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Protein
Submitted name:

Cystic fibrosis transmembrane conductance regulator

Gene

CFTR

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. bicarbonate transmembrane transporter activity Source: Ensembl
  2. chloride channel activity Source: InterPro

GO - Biological processi

  1. cellular response to cAMP Source: Ensembl
  2. cellular response to hormone stimulus Source: Ensembl
  3. cholesterol biosynthetic process Source: Ensembl
  4. cholesterol transport Source: Ensembl
  5. intracellular pH elevation Source: Ensembl
  6. iodide transport Source: Ensembl
  7. lung development Source: Ensembl
  8. membrane hyperpolarization Source: Ensembl
  9. positive regulation of vasodilation Source: Ensembl
  10. response to cytokine Source: Ensembl
  11. response to drug Source: Ensembl
  12. response to estrogen Source: Ensembl
  13. response to peptide hormone Source: Ensembl
  14. sperm capacitation Source: Ensembl
  15. transepithelial chloride transport Source: Ensembl
  16. vasodilation Source: Ensembl
  17. water transport Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Cystic fibrosis transmembrane conductance regulatorImported
Gene namesi
Name:CFTRImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. basolateral plasma membrane Source: Ensembl
  3. cytoplasmic vesicle membrane Source: Ensembl
  4. integral component of membrane Source: UniProtKB-KW
  5. microvillus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiQ6KEG9.
ExpressionAtlasiQ6KEG9. baseline and differential.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ6KEG9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

TransmembraneImported

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR009147. CFTR/ABCC7.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24223:SF19. PTHR24223:SF19. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q6KEG9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
TSLLMVIMGE LEPSEGKIKH SGRISFCSQF SWIMPGTIKE NIIFGVSYDE
60
YRYRSVIKAC QLEE
Length:64
Mass (Da):7,348
Last modified:July 5, 2004 - v1
Checksum:iD56FB2D58CE532D9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei64 – 641Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ574977 Genomic DNA. Translation: CAE00691.1.
AJ574978 Genomic DNA. Translation: CAE00692.1.
AJ574979 Genomic DNA. Translation: CAE00693.1.
UniGeneiHs.489786.
Hs.621460.
Hs.661104.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ574977 Genomic DNA. Translation: CAE00691.1.
AJ574978 Genomic DNA. Translation: CAE00692.1.
AJ574979 Genomic DNA. Translation: CAE00693.1.
UniGeneiHs.489786.
Hs.621460.
Hs.661104.

3D structure databases

ProteinModelPortaliQ6KEG9.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiQ6KEG9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Gene expression databases

BgeeiQ6KEG9.
ExpressionAtlasiQ6KEG9. baseline and differential.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR009147. CFTR/ABCC7.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24223:SF19. PTHR24223:SF19. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "An engineered genomic CFTR construct is expressed and correctly spliced in the human lung sarcoma cell line HT1080."
    Schindelhauer D., Laner A., Cattani S., Christan S., Ramalho A.S., Marques B., Beck S., Penque D., Amaral M.D.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ6KEG9_HUMAN
AccessioniPrimary (citable) accession number: Q6KEG9
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: March 4, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.