Reviewed,
UniProtKB/Swiss-Prot Q6L195 (DNLI_PICTO)
Last modified
June 16, 2009.
Version 34.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: DNA ligase EC=6.5.1.1 Alternative name(s): Polydeoxyribonucleotide synthase [ATP] | ||||
| Gene names |
| ||||
| Organism | Picrophilus torridus [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 82076 [NCBI] | ||||
| Taxonomic lineage | Archaea › Euryarchaeota › Thermoplasmata › Thermoplasmatales › Picrophilaceae › Picrophilus |
Protein attributes
| Sequence length | 585 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. |
| Catalytic activity | ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP MF_00407 |
| Cofactor | Divalent metal cations By similarity. |
| Sequence similarities | Belongs to the ATP-dependent DNA ligase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Cell cycle Cell division DNA damage DNA recombination DNA repair DNA replication |
| Ligand | ATP-binding Metal-binding Nucleotide-binding |
| Molecular function | Ligase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | DNA recombination Inferred from electronic annotation. Source: HAMAP DNA repairInferred from electronic annotation. Source: HAMAP DNA replicationInferred from electronic annotation. Source: HAMAP cell cycleInferred from electronic annotation. Source: UniProtKB-KW cell divisionInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | ATP binding Inferred from electronic annotation. Source: HAMAP DNA bindingInferred from electronic annotation. Source: InterPro DNA ligase (ATP) activityInferred from electronic annotation. Source: HAMAP metal ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 585 | 585 | DNA ligase HAMAP MF_00407 | PRO_0000059610 | |||||
Sites | |||||||||
| Active site | 250 | 1 | N6-AMP-lysine intermediate By similarity | ||||||
| Binding site | 248 | 1 | ATP By similarity | ||||||
| Binding site | 255 | 1 | ATP By similarity | ||||||
| Binding site | 270 | 1 | ATP By similarity | ||||||
| Binding site | 300 | 1 | ATP By similarity | ||||||
| Binding site | 341 | 1 | ATP By similarity | ||||||
| Binding site | 418 | 1 | ATP By similarity | ||||||
| Binding site | 424 | 1 | ATP By similarity | ||||||
Sequences
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References
| [1] | "Genome sequence of Picrophilus torridus and its implications for life around pH 0." Fuetterer O., Angelov A., Liesegang H., Gottschalk G., Schleper C., Schepers B., Dock C., Antranikian G., Liebl W. Proc. Natl. Acad. Sci. U.S.A. 101:9091-9096(2004) [PubMed: 15184674] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828. |
Cross-references
Sequence databases | |
|---|---|
| AE017261 Genomic DNA. Translation: AAT43257.1. Different initiation. | |
| RefSeq | YP_023450.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 2845337. |
| GenomeReviews | Gene locus PTO0672 in contig AE017261_GR. |
| KEGG | pto:PTO0672. |
| NMPDR | fig|263820.1.peg.672. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q6L195. |
Enzyme and pathway databases | |
| BioCyc | PTOR263820:PTO0672-MON. |
| BRENDA | 6.5.1.1. 276518. |
Family and domain databases | |
| HAMAP | MF_00407. [Tree] |
| InterPro | IPR000977. DNA_ligase. IPR012309. DNA_ligase_A_C. IPR012310. DNA_ligase_A_M. IPR012308. DNA_ligase_A_N. IPR016059. DNA_ligase_CS. IPR012340. NA-bd_OB-fold. [Graphical view] |
| Gene3D | G3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit. |
| Pfam | PF04679. DNA_ligase_A_C. 1 hit. PF01068. DNA_ligase_A_M. 1 hit. PF04675. DNA_ligase_A_N. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00574. dnl1. 1 hit. |
| PROSITE | PS00697. DNA_LIGASE_A1. False negative. PS00333. DNA_LIGASE_A2. False negative. PS50160. DNA_LIGASE_A3. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | DNLI_PICTO | ||||||||
| Accession | Primary (citable) accession number: Q6L195 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

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