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Q6L5H6

- P2C50_ORYSJ

UniProt

Q6L5H6 - P2C50_ORYSJ

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Protein

Probable protein phosphatase 2C 50

Gene

Os05g0537400

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi118 – 1181Manganese 1By similarity
Metal bindingi118 – 1181Manganese 2By similarity
Metal bindingi119 – 1191Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi306 – 3061Manganese 2By similarity
Metal bindingi368 – 3681Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein serine/threonine phosphatase activity Source: InterPro

GO - Biological processi

  1. protein dephosphorylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase 2C 50 (EC:3.1.3.16)
Short name:
OsPP2C50
Gene namesi
Ordered Locus Names:Os05g0537400, LOC_Os05g46040
ORF Names:OJ1741_B01.18, OSJNBa0052K01.2
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 5

Organism-specific databases

GrameneiQ6L5H6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 387387Probable protein phosphatase 2C 50PRO_0000363297Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6L5H6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini61 – 370310PP2C-likeAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2 – 98Poly-Ala

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PP2C-like domain.Curated

Phylogenomic databases

eggNOGiCOG0631.
HOGENOMiHOG000233896.
InParanoidiQ6L5H6.
KOiK14497.
OMAiNEEACKV.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PP2C. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6L5H6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAAAAAAI CGEDETAARV GCTGEWAGGI ERVDLGERKE AVAAAGAGKR
60 70 80 90 100
SVYLMDCAPV WGCASTRGRS AEMEDASAAV PRFADVPVRL LASRRDLDAL
110 120 130 140 150
GLDADALRLP AHLFGVFDGH GGAEVANYCR ERIHVVLSEE LKRLGKNLGE
160 170 180 190 200
MGEVDMKEHW DDVFTKCFQR VDDEVSGRVT RVVNGGGEVR SEPVTAENVG
210 220 230 240 250
STAVVALVCS SHVVVANCGD SRIVLCRGKE PVALSIDHKP DRKDERARIE
260 270 280 290 300
AQGGKVIQWN GYRVSGILAM SRSIGDRYLK PFVIPKPEVM VVPRAKDDDC
310 320 330 340 350
LILASDGLWD VVSNEEACKV ARRQILLWHK NNGAASPLSD EGEGSTDPAA
360 370 380
QAAADYLMRL ALKKGSEDNI TVIVVDLKPR KKLKNIS
Length:387
Mass (Da):41,554
Last modified:July 5, 2004 - v1
Checksum:i8DE5BAF0E1CCA2E6
GO
Isoform 2 (identifier: Q6L5H6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     276-296: DRYLKPFVIPKPEVMVVPRAK → MHIDPCARSRLKHLSVSFPCK
     297-387: Missing.

Note: Derived from EST data. No experimental confirmation available.

Show »
Length:296
Mass (Da):31,638
Checksum:i2857CCC23E6DE330
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei276 – 29621DRYLK…VPRAK → MHIDPCARSRLKHLSVSFPC K in isoform 2. CuratedVSP_036271Add
BLAST
Alternative sequencei297 – 38791Missing in isoform 2. CuratedVSP_036272Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC097112 Genomic DNA. Translation: AAT39223.1.
AC119291 Genomic DNA. Translation: AAV59393.1.
AP008211 Genomic DNA. Translation: BAF18083.2.
RefSeqiNP_001056169.2. NM_001062704.2. [Q6L5H6-1]
UniGeneiOs.18094.

Genome annotation databases

GeneIDi4339454.
KEGGiosa:4339454.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC097112 Genomic DNA. Translation: AAT39223.1 .
AC119291 Genomic DNA. Translation: AAV59393.1 .
AP008211 Genomic DNA. Translation: BAF18083.2 .
RefSeqi NP_001056169.2. NM_001062704.2. [Q6L5H6-1 ]
UniGenei Os.18094.

3D structure databases

ProteinModelPortali Q6L5H6.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4339454.
KEGGi osa:4339454.

Organism-specific databases

Gramenei Q6L5H6.

Phylogenomic databases

eggNOGi COG0631.
HOGENOMi HOG000233896.
InParanoidi Q6L5H6.
KOi K14497.
OMAi NEEACKV.

Family and domain databases

Gene3Di 3.60.40.10. 1 hit.
InterProi IPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 1 hit.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 1 hit.
PROSITEi PS01032. PP2C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  3. "The rice annotation project database (RAP-DB): 2008 update."
    The rice annotation project (RAP)
    Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: cv. Nipponbare.
  4. "Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
    Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
    BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiP2C50_ORYSJ
AccessioniPrimary (citable) accession number: Q6L5H6
Secondary accession number(s): Q0DGE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: July 5, 2004
Last modified: November 26, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3