SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q6L195

- DNLI_PICTO

UniProt

Q6L195 - DNLI_PICTO

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
DNA ligase
Gene
lig, PTO0672
Organism
Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei248 – 2481ATP By similarity
Active sitei250 – 2501N6-AMP-lysine intermediate By similarity
Binding sitei255 – 2551ATP By similarity
Binding sitei270 – 2701ATP By similarity
Binding sitei300 – 3001ATP By similarity
Binding sitei341 – 3411ATP By similarity
Binding sitei418 – 4181ATP By similarity
Binding sitei424 – 4241ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA recombination Source: UniProtKB-HAMAP
  2. DNA repair Source: UniProtKB-HAMAP
  3. DNA replication Source: UniProtKB-HAMAP
  4. cell cycle Source: UniProtKB-KW
  5. cell division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPTOR263820:GHA3-697-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligase (EC:6.5.1.1)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:lig
Ordered Locus Names:PTO0672
OrganismiPicrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
Taxonomic identifieri263820 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesPicrophilaceaePicrophilus
ProteomesiUP000000438: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 585585DNA ligaseUniRule annotation
PRO_0000059610Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi263820.PTO0672.

Structurei

3D structure databases

ProteinModelPortaliQ6L195.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036008.
KOiK10747.
OMAiCTDIGEL.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6L195-1 [UniParc]FASTAAdd to Basket

« Hide

MDFSDVASYF SRMEETTKRL ELTSILAELF KRSGDDLKKL VYLVQGKLMP    50
DYLGIELGLS DKLIIKSLSK ASGRSEEDIN RIFSRLGDLG STAEEISSSG 100
IQRPLLKESL TVDYVYNQLI KISGYTGHGS IKTKMDAYID LLINSGPMEI 150
KYITRIITGK LRLGVADSTI LDGLIEAFSE KKYADDIETA YNFHPDLGYI 200
AENLMMGNIN ELLNAGPVPL IPFKVMLAER LQSISDIRNK MGHNASYEYK 250
YDGLRTQLHF LKGGIKIFSR GLEETTSSFP DIVQNFKSYY SFDSCIIDGE 300
SVPYNPETGE LYPFQMVSKR RGRKYELTEK TREVPIVMFI FDILYLNGKS 350
LVNLPYPERR SILEKNFKEN EYFKLAKRIV SDDEHDIMKF FERSIEEGCE 400
GIVAKSNGID SIYRAGARGW LWIKFKRDYQ SELSDSLDLV VVGAFDGHGR 450
RKGTFGALLL ACYNSKDDTF ETVCKLGSGF TDEMLSEMPR LLGDKIVEKK 500
PARVNSSMEP DHWIYPSLVL EIRGAEITVS PVHTCAMNII EKGSGLALRF 550
PRLIKPRDDK KPEDATTTNE IIEMYKAQKK VIEKS 585
Length:585
Mass (Da):66,334
Last modified:March 3, 2009 - v2
Checksum:i9AED5BCA48C11F94
GO

Sequence cautioni

The sequence AAT43257.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017261 Genomic DNA. Translation: AAT43257.1. Different initiation.
RefSeqiYP_023450.1. NC_005877.1.

Genome annotation databases

EnsemblBacteriaiAAT43257; AAT43257; PTO0672.
GeneIDi2845337.
KEGGipto:PTO0672.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017261 Genomic DNA. Translation: AAT43257.1 . Different initiation.
RefSeqi YP_023450.1. NC_005877.1.

3D structure databases

ProteinModelPortali Q6L195.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 263820.PTO0672.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAT43257 ; AAT43257 ; PTO0672 .
GeneIDi 2845337.
KEGGi pto:PTO0672.

Phylogenomic databases

eggNOGi COG1793.
HOGENOMi HOG000036008.
KOi K10747.
OMAi CTDIGEL.

Enzyme and pathway databases

BioCyci PTOR263820:GHA3-697-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828.

Entry informationi

Entry nameiDNLI_PICTO
AccessioniPrimary (citable) accession number: Q6L195
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: March 3, 2009
Last modified: May 14, 2014
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi