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Protein

DNA ligase

Gene

lig

Organism
Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei248ATPUniRule annotation1
Active sitei250N6-AMP-lysine intermediateUniRule annotation1
Binding sitei255ATPUniRule annotation1
Binding sitei270ATPUniRule annotation1
Binding sitei300ATPUniRule annotation1
Binding sitei341ATPUniRule annotation1
Binding sitei418ATPUniRule annotation1
Binding sitei424ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPTOR263820:G1G0U-728-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:PTO0672
OrganismiPicrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
Taxonomic identifieri263820 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesPicrophilaceaePicrophilus
Proteomesi
  • UP000000438 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000596101 – 585DNA ligaseAdd BLAST585

Interactioni

Protein-protein interaction databases

STRINGi263820.PTO0672

Structurei

3D structure databases

ProteinModelPortaliQ6L195
SMRiQ6L195
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01347 Archaea
COG1793 LUCA
HOGENOMiHOG000036008
KOiK10747
OMAiWIKYKRD
OrthoDBiPOG093Z03L0

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

Q6L195-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFSDVASYF SRMEETTKRL ELTSILAELF KRSGDDLKKL VYLVQGKLMP
60 70 80 90 100
DYLGIELGLS DKLIIKSLSK ASGRSEEDIN RIFSRLGDLG STAEEISSSG
110 120 130 140 150
IQRPLLKESL TVDYVYNQLI KISGYTGHGS IKTKMDAYID LLINSGPMEI
160 170 180 190 200
KYITRIITGK LRLGVADSTI LDGLIEAFSE KKYADDIETA YNFHPDLGYI
210 220 230 240 250
AENLMMGNIN ELLNAGPVPL IPFKVMLAER LQSISDIRNK MGHNASYEYK
260 270 280 290 300
YDGLRTQLHF LKGGIKIFSR GLEETTSSFP DIVQNFKSYY SFDSCIIDGE
310 320 330 340 350
SVPYNPETGE LYPFQMVSKR RGRKYELTEK TREVPIVMFI FDILYLNGKS
360 370 380 390 400
LVNLPYPERR SILEKNFKEN EYFKLAKRIV SDDEHDIMKF FERSIEEGCE
410 420 430 440 450
GIVAKSNGID SIYRAGARGW LWIKFKRDYQ SELSDSLDLV VVGAFDGHGR
460 470 480 490 500
RKGTFGALLL ACYNSKDDTF ETVCKLGSGF TDEMLSEMPR LLGDKIVEKK
510 520 530 540 550
PARVNSSMEP DHWIYPSLVL EIRGAEITVS PVHTCAMNII EKGSGLALRF
560 570 580
PRLIKPRDDK KPEDATTTNE IIEMYKAQKK VIEKS
Length:585
Mass (Da):66,334
Last modified:March 3, 2009 - v2
Checksum:i9AED5BCA48C11F94
GO

Sequence cautioni

The sequence AAT43257 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017261 Genomic DNA Translation: AAT43257.1 Different initiation.
RefSeqiWP_048059460.1, NC_005877.1

Genome annotation databases

EnsemblBacteriaiAAT43257; AAT43257; PTO0672
GeneIDi2845337
KEGGipto:PTO0672
PATRICifig|263820.9.peg.707

Similar proteinsi

Entry informationi

Entry nameiDNLI_PICTO
AccessioniPrimary (citable) accession number: Q6L195
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: March 3, 2009
Last modified: March 28, 2018
This is version 87 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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