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Q6KEF9

- Q6KEF9_HUMAN

UniProt

Q6KEF9 - Q6KEF9_HUMAN

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Protein
Submitted name: Cystic fibrosis transmembrane conductance regulator
Gene
CFTR
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein predictedi

Functioni

GO - Molecular functioni

  1. bicarbonate transmembrane transporter activity Source: Ensembl
  2. chloride transmembrane transporter activity Source: Ensembl
Complete GO annotation...

GO - Biological processi

  1. cellular response to cAMP Source: Ensembl
  2. cellular response to hormone stimulus Source: Ensembl
  3. cholesterol biosynthetic process Source: Ensembl
  4. cholesterol transport Source: Ensembl
  5. intracellular pH elevation Source: Ensembl
  6. iodide transport Source: Ensembl
  7. lung development Source: Ensembl
  8. membrane hyperpolarization Source: Ensembl
  9. positive regulation of vasodilation Source: Ensembl
  10. response to cytokine Source: Ensembl
  11. response to drug Source: Ensembl
  12. response to estrogen Source: Ensembl
  13. response to peptide hormone Source: Ensembl
  14. sperm capacitation Source: Ensembl
  15. transepithelial chloride transport Source: Ensembl
  16. vasodilation Source: Ensembl
  17. water transport Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Cystic fibrosis transmembrane conductance regulatorImported
Gene namesi
Name:CFTRImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. basolateral plasma membrane Source: Ensembl
  3. cytoplasmic vesicle membrane Source: Ensembl
  4. integral component of membrane Source: UniProtKB-KW
  5. microvillus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

ArrayExpressiQ6KEF9.
BgeeiQ6KEF9.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ6KEF9.

Family & Domainsi

Keywords - Domaini

TransmembraneImported

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR025837. CFTR_reg_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF14396. CFTR_R. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q6KEF9-1 [UniParc]FASTAAdd to Basket

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CVCKLMANKT RILVTSKMEH LKKADKILIL HEGSSYFYGT FSELQNLQPD    50
FSSKLMGCDS FDQFSAERRN SILTETLHRF SLEGDAPVSW TETKKQSFKQ 100
TGEFGEKRKN SILNPINSIR KFSIVQKTPL QMNGIEEDSD EPLERRLSLV 150
PDSEQGEAIL PRISVISTGP TLQARRRQSV LNLMTHSVNQ GQNIHRKTTA 200
STRKVSLAPQ ANLTELDIYS RRLSQETGLE ISEEINEEDL K 241
Length:241
Mass (Da):27,358
Last modified:July 5, 2004 - v1
Checksum:i5E9DFCBA9A0710C6
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei241 – 2411Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ574987 Genomic DNA. Translation: CAE00701.1.
AJ574988 Genomic DNA. Translation: CAE00702.1.
AJ574989 Genomic DNA. Translation: CAE00703.1.
AJ574990 Genomic DNA. Translation: CAE00704.1.
UniGeneiHs.489786.
Hs.621460.
Hs.661104.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ574987 Genomic DNA. Translation: CAE00701.1 .
AJ574988 Genomic DNA. Translation: CAE00702.1 .
AJ574989 Genomic DNA. Translation: CAE00703.1 .
AJ574990 Genomic DNA. Translation: CAE00704.1 .
UniGenei Hs.489786.
Hs.621460.
Hs.661104.

3D structure databases

ProteinModelPortali Q6KEF9.
ModBasei Search...

Chemistry

BindingDBi Q6KEF9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Gene expression databases

ArrayExpressi Q6KEF9.
Bgeei Q6KEF9.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR025837. CFTR_reg_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF14396. CFTR_R. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "An engineered genomic CFTR construct is expressed and correctly spliced in the human lung sarcoma cell line HT1080."
    Schindelhauer D., Laner A., Cattani S., Christan S., Ramalho A.S., Marques B., Beck S., Penque D., Amaral M.D.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ6KEF9_HUMAN
AccessioniPrimary (citable) accession number: Q6KEF9
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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