Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q6KZD1

- HISX_PICTO

UniProt

Q6KZD1 - HISX_PICTO

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei99 – 991NADUniRule annotation
Binding sitei159 – 1591NADUniRule annotation
Binding sitei181 – 1811NADUniRule annotation
Binding sitei204 – 2041SubstrateUniRule annotation
Metal bindingi226 – 2261ZincUniRule annotation
Binding sitei226 – 2261SubstrateUniRule annotation
Metal bindingi229 – 2291ZincUniRule annotation
Binding sitei229 – 2291SubstrateUniRule annotation
Active sitei274 – 2741Proton acceptorUniRule annotation
Active sitei275 – 2751Proton acceptorUniRule annotation
Binding sitei275 – 2751SubstrateUniRule annotation
Metal bindingi308 – 3081ZincUniRule annotation
Binding sitei308 – 3081SubstrateUniRule annotation
Binding sitei362 – 3621SubstrateUniRule annotation
Metal bindingi367 – 3671ZincUniRule annotation
Binding sitei367 – 3671SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciPTOR263820:GHA3-1385-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:PTO1336
OrganismiPicrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
Taxonomic identifieri263820 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesPicrophilaceaePicrophilus
ProteomesiUP000000438: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 375375Histidinol dehydrogenasePRO_0000135901Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi263820.PTO1336.

Structurei

3D structure databases

ProteinModelPortaliQ6KZD1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiNAMSILL.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 2 hits.
[Graphical view]
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6KZD1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDIYEYVSNI ISDVRINGID ALKRYSEAFD NYSGGFTVTD DEIEDADKSI
60 70 80 90 100
KPGEKDAIKN IYERIYEYHK NQFEGQKINI KNGSIYGIIY RPIDRIGLYV
110 120 130 140 150
PGKRALPSTL MMLGIPARIA GVKSIVLCTA PENGNVNKYT LYIARLLGIR
160 170 180 190 200
EIYKIGGVQA IAAMAYGISM KPVDKIFGPG NKYVNEAKRQ VFGITGIDGL
210 220 230 240 250
YGPSEICLIA DDSANINYIK NDLLSQLEHG EASSAYLITN SLRIYNEVKL
260 270 280 290 300
ENVKKYYKET VEESIELANE IAPEHLELLV NDPLKYLNII RNAGAVYMGE
310 320 330 340 350
YGPVPAGDYF LGVNHVLPTG SSARFSSVLT VYDFMKRISV AMPSKYDFLS
360 370
AVDSGLKLAS IENMKMHYKS MEARI
Length:375
Mass (Da):41,836
Last modified:July 5, 2004 - v1
Checksum:i5DA4E83583844BD1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017261 Genomic DNA. Translation: AAT43921.1.
RefSeqiWP_011178137.1. NC_005877.1.
YP_024114.1. NC_005877.1.

Genome annotation databases

EnsemblBacteriaiAAT43921; AAT43921; PTO1336.
GeneIDi2844768.
KEGGipto:PTO1336.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017261 Genomic DNA. Translation: AAT43921.1 .
RefSeqi WP_011178137.1. NC_005877.1.
YP_024114.1. NC_005877.1.

3D structure databases

ProteinModelPortali Q6KZD1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 263820.PTO1336.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAT43921 ; AAT43921 ; PTO1336 .
GeneIDi 2844768.
KEGGi pto:PTO1336.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi NAMSILL.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci PTOR263820:GHA3-1385-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 2 hits.
[Graphical view ]
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828.

Entry informationi

Entry nameiHISX_PICTO
AccessioniPrimary (citable) accession number: Q6KZD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: July 5, 2004
Last modified: October 1, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3