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Q6L1P9

- ENDA_PICTO

UniProt

Q6L1P9 - ENDA_PICTO

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Protein

tRNA-splicing endonuclease

Gene

endA

Organism
Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp (By similarity).By similarity

Catalytic activityi

PretRNA = a 3'-half-tRNA molecule with a 5'-OH end + a 5'-half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei222 – 2221UniRule annotation
Active sitei229 – 2291UniRule annotation
Active sitei257 – 2571UniRule annotation

GO - Molecular functioni

  1. lyase activity Source: UniProtKB-KW
  2. nucleic acid binding Source: InterPro
  3. tRNA-intron endonuclease activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. tRNA splicing, via endonucleolytic cleavage and ligation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

tRNA processing

Enzyme and pathway databases

BioCyciPTOR263820:GHA3-537-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA-splicing endonucleaseUniRule annotation (EC:4.6.1.16UniRule annotation)
Alternative name(s):
tRNA-intron endonucleaseUniRule annotation
Gene namesi
Name:endAUniRule annotation
Ordered Locus Names:PTO0518
OrganismiPicrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
Taxonomic identifieri263820 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesPicrophilaceaePicrophilus
ProteomesiUP000000438: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 284284tRNA-splicing endonucleasePRO_0000109489Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi263820.PTO0518.

Structurei

3D structure databases

ProteinModelPortaliQ6L1P9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tRNA-intron endonuclease family. Archaeal long subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1676.
HOGENOMiHOG000112369.
KOiK01170.
OMAiPYECLYL.

Family and domain databases

Gene3Di3.40.1350.10. 1 hit.
HAMAPiMF_01834. EndA_long.
InterProiIPR011856. tRNA_endonuc-like_dom.
IPR006677. tRNA_intron_Endonuc_cat-like.
IPR006676. tRNA_splic.
IPR023516. tRNA_splic_arch_long.
[Graphical view]
PfamiPF01974. tRNA_int_endo. 1 hit.
[Graphical view]
SUPFAMiSSF53032. SSF53032. 1 hit.
TIGRFAMsiTIGR00324. endA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6L1P9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDYIIEDGFH FDIKNGKSPS YLINKYRTGH VIGNVYLLNK YEAFYLYLKN
60 70 80 90 100
KISIDDEFFN GNIKFYMAYE NLIGSGLYVK ILNDCFMCRK SRNSRYKKVR
110 120 130 140 150
FMPDDILLSF KDLYSDDSNI YITVDEEYES VYYSMERIDI KGSRKDDFSA
160 170 180 190 200
ASIDVSSGAY FGMNCPEWFG IDFHGKRLLN DYEIRFLNND VKSNVDVIYK
210 220 230 240 250
DLIKRGFIVK SGFKYGSNFR IYKNSMNEHS DYLVNYMDHD LWYVIARAVR
260 270 280
LASNVRKRLI ISGIIDNDPV YIKIERIKDI KTIL
Length:284
Mass (Da):33,533
Last modified:July 5, 2004 - v1
Checksum:i000B863998A7D939
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017261 Genomic DNA. Translation: AAT43103.1.
RefSeqiYP_023296.1. NC_005877.1.

Genome annotation databases

EnsemblBacteriaiAAT43103; AAT43103; PTO0518.
GeneIDi2845336.
KEGGipto:PTO0518.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017261 Genomic DNA. Translation: AAT43103.1 .
RefSeqi YP_023296.1. NC_005877.1.

3D structure databases

ProteinModelPortali Q6L1P9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 263820.PTO0518.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAT43103 ; AAT43103 ; PTO0518 .
GeneIDi 2845336.
KEGGi pto:PTO0518.

Phylogenomic databases

eggNOGi COG1676.
HOGENOMi HOG000112369.
KOi K01170.
OMAi PYECLYL.

Enzyme and pathway databases

BioCyci PTOR263820:GHA3-537-MONOMER.

Family and domain databases

Gene3Di 3.40.1350.10. 1 hit.
HAMAPi MF_01834. EndA_long.
InterProi IPR011856. tRNA_endonuc-like_dom.
IPR006677. tRNA_intron_Endonuc_cat-like.
IPR006676. tRNA_splic.
IPR023516. tRNA_splic_arch_long.
[Graphical view ]
Pfami PF01974. tRNA_int_endo. 1 hit.
[Graphical view ]
SUPFAMi SSF53032. SSF53032. 1 hit.
TIGRFAMsi TIGR00324. endA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828.

Entry informationi

Entry nameiENDA_PICTO
AccessioniPrimary (citable) accession number: Q6L1P9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: July 5, 2004
Last modified: October 1, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3