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Q6L5H6 (P2C50_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable protein phosphatase 2C 50

Short name=OsPP2C50
EC=3.1.3.16
Gene names
Ordered Locus Names:Os05g0537400, LOC_Os05g46040
ORF Names:OJ1741_B01.18, OSJNBa0052K01.2
OrganismOryza sativa subsp. japonica (Rice) [Reference proteome]
Taxonomic identifier39947 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza

Protein attributes

Sequence length387 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Sequence similarities

Belongs to the PP2C family.

Contains 1 PP2C-like domain.

Ontologies

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6L5H6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6L5H6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     276-296: DRYLKPFVIPKPEVMVVPRAK → MHIDPCARSRLKHLSVSFPCK
     297-387: Missing.
Note: Derived from EST data. No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 387387Probable protein phosphatase 2C 50
PRO_0000363297

Regions

Domain61 – 370310PP2C-like
Compositional bias2 – 98Poly-Ala

Sites

Metal binding1181Manganese 1 By similarity
Metal binding1181Manganese 2 By similarity
Metal binding1191Manganese 1; via carbonyl oxygen By similarity
Metal binding3061Manganese 2 By similarity
Metal binding3681Manganese 2 By similarity

Natural variations

Alternative sequence276 – 29621DRYLK…VPRAK → MHIDPCARSRLKHLSVSFPC K in isoform 2.
VSP_036271
Alternative sequence297 – 38791Missing in isoform 2.
VSP_036272

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 8DE5BAF0E1CCA2E6

FASTA38741,554
        10         20         30         40         50         60 
MAAAAAAAAI CGEDETAARV GCTGEWAGGI ERVDLGERKE AVAAAGAGKR SVYLMDCAPV 

        70         80         90        100        110        120 
WGCASTRGRS AEMEDASAAV PRFADVPVRL LASRRDLDAL GLDADALRLP AHLFGVFDGH 

       130        140        150        160        170        180 
GGAEVANYCR ERIHVVLSEE LKRLGKNLGE MGEVDMKEHW DDVFTKCFQR VDDEVSGRVT 

       190        200        210        220        230        240 
RVVNGGGEVR SEPVTAENVG STAVVALVCS SHVVVANCGD SRIVLCRGKE PVALSIDHKP 

       250        260        270        280        290        300 
DRKDERARIE AQGGKVIQWN GYRVSGILAM SRSIGDRYLK PFVIPKPEVM VVPRAKDDDC 

       310        320        330        340        350        360 
LILASDGLWD VVSNEEACKV ARRQILLWHK NNGAASPLSD EGEGSTDPAA QAAADYLMRL 

       370        380 
ALKKGSEDNI TVIVVDLKPR KKLKNIS 

« Hide

Isoform 2 [UniParc].

Checksum: 2857CCC23E6DE330
Show »

FASTA29631,638

References

« Hide 'large scale' references
[1]"A fine physical map of the rice chromosome 5."
Cheng C.-H., Chung M.C., Liu S.-M., Chen S.-K., Kao F.Y., Lin S.-J., Hsiao S.-H., Tseng I.C., Hsing Y.-I.C., Wu H.-P., Chen C.-S., Shaw J.-F., Wu J., Matsumoto T., Sasaki T., Chen H.-C., Chow T.-Y.
Mol. Genet. Genomics 274:337-345(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Nipponbare.
[2]"The map-based sequence of the rice genome."
International rice genome sequencing project (IRGSP)
Nature 436:793-800(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Nipponbare.
[3]"The rice annotation project database (RAP-DB): 2008 update."
The rice annotation project (RAP)
Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: cv. Nipponbare.
[4]"Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC097112 Genomic DNA. Translation: AAT39223.1.
AC119291 Genomic DNA. Translation: AAV59393.1.
AP008211 Genomic DNA. Translation: BAF18083.2.
RefSeqNP_001056169.2. NM_001062704.2. [Q6L5H6-1]
UniGeneOs.18094.

3D structure databases

ProteinModelPortalQ6L5H6.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4339454.
KEGGosa:4339454.

Organism-specific databases

GrameneQ6L5H6.

Phylogenomic databases

eggNOGCOG0631.
HOGENOMHOG000233896.
KOK14497.
OMANEEACKV.

Family and domain databases

Gene3D3.60.40.10. 1 hit.
InterProIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERPTHR13832. PTHR13832. 1 hit.
PfamPF00481. PP2C. 1 hit.
[Graphical view]
SMARTSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMSSF81606. SSF81606. 1 hit.
PROSITEPS01032. PP2C. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameP2C50_ORYSJ
AccessionPrimary (citable) accession number: Q6L5H6
Secondary accession number(s): Q0DGE0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Oryza sativa (rice)

Index of Oryza sativa entries and their corresponding gene designations