Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q6KEF9

- Q6KEF9_HUMAN

UniProt

Q6KEF9 - Q6KEF9_HUMAN

Protein
Submitted name:

Cystic fibrosis transmembrane conductance regulator

Gene

CFTR

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. bicarbonate transmembrane transporter activity Source: Ensembl
    2. chloride transmembrane transporter activity Source: Ensembl

    GO - Biological processi

    1. cellular response to cAMP Source: Ensembl
    2. cellular response to hormone stimulus Source: Ensembl
    3. cholesterol biosynthetic process Source: Ensembl
    4. cholesterol transport Source: Ensembl
    5. intracellular pH elevation Source: Ensembl
    6. iodide transport Source: Ensembl
    7. lung development Source: Ensembl
    8. membrane hyperpolarization Source: Ensembl
    9. positive regulation of vasodilation Source: Ensembl
    10. response to cytokine Source: Ensembl
    11. response to drug Source: Ensembl
    12. response to estrogen Source: Ensembl
    13. response to peptide hormone Source: Ensembl
    14. sperm capacitation Source: Ensembl
    15. transepithelial chloride transport Source: Ensembl
    16. vasodilation Source: Ensembl
    17. water transport Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Cystic fibrosis transmembrane conductance regulatorImported
    Gene namesi
    Name:CFTRImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. basolateral plasma membrane Source: Ensembl
    3. cytoplasmic vesicle membrane Source: Ensembl
    4. integral component of membrane Source: UniProtKB-KW
    5. microvillus Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    Expressioni

    Gene expression databases

    ArrayExpressiQ6KEF9.
    BgeeiQ6KEF9.

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliQ6KEF9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    TransmembraneImported

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR025837. CFTR_reg_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF14396. CFTR_R. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Fragment.

    Q6KEF9-1 [UniParc]FASTAAdd to Basket

    « Hide

    CVCKLMANKT RILVTSKMEH LKKADKILIL HEGSSYFYGT FSELQNLQPD    50
    FSSKLMGCDS FDQFSAERRN SILTETLHRF SLEGDAPVSW TETKKQSFKQ 100
    TGEFGEKRKN SILNPINSIR KFSIVQKTPL QMNGIEEDSD EPLERRLSLV 150
    PDSEQGEAIL PRISVISTGP TLQARRRQSV LNLMTHSVNQ GQNIHRKTTA 200
    STRKVSLAPQ ANLTELDIYS RRLSQETGLE ISEEINEEDL K 241
    Length:241
    Mass (Da):27,358
    Last modified:July 5, 2004 - v1
    Checksum:i5E9DFCBA9A0710C6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei241 – 2411Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ574987 Genomic DNA. Translation: CAE00701.1.
    AJ574988 Genomic DNA. Translation: CAE00702.1.
    AJ574989 Genomic DNA. Translation: CAE00703.1.
    AJ574990 Genomic DNA. Translation: CAE00704.1.
    UniGeneiHs.489786.
    Hs.621460.
    Hs.661104.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ574987 Genomic DNA. Translation: CAE00701.1 .
    AJ574988 Genomic DNA. Translation: CAE00702.1 .
    AJ574989 Genomic DNA. Translation: CAE00703.1 .
    AJ574990 Genomic DNA. Translation: CAE00704.1 .
    UniGenei Hs.489786.
    Hs.621460.
    Hs.661104.

    3D structure databases

    ProteinModelPortali Q6KEF9.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi Q6KEF9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Gene expression databases

    ArrayExpressi Q6KEF9.
    Bgeei Q6KEF9.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR025837. CFTR_reg_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF14396. CFTR_R. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "An engineered genomic CFTR construct is expressed and correctly spliced in the human lung sarcoma cell line HT1080."
      Schindelhauer D., Laner A., Cattani S., Christan S., Ramalho A.S., Marques B., Beck S., Penque D., Amaral M.D.
      Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ6KEF9_HUMAN
    AccessioniPrimary (citable) accession number: Q6KEF9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.