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Q6L1T6

- OGG1_PICTO

UniProt

Q6L1T6 - OGG1_PICTO

Protein

Probable N-glycosylase/DNA lyase

Gene

ogg

Organism
Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites).UniRule annotation

    Catalytic activityi

    The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei132 – 1321UniRule annotation

    GO - Molecular functioni

    1. DNA-(apurinic or apyrimidinic site) lyase activity Source: UniProtKB-HAMAP
    2. hydrolase activity, hydrolyzing N-glycosyl compounds Source: UniProtKB-HAMAP

    GO - Biological processi

    1. base-excision repair Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Glycosidase, Hydrolase, Lyase

    Keywords - Biological processi

    DNA damage, DNA repair

    Enzyme and pathway databases

    BioCyciPTOR263820:GHA3-499-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable N-glycosylase/DNA lyaseUniRule annotation
    Including the following 2 domains:
    8-oxoguanine DNA glycosylaseUniRule annotation (EC:3.2.2.-UniRule annotation)
    DNA-(apurinic or apyrimidinic site) lyaseUniRule annotation (EC:4.2.99.18UniRule annotation)
    Short name:
    AP lyaseUniRule annotation
    Gene namesi
    Name:oggUniRule annotation
    Ordered Locus Names:PTO0481
    OrganismiPicrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
    Taxonomic identifieri263820 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesPicrophilaceaePicrophilus
    ProteomesiUP000000438: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 209209Probable N-glycosylase/DNA lyasePRO_0000159564Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi263820.PTO0481.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6L1T6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the type-2 OGG1 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1059.
    HOGENOMiHOG000224507.
    KOiK03653.
    OMAiCILTANT.

    Family and domain databases

    Gene3Di1.10.340.30. 1 hit.
    HAMAPiMF_00241. Ogg.
    InterProiIPR012092. DNA_glyclase/DNA_lyase_thermo.
    IPR011257. DNA_glycosylase.
    IPR003265. HhH-GPD_domain.
    [Graphical view]
    PIRSFiPIRSF005954. Thrmst_ogg. 1 hit.
    SMARTiSM00478. ENDO3c. 1 hit.
    [Graphical view]
    SUPFAMiSSF48150. SSF48150. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6L1T6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MISSDYIKDK ILEIENIQGN LIRSRISEFK RLKKSDKYTL FKELSFCILT    50
    ANTSAELGLK CQAYINDGFY RLDYNDLREE LIKVHYRFYN KRASYIIGAR 100
    DIIDDLEYIV NMDDHFRARE ILIERVKGIG YKEASHFLRN VGVFDFAILD 150
    KHIIKFMKNN YYIKYENNSS RRRYLENEIV FNELAKKFNM EPGVFDLYIW 200
    YIETGKILK 209
    Length:209
    Mass (Da):25,087
    Last modified:July 5, 2004 - v1
    Checksum:iE896D25066690E1D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017261 Genomic DNA. Translation: AAT43066.1.
    RefSeqiWP_011177282.1. NC_005877.1.
    YP_023259.1. NC_005877.1.

    Genome annotation databases

    EnsemblBacteriaiAAT43066; AAT43066; PTO0481.
    GeneIDi2844848.
    KEGGipto:PTO0481.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017261 Genomic DNA. Translation: AAT43066.1 .
    RefSeqi WP_011177282.1. NC_005877.1.
    YP_023259.1. NC_005877.1.

    3D structure databases

    ProteinModelPortali Q6L1T6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 263820.PTO0481.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAT43066 ; AAT43066 ; PTO0481 .
    GeneIDi 2844848.
    KEGGi pto:PTO0481.

    Phylogenomic databases

    eggNOGi COG1059.
    HOGENOMi HOG000224507.
    KOi K03653.
    OMAi CILTANT.

    Enzyme and pathway databases

    BioCyci PTOR263820:GHA3-499-MONOMER.

    Family and domain databases

    Gene3Di 1.10.340.30. 1 hit.
    HAMAPi MF_00241. Ogg.
    InterProi IPR012092. DNA_glyclase/DNA_lyase_thermo.
    IPR011257. DNA_glycosylase.
    IPR003265. HhH-GPD_domain.
    [Graphical view ]
    PIRSFi PIRSF005954. Thrmst_ogg. 1 hit.
    SMARTi SM00478. ENDO3c. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48150. SSF48150. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828.

    Entry informationi

    Entry nameiOGG1_PICTO
    AccessioniPrimary (citable) accession number: Q6L1T6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3