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Q6KHE8

- TRMB_MYCMO

UniProt

Q6KHE8 - TRMB_MYCMO

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene
trmB, MMOB4960
Organism
Mycoplasma mobile (strain ATCC 43663 / 163K / NCTC 11711)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei34 – 341S-adenosyl-L-methionine By similarity
Binding sitei59 – 591S-adenosyl-L-methionine By similarity
Binding sitei86 – 861S-adenosyl-L-methionine By similarity
Active sitei107 – 1071 By similarity
Binding sitei107 – 1071S-adenosyl-L-methionine By similarity
Binding sitei111 – 1111Substrate By similarity
Binding sitei143 – 1431Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciMMOB267748:GH6Y-526-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:MMOB4960
OrganismiMycoplasma mobile (strain ATCC 43663 / 163K / NCTC 11711)
Taxonomic identifieri267748 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000009072: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 201201tRNA (guanine-N(7)-)-methyltransferaseUniRule annotationPRO_0000171355Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi267748.MMOB4960.

Structurei

3D structure databases

ProteinModelPortaliQ6KHE8.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni181 – 1844Substrate binding Reviewed prediction

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000251689.
KOiK03439.
OMAiGCGKGEY.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6KHE8-1 [UniParc]FASTAAdd to Basket

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MRVRRDKNLE KILDVDPLVI SKFPFKLKQD TIIELGSGKG TMISALALKN    50
PSQNYLCVER DRTIASKAIE KFNDLNLKNI NLIVSDIQHL TEIIENKVNT 100
IWLTFSDPWP KNRHEHRRLT YKTFLDLYKK FLSPQGVIKL KTDNDKFFHY 150
SLESMSEFGM KILYQTNDLH NSIKNLDNEM TDYEKKWSSL GKSINYLEAS 200
F 201
Length:201
Mass (Da):23,579
Last modified:July 5, 2004 - v1
Checksum:iB98F0D6F7B802E5B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017308 Genomic DNA. Translation: AAT27982.1.
RefSeqiWP_011265016.1. NC_006908.1.
YP_016193.1. NC_006908.1.

Genome annotation databases

EnsemblBacteriaiAAT27982; AAT27982; MMOB4960.
GeneIDi2807733.
KEGGimmo:MMOB4960.
PATRICi20016375. VBIMycMob32482_0523.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017308 Genomic DNA. Translation: AAT27982.1 .
RefSeqi WP_011265016.1. NC_006908.1.
YP_016193.1. NC_006908.1.

3D structure databases

ProteinModelPortali Q6KHE8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 267748.MMOB4960.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAT27982 ; AAT27982 ; MMOB4960 .
GeneIDi 2807733.
KEGGi mmo:MMOB4960.
PATRICi 20016375. VBIMycMob32482_0523.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000251689.
KOi K03439.
OMAi GCGKGEY.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci MMOB267748:GH6Y-526-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43663 / 163K / NCTC 11711.

Entry informationi

Entry nameiTRMB_MYCMO
AccessioniPrimary (citable) accession number: Q6KHE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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