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Q6KEJ1

- Q6KEJ1_HUMAN

UniProt

Q6KEJ1 - Q6KEJ1_HUMAN

Protein
Submitted name:

Cystic fibrosis transmembrane conductance regulator

Gene

CFTR

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi
  1. Functioni

    GO - Molecular functioni

    1. ATPase activity, coupled to transmembrane movement of substances Source: InterPro
    2. ATP binding Source: InterPro
    3. bicarbonate transmembrane transporter activity Source: Ensembl
    4. chloride transmembrane transporter activity Source: Ensembl

    GO - Biological processi

    1. cellular response to cAMP Source: Ensembl
    2. cellular response to hormone stimulus Source: Ensembl
    3. cholesterol biosynthetic process Source: Ensembl
    4. cholesterol transport Source: Ensembl
    5. intracellular pH elevation Source: Ensembl
    6. iodide transport Source: Ensembl
    7. lung development Source: Ensembl
    8. membrane hyperpolarization Source: Ensembl
    9. positive regulation of vasodilation Source: Ensembl
    10. response to cytokine Source: Ensembl
    11. response to drug Source: Ensembl
    12. response to estrogen Source: Ensembl
    13. response to peptide hormone Source: Ensembl
    14. sperm capacitation Source: Ensembl
    15. transepithelial chloride transport Source: Ensembl
    16. vasodilation Source: Ensembl
    17. water transport Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Cystic fibrosis transmembrane conductance regulatorImported
    Gene namesi
    Name:CFTRImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. basolateral plasma membrane Source: Ensembl
    3. cytoplasmic vesicle membrane Source: Ensembl
    4. integral component of membrane Source: UniProtKB-KW
    5. microvillus Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    Expressioni

    Gene expression databases

    ArrayExpressiQ6KEJ1.
    BgeeiQ6KEJ1.

    Family & Domainsi

    Keywords - Domaini

    TransmembraneImported

    Family and domain databases

    InterProiIPR011527. ABC1_TM_dom.
    IPR001140. ABC_transptr_TM_dom.
    [Graphical view]
    PfamiPF00664. ABC_membrane. 1 hit.
    [Graphical view]
    SUPFAMiSSF90123. SSF90123. 1 hit.
    PROSITEiPS50929. ABC_TM1F. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q6KEJ1-1 [UniParc]FASTAAdd to Basket

    « Hide

    EVTKAVQPLL LGRIIASYDP DNKEERSIAI YLGIGLCLLF IVRTLLLHPA   50
    IFGLHHIGMQ MRIAMFSLIY KK 72
    Length:72
    Mass (Da):8,165
    Last modified:July 5, 2004 - v1
    Checksum:i4A0A215F3D75AC39
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei72 – 721Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ574942 Genomic DNA. Translation: CAE00656.1.
    AJ574956 Genomic DNA. Translation: CAE00670.1.
    AJ574957 Genomic DNA. Translation: CAE00671.1.
    AJ574958 Genomic DNA. Translation: CAE00672.1.
    UniGeneiHs.489786.
    Hs.621460.
    Hs.661104.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ574942 Genomic DNA. Translation: CAE00656.1 .
    AJ574956 Genomic DNA. Translation: CAE00670.1 .
    AJ574957 Genomic DNA. Translation: CAE00671.1 .
    AJ574958 Genomic DNA. Translation: CAE00672.1 .
    UniGenei Hs.489786.
    Hs.621460.
    Hs.661104.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Gene expression databases

    ArrayExpressi Q6KEJ1.
    Bgeei Q6KEJ1.

    Family and domain databases

    InterProi IPR011527. ABC1_TM_dom.
    IPR001140. ABC_transptr_TM_dom.
    [Graphical view ]
    Pfami PF00664. ABC_membrane. 1 hit.
    [Graphical view ]
    SUPFAMi SSF90123. SSF90123. 1 hit.
    PROSITEi PS50929. ABC_TM1F. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "An engineered genomic CFTR construct is expressed and correctly spliced in the human lung sarcoma cell line HT1080."
      Schindelhauer D., Laner A., Cattani S., Christan S., Ramalho A.S., Marques B., Beck S., Penque D., Amaral M.D.
      Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ6KEJ1_HUMAN
    AccessioniPrimary (citable) accession number: Q6KEJ1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.