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Q6L195 (DNLI_PICTO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA ligase

EC=6.5.1.1
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene names
Name:lig
Ordered Locus Names:PTO0672
OrganismPicrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828) [Complete proteome] [HAMAP]
Taxonomic identifier263820 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesPicrophilaceaePicrophilus

Protein attributes

Sequence length585 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family.

Sequence caution

The sequence AAT43257.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 585585DNA ligase HAMAP-Rule MF_00407
PRO_0000059610

Sites

Active site2501N6-AMP-lysine intermediate By similarity
Binding site2481ATP By similarity
Binding site2551ATP By similarity
Binding site2701ATP By similarity
Binding site3001ATP By similarity
Binding site3411ATP By similarity
Binding site4181ATP By similarity
Binding site4241ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6L195 [UniParc].

Last modified March 3, 2009. Version 2.
Checksum: 9AED5BCA48C11F94

FASTA58566,334
        10         20         30         40         50         60 
MDFSDVASYF SRMEETTKRL ELTSILAELF KRSGDDLKKL VYLVQGKLMP DYLGIELGLS 

        70         80         90        100        110        120 
DKLIIKSLSK ASGRSEEDIN RIFSRLGDLG STAEEISSSG IQRPLLKESL TVDYVYNQLI 

       130        140        150        160        170        180 
KISGYTGHGS IKTKMDAYID LLINSGPMEI KYITRIITGK LRLGVADSTI LDGLIEAFSE 

       190        200        210        220        230        240 
KKYADDIETA YNFHPDLGYI AENLMMGNIN ELLNAGPVPL IPFKVMLAER LQSISDIRNK 

       250        260        270        280        290        300 
MGHNASYEYK YDGLRTQLHF LKGGIKIFSR GLEETTSSFP DIVQNFKSYY SFDSCIIDGE 

       310        320        330        340        350        360 
SVPYNPETGE LYPFQMVSKR RGRKYELTEK TREVPIVMFI FDILYLNGKS LVNLPYPERR 

       370        380        390        400        410        420 
SILEKNFKEN EYFKLAKRIV SDDEHDIMKF FERSIEEGCE GIVAKSNGID SIYRAGARGW 

       430        440        450        460        470        480 
LWIKFKRDYQ SELSDSLDLV VVGAFDGHGR RKGTFGALLL ACYNSKDDTF ETVCKLGSGF 

       490        500        510        520        530        540 
TDEMLSEMPR LLGDKIVEKK PARVNSSMEP DHWIYPSLVL EIRGAEITVS PVHTCAMNII 

       550        560        570        580 
EKGSGLALRF PRLIKPRDDK KPEDATTTNE IIEMYKAQKK VIEKS 

« Hide

References

[1]"Genome sequence of Picrophilus torridus and its implications for life around pH 0."
Fuetterer O., Angelov A., Liesegang H., Gottschalk G., Schleper C., Schepers B., Dock C., Antranikian G., Liebl W.
Proc. Natl. Acad. Sci. U.S.A. 101:9091-9096(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017261 Genomic DNA. Translation: AAT43257.1. Different initiation.
RefSeqYP_023450.1. NC_005877.1.

3D structure databases

ProteinModelPortalQ6L195.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING263820.PTO0672.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAT43257; AAT43257; PTO0672.
GeneID2845337.
KEGGpto:PTO0672.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1793.
HOGENOMHOG000036008.
KOK10747.
OMAYIARFVV.
ProtClustDBPRK01109.

Enzyme and pathway databases

BioCycPTOR263820:GHA3-697-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDNLI_PICTO
AccessionPrimary (citable) accession number: Q6L195
Entry history
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: March 3, 2009
Last modified: April 16, 2014
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families