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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 9 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Histidine biosynthesis bifunctional protein HisIE (hisI)
  3. Histidine biosynthesis bifunctional protein HisIE (hisI)
  4. no protein annotated in this organism
  5. Imidazole glycerol phosphate synthase subunit HisH (hisH)
  6. no protein annotated in this organism
  7. no protein annotated in this organism
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei99NADUniRule annotation1
Binding sitei159NADUniRule annotation1
Binding sitei181NADUniRule annotation1
Binding sitei204SubstrateUniRule annotation1
Metal bindingi226ZincUniRule annotation1
Binding sitei226SubstrateUniRule annotation1
Metal bindingi229ZincUniRule annotation1
Binding sitei229SubstrateUniRule annotation1
Active sitei274Proton acceptorUniRule annotation1
Active sitei275Proton acceptorUniRule annotation1
Binding sitei275SubstrateUniRule annotation1
Metal bindingi308ZincUniRule annotation1
Binding sitei308SubstrateUniRule annotation1
Binding sitei362SubstrateUniRule annotation1
Metal bindingi367ZincUniRule annotation1
Binding sitei367SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:PTO1336
OrganismiPicrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
Taxonomic identifieri263820 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesPicrophilaceaePicrophilus
Proteomesi
  • UP000000438 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001359011 – 375Histidinol dehydrogenaseAdd BLAST375

Interactioni

Protein-protein interaction databases

STRINGi263820.PTO1336.

Structurei

3D structure databases

ProteinModelPortaliQ6KZD1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04352. Archaea.
COG0141. LUCA.
HOGENOMiHOG000243914.
KOiK00013.
OMAiWRGIITP.

Family and domain databases

CDDicd06572. Histidinol_dh. 1 hit.
HAMAPiMF_01024. HisD. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6KZD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIYEYVSNI ISDVRINGID ALKRYSEAFD NYSGGFTVTD DEIEDADKSI
60 70 80 90 100
KPGEKDAIKN IYERIYEYHK NQFEGQKINI KNGSIYGIIY RPIDRIGLYV
110 120 130 140 150
PGKRALPSTL MMLGIPARIA GVKSIVLCTA PENGNVNKYT LYIARLLGIR
160 170 180 190 200
EIYKIGGVQA IAAMAYGISM KPVDKIFGPG NKYVNEAKRQ VFGITGIDGL
210 220 230 240 250
YGPSEICLIA DDSANINYIK NDLLSQLEHG EASSAYLITN SLRIYNEVKL
260 270 280 290 300
ENVKKYYKET VEESIELANE IAPEHLELLV NDPLKYLNII RNAGAVYMGE
310 320 330 340 350
YGPVPAGDYF LGVNHVLPTG SSARFSSVLT VYDFMKRISV AMPSKYDFLS
360 370
AVDSGLKLAS IENMKMHYKS MEARI
Length:375
Mass (Da):41,836
Last modified:July 5, 2004 - v1
Checksum:i5DA4E83583844BD1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017261 Genomic DNA. Translation: AAT43921.1.
RefSeqiWP_011178137.1. NC_005877.1.

Genome annotation databases

EnsemblBacteriaiAAT43921; AAT43921; PTO1336.
GeneIDi2844768.
KEGGipto:PTO1336.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017261 Genomic DNA. Translation: AAT43921.1.
RefSeqiWP_011178137.1. NC_005877.1.

3D structure databases

ProteinModelPortaliQ6KZD1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi263820.PTO1336.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT43921; AAT43921; PTO1336.
GeneIDi2844768.
KEGGipto:PTO1336.

Phylogenomic databases

eggNOGiarCOG04352. Archaea.
COG0141. LUCA.
HOGENOMiHOG000243914.
KOiK00013.
OMAiWRGIITP.

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Family and domain databases

CDDicd06572. Histidinol_dh. 1 hit.
HAMAPiMF_01024. HisD. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHISX_PICTO
AccessioniPrimary (citable) accession number: Q6KZD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.