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Protein

Mitogen-activated protein kinase 17

Gene

MPK17

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei134ATPPROSITE-ProRule annotation1
Active sitei231Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi111 – 119ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-OSA-4086398 Ca2+ pathway
R-OSA-5687128 MAPK6/MAPK4 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase 17 (EC:2.7.11.24)
Short name:
MAP kinase 17
Gene namesi
Name:MPK17
Ordered Locus Names:Os05g0576800, LOC_Os05g50120
ORF Names:OJ1126_B10.5
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002397601 – 582Mitogen-activated protein kinase 17Add BLAST582

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei267PhosphothreonineBy similarity1
Modified residuei269PhosphotyrosineBy similarity1

Post-translational modificationi

Dually phosphorylated on Thr-267 and Tyr-269, which activates the enzyme.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6L5F7

Expressioni

Inductioni

By ethylene and infection with rice blast fungus (M.grisea).1 Publication

Gene expression databases

ExpressionAtlasiQ6L5F7 differential
GenevisibleiQ6L5F7 OS

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os05g50120.1

Structurei

3D structure databases

ProteinModelPortaliQ6L5F7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini105 – 396Protein kinasePROSITE-ProRule annotationAdd BLAST292

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi267 – 269TXY3

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0660 Eukaryota
ENOG410XNY0 LUCA
HOGENOMiHOG000233024
InParanoidiQ6L5F7
OMAiTHLPVRT
OrthoDBiEOG093605CF

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR003527 MAP_kinase_CS
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS01351 MAPK, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequencei

Sequence statusi: Complete.

Q6L5F7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGRARSILR WLRHHRSRRV SSSSFHLTTT GDDTVKDLHD PRREDAEGDG
60 70 80 90 100
WEEVHEGPES DPEEYIALVS EDAGTHLPVR TEPRRMDPSK KEPDFFTEYG
110 120 130 140 150
EANRYKVSEV IGKGSYGVVA AAVDTQTGER VAIKKINDVF DHVSDATRIL
160 170 180 190 200
REIKLLRLLR HPDIVEIKHI MLPPSRREFR DIYVIFELME SDLHQVIKAN
210 220 230 240 250
DDLTPEHHQF FLYQLLRGMK YIHAASVFHR DLKPKNILAN ADCKLKVCDF
260 270 280 290 300
GLARVSFNDT PSAIFWTDYV ATRWYRAPEL CGSFFSKYTP AIDIWSVGCI
310 320 330 340 350
FAELLTGKPL FPGKNVVHQL DLMTDLLGTP SAESLAKIRN EKARRYLSNM
360 370 380 390 400
RKKPRVPFTK KFPGVDPMAL HLLERLLAFD PKDRPSAEEA LTDPYFNGLA
410 420 430 440 450
NSEREPIAQP ISKLEFEFEK RKLAKDDVRE LIYREILEYH PHMLQEYLRG
460 470 480 490 500
GDQMSFMYPS GVDRFKRQFA HLEEGVSKGE KSSPQLRQNA SLPRERAIGN
510 520 530 540 550
KHGDDEYHAK LNVGEKPCHA SVTDGISKPL MSARSLLKSE SISASKCIGE
560 570 580
KPKQDRDQED SLTESMDETA DEVSEKVAQL KT
Length:582
Mass (Da):66,487
Last modified:June 13, 2006 - v2
Checksum:i78DCBD1DEB835292
GO

Sequence cautioni

The sequence AAT39148 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC098571 Genomic DNA Translation: AAT39148.1 Sequence problems.
AP008211 Genomic DNA Translation: BAF18318.1
AP014961 Genomic DNA Translation: BAS95483.1
AK070644 mRNA Translation: BAG92074.1
RefSeqiXP_015637399.1, XM_015781913.1
XP_015637400.1, XM_015781914.1
UniGeneiOs.34647

Genome annotation databases

EnsemblPlantsiOs05t0576800-01; Os05t0576800-01; Os05g0576800
GeneIDi4339697
GrameneiOs05t0576800-01; Os05t0576800-01; Os05g0576800
KEGGiosa:4339697

Similar proteinsi

Entry informationi

Entry nameiMPK17_ORYSJ
AccessioniPrimary (citable) accession number: Q6L5F7
Secondary accession number(s): Q0DFQ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 13, 2006
Last modified: May 23, 2018
This is version 97 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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