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Q6L1F6

- GLYA_PICTO

UniProt

Q6L1F6 - GLYA_PICTO

Protein

Serine hydroxymethyltransferase

Gene

glyA

Organism
Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei35 – 351Pyridoxal phosphateUniRule annotation
    Binding sitei55 – 551Pyridoxal phosphateUniRule annotation
    Binding sitei57 – 571SubstrateUniRule annotation
    Binding sitei64 – 641SubstrateUniRule annotation
    Binding sitei65 – 651Pyridoxal phosphateUniRule annotation
    Binding sitei99 – 991Pyridoxal phosphateUniRule annotation
    Binding sitei121 – 1211Substrate; via carbonyl oxygenUniRule annotation
    Binding sitei176 – 1761Pyridoxal phosphateUniRule annotation
    Binding sitei204 – 2041Pyridoxal phosphateUniRule annotation
    Binding sitei230 – 2301Pyridoxal phosphateUniRule annotation
    Binding sitei366 – 3661Pyridoxal phosphateUniRule annotation

    GO - Molecular functioni

    1. glycine hydroxymethyltransferase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glycine biosynthetic process from serine Source: UniProtKB-HAMAP
    2. one-carbon metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, One-carbon metabolism

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciPTOR263820:GHA3-633-MONOMER.
    UniPathwayiUPA00288; UER01023.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine hydroxymethyltransferaseUniRule annotation (EC:2.1.2.-UniRule annotation)
    Short name:
    SHMTUniRule annotation
    Short name:
    Serine methylaseUniRule annotation
    Gene namesi
    Name:glyAUniRule annotation
    Ordered Locus Names:PTO0611
    OrganismiPicrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
    Taxonomic identifieri263820 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesPicrophilaceaePicrophilus
    ProteomesiUP000000438: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 433433Serine hydroxymethyltransferasePRO_0000113718Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei231 – 2311N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi263820.PTO0611.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6L1F6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni125 – 1273Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the SHMT family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0112.
    HOGENOMiHOG000239403.
    KOiK00600.
    OMAiLEEWNID.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_00051. SHMT.
    InterProiIPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    IPR001085. Ser_HO-MeTrfase.
    IPR019798. Ser_HO-MeTrfase_PLP_BS.
    [Graphical view]
    PANTHERiPTHR11680. PTHR11680. 1 hit.
    PfamiPF00464. SHMT. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000412. SHMT. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    PROSITEiPS00096. SHMT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6L1F6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLDNKKEYLK DAMFIRDMAM QHEQLFRESI PLIASENIMS PLAMEMLLTD    50
    LGFRYAEGLP HHRYYQGNEY VDVIEDKTTE LGKRLFNSKT FDPRPLSGTN 100
    ANMAVLYALT EPGDKISVPP LSGGGHISAA KFGAVGFRGL KTVQYPFDIN 150
    EMNIDIDGTI KTIKNERPKV CWFGQSVFLF PTPLKELQDA FNEVNARVVY 200
    DGAHVAGLIA GGEFQDPLRE GAEIITGSTH KTLPGPQHGM IIGNTDDDTW 250
    KKVQRGVFPG TLSNHHLNAM AALGVTLAEE LDFGRDYAKQ IVKNARHLGE 300
    KLYEFGFNVL GEKNGFTRSH TLAVDVSKNG GGRKVAENLE KSGIILNKNL 350
    LPWDDNKNSQ NPSGIRIGVQ EITRIGFMED DVTELAEILR DAVINEKPVN 400
    EIRRRALELK SRFNNIEYCY GNMKPYSYIK IFE 433
    Length:433
    Mass (Da):48,545
    Last modified:July 5, 2004 - v1
    Checksum:i7667E9DD660C2278
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017261 Genomic DNA. Translation: AAT43196.1.
    RefSeqiWP_011177412.1. NC_005877.1.
    YP_023389.1. NC_005877.1.

    Genome annotation databases

    EnsemblBacteriaiAAT43196; AAT43196; PTO0611.
    GeneIDi2844844.
    KEGGipto:PTO0611.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017261 Genomic DNA. Translation: AAT43196.1 .
    RefSeqi WP_011177412.1. NC_005877.1.
    YP_023389.1. NC_005877.1.

    3D structure databases

    ProteinModelPortali Q6L1F6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 263820.PTO0611.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAT43196 ; AAT43196 ; PTO0611 .
    GeneIDi 2844844.
    KEGGi pto:PTO0611.

    Phylogenomic databases

    eggNOGi COG0112.
    HOGENOMi HOG000239403.
    KOi K00600.
    OMAi LEEWNID.

    Enzyme and pathway databases

    UniPathwayi UPA00288 ; UER01023 .
    BioCyci PTOR263820:GHA3-633-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_00051. SHMT.
    InterProi IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    IPR001085. Ser_HO-MeTrfase.
    IPR019798. Ser_HO-MeTrfase_PLP_BS.
    [Graphical view ]
    PANTHERi PTHR11680. PTHR11680. 1 hit.
    Pfami PF00464. SHMT. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000412. SHMT. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    PROSITEi PS00096. SHMT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828.

    Entry informationi

    Entry nameiGLYA_PICTO
    AccessioniPrimary (citable) accession number: Q6L1F6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3