Q6KH11 (Q6KH11_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Ral guanine nucleotide dissociation stimulator EMBL CAI13417.1

Submitted name:
Ral guanine nucleotide dissociation stimulator A EMBL AAQ13414.1
Submitted name:
Ral guanine nucleotide dissociation stimulator, isoform CRA_d EMBL EAW88040.1
Submitted name:
Uncharacterized protein Ensembl ENSP00000376867

Gene names

Name:	RALGDS Ensembl ENSP00000376867 EMBL CAI13417.1
ORF Names:	hCG_31468 EMBL EAW88040.1, RP11-326L24.1-003 EMBL CAI13417.1

Organism

Homo sapiens (Human) EMBL AAQ13414.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	859 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 N-terminal Ras-GEF domain. SAAS SAAS000651 Contains 1 Ras-GEF domain. SAAS SAAS000651

Ontologies

Keywords
Molecular function	Guanine-nucleotide releasing factor SAAS SAAS000651
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular function	guanyl-nucleotide exchange factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q6KH11 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 938430024246A2BF	FASTA	859	94,690
	10 20 30 40 50 60 MMVDCQSSTQ EIGEELINGV IYSISLRKVQ LHHGGNKGQR WLGYENESAL NLYETCKVRT 70 80 90 100 110 120 VKAGTLEKLV EHLVPAFQGS DLSYVTIFLC TYRAFTTTQQ VLDLLFKRYG RCDALTASSR 130 140 150 160 170 180 YGCILPYSDE DGGPQDQLKN AISSILGTWL DQYSEDFCQP PDFPCLKQLV AYVQLNMPGS 190 200 210 220 230 240 DLERRAHLLL AQLEHSEPIE AEPEALSPVP ALKPTPELEL ALTPARAPSP VPAPAPEPEP 250 260 270 280 290 300 APTPAPGSEL EVAPAPAPEL QQAPEPAVGL ESAPAPALEL EPAPEQDPAP SQTLELEPAP 310 320 330 340 350 360 APVPSLQPSW PSPVVAENGL SEEKPHLLVF PPDLVAEQFT LMDAELFKKV VPYHCLGSIW 370 380 390 400 410 420 SQRDKKGKEH LAPTIRATVT QFNSVANCVI TTCLGNRSTK APDRARVVEH WIEVARECRI 430 440 450 460 470 480 LKNFSSLYAI LSALQSNSIH RLKKTWEDVS RDSFRIFQKL SEIFSDENNY SLSRELLIKE 490 500 510 520 530 540 GTSKFATLEM NPKRAQKRPK ETGIIQGTVP YLGTFLTDLV MLDTAMKDYL YGRLINFEKR 550 560 570 580 590 600 RKEFEVIAQI KLLQSACNNY SIAPDEQFGA WFRAVERLSE TESYNLSCEL EPPSESASNT 610 620 630 640 650 660 LRTKKNTAIV KRWSDRQAPS TELSTSGSSH SKSCDQLRCG PYLSSGDIAD ALSVHSAGSS 670 680 690 700 710 720 SSDVEEINIS FVPESPDGQE KKFWESASQS SPETSGISSA SSSTSSSSAS TTPVAATRTH 730 740 750 760 770 780 KRSVSGLCNS SSALPLYNQQ VGDCCIIRVS LDVDNGNMYK SILVTSQDKA PAVIRKAMDK 790 800 810 820 830 840 HNLEEEEPED YELLQILSDD RKLKIPENAN VFYAMNSTAN YDFVLKKRTF TKGVKVKHGA 850 SSTLPRMKQK GLKIAKGIF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed: 15164053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Yu L., Zhao S.Y. Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	Kimberley A. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[4]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION.
[5]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF027169 mRNA. Translation: AAQ13414.1. AL162417 Genomic DNA. Translation: CAI13417.1. CH471090 Genomic DNA. Translation: EAW88040.1.
IPI	IPI01014166.
RefSeq	NP_001035827.1. NM_001042368.1.
UniGene	Hs.106185.
3D structure databases
ProteinModelPortal	Q6KH11.
SMR	Q6KH11. Positions 330-593, 738-830.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6KH11.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000393160; ENSP00000376867; ENSG00000160271.
GeneID	5900.
KEGG	hsa:5900.
UCSC	uc004ccr.1. human.
Organism-specific databases
CTD	5900.
HGNC	HGNC:9842. RALGDS.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG005864.
Gene expression databases
ArrayExpress	Q6KH11.
Bgee	Q6KH11.
Family and domain databases
InterPro	IPR015758. RalGDS. IPR000159. Ras-assoc. IPR000651. Ras-like_Gua-exchang_fac_N. IPR019804. Ras_G-nucl-exch_fac_CS. IPR008937. Ras_GEF. IPR023578. Ras_GEF_dom. IPR001895. RasGRF_CDC25. [Graphical view]
Gene3D	G3DSA:1.10.840.10. RasGRF_CDC25. 1 hit.
KO	K08732.
PANTHER	PTHR23113:SF35. RalGDS. 1 hit. PTHR23113. Ras_GEF. 1 hit.
Pfam	PF00788. RA. 1 hit. PF00617. RasGEF. 1 hit. PF00618. RasGEF_N. 1 hit. [Graphical view]
SMART	SM00314. RA. 1 hit. SM00147. RasGEF. 1 hit. SM00229. RasGEFN. 1 hit. [Graphical view]
SUPFAM	SSF48366. Ras_GEF. 1 hit.
PROSITE	PS50200. RA. 1 hit. PS00720. RASGEF. 1 hit. PS50009. RASGEF_CAT. 1 hit. PS50212. RASGEF_NTER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	22950.

Entry information

Entry name

Q6KH11_HUMAN

Accession

Primary (citable) accession number: Q6KH11

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	November 16, 2011
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.