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Q6L2M4

- NADK_PICTO

UniProt

Q6L2M4 - NADK_PICTO

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Protein

NAD kinase

Gene
nadK, PTO0193
Organism
Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei62 – 621Proton acceptor By similarity
Binding sitei67 – 671NAD By similarity
Binding sitei140 – 1401NAD By similarity
Binding sitei159 – 1591NAD By similarity
Binding sitei167 – 1671NAD; via carbonyl oxygen By similarity
Binding sitei194 – 1941NAD; via carbonyl oxygen By similarity
Binding sitei227 – 2271NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi62 – 632NAD By similarity
Nucleotide bindingi129 – 1302NAD By similarity
Nucleotide bindingi170 – 1756NAD By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciPTOR263820:GHA3-196-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase (EC:2.7.1.23)
Alternative name(s):
ATP-dependent NAD kinase
Gene namesi
Name:nadK
Ordered Locus Names:PTO0193
OrganismiPicrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
Taxonomic identifieri263820 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesPicrophilaceaePicrophilus
ProteomesiUP000000438: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 270270NAD kinaseUniRule annotationPRO_0000120704Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi263820.PTO0193.

Structurei

3D structure databases

ProteinModelPortaliQ6L2M4.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227222.
KOiK00858.
OMAiFPRENFL.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6L2M4-1 [UniParc]FASTAAdd to Basket

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MKVAIVTKIN CKSCINIARI IISALPSDWD IIYEKSLARA IKKPGLEINE    50
INADIIIVIG GDGTILRTAQ FAHGNILGIN VGGLGFLSEI EIGNIEASIL 100
KLIRNEYTII EYMGLDVYVN GVYSGKAIND AVIHTDKVSK IRKFRLYENN 150
YFIETTSADG VIVATPIGST SYSFSAGGPI LMPNLNGIVV SYIAPVGFRS 200
RSIVFSEKTD LKIAIVGERS LLTIDGQIEK KLSKNDVVNI RVSENGARFI 250
SMYTNFYEKL REKLIKDVVN 270
Length:270
Mass (Da):29,696
Last modified:July 5, 2004 - v1
Checksum:i4C18397D58276077
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017261 Genomic DNA. Translation: AAT42778.1.
RefSeqiWP_011176994.1. NC_005877.1.
YP_022971.1. NC_005877.1.

Genome annotation databases

EnsemblBacteriaiAAT42778; AAT42778; PTO0193.
GeneIDi2845016.
KEGGipto:PTO0193.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017261 Genomic DNA. Translation: AAT42778.1 .
RefSeqi WP_011176994.1. NC_005877.1.
YP_022971.1. NC_005877.1.

3D structure databases

ProteinModelPortali Q6L2M4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 263820.PTO0193.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAT42778 ; AAT42778 ; PTO0193 .
GeneIDi 2845016.
KEGGi pto:PTO0193.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000227222.
KOi K00858.
OMAi FPRENFL.

Enzyme and pathway databases

BioCyci PTOR263820:GHA3-196-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828.

Entry informationi

Entry nameiNADK_PICTO
AccessioniPrimary (citable) accession number: Q6L2M4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3