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Q6L0C3

- MDH_PICTO

UniProt

Q6L0C3 - MDH_PICTO

Protein

Malate dehydrogenase

Gene

mdh

Organism
Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei34 – 341NADUniRule annotation
    Binding sitei88 – 881SubstrateUniRule annotation
    Binding sitei94 – 941SubstrateUniRule annotation
    Binding sitei101 – 1011NADUniRule annotation
    Binding sitei126 – 1261SubstrateUniRule annotation
    Binding sitei157 – 1571SubstrateUniRule annotation
    Active sitei181 – 1811Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 156NADUniRule annotation
    Nucleotide bindingi124 – 1263NADUniRule annotation

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciPTOR263820:GHA3-1036-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
    Gene namesi
    Name:mdhUniRule annotation
    Ordered Locus Names:PTO0994
    OrganismiPicrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
    Taxonomic identifieri263820 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesPicrophilaceaePicrophilus
    ProteomesiUP000000438: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 324324Malate dehydrogenasePRO_0000113490Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi263820.PTO0994.

    Structurei

    Secondary structure

    1
    324
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi5 – 95
    Helixi13 – 2412
    Beta strandi28 – 369
    Helixi39 – 4810
    Helixi51 – 544
    Beta strandi60 – 645
    Helixi68 – 747
    Beta strandi78 – 825
    Helixi94 – 11522
    Beta strandi120 – 1234
    Beta strandi125 – 1273
    Helixi128 – 13912
    Helixi143 – 1453
    Beta strandi146 – 1483
    Helixi151 – 16616
    Helixi170 – 1723
    Beta strandi173 – 1797
    Helixi182 – 1843
    Beta strandi185 – 19410
    Helixi199 – 2013
    Helixi205 – 21612
    Helixi218 – 2269
    Beta strandi227 – 2293
    Helixi233 – 24715
    Beta strandi252 – 2609
    Helixi263 – 2686
    Beta strandi272 – 28211
    Beta strandi285 – 2895
    Helixi296 – 32227

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4BGVX-ray1.81A/B/C/D2-324[»]
    ProteinModelPortaliQ6L0C3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0039.
    HOGENOMiHOG000213794.
    KOiK00024.
    OMAiCTADESK.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPiMF_00487. Malate_dehydrog_3.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11540. PTHR11540. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSiPR00086. LLDHDRGNASE.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6L0C3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARSKISVIG AGAVGATVAQ TLAIRQTGDI YIFDIVDGLA EGKALDILEG    50
    APHWGYDLDI KGFCTADESK YAEMKGSDVI VVTAGLARKP GMSRDDLLLK 100
    NIGIMKSVGE AIKKYSPESK IVVVTNPADI MAYAIYKASG ISPERIIGLG 150
    GSLDSTRFRT FLAQELNVSF EDVNAFVIGG HGDDMVPFIR YSNVSGIPIE 200
    DLLPREKIDE IVKRTRFGGG EIVNLYKTGS AFYAPGISIA VMVESIVNDR 250
    KRVIPCAAYI TGEHSKTYLV NNLFIGVPIK IGKNGVEKIY DLKFNEDELE 300
    AWKKSVESVK KNSAIADDYF AKNQ 324
    Length:324
    Mass (Da):35,215
    Last modified:July 5, 2004 - v1
    Checksum:i86937A7F6AC89D4C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017261 Genomic DNA. Translation: AAT43579.1.
    RefSeqiYP_023772.1. NC_005877.1.

    Genome annotation databases

    EnsemblBacteriaiAAT43579; AAT43579; PTO0994.
    GeneIDi2844444.
    KEGGipto:PTO0994.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017261 Genomic DNA. Translation: AAT43579.1 .
    RefSeqi YP_023772.1. NC_005877.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4BGV X-ray 1.81 A/B/C/D 2-324 [» ]
    ProteinModelPortali Q6L0C3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 263820.PTO0994.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAT43579 ; AAT43579 ; PTO0994 .
    GeneIDi 2844444.
    KEGGi pto:PTO0994.

    Phylogenomic databases

    eggNOGi COG0039.
    HOGENOMi HOG000213794.
    KOi K00024.
    OMAi CTADESK.

    Enzyme and pathway databases

    BioCyci PTOR263820:GHA3-1036-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPi MF_00487. Malate_dehydrog_3.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11540. PTHR11540. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSi PR00086. LLDHDRGNASE.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828.

    Entry informationi

    Entry nameiMDH_PICTO
    AccessioniPrimary (citable) accession number: Q6L0C3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3