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Protein

GTP cyclohydrolase MptA

Gene

mptA

Organism
Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate + diphosphate.UniRule annotation

Cofactori

Fe2+UniRule annotationNote: Binds 1 Fe2+ ion per subunit.UniRule annotation

Pathwayi: 5,6,7,8-tetrahydromethanopterin biosynthesis

This protein is involved in the pathway 5,6,7,8-tetrahydromethanopterin biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway 5,6,7,8-tetrahydromethanopterin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei136May be catalytically importantUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandIron, Metal-binding

Enzyme and pathway databases

BioCyciPTOR263820:G1G0U-1081-MONOMER
UniPathwayiUPA00065

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase MptAUniRule annotation (EC:3.5.4.39UniRule annotation)
Alternative name(s):
GTP cyclohydrolase IVUniRule annotation
Gene namesi
Name:mptAUniRule annotation
Ordered Locus Names:PTO1009
OrganismiPicrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
Taxonomic identifieri263820 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesPicrophilaceaePicrophilus
Proteomesi
  • UP000000438 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001477481 – 273GTP cyclohydrolase MptAAdd BLAST273

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi263820.PTO1009

Structurei

3D structure databases

ProteinModelPortaliQ6L0A8
SMRiQ6L0A8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04301 Archaea
COG1469 LUCA
HOGENOMiHOG000280680
KOiK17488
OMAiIPTFDIF
OrthoDBiPOG093Z06SZ

Family and domain databases

HAMAPiMF_01527_A GTP_cyclohydrol_A, 1 hit
InterProiView protein in InterPro
IPR003801 GTP_cyclohydrolase_FolE2/MptA
IPR022840 GTP_cyclohydrolase_MptA
PANTHERiPTHR36445 PTHR36445, 1 hit
PfamiView protein in Pfam
PF02649 GCHY-1, 1 hit

Sequencei

Sequence statusi: Complete.

Q6L0A8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIELKDVQGF RPDYEIPIKR AGIKSFKRRV KLNYNNESFD SYVDVSISVS
60 70 80 90 100
LNPDRKGLDM SRTIESVRSS YNLNDVAYDI YNDLFSRINY SSSGYVNVSF
110 120 130 140 150
DFYYNNKIYP VSLIAEGDKN DVKRYVEVSA EGMTVCPCAM ETIRSIMLYD
160 170 180 190 200
YNVSYGDIGI SHNQRNKASL KIQYIKDAHL ERLIDILESS FSYPVRNMLK
210 220 230 240 250
RYDEGKMIIE AHKRPKFVED VVREIAYKAA FMEPEMNLYM DVRSESFESI
260 270
HPHNAYAEIE DYTANIRSYL KNR
Length:273
Mass (Da):31,893
Last modified:July 5, 2004 - v1
Checksum:i2B16FB934F1E8F9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017261 Genomic DNA Translation: AAT43594.1
RefSeqiWP_011177810.1, NC_005877.1

Genome annotation databases

EnsemblBacteriaiAAT43594; AAT43594; PTO1009
GeneIDi2844622
KEGGipto:PTO1009

Similar proteinsi

Entry informationi

Entry nameiMPTA_PICTO
AccessioniPrimary (citable) accession number: Q6L0A8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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