Q6KHN3 (RNC_MYCMO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribonuclease 3
EC=3.1.26.3

Alternative name(s):
Ribonuclease III
Short name=RNase III

Gene names

Name:	rnc
Ordered Locus Names:	MMOB4110

Organism

Mycoplasma mobile (strain ATCC 43663 / 163K / NCTC 11711) [Complete proteome] [HAMAP]

Taxonomic identifier

267748 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length	246 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs By similarity. HAMAP MF_00104
Catalytic activity	Endonucleolytic cleavage to 5'-phosphomonoester. HAMAP MF_00104
Subcellular location	Cytoplasm By similarity HAMAP MF_00104.
Sequence similarities	Contains 1 DRBM (double-stranded RNA-binding) domain. Contains 1 RNase III domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	RNA-binding
Molecular function	Endonuclease Hydrolase Nuclease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	RNA processing Inferred from electronic annotation. Source: InterPro rRNA catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	double-stranded RNA binding Inferred from electronic annotation. Source: InterPro ribonuclease III activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 246	246	Ribonuclease 3 HAMAP MF_00104		PRO_0000228550
Regions
	Domain	10 – 135	126	RNase III
	Domain	161 – 230	70	DRBM

Sequences

	Sequence		Length	Mass (Da)
	Q6KHN3 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: B24A66561862B71E	FASTA	246	28,099
	10 20 30 40 50 60 MNKKTKIEGL ENFLTLNNII FKDIKYYIQA LTHKTYANEH ANIESYDILE FIGDAILQMK 70 80 90 100 110 120 SSIFIFQHFQ NITEGEASLI RAKNVCSSGL SELSKKLGLS KLLLISKGSE HLRENVKINA 130 140 150 160 170 180 DLFESFVAAI YLDLGDEKLE EFLKEIFYPY ISTTNLESIK DPKSSFQEYI QSYSNEIIEY 190 200 210 220 230 240 KITQLENELR SELFKAELMH NGITYGVGFG KTKKVAEEEA ATRALETLKA PSKQTIKKAI KAEKKE

References

[1]

"The complete genome and proteome of Mycoplasma mobile." Jaffe J.D., Stange-Thomann N., Smith C., DeCaprio D., Fisher S., Butler J., Calvo S., Elkins T., FitzGerald M.G., Hafez N., Kodira C.D., Major J., Wang S., Wilkinson J., Nicol R., Nusbaum C., Birren B., Berg H.C., Church G.M. Genome Res. 14:1447-1461(2004) [PubMed: 15289470] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43663 / 163K / NCTC 11711.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017308 Genomic DNA. Translation: AAT27897.1.
RefSeq	YP_016108.1. NC_006908.1.
3D structure databases
ProteinModelPortal	Q6KHN3.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2807434.
GenomeReviews	Gene locus MMOB4110 in contig AE017308_GR.
KEGG	mmo:MMOB4110.
PATRIC	20016181. VBIMycMob32482_0433.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG744556.
OMA	SAYANLF.
PhylomeDB	Q6KHN3.
Enzyme and pathway databases
BioCyc	MMOB267748:MMOB4110-MONOMER.
Family and domain databases
HAMAP	MF_00104. RNase_III. [Tree]
InterPro	IPR001159. Ds-RNA-bd. IPR014720. dsRNA-bd-like. IPR000999. RNase_III. IPR011907. RNase_III_bac. [Graphical view]
Gene3D	G3DSA:3.30.160.20. dsRNA-bd-like. 1 hit. G3DSA:1.10.1520.10. RNase_III. 1 hit.
KO	K03685.
PANTHER	PTHR11207. PTHR11207. 1 hit.
Pfam	PF00035. dsrm. 1 hit. PF00636. Ribonuclease_3. 1 hit. [Graphical view]
SMART	SM00358. DSRM. 1 hit. SM00535. RIBOc. 1 hit. [Graphical view]
SUPFAM	SSF69065. RNase_III. 1 hit.
TIGRFAMs	TIGR02191. RNaseIII. 1 hit.
PROSITE	PS50137. DS_RBD. 1 hit. PS00517. RNASE_3_1. False negative. PS50142. RNASE_3_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RNC_MYCMO

Accession

Primary (citable) accession number: Q6KHN3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program