SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q6KHE8

- TRMB_MYCMO

UniProt

Q6KHE8 - TRMB_MYCMO

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, MMOB4960
Organism
Mycoplasma mobile (strain ATCC 43663 / 163K / NCTC 11711)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei34 – 341S-adenosyl-L-methionine By similarity
Binding sitei59 – 591S-adenosyl-L-methionine By similarity
Binding sitei86 – 861S-adenosyl-L-methionine By similarity
Active sitei107 – 1071 By similarity
Binding sitei107 – 1071S-adenosyl-L-methionine By similarity
Binding sitei111 – 1111Substrate By similarity
Binding sitei143 – 1431Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciMMOB267748:GH6Y-526-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferase
    tRNA(m7G46)-methyltransferase
    Gene namesi
    Name:trmB
    Ordered Locus Names:MMOB4960
    OrganismiMycoplasma mobile (strain ATCC 43663 / 163K / NCTC 11711)
    Taxonomic identifieri267748 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000009072: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 201201tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
    PRO_0000171355Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi267748.MMOB4960.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6KHE8.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni181 – 1844Substrate binding Reviewed prediction

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000251689.
    KOiK03439.
    OMAiGCGKGEY.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6KHE8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRVRRDKNLE KILDVDPLVI SKFPFKLKQD TIIELGSGKG TMISALALKN    50
    PSQNYLCVER DRTIASKAIE KFNDLNLKNI NLIVSDIQHL TEIIENKVNT 100
    IWLTFSDPWP KNRHEHRRLT YKTFLDLYKK FLSPQGVIKL KTDNDKFFHY 150
    SLESMSEFGM KILYQTNDLH NSIKNLDNEM TDYEKKWSSL GKSINYLEAS 200
    F 201
    Length:201
    Mass (Da):23,579
    Last modified:July 5, 2004 - v1
    Checksum:iB98F0D6F7B802E5B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017308 Genomic DNA. Translation: AAT27982.1.
    RefSeqiWP_011265016.1. NC_006908.1.
    YP_016193.1. NC_006908.1.

    Genome annotation databases

    EnsemblBacteriaiAAT27982; AAT27982; MMOB4960.
    GeneIDi2807733.
    KEGGimmo:MMOB4960.
    PATRICi20016375. VBIMycMob32482_0523.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017308 Genomic DNA. Translation: AAT27982.1 .
    RefSeqi WP_011265016.1. NC_006908.1.
    YP_016193.1. NC_006908.1.

    3D structure databases

    ProteinModelPortali Q6KHE8.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 267748.MMOB4960.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAT27982 ; AAT27982 ; MMOB4960 .
    GeneIDi 2807733.
    KEGGi mmo:MMOB4960.
    PATRICi 20016375. VBIMycMob32482_0523.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000251689.
    KOi K03439.
    OMAi GCGKGEY.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci MMOB267748:GH6Y-526-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43663 / 163K / NCTC 11711.

    Entry informationi

    Entry nameiTRMB_MYCMO
    AccessioniPrimary (citable) accession number: Q6KHE8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: July 5, 2004
    Last modified: September 3, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

    Similar proteinsi