Q6L1Q1 (GUAAB_PICTO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GMP synthase [glutamine-hydrolyzing] subunit B
EC=6.3.5.2

Alternative name(s):
GMP synthetase

Gene names

Name:	guaAB
Ordered Locus Names:	PTO0516

Organism

Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828) [Complete proteome] [HAMAP]

Taxonomic identifier

263820 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermoplasmata › Thermoplasmatales › Picrophilaceae › Picrophilus

Protein attributes

Sequence length	305 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the synthesis of GMP from XMP By similarity. HAMAP MF_00345
Catalytic activity	ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate. HAMAP MF_00345
Pathway	Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1. HAMAP MF_00345
Subunit structure	Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B) Potential.
Sequence similarities	Contains 1 GMP-binding domain.

Ontologies

Keywords
Biological process	GMP biosynthesis Purine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	GMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW GMP synthase (glutamine-hydrolyzing) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 305	305	GMP synthase [glutamine-hydrolyzing] subunit B HAMAP MF_00345		PRO_0000140246
Regions
	Domain	31 – 183	153	GMP-binding
	Nucleotide binding	27 – 33	7	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6L1Q1-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: B3A18B114921C7CF	FASTA	305	34,511
	10 20 30 40 50 60 MLDPEKFIKD SVSFIEKNVK RGILACSGGQ DSTLLAVISS MAKTDILTVF IDTGLLRNND 70 80 90 100 110 120 IKRIKEIFSS YNVNGRILDR SSLFISRLRN VTDPEEKRKI IGRTFIEVFE EEAKNYGAES 130 140 150 160 170 180 LLQGTIAPDW IESGGGSRDT IKSHHNVGGL PEKMNLRLVE PLRDLYKDEV REVSRYLGLP 190 200 210 220 230 240 EVQPFPGPGL AIRIIGEVTE EKLNILRRAT DIVEYESSKL NDKPWQYFPV LLPVRTTGIH 250 260 270 280 290 300 GDQRTYGLTI AIRFIDTIDG MSGTFSRPDW SVLENISNRI TDEIPEINRV VYDITSKPPA TIEWE

References

[1]

"Genome sequence of Picrophilus torridus and its implications for life around pH 0." Fuetterer O., Angelov A., Liesegang H., Gottschalk G., Schleper C., Schepers B., Dock C., Antranikian G., Liebl W. Proc. Natl. Acad. Sci. U.S.A. 101:9091-9096(2004) [PubMed: 15184674] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017261 Genomic DNA. Translation: AAT43101.1.
RefSeq	YP_023294.1.
3D structure databases
ProteinModelPortal	Q6L1Q1.
SMR	Q6L1Q1. Positions 2-305.
ModBase	Search...
Genome annotation databases
GeneID	2845437.
GenomeReviews	Gene locus PTO0516 in contig AE017261_GR.
KEGG	pto:PTO0516.
NMPDR	fig|263820.1.peg.516.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG391775.
OMA	QGTIAPD.
ProtClustDB	PRK00919.
Enzyme and pathway databases
BioCyc	PTOR263820:PTO0516-MONOMER.
BRENDA	6.3.5.2. 276518.
Family and domain databases
HAMAP	MF_00345. GMP_synthase_B. [Tree]
InterPro	IPR001674. GMP_synth_C. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
Pfam	PF00958. GMP_synt_C. 1 hit. [Graphical view]
TIGRFAMs	TIGR00884. guaA_Cterm. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GUAAB_PICTO

Accession

Primary (citable) accession number: Q6L1Q1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	July 5, 2004
Last modified:	August 10, 2010
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)