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Q6KZM3

- FTHS_PICTO

UniProt

Q6KZM3 - FTHS_PICTO

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, PTO1244
Organism
Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi50 – 578ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPTOR263820:GHA3-1291-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:PTO1244
OrganismiPicrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
Taxonomic identifieri263820 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesPicrophilaceaePicrophilus
ProteomesiUP000000438: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 535535Formate--tetrahydrofolate ligaseUniRule annotation
PRO_0000199414Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi263820.PTO1244.

Structurei

3D structure databases

ProteinModelPortaliQ6KZM3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiINIPEDY.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6KZM3-1 [UniParc]FASTAAdd to Basket

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MKNISEIINI PEDYYDLYGR YIAKVSLNVL DYLKNKRYGK LILVTAMTPT    50
PAGEGKTTTA IGLGNALKLL GKNAGIAIRE PSLGPCFGVK GGATGGGKST 100
VEPSNKINLM FTGDFPAVSA AHNLLSAVIN NHMYHGNELK LDPKNIVFPR 150
TIDMDDRSLR SIIVGSGDRS TGVMMNDKYV ITAASEVMAI LALSRNYNEL 200
KQRLGNIMIG YNLNKAPIFA RDLKVHGAMA SLLVDALRPN IAQTSEHVPA 250
IIHTGPFGNI AHGTSSILGD IIGLKMFDYL VTEAGFGSDL GFEKFIDIVL 300
RLSDFKLSAV VLVATVRAMR YHGGGRINEP DVNAVLRGSE NLMWHVQNIK 350
KFGFNPVVAI NRHSNDTDAE INAISNILTK NGVEFSISDA YSDGGHGALD 400
LAGKVLKSIS DYNPRYIYGI NDDPEEKISK IAMNVYNANS VEFSHDAVKT 450
MKLIKDDFSD LYVCMAKTQS SISDNAKLIN VPEGFTVKIN GININSGSGF 500
IIPLLGNIMT MPGLPRRPAS ENIDIDDYGN ITGLQ 535
Length:535
Mass (Da):58,003
Last modified:July 5, 2004 - v1
Checksum:i73212E2A14961B67
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017261 Genomic DNA. Translation: AAT43829.1.
RefSeqiYP_024022.1. NC_005877.1.

Genome annotation databases

EnsemblBacteriaiAAT43829; AAT43829; PTO1244.
GeneIDi2844250.
KEGGipto:PTO1244.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017261 Genomic DNA. Translation: AAT43829.1 .
RefSeqi YP_024022.1. NC_005877.1.

3D structure databases

ProteinModelPortali Q6KZM3.
ModBasei Search...

Protein-protein interaction databases

STRINGi 263820.PTO1244.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAT43829 ; AAT43829 ; PTO1244 .
GeneIDi 2844250.
KEGGi pto:PTO1244.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi INIPEDY.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci PTOR263820:GHA3-1291-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828.

Entry informationi

Entry nameiFTHS_PICTO
AccessioniPrimary (citable) accession number: Q6KZM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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