Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q6L198 (Q6L198_PICTO) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Amidophosphoribosyltransferase PIRNR PIRNR000485
Short name=ATase PIRNR PIRNR000485
EC=2.4.2.14 PIRNR PIRNR000485
Alternative name(s):
Glutamine phosphoribosylpyrophosphate amidotransferase PIRNR PIRNR000485
Gene names
Ordered Locus Names:PTO0669
OrganismPicrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828) [Complete proteome] [HAMAP] EMBL AAT43254.1
Taxonomic identifier263820 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Thermoplasmata › Thermoplasmatales › Picrophilaceae › Picrophilus

Protein attributes

Sequence length460 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O. PIRNR PIRNR000485

Cofactor

Binds 1 4Fe-4S cluster per subunit By similarity. PIRSR PIRSR000485-3

Binds 1 magnesium ion per subunit By similarity. PIRNR PIRNR000485

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2. PIRNR PIRNR000485

Sequence similarities

In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. PIRNR PIRNR000485

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site201For GATase activity By similarity PIRSR PIRSR000485-1
Metal binding2501Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3
Metal binding3961Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3
Metal binding4451Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3
Metal binding4481Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3

Sequences

Sequence LengthMass (Da)Tools
Q6L198 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 4755435712C8B1B5

FASTA46050,377
        10         20         30         40         50         60 
MDSQPQESDI TTGQKVNEDC AVIGFSGGGV YSSIIAGLRS LQHRGQESSG IITYDGKIHV 

        70         80         90        100        110        120 
KKGMGLVSEV FKNADPMPGI VGIGHNRYST SGSKGIENAG PFVISCSLGY IGITHNGEIT 

       130        140        150        160        170        180 
NEHELREELK HDGYIFTSSS DTEVMLIEFV KEISRYGINE GIKRGMERLK GAYAAVLMIN 

       190        200        210        220        230        240 
DRLYAIRDKF GFRPLVLGRT FNGYIIASET CAIDALSGET IKNVEPGEVI EVFNNSYKTI 

       250        260        270        280        290        300 
FKLDGDVSHC MFEYVYFARP DSIIDNIEVF QARVRMGMRL AVESPVDADV VVPVPDSGRA 

       310        320        330        340        350        360 
QALGFSKATG IPYSEGLIKN RYSERTFIMP DQKSRLAAIK IKLNAIKSEI SNKRIVLVDD 

       370        380        390        400        410        420 
SIVRGNTMKY IVKIVRDAGA SEVHVRISSP PITAPCFYGV DMKTKNEFIA ANKTIESIKN 

       430        440        450        460 
EIGADSLAYL SIDGLKQAIG IKSICISCLT GIYPEYVPLS

« Hide

References

[1]"Genome sequence of Picrophilus torridus and its implications for life around pH 0."
Fuetterer O., Angelov A., Liesegang H., Gottschalk G., Schleper C., Schepers B., Dock C., Antranikian G., Liebl W.
Proc. Natl. Acad. Sci. U.S.A. 101:9091-9096(2004) [PubMed: 15184674] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE017261 Genomic DNA. Translation: AAT43254.1.
RefSeqYP_023447.1. NC_005877.1.

3D structure databases

HSSPHSSP built from PDB template 1AO0 based on UniProtKB P00497.
ProteinModelPortalQ6L198.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2844160.
GenomeReviewsGene locus PTO0669 in contig AE017261_GR.
KEGGpto:PTO0669.
NMPDRfig|263820.1.peg.669.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG392416.
OMADSMFEDQ.
PhylomeDBQ6L198.
ProtClustDBPRK06388.

Enzyme and pathway databases

BioCycPTOR263820:PTO0669-MONOMER.

Family and domain databases

InterProIPR005854. Amd_phspho_trans.
IPR000583. GATase_2.
IPR017932. GATase_II.
IPR000836. PRibTrfase.
[Graphical view]
KOK00764.
PANTHERPTHR11907. Amd_phspho_trans. 1 hit.
PfamPF00310. GATase_2. 1 hit.
PF00156. Pribosyltran. 1 hit.
[Graphical view]
PIRSFPIRSF000485. Amd_phspho_trans. 1 hit.
TIGRFAMsTIGR01134. PurF. 1 hit.
PROSITEPS51278. GATASE_TYPE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ6L198_PICTO
AccessionPrimary (citable) accession number: Q6L198
Entry history
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info