Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Malate dehydrogenase

Gene

mdh

Organism
Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.By similarity

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei34NADBy similarity1
Binding sitei88SubstrateBy similarity1
Binding sitei94SubstrateBy similarity1
Binding sitei101NADBy similarity1
Binding sitei126SubstrateBy similarity1
Binding sitei157SubstrateBy similarity1
Active sitei181Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 15NADBy similarity6
Nucleotide bindingi124 – 126NADBy similarity3

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseBy similarity (EC:1.1.1.37By similarity)
Gene namesi
Name:mdh
Ordered Locus Names:PTO0994
OrganismiPicrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
Taxonomic identifieri263820 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesPicrophilaceaePicrophilus
Proteomesi
  • UP000000438 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001134901 – 324Malate dehydrogenaseAdd BLAST324

Interactioni

Protein-protein interaction databases

STRINGi263820.PTO0994.

Structurei

Secondary structure

1324
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 9Combined sources5
Helixi13 – 24Combined sources12
Beta strandi28 – 36Combined sources9
Helixi39 – 48Combined sources10
Helixi51 – 54Combined sources4
Beta strandi60 – 64Combined sources5
Helixi68 – 74Combined sources7
Beta strandi78 – 82Combined sources5
Helixi94 – 115Combined sources22
Beta strandi120 – 123Combined sources4
Beta strandi125 – 127Combined sources3
Helixi128 – 139Combined sources12
Helixi143 – 145Combined sources3
Beta strandi146 – 148Combined sources3
Helixi151 – 166Combined sources16
Helixi170 – 172Combined sources3
Beta strandi173 – 179Combined sources7
Helixi182 – 184Combined sources3
Beta strandi185 – 194Combined sources10
Helixi199 – 201Combined sources3
Helixi205 – 216Combined sources12
Helixi218 – 226Combined sources9
Beta strandi227 – 229Combined sources3
Helixi233 – 247Combined sources15
Beta strandi252 – 260Combined sources9
Helixi263 – 268Combined sources6
Beta strandi272 – 282Combined sources11
Beta strandi285 – 289Combined sources5
Helixi296 – 322Combined sources27

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4BGVX-ray1.81A/B/C/D2-324[»]
ProteinModelPortaliQ6L0C3.
SMRiQ6L0C3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.Curated

Phylogenomic databases

eggNOGiarCOG00246. Archaea.
COG0039. LUCA.
HOGENOMiHOG000213794.
KOiK00024.
OMAiMDLMQTA.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6L0C3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARSKISVIG AGAVGATVAQ TLAIRQTGDI YIFDIVDGLA EGKALDILEG
60 70 80 90 100
APHWGYDLDI KGFCTADESK YAEMKGSDVI VVTAGLARKP GMSRDDLLLK
110 120 130 140 150
NIGIMKSVGE AIKKYSPESK IVVVTNPADI MAYAIYKASG ISPERIIGLG
160 170 180 190 200
GSLDSTRFRT FLAQELNVSF EDVNAFVIGG HGDDMVPFIR YSNVSGIPIE
210 220 230 240 250
DLLPREKIDE IVKRTRFGGG EIVNLYKTGS AFYAPGISIA VMVESIVNDR
260 270 280 290 300
KRVIPCAAYI TGEHSKTYLV NNLFIGVPIK IGKNGVEKIY DLKFNEDELE
310 320
AWKKSVESVK KNSAIADDYF AKNQ
Length:324
Mass (Da):35,215
Last modified:July 5, 2004 - v1
Checksum:i86937A7F6AC89D4C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017261 Genomic DNA. Translation: AAT43579.1.
RefSeqiWP_011177795.1. NC_005877.1.

Genome annotation databases

EnsemblBacteriaiAAT43579; AAT43579; PTO0994.
GeneIDi2844444.
KEGGipto:PTO0994.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017261 Genomic DNA. Translation: AAT43579.1.
RefSeqiWP_011177795.1. NC_005877.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4BGVX-ray1.81A/B/C/D2-324[»]
ProteinModelPortaliQ6L0C3.
SMRiQ6L0C3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi263820.PTO0994.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT43579; AAT43579; PTO0994.
GeneIDi2844444.
KEGGipto:PTO0994.

Phylogenomic databases

eggNOGiarCOG00246. Archaea.
COG0039. LUCA.
HOGENOMiHOG000213794.
KOiK00024.
OMAiMDLMQTA.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMDH_PICTO
AccessioniPrimary (citable) accession number: Q6L0C3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.