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Q6KHX0 (K6PF_MYCMO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
6-phosphofructokinase

Short name=Phosphofructokinase
EC=2.7.1.11
Alternative name(s):
Phosphohexokinase
Gene names
Name:pfkA
Ordered Locus Names:MMOB3200
OrganismMycoplasma mobile (strain ATCC 43663 / 163K / NCTC 11711) [Complete proteome] [HAMAP]
Taxonomic identifier267748 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length325 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. HAMAP-Rule MF_00339

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4. HAMAP-Rule MF_00339

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00339.

Sequence similarities

Belongs to the phosphofructokinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Magnesium
Metal-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfructose 6-phosphate metabolic process

Inferred from electronic annotation. Source: InterPro

glycolysis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_component6-phosphofructokinase complex

Inferred from electronic annotation. Source: InterPro

   Molecular_function6-phosphofructokinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

ATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3253256-phosphofructokinase HAMAP-Rule MF_00339
PRO_1000059782

Regions

Nucleotide binding22 – 265ATP By similarity
Nucleotide binding155 – 1595ATP By similarity
Nucleotide binding172 – 18817ATP By similarity

Sites

Active site1281Proton acceptor By similarity
Metal binding1861Magnesium; via carbonyl oxygen By similarity
Metal binding1881Magnesium By similarity
Binding site1631Substrate By similarity
Binding site2461Substrate By similarity
Binding site2521Substrate By similarity
Binding site2551Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6KHX0 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 2110A703E6D31D1D

FASTA32535,000
        10         20         30         40         50         60 
MAKKIAILTS GGDSPGMNNA IRTIVKTSKI HGIEVFLVYN GYKGLVEKTI KNANEINVDQ 

        70         80         90        100        110        120 
YIGSGGTFIG SARYLEFKKL EVRQKAVQNL KEMGIDSLVV IGGDGSYAGA QLLHELGVKT 

       130        140        150        160        170        180 
IGLPGTIDND IASTEYTIGL DTALNTIVEN VDRLRDTMNS MNMVALVEVM GHGAGDLAML 

       190        200        210        220        230        240 
SGLATGAEII VTNAHRKSID EMIEIVKDQM IAKTKRSVIG IVSEFIYDDL KKVAKEIEDK 

       250        260        270        280        290        300 
TGIRTRAIIL AHTQRGGNPK AYERINASFL GIAAVESLLK NESGVALGFK GNKIISTPIP 

       310        320 
EALKAQNSAK NENELVTKIN KINQS 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017308 Genomic DNA. Translation: AAT27806.1.
RefSeqYP_016017.1. NC_006908.1.

3D structure databases

ProteinModelPortalQ6KHX0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING267748.MMOB3200.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAT27806; AAT27806; MMOB3200.
GeneID2807302.
KEGGmmo:MMOB3200.
PATRIC20015975. VBIMycMob32482_0338.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0205.
HOGENOMHOG000248870.
KOK00850.
OMAYRRGKLH.
OrthoDBEOG644ZRM.
ProtClustDBPRK03202.

Enzyme and pathway databases

BioCycMMOB267748:GH6Y-334-MONOMER.
UniPathwayUPA00109; UER00182.

Family and domain databases

HAMAPMF_00339. Phosphofructokinase.
InterProIPR012003. ATP_PFK_prok.
IPR012828. PFKA_ATP.
IPR022953. Phosphofructokinase.
IPR015912. Phosphofructokinase_CS.
IPR000023. Phosphofructokinase_dom.
[Graphical view]
PfamPF00365. PFK. 1 hit.
[Graphical view]
PIRSFPIRSF000532. ATP_PFK_prok. 1 hit.
PRINTSPR00476. PHFRCTKINASE.
SUPFAMSSF53784. SSF53784. 1 hit.
TIGRFAMsTIGR02482. PFKA_ATP. 1 hit.
PROSITEPS00433. PHOSPHOFRUCTOKINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameK6PF_MYCMO
AccessionPrimary (citable) accession number: Q6KHX0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways