K01.2
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 5

    Organism-specific databases

    GrameneiQ6L5H6.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 387387Probable protein phosphatase 2C 50PRO_0000363297Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ6L5H6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini61 – 370310PP2C-likeAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi2 – 98Poly-Ala

    Sequence similaritiesi

    Belongs to the PP2C family.Curated
    Contains 1 PP2C-like domain.Curated

    Phylogenomic databases

    eggNOGiCOG0631.
    HOGENOMiHOG000233896.
    KOiK14497.
    OMAiNEEACKV.

    Family and domain databases

    Gene3Di3.60.40.10. 1 hit.
    InterProiIPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 1 hit.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 1 hit.
    PROSITEiPS01032. PP2C. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6L5H6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAAAAAAAI CGEDETAARV GCTGEWAGGI ERVDLGERKE AVAAAGAGKR    50
    SVYLMDCAPV WGCASTRGRS AEMEDASAAV PRFADVPVRL LASRRDLDAL 100
    GLDADALRLP AHLFGVFDGH GGAEVANYCR ERIHVVLSEE LKRLGKNLGE 150
    MGEVDMKEHW DDVFTKCFQR VDDEVSGRVT RVVNGGGEVR SEPVTAENVG 200
    STAVVALVCS SHVVVANCGD SRIVLCRGKE PVALSIDHKP DRKDERARIE 250
    AQGGKVIQWN GYRVSGILAM SRSIGDRYLK PFVIPKPEVM VVPRAKDDDC 300
    LILASDGLWD VVSNEEACKV ARRQILLWHK NNGAASPLSD EGEGSTDPAA 350
    QAAADYLMRL ALKKGSEDNI TVIVVDLKPR KKLKNIS 387
    Length:387
    Mass (Da):41,554
    Last modified:July 5, 2004 - v1
    Checksum:i8DE5BAF0E1CCA2E6
    GO
    Isoform 2 (identifier: Q6L5H6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         276-296: DRYLKPFVIPKPEVMVVPRAK → MHIDPCARSRLKHLSVSFPCK
         297-387: Missing.

    Note: Derived from EST data. No experimental confirmation available.

    Show »
    Length:296
    Mass (Da):31,638
    Checksum:i2857CCC23E6DE330
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei276 – 29621DRYLK…VPRAK → MHIDPCARSRLKHLSVSFPC K in isoform 2. CuratedVSP_036271Add
    BLAST
    Alternative sequencei297 – 38791Missing in isoform 2. CuratedVSP_036272Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC097112 Genomic DNA. Translation: AAT39223.1.
    AC119291 Genomic DNA. Translation: AAV59393.1.
    AP008211 Genomic DNA. Translation: BAF18083.2.
    RefSeqiNP_001056169.2. NM_001062704.2. [Q6L5H6-1]
    UniGeneiOs.18094.

    Genome annotation databases

    GeneIDi4339454.
    KEGGiosa:4339454.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC097112 Genomic DNA. Translation: AAT39223.1 .
    AC119291 Genomic DNA. Translation: AAV59393.1 .
    AP008211 Genomic DNA. Translation: BAF18083.2 .
    RefSeqi NP_001056169.2. NM_001062704.2. [Q6L5H6-1 ]
    UniGenei Os.18094.

    3D structure databases

    ProteinModelPortali Q6L5H6.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4339454.
    KEGGi osa:4339454.

    Organism-specific databases

    Gramenei Q6L5H6.

    Phylogenomic databases

    eggNOGi COG0631.
    HOGENOMi HOG000233896.
    KOi K14497.
    OMAi NEEACKV.

    Family and domain databases

    Gene3Di 3.60.40.10. 1 hit.
    InterProi IPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 1 hit.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 1 hit.
    PROSITEi PS01032. PP2C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    3. "The rice annotation project database (RAP-DB): 2008 update."
      The rice annotation project (RAP)
      Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: cv. Nipponbare.
    4. "Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
      Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
      BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.

    Entry informationi

    Entry nameiP2C50_ORYSJ
    AccessioniPrimary (citable) accession number: Q6L5H6
    Secondary accession number(s): Q0DGE0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 10, 2009
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3