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Protein

Calcium-binding mitochondrial carrier protein SCaMC-2

Gene

SLC25A25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi60 – 71121PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Calcium, Metal-binding

Protein family/group databases

TCDBi2.A.29.23.1. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding mitochondrial carrier protein SCaMC-2
Alternative name(s):
Mitochondrial ATP-Mg/Pi carrier protein 3
Mitochondrial Ca(2+)-dependent solute carrier protein 3
Small calcium-binding mitochondrial carrier protein 2
Solute carrier family 25 member 25
Gene namesi
Name:SLC25A25
Synonyms:APC3, KIAA1896, MCSC3, SCAMC2
ORF Names:UNQ549/PRO1106
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:20663. SLC25A25.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 189189Mitochondrial intermembraneSequence analysisAdd
BLAST
Transmembranei190 – 20718Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini208 – 24437Mitochondrial matrixSequence analysisAdd
BLAST
Transmembranei245 – 26420Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini265 – 28723Mitochondrial intermembraneSequence analysisAdd
BLAST
Transmembranei288 – 30114Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini302 – 33736Mitochondrial matrixSequence analysisAdd
BLAST
Transmembranei338 – 35720Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini358 – 38023Mitochondrial intermembraneSequence analysisAdd
BLAST
Transmembranei381 – 39818Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini399 – 43739Mitochondrial matrixSequence analysisAdd
BLAST
Transmembranei438 – 45720Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini458 – 46912Mitochondrial intermembraneSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134952319.

Polymorphism and mutation databases

BioMutaiSLC25A25.
DMDMi74758042.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 469469Calcium-binding mitochondrial carrier protein SCaMC-2PRO_0000317602Add
BLAST

Proteomic databases

EPDiQ6KCM7.
MaxQBiQ6KCM7.
PaxDbiQ6KCM7.
PRIDEiQ6KCM7.

PTM databases

iPTMnetiQ6KCM7.
PhosphoSiteiQ6KCM7.

Expressioni

Tissue specificityi

Present in various cell lines (at protein level). Widely expressed. Expressed in fetal and adult liver, skeletal muscle, testis, ovary, hippocampus and caudate nucleus. Isoform 1 is present in all tissues tested. Isoform 2 expression is restricted to kidney and lung.2 Publications

Gene expression databases

BgeeiQ6KCM7.
ExpressionAtlasiQ6KCM7. baseline and differential.
GenevisibleiQ6KCM7. HS.

Organism-specific databases

HPAiHPA020381.

Interactioni

Protein-protein interaction databases

BioGridi125351. 11 interactions.
IntActiQ6KCM7. 3 interactions.
STRINGi9606.ENSP00000362159.

Structurei

3D structure databases

ProteinModelPortaliQ6KCM7.
SMRiQ6KCM7. Positions 13-165, 188-445.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 8034EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini78 – 11336EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini114 – 14936EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Repeati184 – 27087Solcar 1Add
BLAST
Repeati278 – 36386Solcar 2Add
BLAST
Repeati375 – 46389Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 EF-hand domains.PROSITE-ProRule annotation
Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0036. Eukaryota.
ENOG410XQ4P. LUCA.
GeneTreeiENSGT00760000119245.
HOVERGENiHBG108464.
InParanoidiQ6KCM7.
KOiK14684.
OMAiKLLTRMD.
OrthoDBiEOG7V7661.
PhylomeDBiQ6KCM7.
TreeFamiTF313492.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.50.40.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR002167. Graves_DC.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
PF13833. EF-hand_8. 1 hit.
PF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00928. GRAVESDC.
PR00926. MITOCARRIER.
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
SSF47473. SSF47473. 1 hit.
PROSITEiPS50222. EF_HAND_2. 3 hits.
PS50920. SOLCAR. 3 hits.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6KCM7-1) [UniParc]FASTAAdd to basket

