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Q6L4R7 (P2C53_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable protein phosphatase 2C 53

Short name=OsPP2C53
EC=3.1.3.16
Gene names
Ordered Locus Names:Os05g0592800, LOC_Os05g51510
ORF Names:OsJ_018965, P0663C08.11
OrganismOryza sativa subsp. japonica (Rice) [Reference proteome]
Taxonomic identifier39947 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza

Protein attributes

Sequence length445 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Sequence similarities

Belongs to the PP2C family.

Contains 1 PP2C-like domain.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   DomainSignal
   LigandMagnesium
Manganese
Metal-binding
   Molecular functionHydrolase
Protein phosphatase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein dephosphorylation

Inferred from electronic annotation. Source: InterPro

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein serine/threonine phosphatase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6L4R7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6L4R7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-144: Missing.
     145-186: PRFFDLPLWM...AVYDGHGGVQ → MPWSRDFSTF...PISSPSTMAT
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Chain30 – 445416Probable protein phosphatase 2C 53
PRO_0000363300

Regions

Domain123 – 428306PP2C-like
Compositional bias5 – 113109Ala-rich

Sites

Metal binding1801Manganese 1 By similarity
Metal binding1801Manganese 2 By similarity
Metal binding1811Manganese 1; via carbonyl oxygen By similarity
Metal binding3621Manganese 2 By similarity
Metal binding4261Manganese 2 By similarity

Natural variations

Alternative sequence1 – 144144Missing in isoform 2.
VSP_036273
Alternative sequence145 – 18642PRFFD…HGGVQ → MPWSRDFSTFLCGWLPATRQ STASTGPPSAFQPISSPSTM AT in isoform 2.
VSP_036274

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: E06D4D4A57E97FC1

FASTA44546,684
        10         20         30         40         50         60 
MEDLALPAAP PAPTLSFTLL AAAAAVAEAM EEALGAALPP LTAPVPAPGD DSACGSPCSV 

        70         80         90        100        110        120 
ASDCSSVASA DFEGFAELGT SLLAGPAVLF DDLTAASVAV AEAAEPRAVG ATARSVFAMD 

       130        140        150        160        170        180 
CVPLWGLESI CGRRPEMEDD YAVVPRFFDL PLWMVAGDAA VDGLDRASFR LPAHFFAVYD 

       190        200        210        220        230        240 
GHGGVQVANY CRKRIHAVLT EELRRAEDDA CGSDLSGLES KKLWEKAFVD CFSRVDAEVG 

       250        260        270        280        290        300 
GNAASGAPPV APDTVGSTAV VAVVCSSHVI VANCGDSRAV LCRGKQPLPL SLDHKPNRED 

       310        320        330        340        350        360 
EYARIEALGG KVIQWNGYRV LGVLAMSRSI GDKYLKPYII PVPEVTVVAR AKDDDCLILA 

       370        380        390        400        410        420 
SDGLWDVMSN EEVCDAARKR ILLWHKKNAA TASTSSAQIS GDSSDPAAQA AADYLSKLAL 

       430        440 
QKGSKDNITV VVIDLKAHRK FKSKA 

« Hide

Isoform 2 [UniParc].

Checksum: 3EB37EADBA7F3952
Show »

FASTA30132,306

References

« Hide 'large scale' references
[1]"A fine physical map of the rice chromosome 5."
Cheng C.-H., Chung M.C., Liu S.-M., Chen S.-K., Kao F.Y., Lin S.-J., Hsiao S.-H., Tseng I.C., Hsing Y.-I.C., Wu H.-P., Chen C.-S., Shaw J.-F., Wu J., Matsumoto T., Sasaki T., Chen H.-C., Chow T.-Y.
Mol. Genet. Genomics 274:337-345(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Nipponbare.
[2]"The map-based sequence of the rice genome."
International rice genome sequencing project (IRGSP)
Nature 436:793-800(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Nipponbare.
[3]"The rice annotation project database (RAP-DB): 2008 update."
The rice annotation project (RAP)
Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: cv. Nipponbare.
[4]"The genomes of Oryza sativa: a history of duplications."
Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L. expand/collapse author list , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Nipponbare.
[5]"Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
The rice full-length cDNA consortium
Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: cv. Nipponbare.
[6]"Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC130728 Genomic DNA. Translation: AAT44303.1.
AP008211 Genomic DNA. Translation: BAF18412.1.
CM000142 Genomic DNA. Translation: EAZ35482.1.
AK067627 mRNA. Translation: BAG90506.1.
AK070388 mRNA. Translation: BAG91921.1.
RefSeqNP_001056498.1. NM_001063033.1. [Q6L4R7-1]
UniGeneOs.52518.

3D structure databases

ProteinModelPortalQ6L4R7.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsOS05T0592800-02; OS05T0592800-02; OS05G0592800. [Q6L4R7-1]
OS05T0592800-03; OS05T0592800-03; OS05G0592800. [Q6L4R7-1]
GeneID4339797.
KEGGosa:4339797.

Organism-specific databases

GrameneQ6L4R7.

Phylogenomic databases

eggNOGCOG0631.
KOK14497.
OMACFLKVDS.

Family and domain databases

Gene3D3.60.40.10. 1 hit.
InterProIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERPTHR13832. PTHR13832. 1 hit.
PfamPF00481. PP2C. 1 hit.
[Graphical view]
SMARTSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMSSF81606. SSF81606. 1 hit.
PROSITEPS01032. PP2C. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameP2C53_ORYSJ
AccessionPrimary (citable) accession number: Q6L4R7
Secondary accession number(s): B7EHS4
Entry history
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Oryza sativa (rice)

Index of Oryza sativa entries and their corresponding gene designations