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Q6KIQ6

- TYSY_MYCMO

UniProt

Q6KIQ6 - TYSY_MYCMO

Protein

Thymidylate synthase

Gene

thyA

Organism
Mycoplasma mobile (strain ATCC 43663 / 163K / NCTC 11711)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    • Comment

    Functioni

    Provides the sole de novo source of dTMP for DNA biosynthesis.UniRule annotation

    Catalytic activityi

    5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei170 – 1701UniRule annotation

    GO - Molecular functioni

    1. thymidylate synthase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dTMP biosynthetic process Source: UniProtKB-HAMAP
    2. dTTP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Nucleotide biosynthesis

    Enzyme and pathway databases

    BioCyciMMOB267748:GH6Y-34-MONOMER.
    UniPathwayiUPA00575.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidylate synthaseUniRule annotation (EC:2.1.1.45UniRule annotation)
    Short name:
    TSUniRule annotation
    Short name:
    TSaseUniRule annotation
    Gene namesi
    Name:thyAUniRule annotation
    Ordered Locus Names:MMOB0340
    OrganismiMycoplasma mobile (strain ATCC 43663 / 163K / NCTC 11711)
    Taxonomic identifieri267748 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000009072: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 288288Thymidylate synthasePRO_0000140984Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi267748.MMOB0340.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6KIQ6.
    SMRiQ6KIQ6. Positions 2-288.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0207.
    HOGENOMiHOG000257899.
    KOiK00560.
    OMAiLQTAYGR.
    OrthoDBiEOG6K6V53.

    Family and domain databases

    Gene3Di3.30.572.10. 1 hit.
    HAMAPiMF_00008. Thymidy_synth_bact.
    InterProiIPR023451. Thymidate_synth/dCMP_Mease.
    IPR000398. Thymidylate_synthase.
    [Graphical view]
    PfamiPF00303. Thymidylat_synt. 1 hit.
    [Graphical view]
    PRINTSiPR00108. THYMDSNTHASE.
    SUPFAMiSSF55831. SSF55831. 1 hit.
    TIGRFAMsiTIGR03284. thym_sym. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6KIQ6-1 [UniParc]FASTAAdd to Basket

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    MEQYLSLLKE ILEKGQKKED RTNTGTISYF GTQRRYDLSK GFPLVTTKKV    50
    HLKSIIFELL WFIKGDTNIK YLVDNGVNIW NEWPYETFKK SKDFNGESLA 100
    DFVLKIKSDT LFAKKYGELG PVYGKQWRNF NGTDQLFDAI ETIKKNPDSR 150
    RIIVSAWAAN EISKMALPPC HAFFQFYVNN NKLSLQLYQR SGDTFLGVPF 200
    NIASYSILLA MVAQITNYEV GEFIHTIGDT HIYLNHLEQV EEQLSRKPLK 250
    LPKLVLNKKI KNIDDFKYED IEIIDYESHP AIKAKVAV 288
    Length:288
    Mass (Da):33,365
    Last modified:July 5, 2004 - v1
    Checksum:i77BF7066E99FD250
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017308 Genomic DNA. Translation: AAT27520.1.
    RefSeqiWP_011264554.1. NC_006908.1.
    YP_015731.1. NC_006908.1.

    Genome annotation databases

    EnsemblBacteriaiAAT27520; AAT27520; MMOB0340.
    GeneIDi2807843.
    KEGGimmo:MMOB0340.
    PATRICi20015345. VBIMycMob32482_0036.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017308 Genomic DNA. Translation: AAT27520.1 .
    RefSeqi WP_011264554.1. NC_006908.1.
    YP_015731.1. NC_006908.1.

    3D structure databases

    ProteinModelPortali Q6KIQ6.
    SMRi Q6KIQ6. Positions 2-288.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 267748.MMOB0340.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAT27520 ; AAT27520 ; MMOB0340 .
    GeneIDi 2807843.
    KEGGi mmo:MMOB0340.
    PATRICi 20015345. VBIMycMob32482_0036.

    Phylogenomic databases

    eggNOGi COG0207.
    HOGENOMi HOG000257899.
    KOi K00560.
    OMAi LQTAYGR.
    OrthoDBi EOG6K6V53.

    Enzyme and pathway databases

    UniPathwayi UPA00575 .
    BioCyci MMOB267748:GH6Y-34-MONOMER.

    Family and domain databases

    Gene3Di 3.30.572.10. 1 hit.
    HAMAPi MF_00008. Thymidy_synth_bact.
    InterProi IPR023451. Thymidate_synth/dCMP_Mease.
    IPR000398. Thymidylate_synthase.
    [Graphical view ]
    Pfami PF00303. Thymidylat_synt. 1 hit.
    [Graphical view ]
    PRINTSi PR00108. THYMDSNTHASE.
    SUPFAMi SSF55831. SSF55831. 1 hit.
    TIGRFAMsi TIGR03284. thym_sym. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43663 / 163K / NCTC 11711.

    Entry informationi

    Entry nameiTYSY_MYCMO
    AccessioniPrimary (citable) accession number: Q6KIQ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3