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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei99 – 991NADUniRule annotation
Binding sitei159 – 1591NADUniRule annotation
Binding sitei181 – 1811NADUniRule annotation
Binding sitei204 – 2041SubstrateUniRule annotation
Metal bindingi226 – 2261ZincUniRule annotation
Binding sitei226 – 2261SubstrateUniRule annotation
Metal bindingi229 – 2291ZincUniRule annotation
Binding sitei229 – 2291SubstrateUniRule annotation
Active sitei274 – 2741Proton acceptorUniRule annotation
Active sitei275 – 2751Proton acceptorUniRule annotation
Binding sitei275 – 2751SubstrateUniRule annotation
Metal bindingi308 – 3081ZincUniRule annotation
Binding sitei308 – 3081SubstrateUniRule annotation
Binding sitei362 – 3621SubstrateUniRule annotation
Metal bindingi367 – 3671ZincUniRule annotation
Binding sitei367 – 3671SubstrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciPTOR263820:GHA3-1385-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:PTO1336
OrganismiPicrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
Taxonomic identifieri263820 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesPicrophilaceaePicrophilus
ProteomesiUP000000438 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 375375Histidinol dehydrogenasePRO_0000135901Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi263820.PTO1336.

Structurei

3D structure databases

ProteinModelPortaliQ6KZD1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiLPNIRHA.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 2 hits.
[Graphical view]
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6KZD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIYEYVSNI ISDVRINGID ALKRYSEAFD NYSGGFTVTD DEIEDADKSI
60 70 80 90 100
KPGEKDAIKN IYERIYEYHK NQFEGQKINI KNGSIYGIIY RPIDRIGLYV
110 120 130 140 150
PGKRALPSTL MMLGIPARIA GVKSIVLCTA PENGNVNKYT LYIARLLGIR
160 170 180 190 200
EIYKIGGVQA IAAMAYGISM KPVDKIFGPG NKYVNEAKRQ VFGITGIDGL
210 220 230 240 250
YGPSEICLIA DDSANINYIK NDLLSQLEHG EASSAYLITN SLRIYNEVKL
260 270 280 290 300
ENVKKYYKET VEESIELANE IAPEHLELLV NDPLKYLNII RNAGAVYMGE
310 320 330 340 350
YGPVPAGDYF LGVNHVLPTG SSARFSSVLT VYDFMKRISV AMPSKYDFLS
360 370
AVDSGLKLAS IENMKMHYKS MEARI
Length:375
Mass (Da):41,836
Last modified:July 5, 2004 - v1
Checksum:i5DA4E83583844BD1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017261 Genomic DNA. Translation: AAT43921.1.
RefSeqiWP_011178137.1. NC_005877.1.
YP_024114.1. NC_005877.1.

Genome annotation databases

EnsemblBacteriaiAAT43921; AAT43921; PTO1336.
GeneIDi2844768.
KEGGipto:PTO1336.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017261 Genomic DNA. Translation: AAT43921.1.
RefSeqiWP_011178137.1. NC_005877.1.
YP_024114.1. NC_005877.1.

3D structure databases

ProteinModelPortaliQ6KZD1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi263820.PTO1336.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT43921; AAT43921; PTO1336.
GeneIDi2844768.
KEGGipto:PTO1336.

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiLPNIRHA.

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.
BioCyciPTOR263820:GHA3-1385-MONOMER.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 2 hits.
[Graphical view]
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828.

Entry informationi

Entry nameiHISX_PICTO
AccessioniPrimary (citable) accession number: Q6KZD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: July 5, 2004
Last modified: April 29, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.