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Q6KEB2

- Q6KEB2_HUMAN

UniProt

Q6KEB2 - Q6KEB2_HUMAN

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Protein
Submitted name:

Cystic fibrosis transmembrane conductance regulator

Gene

CFTR

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. bicarbonate transmembrane transporter activity Source: Ensembl
  2. chloride transmembrane transporter activity Source: Ensembl

GO - Biological processi

  1. cellular response to cAMP Source: Ensembl
  2. cellular response to hormone stimulus Source: Ensembl
  3. cholesterol biosynthetic process Source: Ensembl
  4. cholesterol transport Source: Ensembl
  5. intracellular pH elevation Source: Ensembl
  6. iodide transport Source: Ensembl
  7. lung development Source: Ensembl
  8. membrane hyperpolarization Source: Ensembl
  9. positive regulation of vasodilation Source: Ensembl
  10. response to cytokine Source: Ensembl
  11. response to drug Source: Ensembl
  12. response to estrogen Source: Ensembl
  13. response to peptide hormone Source: Ensembl
  14. sperm capacitation Source: Ensembl
  15. transepithelial chloride transport Source: Ensembl
  16. vasodilation Source: Ensembl
  17. water transport Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Cystic fibrosis transmembrane conductance regulatorImported
Gene namesi
Name:CFTRImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. basolateral plasma membrane Source: Ensembl
  3. cytoplasmic vesicle membrane Source: Ensembl
  4. integral component of membrane Source: UniProtKB-KW
  5. microvillus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiQ6KEB2.
ExpressionAtlasiQ6KEB2. baseline and differential.

Family & Domainsi

Keywords - Domaini

TransmembraneImported

Sequencei

Sequence statusi: Fragment.

Q6KEB2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30
KVFIFSGTFR KNLDPYEQWS DQEIWKVADE
Length:30
Mass (Da):3,677
Last modified:July 5, 2004 - v1
Checksum:i42952348009026CD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei30 – 301Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ575034 Genomic DNA. Translation: CAE00748.1.
AJ575035 Genomic DNA. Translation: CAE00749.1.
AJ575036 Genomic DNA. Translation: CAE00750.1.
AJ575037 Genomic DNA. Translation: CAE00751.1.
AJ575038 Genomic DNA. Translation: CAE00752.1.
AJ575039 Genomic DNA. Translation: CAE00753.1.
AJ575040 Genomic DNA. Translation: CAE00754.1.
UniGeneiHs.489786.
Hs.621460.
Hs.661104.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ575034 Genomic DNA. Translation: CAE00748.1 .
AJ575035 Genomic DNA. Translation: CAE00749.1 .
AJ575036 Genomic DNA. Translation: CAE00750.1 .
AJ575037 Genomic DNA. Translation: CAE00751.1 .
AJ575038 Genomic DNA. Translation: CAE00752.1 .
AJ575039 Genomic DNA. Translation: CAE00753.1 .
AJ575040 Genomic DNA. Translation: CAE00754.1 .
UniGenei Hs.489786.
Hs.621460.
Hs.661104.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Gene expression databases

Bgeei Q6KEB2.
ExpressionAtlasi Q6KEB2. baseline and differential.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "An engineered genomic CFTR construct is expressed and correctly spliced in the human lung sarcoma cell line HT1080."
    Schindelhauer D., Laner A., Cattani S., Christan S., Ramalho A.S., Marques B., Beck S., Penque D., Amaral M.D.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ6KEB2_HUMAN
AccessioniPrimary (citable) accession number: Q6KEB2
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.