Also known as: SCaMC-2a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLCLCLYVPV IGEAQTEFQY FESKGLPAEL KSIFKLSVFI PSQEFSTYRQ
60 70 80 90 100
WKQKIVQAGD KDLDGQLDFE EFVHYLQDHE KKLRLVFKSL DKKNDGRIDA
110 120 130 140 150
QEIMQSLRDL GVKISEQQAE KILKSMDKNG TMTIDWNEWR DYHLLHPVEN
160 170 180 190 200
IPEIILYWKH STIFDVGENL TVPDEFTVEE RQTGMWWRHL VAGGGAGAVS
210 220 230 240 250
RTCTAPLDRL KVLMQVHASR SNNMGIVGGF TQMIREGGAR SLWRGNGINV
260 270 280 290 300
LKIAPESAIK FMAYEQIKRL VGSDQETLRI HERLVAGSLA GAIAQSSIYP
310 320 330 340 350
MEVLKTRMAL RKTGQYSGML DCARRILARE GVAAFYKGYV PNMLGIIPYA
360 370 380 390 400
GIDLAVYETL KNAWLQHYAV NSADPGVFVL LACGTMSSTC GQLASYPLAL
410 420 430 440 450
VRTRMQAQAS IEGAPEVTMS SLFKHILRTE GAFGLYRGLA PNFMKVIPAV
460
SISYVVYENL KITLGVQSR
Length:469
Mass (Da):52,663
Last modified:July 5, 2004 - v1
Checksum:iA50825AA95DBD4BE
GO
Isoform 2 (identifier: Q6KCM7-2) [UniParc]FASTAAdd to basket

Also known as: SCaMC-2b

The sequence of this isoform differs from the canonical sequence as follows:
     1-52: MLCLCLYVPV...QEFSTYRQWK → MVSSVLCRCV...LGLHRTEGEL

Show »
Length:503
Mass (Da):55,398
Checksum:i01F0C668941DA37F
GO
Isoform 3 (identifier: Q6KCM7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-52: MLCLCLYVPV...QEFSTYRQWK → MVSSVLCRCV...LGLHRTEGEL
     125-125: S → RIRTGHFWGPVTY

Show »
Length:515
Mass (Da):56,883
Checksum:iF7549BDE9AB03F09
GO
Isoform 4 (identifier: Q6KCM7-4) [UniParc]FASTAAdd to basket

Also known as: SCaMC-2c

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: MLCLCLYVPV...EFSTYRQWKQ → MLQMLWHFLA...VVGPAEQFPK

Show »
Length:489
Mass (Da):54,638
Checksum:i1BD8AAB1C40592DB
GO
Isoform 5 (identifier: Q6KCM7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: MLCLCLYVPV...EFSTYRQWKQ → MLQMLWHFLA...VVGPAEQFPK
     125-125: S → RIRTGHFWGPVTY

Show »
Length:501
Mass (Da):56,123
Checksum:i9F5ADEE4BB6BEEEA
GO
Isoform 6 (identifier: Q6KCM7-6) [UniParc]FASTAAdd to basket

Also known as: SCaMC-2d

The sequence of this isoform differs from the canonical sequence as follows:
     1-103: Missing.

Show »
Length:366
Mass (Da):40,589
Checksum:iC02E524BE6120F90
GO

Sequence cautioni

The sequence BAB67789.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAH73133.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI13826.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti89 – 891S → I in AAQ88879 (PubMed:12975309).Curated
Sequence conflicti162 – 1621T → Q in AAH05163 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 103103Missing in isoform 6. 1 PublicationVSP_031067Add
BLAST
Alternative sequencei1 – 5353MLCLC…RQWKQ → MLQMLWHFLASFFPRAGCHG SREGDDREVRGTPAPAWRDQ MASFLGKQDGRAEATEKRPT ILLVVGPAEQFPK in isoform 4 and isoform 5. 3 PublicationsVSP_031068Add
BLAST
Alternative sequencei1 – 5252MLCLC…YRQWK → MVSSVLCRCVASPPPDAAAT AASSSASSPASVGDPCGGAI CGGPDHRLRLWRLFQTLDVN RDGGLCVNDLAVGLRRLGLH RTEGEL in isoform 2 and isoform 3. 2 PublicationsVSP_031069Add
BLAST
Alternative sequencei125 – 1251S → RIRTGHFWGPVTY in isoform 3 and isoform 5. 1 PublicationVSP_031070

