Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine hydroxymethyltransferase

Gene

glyA

Organism
Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: glycine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes glycine from L-serine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Serine hydroxymethyltransferase (glyA)
This subpathway is part of the pathway glycine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes glycine from L-serine, the pathway glycine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei35Pyridoxal phosphateUniRule annotation1
Binding sitei55Pyridoxal phosphateUniRule annotation1
Binding sitei57SubstrateUniRule annotation1
Binding sitei64SubstrateUniRule annotation1
Binding sitei65Pyridoxal phosphateUniRule annotation1
Binding sitei99Pyridoxal phosphateUniRule annotation1
Binding sitei121Substrate; via carbonyl oxygenUniRule annotation1
Binding sitei176Pyridoxal phosphateUniRule annotation1
Binding sitei204Pyridoxal phosphateUniRule annotation1
Binding sitei230Pyridoxal phosphateUniRule annotation1
Binding sitei366Pyridoxal phosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Amino-acid biosynthesis, One-carbon metabolism

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00288; UER01023.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine hydroxymethyltransferaseUniRule annotation (EC:2.1.2.-UniRule annotation)
Short name:
SHMTUniRule annotation
Short name:
Serine methylaseUniRule annotation
Gene namesi
Name:glyAUniRule annotation
Ordered Locus Names:PTO0611
OrganismiPicrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
Taxonomic identifieri263820 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesPicrophilaceaePicrophilus
Proteomesi
  • UP000000438 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001137181 – 433Serine hydroxymethyltransferaseAdd BLAST433

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei231N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi263820.PTO0611.

Structurei

3D structure databases

ProteinModelPortaliQ6L1F6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni125 – 127Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the SHMT family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00070. Archaea.
COG0112. LUCA.
HOGENOMiHOG000239403.
KOiK00600.
OMAiDANNPAV.

Family and domain databases

CDDicd00378. SHMT. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_00051. SHMT. 1 hit.
InterProiIPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR001085. Ser_HO-MeTrfase.
IPR019798. Ser_HO-MeTrfase_PLP_BS.
[Graphical view]
PANTHERiPTHR11680. PTHR11680. 1 hit.
PfamiPF00464. SHMT. 1 hit.
[Graphical view]
PIRSFiPIRSF000412. SHMT. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00096. SHMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6L1F6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDNKKEYLK DAMFIRDMAM QHEQLFRESI PLIASENIMS PLAMEMLLTD
60 70 80 90 100
LGFRYAEGLP HHRYYQGNEY VDVIEDKTTE LGKRLFNSKT FDPRPLSGTN
110 120 130 140 150
ANMAVLYALT EPGDKISVPP LSGGGHISAA KFGAVGFRGL KTVQYPFDIN
160 170 180 190 200
EMNIDIDGTI KTIKNERPKV CWFGQSVFLF PTPLKELQDA FNEVNARVVY
210 220 230 240 250
DGAHVAGLIA GGEFQDPLRE GAEIITGSTH KTLPGPQHGM IIGNTDDDTW
260 270 280 290 300
KKVQRGVFPG TLSNHHLNAM AALGVTLAEE LDFGRDYAKQ IVKNARHLGE
310 320 330 340 350
KLYEFGFNVL GEKNGFTRSH TLAVDVSKNG GGRKVAENLE KSGIILNKNL
360 370 380 390 400
LPWDDNKNSQ NPSGIRIGVQ EITRIGFMED DVTELAEILR DAVINEKPVN
410 420 430
EIRRRALELK SRFNNIEYCY GNMKPYSYIK IFE
Length:433
Mass (Da):48,545
Last modified:July 5, 2004 - v1
Checksum:i7667E9DD660C2278
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017261 Genomic DNA. Translation: AAT43196.1.
RefSeqiWP_011177412.1. NC_005877.1.

Genome annotation databases

EnsemblBacteriaiAAT43196; AAT43196; PTO0611.
GeneIDi2844844.
KEGGipto:PTO0611.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017261 Genomic DNA. Translation: AAT43196.1.
RefSeqiWP_011177412.1. NC_005877.1.

3D structure databases

ProteinModelPortaliQ6L1F6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi263820.PTO0611.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT43196; AAT43196; PTO0611.
GeneIDi2844844.
KEGGipto:PTO0611.

Phylogenomic databases

eggNOGiarCOG00070. Archaea.
COG0112. LUCA.
HOGENOMiHOG000239403.
KOiK00600.
OMAiDANNPAV.

Enzyme and pathway databases

UniPathwayiUPA00288; UER01023.

Family and domain databases

CDDicd00378. SHMT. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_00051. SHMT. 1 hit.
InterProiIPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR001085. Ser_HO-MeTrfase.
IPR019798. Ser_HO-MeTrfase_PLP_BS.
[Graphical view]
PANTHERiPTHR11680. PTHR11680. 1 hit.
PfamiPF00464. SHMT. 1 hit.
[Graphical view]
PIRSFiPIRSF000412. SHMT. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00096. SHMT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLYA_PICTO
AccessioniPrimary (citable) accession number: Q6L1F6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.