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Protein

5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

Gene

metE

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.UniRule annotation

Catalytic activityi

5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: L-methionine biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes L-methionine from L-homocysteine (MetE route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (metE), 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (metE), 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (metE), 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (metE), 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (metE), 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (metE), 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (metE), 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (metE), 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (metE), 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (metE), 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (metE), 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (metE), 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (metE), 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (metE), 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (metE), 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (metE)
This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-methionine from L-homocysteine (MetE route), the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi645ZincUniRule annotation1
Metal bindingi647ZincUniRule annotation1
Metal bindingi730ZincUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processAmino-acid biosynthesis, Methionine biosynthesis
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00051; UER00082

Names & Taxonomyi

Protein namesi
Recommended name:
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferaseUniRule annotation (EC:2.1.1.14UniRule annotation)
Alternative name(s):
Cobalamin-independent methionine synthaseUniRule annotation
Methionine synthase, vitamin-B12 independent isozymeUniRule annotation
Gene namesi
Name:metEUniRule annotation
Ordered Locus Names:BA_4218, GBAA_4218, BAS3912
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome
  • UP000000427 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000986091 – 7625-methyltetrahydropteroyltriglutamate--homocysteine methyltransferaseAdd BLAST762

Proteomic databases

PRIDEiQ6KNA9

Interactioni

Protein-protein interaction databases

IntActiQ6KNA9, 21 interactors
STRINGi260799.BAS3912

Structurei

3D structure databases

ProteinModelPortaliQ6KNA9
SMRiQ6KNA9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the vitamin-B12 independent methionine synthase family.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4107QYE Bacteria
COG0620 LUCA
HOGENOMiHOG000246221
KOiK00549
OMAiGRNIWKN

Family and domain databases

Gene3Di3.20.20.210, 4 hits
HAMAPiMF_00172 Meth_synth, 1 hit
InterProiView protein in InterPro
IPR013215 Cbl-indep_Met_Synth_N
IPR006276 Cobalamin-indep_Met_synthase
IPR002629 Met_Synth_C/arc
IPR038071 UROD/MetE-like_sf
PfamiView protein in Pfam
PF08267 Meth_synt_1, 1 hit
PF01717 Meth_synt_2, 1 hit
PIRSFiPIRSF000382 MeTrfase_B12_ind, 1 hit
SUPFAMiSSF51726 SSF51726, 2 hits
TIGRFAMsiTIGR01371 met_syn_B12ind, 1 hit

Sequencei

Sequence statusi: Complete.

Q6KNA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIQTSNLGY PRIGLQREWK KTLEAFWSNK INEEQFLTTM KEIRLQHVKV
60 70 80 90 100
QQEKGIELIP IGDFTYYDHV LDTAYMLGFI PSRFSEFTSY LDVYFAMARG
110 120 130 140 150
SKDHVASEMT KWFNTNYHYI VPEYEEGLQI SLKDNRPLRL YEEAKQELGV
160 170 180 190 200
DGKPVILGPY TFLKLAKGYT QEQFATILKQ LVAPYVQLLS ELHAAGAQII
210 220 230 240 250
QVDEPIFASL TKEEVQQAKE IYEAIRKEVP NATLLLQTYF DSVEENYEEI
260 270 280 290 300
ITFPVSSIGL DFVHGKEGNL NAISKYGFPA DKTLAVGCID GRNIWRADLD
310 320 330 340 350
EVLTLFTTLQ KQVQTKDLIV QPSCSLLHTP IDKTEETHLS TELFDALAFA
360 370 380 390 400
NQKLEELVLI HSALTQGTES ISNELETYRN VHHTIRSSAA RNREDVKAAR
410 420 430 440 450
TALKEEDFSR PLPFEKRYEL QQVALKLPLL PTTTIGSFPQ TTEVRQTRKE
460 470 480 490 500
WRNGIISNEQ YEQFIEKETE KWIRYQEEIG LDVLVHGEFE RTDMVEYFGE
510 520 530 540 550
RLAGFSFTKN GWVQSYGSRC VKPPVIYGDV AFINGMTIKE TVYAQSLTEK
560 570 580 590 600
VVKGMLTGPV TILNWSFVRN DIPRKEVSYQ IALALRHEIE LLESSGIRVI
610 620 630 640 650
QVDEPALREG MPLKEKDWDA YITWAVQSFL LATSSVANET QIHTHMCYSN
660 670 680 690 700
FEDIVDAIRA LDADVISIET SRSHGEFIDT LKHTTYEKGI GLGVYDIHSP
710 720 730 740 750
RVPSKDEMYK IVEQSLQVCD PKYFWINPDC GLKTRRTEEV IPALEHMVQA
760
AKDARSLLKT NA
Length:762
Mass (Da):87,232
Last modified:July 5, 2004 - v1
Checksum:i6FBC8EB3CF60C349
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA Translation: AAP27939.1
AE017334 Genomic DNA Translation: AAT33335.1
AE017225 Genomic DNA Translation: AAT56213.1
RefSeqiNP_846453.1, NC_003997.3
WP_001007635.1, NZ_PPES01000010.1
YP_030162.1, NC_005945.1

Genome annotation databases

EnsemblBacteriaiAAP27939; AAP27939; BA_4218
AAT33335; AAT33335; GBAA_4218
AAT56213; AAT56213; BAS3912
GeneIDi1088935
2850686
KEGGiban:BA_4218
bar:GBAA_4218
bat:BAS3912
PATRICifig|198094.11.peg.4187

Similar proteinsi

Entry informationi

Entry nameiMETE_BACAN
AccessioniPrimary (citable) accession number: Q6KNA9
Secondary accession number(s): Q6HU26, Q81MM9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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