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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi50 – 57ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processOne-carbon metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPTOR263820:G1G0U-1325-MONOMER
UniPathwayiUPA00193

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:PTO1244
OrganismiPicrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
Taxonomic identifieri263820 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesPicrophilaceaePicrophilus
Proteomesi
  • UP000000438 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001994141 – 535Formate--tetrahydrofolate ligaseAdd BLAST535

Proteomic databases

PRIDEiQ6KZM3

Interactioni

Protein-protein interaction databases

STRINGi263820.PTO1244

Structurei

3D structure databases

ProteinModelPortaliQ6KZM3
SMRiQ6KZM3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04541 Archaea
COG2759 LUCA
HOGENOMiHOG000040280
KOiK01938
OMAiCGEIMTM
OrthoDBiPOG093Z01EG

Family and domain databases

HAMAPiMF_01543 FTHFS, 1 hit
InterProiView protein in InterPro
IPR000559 Formate_THF_ligase
IPR020628 Formate_THF_ligase_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01268 FTHFS, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00721 FTHFS_1, 1 hit
PS00722 FTHFS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6KZM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNISEIINI PEDYYDLYGR YIAKVSLNVL DYLKNKRYGK LILVTAMTPT
60 70 80 90 100
PAGEGKTTTA IGLGNALKLL GKNAGIAIRE PSLGPCFGVK GGATGGGKST
110 120 130 140 150
VEPSNKINLM FTGDFPAVSA AHNLLSAVIN NHMYHGNELK LDPKNIVFPR
160 170 180 190 200
TIDMDDRSLR SIIVGSGDRS TGVMMNDKYV ITAASEVMAI LALSRNYNEL
210 220 230 240 250
KQRLGNIMIG YNLNKAPIFA RDLKVHGAMA SLLVDALRPN IAQTSEHVPA
260 270 280 290 300
IIHTGPFGNI AHGTSSILGD IIGLKMFDYL VTEAGFGSDL GFEKFIDIVL
310 320 330 340 350
RLSDFKLSAV VLVATVRAMR YHGGGRINEP DVNAVLRGSE NLMWHVQNIK
360 370 380 390 400
KFGFNPVVAI NRHSNDTDAE INAISNILTK NGVEFSISDA YSDGGHGALD
410 420 430 440 450
LAGKVLKSIS DYNPRYIYGI NDDPEEKISK IAMNVYNANS VEFSHDAVKT
460 470 480 490 500
MKLIKDDFSD LYVCMAKTQS SISDNAKLIN VPEGFTVKIN GININSGSGF
510 520 530
IIPLLGNIMT MPGLPRRPAS ENIDIDDYGN ITGLQ
Length:535
Mass (Da):58,003
Last modified:July 5, 2004 - v1
Checksum:i73212E2A14961B67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017261 Genomic DNA Translation: AAT43829.1
RefSeqiWP_011178045.1, NC_005877.1

Genome annotation databases

EnsemblBacteriaiAAT43829; AAT43829; PTO1244
GeneIDi2844250
KEGGipto:PTO1244
PATRICifig|263820.9.peg.1292

Similar proteinsi

Entry informationi

Entry nameiFTHS_PICTO
AccessioniPrimary (citable) accession number: Q6KZM3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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