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ619989 mRNA. Translation: CAF04495.1.
AJ619990 mRNA. Translation: CAF04496.1.
AJ619991 mRNA. Translation: CAF04497.1.
AJ619992 mRNA. Translation: CAF04498.1.
AJ619963 mRNA. Translation: CAF04060.1.
AB067483 mRNA. Translation: BAB67789.1. Different initiation.
AY358515 mRNA. Translation: AAQ88879.1.
AK290705 mRNA. Translation: BAF83394.1.
AK290991 mRNA. Translation: BAF83680.1.
CH471090 Genomic DNA. Translation: EAW87739.1.
AL360268, AL590708 Genomic DNA. Translation: CAH73133.1. Sequence problems.
AL360268, AL590708 Genomic DNA. Translation: CAH73134.1.
AL360268, AL590708 Genomic DNA. Translation: CAH73135.1.
AL360268, AL590708 Genomic DNA. Translation: CAH73136.1.
AL590708, AL360268 Genomic DNA. Translation: CAI13826.1. Sequence problems.
AL590708, AL360268 Genomic DNA. Translation: CAI13827.1.
AL590708, AL360268 Genomic DNA. Translation: CAI13836.1.
AL590708, AL360268 Genomic DNA. Translation: CAI13838.1.
BC005163 mRNA. Translation: AAH05163.2.
BC089448 mRNA. Translation: AAH89448.1.
BC103930 mRNA. Translation: AAI03931.1.
BC103931 mRNA. Translation: AAI03932.1.
BC103932 mRNA. Translation: AAI03933.1.
BC103933 mRNA. Translation: AAI03934.1.
CCDSiCCDS35151.1. [Q6KCM7-2]
CCDS48031.1. [Q6KCM7-4]
CCDS59146.1. [Q6KCM7-5]
CCDS6890.1. [Q6KCM7-1]
RefSeqiNP_001006642.1. NM_001006641.3. [Q6KCM7-2]
NP_001006643.1. NM_001006642.3. [Q6KCM7-4]
NP_001252543.1. NM_001265614.2. [Q6KCM7-5]
NP_443133.2. NM_052901.4. [Q6KCM7-1]
XP_005251745.1. XM_005251688.1. [Q6KCM7-3]
XP_005251746.1. XM_005251689.3. [Q6KCM7-6]
UniGeneiHs.5476.
Hs.729700.

