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Q6L1N7

- ASSY_PICTO

UniProt

Q6L1N7 - ASSY_PICTO

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Protein
Argininosuccinate synthase
Gene
argG, PTO0530
Organism
Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei83 – 831Citrulline By similarity
Binding sitei113 – 1131ATP; via amide nitrogen By similarity
Binding sitei115 – 1151Aspartate By similarity
Binding sitei119 – 1191Aspartate By similarity
Binding sitei119 – 1191Citrulline By similarity
Binding sitei120 – 1201Aspartate By similarity
Binding sitei123 – 1231Citrulline By similarity
Binding sitei169 – 1691Citrulline By similarity
Binding sitei178 – 1781Citrulline By similarity
Binding sitei253 – 2531Citrulline By similarity
Binding sitei265 – 2651Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 159ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. argininosuccinate synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPTOR263820:GHA3-549-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:PTO0530
OrganismiPicrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
Taxonomic identifieri263820 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesPicrophilaceaePicrophilus
ProteomesiUP000000438: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 395395Argininosuccinate synthaseUniRule annotation
PRO_0000148682Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi263820.PTO0530.

Structurei

3D structure databases

ProteinModelPortaliQ6L1N7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiRFESTIR.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6L1N7-1 [UniParc]FASTAAdd to Basket

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MEKALLLYSG GLDTSVMVRW IKEKMNMDVV TLTLDIGNSD LEEIKEKALK    50
LGAIDAITLD VKKEFADNYI SREIHANGLY GEYPLSTALA RPLMAEKAVS 100
VANENDIKFI AHGSTGKGND QVRFEVSINA LDNNIKVIAP VREWNMTRAD 150
ELEYAKMNNI YVKSDGKYSV DENIWGRSIE GSSIENINEP VNDDAFEWVT 200
PPQYCGSGEP VSIEFYKGLP SSLNGKSMDL LSIIKNLNII AGRNGIGIIN 250
MIESRLIGLK SHEVYECPAA SVILKAHKYL ENLILNKNEL SVKNYIDNFW 300
SNMVYNGLWF DPSMEHMNQF EKSSNQYITG SVNLRLYRGN MILEGIESPY 350
SLYDYNTINY ETGVFDQGSS KGFIDIYKNE TVRSNRVKKA LTVIH 395
Length:395
Mass (Da):44,509
Last modified:July 5, 2004 - v1
Checksum:i4502119ACC1D5581
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017261 Genomic DNA. Translation: AAT43115.1.
RefSeqiWP_011177331.1. NC_005877.1.
YP_023308.1. NC_005877.1.

Genome annotation databases

EnsemblBacteriaiAAT43115; AAT43115; PTO0530.
GeneIDi2844608.
KEGGipto:PTO0530.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017261 Genomic DNA. Translation: AAT43115.1 .
RefSeqi WP_011177331.1. NC_005877.1.
YP_023308.1. NC_005877.1.

3D structure databases

ProteinModelPortali Q6L1N7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 263820.PTO0530.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAT43115 ; AAT43115 ; PTO0530 .
GeneIDi 2844608.
KEGGi pto:PTO0530.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi RFESTIR.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci PTOR263820:GHA3-549-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828.

Entry informationi

Entry nameiASSY_PICTO
AccessioniPrimary (citable) accession number: Q6L1N7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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