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Protein

NAD kinase

Gene

nadK

Organism
Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei62 – 621Proton acceptorUniRule annotation
Binding sitei67 – 671NADUniRule annotation
Binding sitei140 – 1401NADUniRule annotation
Binding sitei159 – 1591NADUniRule annotation
Binding sitei167 – 1671NAD; via carbonyl oxygenUniRule annotation
Binding sitei194 – 1941NAD; via carbonyl oxygenUniRule annotation
Binding sitei227 – 2271NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi62 – 632NADUniRule annotation
Nucleotide bindingi129 – 1302NADUniRule annotation
Nucleotide bindingi170 – 1756NADUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciPTOR263820:GHA3-196-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:PTO0193
OrganismiPicrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
Taxonomic identifieri263820 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesPicrophilaceaePicrophilus
ProteomesiUP000000438 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 270270NAD kinasePRO_0000120704Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi263820.PTO0193.

Structurei

3D structure databases

ProteinModelPortaliQ6L2M4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227222.
KOiK00858.
OMAiIARFRWW.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR016064. NAD/diacylglycerol_kinase.
IPR002504. NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6L2M4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVAIVTKIN CKSCINIARI IISALPSDWD IIYEKSLARA IKKPGLEINE
60 70 80 90 100
INADIIIVIG GDGTILRTAQ FAHGNILGIN VGGLGFLSEI EIGNIEASIL
110 120 130 140 150
KLIRNEYTII EYMGLDVYVN GVYSGKAIND AVIHTDKVSK IRKFRLYENN
160 170 180 190 200
YFIETTSADG VIVATPIGST SYSFSAGGPI LMPNLNGIVV SYIAPVGFRS
210 220 230 240 250
RSIVFSEKTD LKIAIVGERS LLTIDGQIEK KLSKNDVVNI RVSENGARFI
260 270
SMYTNFYEKL REKLIKDVVN
Length:270
Mass (Da):29,696
Last modified:July 5, 2004 - v1
Checksum:i4C18397D58276077
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017261 Genomic DNA. Translation: AAT42778.1.
RefSeqiWP_011176994.1. NC_005877.1.
YP_022971.1. NC_005877.1.

Genome annotation databases

EnsemblBacteriaiAAT42778; AAT42778; PTO0193.
GeneIDi2845016.
KEGGipto:PTO0193.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017261 Genomic DNA. Translation: AAT42778.1.
RefSeqiWP_011176994.1. NC_005877.1.
YP_022971.1. NC_005877.1.

3D structure databases

ProteinModelPortaliQ6L2M4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi263820.PTO0193.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT42778; AAT42778; PTO0193.
GeneIDi2845016.
KEGGipto:PTO0193.

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227222.
KOiK00858.
OMAiIARFRWW.

Enzyme and pathway databases

BioCyciPTOR263820:GHA3-196-MONOMER.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR016064. NAD/diacylglycerol_kinase.
IPR002504. NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828.

Entry informationi

Entry nameiNADK_PICTO
AccessioniPrimary (citable) accession number: Q6L2M4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: July 5, 2004
Last modified: May 27, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.