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Protein

DNA polymerase II large subunit

Gene

polC

Organism
Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity).By similarity

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotation
Degradation of single-stranded DNA. It acts progressively in a 3'- to 5'-direction, releasing nucleoside 5'-phosphates.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Exonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciPTOR263820:GHA3-578-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase II large subunitUniRule annotation (EC:2.7.7.7UniRule annotation)
Short name:
Pol IIUniRule annotation
Gene namesi
Name:polCUniRule annotation
Ordered Locus Names:PTO0558
OrganismiPicrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
Taxonomic identifieri263820 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesPicrophilaceaePicrophilus
Proteomesi
  • UP000000438 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10801080DNA polymerase II large subunitPRO_0000294699Add
BLAST

Interactioni

Subunit structurei

Heterodimer of a large subunit and a small subunit.UniRule annotation

Protein-protein interaction databases

STRINGi263820.PTO0558.

Family & Domainsi

Sequence similaritiesi

Belongs to the archaeal DNA polymerase II family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04447. Archaea.
COG1933. LUCA.
HOGENOMiHOG000286435.
KOiK02322.
OMAiRNCDGDE.

Family and domain databases

HAMAPiMF_00324. DNApol_II_L_arch.
InterProiIPR004475. PolC_DP2.
IPR016033. PolC_DP2_N.
[Graphical view]
PfamiPF03833. PolC_DP2. 1 hit.
[Graphical view]
PIRSFiPIRSF016275. PolC_DP2. 1 hit.
TIGRFAMsiTIGR00354. polC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6L1K9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDHSLFDYN ERLRKETYEC YEIAKKARAM GLDVSDEVEI PIANDMAERV
60 70 80 90 100
EELIHISGIA GEIRELSKSM SREELSLHIS KKVASLLKDN RVEALDKAVR
110 120 130 140 150
VGLAILTEGI LVAPLEGIKD VKINKNDDGT EYVSIVYSGP IRSAGGTAQA
160 170 180 190 200
LSVLIADIVR RELNIGSFSP TDDEIERYIE EVEAYNRLKH LQYMPTPDEI
210 220 230 240 250
RLVLKNSPVM IDGEGSEEEE VSGHRDMKRI TTNRIRGGMC LVLCEGLIQK
260 270 280 290 300
AKKVLKYTNV MHLNEWNILE NIGKNKSDEK TENKSEKYLK DIIAGRPVFG
310 320 330 340 350
YPNRPGGFRL RYGRSRVSGL AAASINPVTM KILNDFIAIG SQIKVELPGK
360 370 380 390 400
AAAITPCDSI DGPMVLTRSG DHIKVKSIEQ AEKIKNDIER ITDLGEILIA
410 420 430 440 450
YGDFLENNRN LDLSPFTREW WEYYLNDELS IYKSRDPDQF DAVNISRKYK
460 470 480 490 500
MPMFPGYDYF WHDITMEELN LLINAIANGI INDDSMMLDA SVSEILIKLG
510 520 530 540 550
IEFKKHNNKL ILHEYYPLIV SCGFDLINEK IVKVSDERKN DVLGTVNALS
560 570 580 590 600
GIEIKPRAPV RVGARLGRPE KAGDRKMKPK VHGLFPLMNY GGSTRSIINA
610 620 630 640 650
ARSGSIMDIE LGARICRACG TETPFVRCPK CGMPTEDSDS EKKFKIDISK
660 670 680 690 700
ALDDAALRVS TDIGTIKELK GVKKLMSRRS VIEPLEKAIL RAKHGISINK
710 720 730 740 750
DGTCRYDMSD IPITHFKYNE ISLTRQRLME LGYSDSDINE IYPQDIIIPR
760 770 780 790 800
DAASYLLNVS KFIDDLLVNY YGLGPYYMCN SEDDLIGHLV IGLAPHTSGG
810 820 830 840 850
IVGRIIGFSD VNGCYAHPFF HAAKRRNCDG DEDSIMLLLD GLLNFSKKYL
860 870 880 890 900
PSTTGGLMDA PLVLTLILDP EEIDKEALNV DTLQRYPLDF YIATEKNAPP
910 920 930 940 950
ASIENMMKTM KVLIKDGRYT GISYSFDTGD ISYGTRLSAY KTIGSMEEKI
960 970 980 990 1000
EKQLGLARIL RSVDENDVAA RVLSSHFLPD IYGNFRSFFT QEFRCTKCNA
1010 1020 1030 1040 1050
KYRRVPLSGR CLRCGSSNII LTIHHGSIVK YLNETKKVMN EYKLPDYLVF
1060 1070 1080
RINRLLEQIE STFDIENGND TTLDALIENE
Length:1,080
Mass (Da):121,576
Last modified:July 5, 2004 - v1
Checksum:i02273EA4918062BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017261 Genomic DNA. Translation: AAT43143.1.
RefSeqiWP_011177359.1. NC_005877.1.

Genome annotation databases

EnsemblBacteriaiAAT43143; AAT43143; PTO0558.
GeneIDi2844296.
KEGGipto:PTO0558.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017261 Genomic DNA. Translation: AAT43143.1.
RefSeqiWP_011177359.1. NC_005877.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi263820.PTO0558.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT43143; AAT43143; PTO0558.
GeneIDi2844296.
KEGGipto:PTO0558.

Phylogenomic databases

eggNOGiarCOG04447. Archaea.
COG1933. LUCA.
HOGENOMiHOG000286435.
KOiK02322.
OMAiRNCDGDE.

Enzyme and pathway databases

BioCyciPTOR263820:GHA3-578-MONOMER.

Family and domain databases

HAMAPiMF_00324. DNApol_II_L_arch.
InterProiIPR004475. PolC_DP2.
IPR016033. PolC_DP2_N.
[Graphical view]
PfamiPF03833. PolC_DP2. 1 hit.
[Graphical view]
PIRSFiPIRSF016275. PolC_DP2. 1 hit.
TIGRFAMsiTIGR00354. polC. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828.

Entry informationi

Entry nameiDP2L_PICTO
AccessioniPrimary (citable) accession number: Q6L1K9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 5, 2004
Last modified: November 11, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.