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Q6KHN3 (RNC_MYCMO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonuclease 3

EC=3.1.26.3
Alternative name(s):
Ribonuclease III
Short name=RNase III
Gene names
Name:rnc
Ordered Locus Names:MMOB4110
OrganismMycoplasma mobile (strain ATCC 43663 / 163K / NCTC 11711) [Complete proteome] [HAMAP]
Taxonomic identifier267748 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length246 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon By similarity. HAMAP-Rule MF_00104

Catalytic activity

Endonucleolytic cleavage to 5'-phosphomonoester. HAMAP-Rule MF_00104

Cofactor

Mg2+ By similarity. HAMAP-Rule MF_00104

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00104

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00104.

Sequence similarities

Contains 1 DRBM (double-stranded RNA-binding) domain.

Contains 1 RNase III domain.

Ontologies

Keywords
   Biological processmRNA processing
rRNA processing
tRNA processing
   Cellular componentCytoplasm
   LigandMagnesium
Metal-binding
RNA-binding
rRNA-binding
   Molecular functionEndonuclease
Hydrolase
Nuclease
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processmRNA processing

Inferred from electronic annotation. Source: UniProtKB-HAMAP

rRNA catabolic process

Inferred from electronic annotation. Source: InterPro

rRNA processing

Inferred from electronic annotation. Source: UniProtKB-HAMAP

tRNA processing

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

rRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

ribonuclease III activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 246246Ribonuclease 3 HAMAP-Rule MF_00104
PRO_0000228550

Regions

Domain10 – 135126RNase III
Domain161 – 23070DRBM

Sites

Active site541 Potential
Active site1241 By similarity
Metal binding501Magnesium By similarity
Metal binding1211Magnesium By similarity
Metal binding1241Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6KHN3 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: B24A66561862B71E

FASTA24628,099
        10         20         30         40         50         60 
MNKKTKIEGL ENFLTLNNII FKDIKYYIQA LTHKTYANEH ANIESYDILE FIGDAILQMK 

        70         80         90        100        110        120 
SSIFIFQHFQ NITEGEASLI RAKNVCSSGL SELSKKLGLS KLLLISKGSE HLRENVKINA 

       130        140        150        160        170        180 
DLFESFVAAI YLDLGDEKLE EFLKEIFYPY ISTTNLESIK DPKSSFQEYI QSYSNEIIEY 

       190        200        210        220        230        240 
KITQLENELR SELFKAELMH NGITYGVGFG KTKKVAEEEA ATRALETLKA PSKQTIKKAI 


KAEKKE 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017308 Genomic DNA. Translation: AAT27897.1.
RefSeqYP_016108.1. NC_006908.1.

3D structure databases

ProteinModelPortalQ6KHN3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING267748.MMOB4110.

Proteomic databases

PRIDEQ6KHN3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAT27897; AAT27897; MMOB4110.
GeneID2807434.
KEGGmmo:MMOB4110.
PATRIC20016181. VBIMycMob32482_0433.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0571.
HOGENOMHOG000246808.
KOK03685.
OMATETNFKS.
OrthoDBEOG6T1WVS.

Enzyme and pathway databases

BioCycMMOB267748:GH6Y-434-MONOMER.

Family and domain databases

Gene3D1.10.1520.10. 1 hit.
3.30.160.20. 1 hit.
HAMAPMF_00104. RNase_III.
InterProIPR014720. dsRNA-bd_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view]
PANTHERPTHR11207. PTHR11207. 1 hit.
PfamPF00035. dsrm. 1 hit.
PF00636. Ribonuclease_3. 1 hit.
[Graphical view]
SMARTSM00358. DSRM. 1 hit.
SM00535. RIBOc. 1 hit.
[Graphical view]
SUPFAMSSF69065. SSF69065. 1 hit.
TIGRFAMsTIGR02191. RNaseIII. 1 hit.
PROSITEPS50137. DS_RBD. 1 hit.
PS50142. RNASE_3_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRNC_MYCMO
AccessionPrimary (citable) accession number: Q6KHN3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families