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Protein

Dihydroneopterin aldolase

Gene

mptD

Organism
Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).UniRule annotation

Catalytic activityi

7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei20SubstrateUniRule annotation1
Binding sitei114Substrate; via amide nitrogen and carbonyl oxygenUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionLyase

Enzyme and pathway databases

BioCyciPTOR263820:G1G0U-237-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydroneopterin aldolaseUniRule annotation (EC:4.1.2.25UniRule annotation)
Short name:
DHNAUniRule annotation
Alternative name(s):
7,8-dihydroneopterin aldolaseUniRule annotation
Gene namesi
Name:mptDUniRule annotation
Ordered Locus Names:PTO0218
OrganismiPicrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
Taxonomic identifieri263820 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesPicrophilaceaePicrophilus
Proteomesi
  • UP000000438 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004203541 – 120Dihydroneopterin aldolaseAdd BLAST120

Proteomic databases

PRIDEiQ6L2J9

Interactioni

Subunit structurei

Homotetramer.UniRule annotation1 Publication

Protein-protein interaction databases

STRINGi263820.PTO0218

Structurei

Secondary structure

1120
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 8Combined sources3
Helixi13 – 32Combined sources20
Turni39 – 41Combined sources3
Helixi42 – 53Combined sources12
Beta strandi59 – 66Combined sources8
Turni83 – 85Combined sources3
Beta strandi86 – 94Combined sources9
Beta strandi97 – 106Combined sources10
Turni107 – 110Combined sources4
Beta strandi111 – 119Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2I52X-ray2.08A/B/C/D/E/F2-120[»]
ProteinModelPortaliQ6L2J9
SMRiQ6L2J9
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6L2J9

Family & Domainsi

Sequence similaritiesi

Belongs to the archaeal dihydroneopterin aldolase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04705 Archaea
COG2098 LUCA
HOGENOMiHOG000229383
KOiK09739
OMAiHQFVGTP
OrthoDBiPOG093Z0ISO

Family and domain databases

Gene3Di3.30.1300.20, 1 hit
HAMAPiMF_02130 DHNA_arch, 1 hit
InterProiView protein in InterPro
IPR027508 DHN_aldolase_MptD
IPR036839 MptD_sf
IPR007181 MtpD_C
IPR007179 MtpD_N
PfamiView protein in Pfam
PF04038 DHNA, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD027636 DUF372, 1 hit
SUPFAMiSSF143560 SSF143560, 1 hit

Sequencei

Sequence statusi: Complete.

Q6L2J9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYDPAEKYFN CTDIQRAFFE AGIKLGAIFH QYTGIPVNSE NASMAEEFIE
60 70 80 90 100
RSTMIQPFVE NVRISINNVK RSSGTYSYSS LNEKMLHAEV LINYNGKKVL
110 120
GVLNYDEGLD YPVMYAKEVL
Length:120
Mass (Da):13,692
Last modified:July 5, 2004 - v1
Checksum:iFE6A54DA26CF085F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017261 Genomic DNA Translation: AAT42803.1
RefSeqiWP_011177019.1, NC_005877.1

Genome annotation databases

EnsemblBacteriaiAAT42803; AAT42803; PTO0218
GeneIDi2844002
KEGGipto:PTO0218
PATRICifig|263820.9.peg.236

Similar proteinsi

Entry informationi

Entry nameiMPTD_PICTO
AccessioniPrimary (citable) accession number: Q6L2J9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2012
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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