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Protein
Submitted name:

Leucyl-tRNA synthetase

Gene

leuS

Organism
Mycoplasma mobile (strain ATCC 43663 / 163K / NCTC 11711)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. leucine-tRNA ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetaseImported, Ligase

Enzyme and pathway databases

BioCyciMMOB267748:GH6Y-572-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Leucyl-tRNA synthetaseImported (EC:6.1.1.4Imported)
Gene namesi
Name:leuSImported
Ordered Locus Names:MMOB5390Imported
OrganismiMycoplasma mobile (strain ATCC 43663 / 163K / NCTC 11711)Imported
Taxonomic identifieri267748 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000009072 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi267748.MMOB5390.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZIUX-ray2.07A/B1-630[»]
ProteinModelPortaliQ6KHA5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000200748.
KOiK01869.
OMAiHVKGYLA.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 1 hit.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6KHA5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYNHNEIEKK WQTRWEKTKA FKTTNKSKDK FYALDMFPYP SGSGLHVGHP
60 70 80 90 100
EGYTATDIIS RYKRLKGFDV LHPIGWDAFG LPAEQYALSS GKHPQPFTLK
110 120 130 140 150
NIENFRRQLK SLGFSFDYEK EVNTTDPSYY RWTQWIFKQI YKKGLAEIRE
160 170 180 190 200
VDVNWCPGLG TVLANEEIVE NDKGEMVSER GSFPVYKKPM KQWVLKITNY
210 220 230 240 250
ADRLLEDLNL LDWPDSLKKL QTNWIGKEEI DGKITYKLQD WIFARQRYWG
260 270 280 290 300
EPFPVYFDED NNVYLIDELV ELPHMENIMP SGTGEGPLAT NTEWVQYKKN
310 320 330 340 350
NKIFKRDTNT MPQWAGSCWY YLAYIMKQED GTYLPIDSKK AYEAFSKWLP
360 370 380 390 400
VDLYIGGQEH AVLHLLYARF WHKILYDLKI VPTKEPFQKL INQGMILGKD
410 420 430 440 450
GQKMSKSLGN VVNPDEIIQN FGADTLRVYE MFMGPLTDTK KWNESTVEAT
460 470 480 490 500
YKWILRVKRI FQIFIEDKSK INSLHKDDQF ISEHNLLIKE ITQDIEDLKF
510 520 530 540 550
NIMISKLMIF VNSLYKKEKI YSLKPLKDFA IMFSTIAPHI SEELLESLGE
560 570 580 590 600
KEIMFQSWPT YENNKILLTK DIVAIQVNGK LRETFEIEND WDEKRVIEEA
610 620 630
KKLPNVKKHL ENKIIKKEIY IAKKILNFII
Length:630
Mass (Da):74,275
Last modified:July 5, 2004 - v1
Checksum:iBFFD6A92E79B2F2E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017308 Genomic DNA. Translation: AAT28025.1.
RefSeqiWP_011265059.1. NC_006908.1.
YP_016236.1. NC_006908.1.

Genome annotation databases

EnsemblBacteriaiAAT28025; AAT28025; MMOB5390.
KEGGimmo:MMOB5390.
PATRICi20016465. VBIMycMob32482_0566.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017308 Genomic DNA. Translation: AAT28025.1.
RefSeqiWP_011265059.1. NC_006908.1.
YP_016236.1. NC_006908.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZIUX-ray2.07A/B1-630[»]
ProteinModelPortaliQ6KHA5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi267748.MMOB5390.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT28025; AAT28025; MMOB5390.
KEGGimmo:MMOB5390.
PATRICi20016465. VBIMycMob32482_0566.

Phylogenomic databases

HOGENOMiHOG000200748.
KOiK01869.
OMAiHVKGYLA.
OrthoDBiEOG63Z74X.

Enzyme and pathway databases

BioCyciMMOB267748:GH6Y-572-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 1 hit.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43663 / 163K / NCTC 11711Imported.
  2. "Leucyl-tRNA synthetase editing domain functions as a molecular rheostat to control codon ambiguity in Mycoplasma pathogens."
    Li L., Palencia A., Lukk T., Li Z., Luthey-Schulten Z.A., Cusack S., Martinis S.A., Boniecki M.T.
    Proc. Natl. Acad. Sci. U.S.A. 110:3817-3822(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.07 ANGSTROMS).

Entry informationi

Entry nameiQ6KHA5_MYCMO
AccessioniPrimary (citable) accession number: Q6KHA5
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: April 1, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.