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Q6KZM3 (FTHS_PICTO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:PTO1244
OrganismPicrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828) [Complete proteome] [HAMAP]
Taxonomic identifier263820 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesPicrophilaceaePicrophilus

Protein attributes

Sequence length535 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 535535Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000199414

Regions

Nucleotide binding50 – 578ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6KZM3 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 73212E2A14961B67

FASTA53558,003
        10         20         30         40         50         60 
MKNISEIINI PEDYYDLYGR YIAKVSLNVL DYLKNKRYGK LILVTAMTPT PAGEGKTTTA 

        70         80         90        100        110        120 
IGLGNALKLL GKNAGIAIRE PSLGPCFGVK GGATGGGKST VEPSNKINLM FTGDFPAVSA 

       130        140        150        160        170        180 
AHNLLSAVIN NHMYHGNELK LDPKNIVFPR TIDMDDRSLR SIIVGSGDRS TGVMMNDKYV 

       190        200        210        220        230        240 
ITAASEVMAI LALSRNYNEL KQRLGNIMIG YNLNKAPIFA RDLKVHGAMA SLLVDALRPN 

       250        260        270        280        290        300 
IAQTSEHVPA IIHTGPFGNI AHGTSSILGD IIGLKMFDYL VTEAGFGSDL GFEKFIDIVL 

       310        320        330        340        350        360 
RLSDFKLSAV VLVATVRAMR YHGGGRINEP DVNAVLRGSE NLMWHVQNIK KFGFNPVVAI 

       370        380        390        400        410        420 
NRHSNDTDAE INAISNILTK NGVEFSISDA YSDGGHGALD LAGKVLKSIS DYNPRYIYGI 

       430        440        450        460        470        480 
NDDPEEKISK IAMNVYNANS VEFSHDAVKT MKLIKDDFSD LYVCMAKTQS SISDNAKLIN 

       490        500        510        520        530 
VPEGFTVKIN GININSGSGF IIPLLGNIMT MPGLPRRPAS ENIDIDDYGN ITGLQ 

« Hide

References

[1]"Genome sequence of Picrophilus torridus and its implications for life around pH 0."
Fuetterer O., Angelov A., Liesegang H., Gottschalk G., Schleper C., Schepers B., Dock C., Antranikian G., Liebl W.
Proc. Natl. Acad. Sci. U.S.A. 101:9091-9096(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017261 Genomic DNA. Translation: AAT43829.1.
RefSeqYP_024022.1. NC_005877.1.

3D structure databases

ProteinModelPortalQ6KZM3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING263820.PTO1244.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAT43829; AAT43829; PTO1244.
GeneID2844250.
KEGGpto:PTO1244.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMACGEIMTM.
ProtClustDBCLSK228062.

Enzyme and pathway databases

BioCycPTOR263820:GHA3-1291-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_PICTO
AccessionPrimary (citable) accession number: Q6KZM3
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways