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Q6L0C3

- MDH_PICTO

UniProt

Q6L0C3 - MDH_PICTO

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Protein

Malate dehydrogenase

Gene

mdh

Organism
Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei34 – 341NADUniRule annotation
Binding sitei88 – 881SubstrateUniRule annotation
Binding sitei94 – 941SubstrateUniRule annotation
Binding sitei101 – 1011NADUniRule annotation
Binding sitei126 – 1261SubstrateUniRule annotation
Binding sitei157 – 1571SubstrateUniRule annotation
Active sitei181 – 1811Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 156NADUniRule annotation
Nucleotide bindingi124 – 1263NADUniRule annotation

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciPTOR263820:GHA3-1036-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:PTO0994
OrganismiPicrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
Taxonomic identifieri263820 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesPicrophilaceaePicrophilus
ProteomesiUP000000438: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 324324Malate dehydrogenasePRO_0000113490Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi263820.PTO0994.

Structurei

Secondary structure

1
324
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi5 – 95Combined sources
Helixi13 – 2412Combined sources
Beta strandi28 – 369Combined sources
Helixi39 – 4810Combined sources
Helixi51 – 544Combined sources
Beta strandi60 – 645Combined sources
Helixi68 – 747Combined sources
Beta strandi78 – 825Combined sources
Helixi94 – 11522Combined sources
Beta strandi120 – 1234Combined sources
Beta strandi125 – 1273Combined sources
Helixi128 – 13912Combined sources
Helixi143 – 1453Combined sources
Beta strandi146 – 1483Combined sources
Helixi151 – 16616Combined sources
Helixi170 – 1723Combined sources
Beta strandi173 – 1797Combined sources
Helixi182 – 1843Combined sources
Beta strandi185 – 19410Combined sources
Helixi199 – 2013Combined sources
Helixi205 – 21612Combined sources
Helixi218 – 2269Combined sources
Beta strandi227 – 2293Combined sources
Helixi233 – 24715Combined sources
Beta strandi252 – 2609Combined sources
Helixi263 – 2686Combined sources
Beta strandi272 – 28211Combined sources
Beta strandi285 – 2895Combined sources
Helixi296 – 32227Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4BGVX-ray1.81A/B/C/D2-324[»]
ProteinModelPortaliQ6L0C3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000213794.
KOiK00024.
OMAiCTADESK.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6L0C3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARSKISVIG AGAVGATVAQ TLAIRQTGDI YIFDIVDGLA EGKALDILEG
60 70 80 90 100
APHWGYDLDI KGFCTADESK YAEMKGSDVI VVTAGLARKP GMSRDDLLLK
110 120 130 140 150
NIGIMKSVGE AIKKYSPESK IVVVTNPADI MAYAIYKASG ISPERIIGLG
160 170 180 190 200
GSLDSTRFRT FLAQELNVSF EDVNAFVIGG HGDDMVPFIR YSNVSGIPIE
210 220 230 240 250
DLLPREKIDE IVKRTRFGGG EIVNLYKTGS AFYAPGISIA VMVESIVNDR
260 270 280 290 300
KRVIPCAAYI TGEHSKTYLV NNLFIGVPIK IGKNGVEKIY DLKFNEDELE
310 320
AWKKSVESVK KNSAIADDYF AKNQ
Length:324
Mass (Da):35,215
Last modified:July 5, 2004 - v1
Checksum:i86937A7F6AC89D4C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017261 Genomic DNA. Translation: AAT43579.1.
RefSeqiWP_011177795.1. NC_005877.1.
YP_023772.1. NC_005877.1.

Genome annotation databases

EnsemblBacteriaiAAT43579; AAT43579; PTO0994.
GeneIDi2844444.
KEGGipto:PTO0994.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017261 Genomic DNA. Translation: AAT43579.1 .
RefSeqi WP_011177795.1. NC_005877.1.
YP_023772.1. NC_005877.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4BGV X-ray 1.81 A/B/C/D 2-324 [» ]
ProteinModelPortali Q6L0C3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 263820.PTO0994.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAT43579 ; AAT43579 ; PTO0994 .
GeneIDi 2844444.
KEGGi pto:PTO0994.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000213794.
KOi K00024.
OMAi CTADESK.

Enzyme and pathway databases

BioCyci PTOR263820:GHA3-1036-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_00487. Malate_dehydrog_3.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828.

Entry informationi

Entry nameiMDH_PICTO
AccessioniPrimary (citable) accession number: Q6L0C3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: July 5, 2004
Last modified: November 26, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3