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Q6KZM3

- FTHS_PICTO

UniProt

Q6KZM3 - FTHS_PICTO

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi50 – 578ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPTOR263820:GHA3-1291-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:PTO1244
    OrganismiPicrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
    Taxonomic identifieri263820 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesPicrophilaceaePicrophilus
    ProteomesiUP000000438: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 535535Formate--tetrahydrofolate ligasePRO_0000199414Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi263820.PTO1244.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6KZM3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiINIPEDY.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6KZM3-1 [UniParc]FASTAAdd to Basket

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    MKNISEIINI PEDYYDLYGR YIAKVSLNVL DYLKNKRYGK LILVTAMTPT    50
    PAGEGKTTTA IGLGNALKLL GKNAGIAIRE PSLGPCFGVK GGATGGGKST 100
    VEPSNKINLM FTGDFPAVSA AHNLLSAVIN NHMYHGNELK LDPKNIVFPR 150
    TIDMDDRSLR SIIVGSGDRS TGVMMNDKYV ITAASEVMAI LALSRNYNEL 200
    KQRLGNIMIG YNLNKAPIFA RDLKVHGAMA SLLVDALRPN IAQTSEHVPA 250
    IIHTGPFGNI AHGTSSILGD IIGLKMFDYL VTEAGFGSDL GFEKFIDIVL 300
    RLSDFKLSAV VLVATVRAMR YHGGGRINEP DVNAVLRGSE NLMWHVQNIK 350
    KFGFNPVVAI NRHSNDTDAE INAISNILTK NGVEFSISDA YSDGGHGALD 400
    LAGKVLKSIS DYNPRYIYGI NDDPEEKISK IAMNVYNANS VEFSHDAVKT 450
    MKLIKDDFSD LYVCMAKTQS SISDNAKLIN VPEGFTVKIN GININSGSGF 500
    IIPLLGNIMT MPGLPRRPAS ENIDIDDYGN ITGLQ 535
    Length:535
    Mass (Da):58,003
    Last modified:July 5, 2004 - v1
    Checksum:i73212E2A14961B67
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017261 Genomic DNA. Translation: AAT43829.1.
    RefSeqiYP_024022.1. NC_005877.1.

    Genome annotation databases

    EnsemblBacteriaiAAT43829; AAT43829; PTO1244.
    GeneIDi2844250.
    KEGGipto:PTO1244.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017261 Genomic DNA. Translation: AAT43829.1 .
    RefSeqi YP_024022.1. NC_005877.1.

    3D structure databases

    ProteinModelPortali Q6KZM3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 263820.PTO1244.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAT43829 ; AAT43829 ; PTO1244 .
    GeneIDi 2844250.
    KEGGi pto:PTO1244.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi INIPEDY.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci PTOR263820:GHA3-1291-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828.

    Entry informationi

    Entry nameiFTHS_PICTO
    AccessioniPrimary (citable) accession number: Q6KZM3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3