Q6L0R7 (G1PDH_PICTO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glycerol-1-phosphate dehydrogenase [NAD(P)+]
Short name=G1P dehydrogenase
Short name=G1PDH
EC=1.1.1.261

Alternative name(s):
Enantiomeric glycerophosphate synthase
sn-glycerol-1-phosphate dehydrogenase

Gene names

Name:	egsA
Ordered Locus Names:	PTO0850

Organism

Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828) [Complete proteome] [HAMAP]

Taxonomic identifier

263820 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermoplasmata › Thermoplasmatales › Picrophilaceae › Picrophilus

Protein attributes

Sequence length	350 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol-1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea By similarity. HAMAP MF_00497_A
Catalytic activity	sn-glycerol-1-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H. HAMAP MF_00497_A
Cofactor	Binds 1 zinc ion per subunit By similarity. HAMAP MF_00497_A
Pathway	Membrane lipid metabolism; glycerophospholipid metabolism. HAMAP MF_00497_A
Subcellular location	Cytoplasm Potential HAMAP MF_00497_A.
Sequence similarities	Belongs to the glycerol-1-phosphate dehydrogenase family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Cytoplasm
Ligand	Metal-binding NAD NADP Zinc
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glycerol-1-phosphate dehydrogenase [NAD(P)+] activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 350	350	Glycerol-1-phosphate dehydrogenase [NAD(P)+] HAMAP MF_00497_A		PRO_0000157346
Regions
	Nucleotide binding	97 – 101	5	NAD By similarity
	Nucleotide binding	119 – 122	4	NAD By similarity
Sites
	Metal binding	171	1	Zinc; catalytic By similarity
	Metal binding	251	1	Zinc; catalytic By similarity
	Metal binding	267	1	Zinc; catalytic By similarity
	Binding site	124	1	Substrate By similarity
	Binding site	128	1	NAD By similarity
	Binding site	171	1	Substrate By similarity
	Binding site	255	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6L0R7 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: DA3D632F5653284B	FASTA	350	37,580
	10 20 30 40 50 60 MNFNKIKSMH FPSDVYIGHD AILNIGSVVS KFLKSGEVLL ITGENTYNIA GKKVLSNLND 70 80 90 100 110 120 FDVNVIIASR ATRDSIKSIE ESLKNRRSGI VLGVGGGSKI DIAKKIAYDL GIPFISVPTT 130 140 150 160 170 180 PSHDGIASPR ASIYDGKSVY SEEATMPSAI VADTSIMVLA PYRYVAAGAA DVISNITAVL 190 200 210 220 230 240 DWKLANRLKG EEFSSTAAVM SEYAGRELIE RSSMIQPGLE ESIWLVTKQI LASGAAMAIA 250 260 270 280 290 300 GSSRPASGSE HLFSHAIEIL GPGSSIHGEQ CAMGSLISMY LHGGDWELLK NTYRKIGLNT 310 320 330 340 350 RAESYGIGRE VAIKALSIAH RIRPSRYTIL GESDLSYNVA ERILSITGII

References

[1]

"Genome sequence of Picrophilus torridus and its implications for life around pH 0." Fuetterer O., Angelov A., Liesegang H., Gottschalk G., Schleper C., Schepers B., Dock C., Antranikian G., Liebl W. Proc. Natl. Acad. Sci. U.S.A. 101:9091-9096(2004) [PubMed: 15184674] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017261 Genomic DNA. Translation: AAT43435.1.
RefSeq	YP_023628.1. NC_005877.1.
3D structure databases
ProteinModelPortal	Q6L0R7.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2845253.
GenomeReviews	Gene locus PTO0850 in contig AE017261_GR.
KEGG	pto:PTO0850.
NMPDR	fig|263820.1.peg.850.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG672951.
OMA	CGVGTIM.
PhylomeDB	Q6L0R7.
ProtClustDB	PRK00843.
Enzyme and pathway databases
BioCyc	PTOR263820:PTO0850-MONOMER.
Family and domain databases
HAMAP	MF_00497_A. G1P_dehydrogenase_A. [Tree]
InterPro	IPR023002. G1P_dehydrogenase_arc. IPR016205. Glycerol_DH. [Graphical view]
KO	K00096.
PIRSF	PIRSF000112. Glycerol_dehydrogenase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

G1PDH_PICTO

Accession

Primary (citable) accession number: Q6L0R7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 21, 2004
Last sequence update:	July 5, 2004
Last modified:	December 14, 2011
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program