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Q6L1P9

- ENDA_PICTO

UniProt

Q6L1P9 - ENDA_PICTO

Protein

tRNA-splicing endonuclease

Gene

endA

Organism
Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp By similarity.By similarity

    Catalytic activityi

    PretRNA = a 3'-half-tRNA molecule with a 5'-OH end + a 5'-half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei222 – 2221UniRule annotation
    Active sitei229 – 2291UniRule annotation
    Active sitei257 – 2571UniRule annotation

    GO - Molecular functioni

    1. lyase activity Source: UniProtKB-KW
    2. nucleic acid binding Source: InterPro
    3. tRNA-intron endonuclease activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. tRNA splicing, via endonucleolytic cleavage and ligation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    tRNA processing

    Enzyme and pathway databases

    BioCyciPTOR263820:GHA3-537-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA-splicing endonucleaseUniRule annotation (EC:4.6.1.16UniRule annotation)
    Alternative name(s):
    tRNA-intron endonucleaseUniRule annotation
    Gene namesi
    Name:endAUniRule annotation
    Ordered Locus Names:PTO0518
    OrganismiPicrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
    Taxonomic identifieri263820 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesPicrophilaceaePicrophilus
    ProteomesiUP000000438: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 284284tRNA-splicing endonucleasePRO_0000109489Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi263820.PTO0518.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6L1P9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tRNA-intron endonuclease family. Archaeal long subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1676.
    HOGENOMiHOG000112369.
    KOiK01170.
    OMAiPYECLYL.

    Family and domain databases

    Gene3Di3.40.1350.10. 1 hit.
    HAMAPiMF_01834. EndA_long.
    InterProiIPR011856. tRNA_endonuc-like_dom.
    IPR006677. tRNA_intron_Endonuc_cat-like.
    IPR006676. tRNA_splic.
    IPR023516. tRNA_splic_arch_long.
    [Graphical view]
    PfamiPF01974. tRNA_int_endo. 1 hit.
    [Graphical view]
    SUPFAMiSSF53032. SSF53032. 1 hit.
    TIGRFAMsiTIGR00324. endA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6L1P9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDYIIEDGFH FDIKNGKSPS YLINKYRTGH VIGNVYLLNK YEAFYLYLKN    50
    KISIDDEFFN GNIKFYMAYE NLIGSGLYVK ILNDCFMCRK SRNSRYKKVR 100
    FMPDDILLSF KDLYSDDSNI YITVDEEYES VYYSMERIDI KGSRKDDFSA 150
    ASIDVSSGAY FGMNCPEWFG IDFHGKRLLN DYEIRFLNND VKSNVDVIYK 200
    DLIKRGFIVK SGFKYGSNFR IYKNSMNEHS DYLVNYMDHD LWYVIARAVR 250
    LASNVRKRLI ISGIIDNDPV YIKIERIKDI KTIL 284
    Length:284
    Mass (Da):33,533
    Last modified:July 5, 2004 - v1
    Checksum:i000B863998A7D939
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017261 Genomic DNA. Translation: AAT43103.1.
    RefSeqiYP_023296.1. NC_005877.1.

    Genome annotation databases

    EnsemblBacteriaiAAT43103; AAT43103; PTO0518.
    GeneIDi2845336.
    KEGGipto:PTO0518.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017261 Genomic DNA. Translation: AAT43103.1 .
    RefSeqi YP_023296.1. NC_005877.1.

    3D structure databases

    ProteinModelPortali Q6L1P9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 263820.PTO0518.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAT43103 ; AAT43103 ; PTO0518 .
    GeneIDi 2845336.
    KEGGi pto:PTO0518.

    Phylogenomic databases

    eggNOGi COG1676.
    HOGENOMi HOG000112369.
    KOi K01170.
    OMAi PYECLYL.

    Enzyme and pathway databases

    BioCyci PTOR263820:GHA3-537-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1350.10. 1 hit.
    HAMAPi MF_01834. EndA_long.
    InterProi IPR011856. tRNA_endonuc-like_dom.
    IPR006677. tRNA_intron_Endonuc_cat-like.
    IPR006676. tRNA_splic.
    IPR023516. tRNA_splic_arch_long.
    [Graphical view ]
    Pfami PF01974. tRNA_int_endo. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53032. SSF53032. 1 hit.
    TIGRFAMsi TIGR00324. endA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828.

    Entry informationi

    Entry nameiENDA_PICTO
    AccessioniPrimary (citable) accession number: Q6L1P9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3