Q6KZF6 (Q6KZF6_PICTO) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Delta-aminolevulinic acid dehydratase EMBL AAT43896.1
EC=4.2.1.24 EMBL AAT43896.1

Gene names

Ordered Locus Names:

PTO1311

Organism

Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828) [Complete proteome] [HAMAP] EMBL AAT43896.1

Taxonomic identifier

263820 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermoplasmata › Thermoplasmatales › Picrophilaceae › Picrophilus

Protein attributes

Sequence length	319 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subunit structure

Homooctamer By similarity. PIRSR PIRSR001415-3

Ontologies

Keywords
Ligand	Magnesium PIRSR PIRSR001415-5 Metal-binding PIRSR PIRSR001415-5 Zinc PIRSR PIRSR001415-3
Molecular function	Lyase EMBL AAT43896.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW porphobilinogen synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	193	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Active site	246	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Metal binding	118	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	120	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	128	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	231	1	Magnesium By similarity PIRSR PIRSR001415-5
	Binding site	203	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	215	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	272	1	Substrate 2 By similarity PIRSR PIRSR001415-2
	Binding site	310	1	Substrate 2 By similarity PIRSR PIRSR001415-2

Sequences

	Sequence		Length	Mass (Da)
	Q6KZF6 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 939FDD136BBA01F8	FASTA	319	36,286
	10 20 30 40 50 60 MFPVTRMRRY RINENIRDIF KETVIRTEKL IMPVFVDETE KDKREIDSMP GIYRYSLDSY 70 80 90 100 110 120 EDYIKYLEEI GVKNVILFGI PAHKDSTGSS SYDRNGIIQR AIRIAKDNTR LNVIADLCLC 130 140 150 160 170 180 EYTDTGHCGI IKDNYIDNDA TLSIYQKEAL SYADAGVDII APSGMMDGQV KAIREILDKN 190 200 210 220 230 240 DYKNTIIMAY SAKFASNLYG PFRDAADSTP QFGDRKSYQM DYHNGNEAIR EVDLDVKEGA 250 260 270 280 290 300 DIVMVKPGLF YLDIINRVKS IYKMPVATYS VSGEYSMIKN AIKSGLLNAD ARDEALTALF 310 RAGSDLVITY FAEEYIKDH

References

[1]

"Genome sequence of Picrophilus torridus and its implications for life around pH 0." Fuetterer O., Angelov A., Liesegang H., Gottschalk G., Schleper C., Schepers B., Dock C., Antranikian G., Liebl W. Proc. Natl. Acad. Sci. U.S.A. 101:9091-9096(2004) [PubMed: 15184674] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017261 Genomic DNA. Translation: AAT43896.1.
RefSeq	YP_024089.1. NC_005877.1.
3D structure databases
HSSP	HSSP built from PDB template 1B4K based on UniProtKB Q59643.
ProteinModelPortal	Q6KZF6.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2845363.
GenomeReviews	Gene locus PTO1311 in contig AE017261_GR.
KEGG	pto:PTO1311.
NMPDR	fig|263820.1.peg.1311.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG285270.
OMA	HCGVVEN.
PhylomeDB	Q6KZF6.
ProtClustDB	PRK09283.
Enzyme and pathway databases
BioCyc	PTOR263820:PTO1311-MONOMER.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR001731. Porphobilinogen_synth. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01698.
PANTHER	PTHR11458. AlaD_dehydratase. 1 hit.
Pfam	PF00490. ALAD. 1 hit. [Graphical view]
PIRSF	PIRSF001415. Porphbilin_synth. 1 hit.
PRINTS	PR00144. DALDHYDRTASE.
SMART	SM01004. ALAD. 1 hit. [Graphical view]
PROSITE	PS00169. D_ALA_DEHYDRATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q6KZF6_PICTO

Accession

Primary (citable) accession number: Q6KZF6

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)