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Q6L1F6

- GLYA_PICTO

UniProt

Q6L1F6 - GLYA_PICTO

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Protein
Serine hydroxymethyltransferase
Gene
glyA, PTO0611
Organism
Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism By similarity.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei35 – 351Pyridoxal phosphate By similarity
Binding sitei55 – 551Pyridoxal phosphate By similarity
Binding sitei57 – 571Substrate By similarity
Binding sitei64 – 641Substrate By similarity
Binding sitei65 – 651Pyridoxal phosphate By similarity
Binding sitei99 – 991Pyridoxal phosphate By similarity
Binding sitei121 – 1211Substrate; via carbonyl oxygen By similarity
Binding sitei176 – 1761Pyridoxal phosphate By similarity
Binding sitei204 – 2041Pyridoxal phosphate By similarity
Binding sitei230 – 2301Pyridoxal phosphate By similarity
Binding sitei366 – 3661Pyridoxal phosphate By similarity

GO - Molecular functioni

  1. glycine hydroxymethyltransferase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycine biosynthetic process from serine Source: UniProtKB-HAMAP
  2. one-carbon metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Amino-acid biosynthesis, One-carbon metabolism

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciPTOR263820:GHA3-633-MONOMER.
UniPathwayiUPA00288; UER01023.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine hydroxymethyltransferase (EC:2.1.2.-)
Short name:
SHMT
Short name:
Serine methylase
Gene namesi
Name:glyA
Ordered Locus Names:PTO0611
OrganismiPicrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
Taxonomic identifieri263820 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesPicrophilaceaePicrophilus
ProteomesiUP000000438: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Serine hydroxymethyltransferaseUniRule annotation
PRO_0000113718Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei231 – 2311N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi263820.PTO0611.

Structurei

3D structure databases

ProteinModelPortaliQ6L1F6.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni125 – 1273Substrate binding By similarity

Sequence similaritiesi

Belongs to the SHMT family.

Phylogenomic databases

eggNOGiCOG0112.
HOGENOMiHOG000239403.
KOiK00600.
OMAiLEEWNID.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_00051. SHMT.
InterProiIPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR001085. Ser_HO-MeTrfase.
IPR019798. Ser_HO-MeTrfase_PLP_BS.
[Graphical view]
PANTHERiPTHR11680. PTHR11680. 1 hit.
PfamiPF00464. SHMT. 1 hit.
[Graphical view]
PIRSFiPIRSF000412. SHMT. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00096. SHMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6L1F6-1 [UniParc]FASTAAdd to Basket

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MLDNKKEYLK DAMFIRDMAM QHEQLFRESI PLIASENIMS PLAMEMLLTD    50
LGFRYAEGLP HHRYYQGNEY VDVIEDKTTE LGKRLFNSKT FDPRPLSGTN 100
ANMAVLYALT EPGDKISVPP LSGGGHISAA KFGAVGFRGL KTVQYPFDIN 150
EMNIDIDGTI KTIKNERPKV CWFGQSVFLF PTPLKELQDA FNEVNARVVY 200
DGAHVAGLIA GGEFQDPLRE GAEIITGSTH KTLPGPQHGM IIGNTDDDTW 250
KKVQRGVFPG TLSNHHLNAM AALGVTLAEE LDFGRDYAKQ IVKNARHLGE 300
KLYEFGFNVL GEKNGFTRSH TLAVDVSKNG GGRKVAENLE KSGIILNKNL 350
LPWDDNKNSQ NPSGIRIGVQ EITRIGFMED DVTELAEILR DAVINEKPVN 400
EIRRRALELK SRFNNIEYCY GNMKPYSYIK IFE 433
Length:433
Mass (Da):48,545
Last modified:July 5, 2004 - v1
Checksum:i7667E9DD660C2278
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017261 Genomic DNA. Translation: AAT43196.1.
RefSeqiWP_011177412.1. NC_005877.1.
YP_023389.1. NC_005877.1.

Genome annotation databases

EnsemblBacteriaiAAT43196; AAT43196; PTO0611.
GeneIDi2844844.
KEGGipto:PTO0611.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017261 Genomic DNA. Translation: AAT43196.1 .
RefSeqi WP_011177412.1. NC_005877.1.
YP_023389.1. NC_005877.1.

3D structure databases

ProteinModelPortali Q6L1F6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 263820.PTO0611.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAT43196 ; AAT43196 ; PTO0611 .
GeneIDi 2844844.
KEGGi pto:PTO0611.

Phylogenomic databases

eggNOGi COG0112.
HOGENOMi HOG000239403.
KOi K00600.
OMAi LEEWNID.

Enzyme and pathway databases

UniPathwayi UPA00288 ; UER01023 .
BioCyci PTOR263820:GHA3-633-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_00051. SHMT.
InterProi IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR001085. Ser_HO-MeTrfase.
IPR019798. Ser_HO-MeTrfase_PLP_BS.
[Graphical view ]
PANTHERi PTHR11680. PTHR11680. 1 hit.
Pfami PF00464. SHMT. 1 hit.
[Graphical view ]
PIRSFi PIRSF000412. SHMT. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
PROSITEi PS00096. SHMT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828.

Entry informationi

Entry nameiGLYA_PICTO
AccessioniPrimary (citable) accession number: Q6L1F6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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