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Protein

Dihydroneopterin aldolase

Gene

mptD

Organism
Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).UniRule annotation

Catalytic activityi

7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei20 – 201SubstrateUniRule annotation
Binding sitei114 – 1141Substrate; via amide nitrogen and carbonyl oxygenUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Enzyme and pathway databases

BioCyciPTOR263820:GHA3-222-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydroneopterin aldolaseUniRule annotation (EC:4.1.2.25UniRule annotation)
Short name:
DHNAUniRule annotation
Alternative name(s):
7,8-dihydroneopterin aldolaseUniRule annotation
Gene namesi
Name:mptDUniRule annotation
Ordered Locus Names:PTO0218
OrganismiPicrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
Taxonomic identifieri263820 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesPicrophilaceaePicrophilus
Proteomesi
  • UP000000438 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 120120Dihydroneopterin aldolasePRO_0000420354Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation1 Publication

Protein-protein interaction databases

STRINGi263820.PTO0218.

Structurei

Secondary structure

1
120
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 83Combined sources
Helixi13 – 3220Combined sources
Turni39 – 413Combined sources
Helixi42 – 5312Combined sources
Beta strandi59 – 668Combined sources
Turni83 – 853Combined sources
Beta strandi86 – 949Combined sources
Beta strandi97 – 10610Combined sources
Turni107 – 1104Combined sources
Beta strandi111 – 1199Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2I52X-ray2.08A/B/C/D/E/F2-120[»]
ProteinModelPortaliQ6L2J9.
SMRiQ6L2J9. Positions 1-120.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6L2J9.

Family & Domainsi

Sequence similaritiesi

Belongs to the archaeal dihydroneopterin aldolase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04705. Archaea.
COG2098. LUCA.
HOGENOMiHOG000229383.
KOiK09739.
OMAiMKNQPCV.

Family and domain databases

Gene3Di3.30.1300.20. 1 hit.
HAMAPiMF_02130. DHNA_arch.
InterProiIPR027508. DHN_aldolase_MptD.
IPR007181. MtpD_C.
IPR007179. MtpD_N.
[Graphical view]
PfamiPF04038. DHNA. 1 hit.
[Graphical view]
ProDomiPD027636. DUF372. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF143560. SSF143560. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6L2J9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYDPAEKYFN CTDIQRAFFE AGIKLGAIFH QYTGIPVNSE NASMAEEFIE
60 70 80 90 100
RSTMIQPFVE NVRISINNVK RSSGTYSYSS LNEKMLHAEV LINYNGKKVL
110 120
GVLNYDEGLD YPVMYAKEVL
Length:120
Mass (Da):13,692
Last modified:July 5, 2004 - v1
Checksum:iFE6A54DA26CF085F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017261 Genomic DNA. Translation: AAT42803.1.
RefSeqiWP_011177019.1. NC_005877.1.

Genome annotation databases

EnsemblBacteriaiAAT42803; AAT42803; PTO0218.
GeneIDi2844002.
KEGGipto:PTO0218.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017261 Genomic DNA. Translation: AAT42803.1.
RefSeqiWP_011177019.1. NC_005877.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2I52X-ray2.08A/B/C/D/E/F2-120[»]
ProteinModelPortaliQ6L2J9.
SMRiQ6L2J9. Positions 1-120.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi263820.PTO0218.

Protocols and materials databases

DNASUi2844002.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT42803; AAT42803; PTO0218.
GeneIDi2844002.
KEGGipto:PTO0218.

Phylogenomic databases

eggNOGiarCOG04705. Archaea.
COG2098. LUCA.
HOGENOMiHOG000229383.
KOiK09739.
OMAiMKNQPCV.

Enzyme and pathway databases

BioCyciPTOR263820:GHA3-222-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ6L2J9.

Family and domain databases

Gene3Di3.30.1300.20. 1 hit.
HAMAPiMF_02130. DHNA_arch.
InterProiIPR027508. DHN_aldolase_MptD.
IPR007181. MtpD_C.
IPR007179. MtpD_N.
[Graphical view]
PfamiPF04038. DHNA. 1 hit.
[Graphical view]
ProDomiPD027636. DUF372. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF143560. SSF143560. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828.
  2. "Structure of hypothetical protein PTO0218 from Picrophilus torridus."
    New York structural genomix research consortium (NYSGXRC)
    Submitted (JUL-2011) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.08 ANGSTROMS) OF 2-120, SUBUNIT.

Entry informationi

Entry nameiMPTD_PICTO
AccessioniPrimary (citable) accession number: Q6L2J9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2012
Last sequence update: July 5, 2004
Last modified: November 11, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.