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Q6KEI8

- Q6KEI8_HUMAN

UniProt

Q6KEI8 - Q6KEI8_HUMAN

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Protein
Submitted name:

Cystic fibrosis transmembrane conductance regulator

Gene

CFTR

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. bicarbonate transmembrane transporter activity Source: Ensembl
  2. chloride channel activity Source: InterPro

GO - Biological processi

  1. cellular response to cAMP Source: Ensembl
  2. cellular response to hormone stimulus Source: Ensembl
  3. cholesterol biosynthetic process Source: Ensembl
  4. cholesterol transport Source: Ensembl
  5. intracellular pH elevation Source: Ensembl
  6. iodide transport Source: Ensembl
  7. lung development Source: Ensembl
  8. membrane hyperpolarization Source: Ensembl
  9. positive regulation of vasodilation Source: Ensembl
  10. response to cytokine Source: Ensembl
  11. response to drug Source: Ensembl
  12. response to estrogen Source: Ensembl
  13. response to peptide hormone Source: Ensembl
  14. sperm capacitation Source: Ensembl
  15. transepithelial chloride transport Source: Ensembl
  16. vasodilation Source: Ensembl
  17. water transport Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Cystic fibrosis transmembrane conductance regulatorImported
Gene namesi
Name:CFTRImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. basolateral plasma membrane Source: Ensembl
  3. cytoplasmic vesicle membrane Source: Ensembl
  4. integral component of membrane Source: UniProtKB-KW
  5. microvillus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiQ6KEI8.
ExpressionAtlasiQ6KEI8. baseline and differential.

Family & Domainsi

Keywords - Domaini

TransmembraneImported

Family and domain databases

InterProiIPR009147. CysFib_conduc_TM.
[Graphical view]
PRINTSiPR01851. CYSFIBREGLTR.

Sequencei

Sequence statusi: Fragment.

Q6KEI8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
GLALAHFVWI APLQVALLMG LIWELLQASA FCGLGFLIVL ALFQAGLGRM

MMKY
Length:54
Mass (Da):5,908
Last modified:July 5, 2004 - v1
Checksum:i35DC2C8EAAEA7BBD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei54 – 541Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ574944 Genomic DNA. Translation: CAE00658.1.
AJ574959 Genomic DNA. Translation: CAE00673.1.
AJ574963 Genomic DNA. Translation: CAE00677.1.
AJ574964 Genomic DNA. Translation: CAE00678.1.
UniGeneiHs.489786.
Hs.621460.
Hs.661104.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ574944 Genomic DNA. Translation: CAE00658.1 .
AJ574959 Genomic DNA. Translation: CAE00673.1 .
AJ574963 Genomic DNA. Translation: CAE00677.1 .
AJ574964 Genomic DNA. Translation: CAE00678.1 .
UniGenei Hs.489786.
Hs.621460.
Hs.661104.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Gene expression databases

Bgeei Q6KEI8.
ExpressionAtlasi Q6KEI8. baseline and differential.

Family and domain databases

InterProi IPR009147. CysFib_conduc_TM.
[Graphical view ]
PRINTSi PR01851. CYSFIBREGLTR.
ProtoNeti Search...

Publicationsi

  1. "An engineered genomic CFTR construct is expressed and correctly spliced in the human lung sarcoma cell line HT1080."
    Schindelhauer D., Laner A., Cattani S., Christan S., Ramalho A.S., Marques B., Beck S., Penque D., Amaral M.D.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ6KEI8_HUMAN
AccessioniPrimary (citable) accession number: Q6KEI8
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.