Genome annotation databases

EnsembliENST00000373064; ENSP00000362155; ENSG00000148339. [Q6KCM7-1]
ENST00000373066; ENSP00000362157; ENSG00000148339. [Q6KCM7-5]
ENST00000373068; ENSP00000362159; ENSG00000148339. [Q6KCM7-2]
ENST00000373069; ENSP00000362160; ENSG00000148339. [Q6KCM7-3]
ENST00000432073; ENSP00000410053; ENSG00000148339. [Q6KCM7-4]
GeneIDi114789.
KEGGihsa:114789.
UCSCiuc004btb.5. human. [Q6KCM7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ619989 mRNA. Translation: CAF04495.1.
AJ619990 mRNA. Translation: CAF04496.1.
AJ619991 mRNA. Translation: CAF04497.1.
AJ619992 mRNA. Translation: CAF04498.1.
AJ619963 mRNA. Translation: CAF04060.1.
AB067483 mRNA. Translation: BAB67789.1. Different initiation.
AY358515 mRNA. Translation: AAQ88879.1.
AK290705 mRNA. Translation: BAF83394.1.
AK290991 mRNA. Translation: BAF83680.1.
CH471090 Genomic DNA. Translation: EAW87739.1.
AL360268, AL590708 Genomic DNA. Translation: CAH73133.1. Sequence problems.
AL360268, AL590708 Genomic DNA. Translation: CAH73134.1.
AL360268, AL590708 Genomic DNA. Translation: CAH73135.1.
AL360268, AL590708 Genomic DNA. Translation: CAH73136.1.
AL590708, AL360268 Genomic DNA. Translation: CAI13826.1. Sequence problems.
AL590708, AL360268 Genomic DNA. Translation: CAI13827.1.
AL590708, AL360268 Genomic DNA. Translation: CAI13836.1.
AL590708, AL360268 Genomic DNA. Translation: CAI13838.1.
BC005163 mRNA. Translation: AAH05163.2.
BC089448 mRNA. Translation: AAH89448.1.
BC103930 mRNA. Translation: AAI03931.1.
BC103931 mRNA. Translation: AAI03932.1.
BC103932 mRNA. Translation: AAI03933.1.
BC103933 mRNA. Translation: AAI03934.1.
CCDSiCCDS35151.1. [Q6KCM7-2]
CCDS48031.1. [Q6KCM7-4]
CCDS59146.1. [Q6KCM7-5]
CCDS6890.1. [Q6KCM7-1]
RefSeqiNP_001006642.1. NM_001006641.3. [Q6KCM7-2]
NP_001006643.1. NM_001006642.3. [Q6KCM7-4]
NP_001252543.1. NM_001265614.2. [Q6KCM7-5]
NP_443133.2. NM_052901.4. [Q6KCM7-1]
XP_005251745.1. XM_005251688.1. [Q6KCM7-3]
XP_005251746.1. XM_005251689.3. [Q6KCM7-6]
UniGeneiHs.5476.
Hs.729700.

3D structure databases

ProteinModelPortaliQ6KCM7.
SMRiQ6KCM7. Positions 13-165, 188-445.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125351. 11 interactions.
IntActiQ6KCM7. 3 interactions.
STRINGi9606.ENSP00000362159.

Protein family/group databases

TCDBi2.A.29.23.1. the mitochondrial carrier (mc) family.

PTM databases

iPTMnetiQ6KCM7.
PhosphoSiteiQ6KCM7.

Polymorphism and mutation databases

BioMutaiSLC25A25.
DMDMi74758042.

Proteomic databases

EPDiQ6KCM7.
MaxQBiQ6KCM7.
PaxDbiQ6KCM7.
PRIDEiQ6KCM7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373064; ENSP00000362155; ENSG00000148339. [Q6KCM7-1]
ENST00000373066; ENSP00000362157; ENSG00000148339. [Q6KCM7-5]
ENST00000373068; ENSP00000362159; ENSG00000148339. [Q6KCM7-2]
ENST00000373069; ENSP00000362160; ENSG00000148339. [Q6KCM7-3]
ENST00000432073; ENSP00000410053; ENSG00000148339. [Q6KCM7-4]
GeneIDi114789.
KEGGihsa:114789.
UCSCiuc004btb.5. human. [Q6KCM7-1]

Organism-specific databases

CTDi114789.
GeneCardsiSLC25A25.
HGNCiHGNC:20663. SLC25A25.
HPAiHPA020381.
MIMi608745. gene.
neXtProtiNX_Q6KCM7.
PharmGKBiPA134952319.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0036. Eukaryota.
ENOG410XQ4P. LUCA.
GeneTreeiENSGT00760000119245.
HOVERGENiHBG108464.
InParanoidiQ6KCM7.
KOiK14684.
OMAiKLLTRMD.
OrthoDBiEOG7V7661.
PhylomeDBiQ6KCM7.
TreeFamiTF313492.

Miscellaneous databases

ChiTaRSiSLC25A25. human.
GenomeRNAii114789.
PROiQ6KCM7.
SOURCEiSearch...

Gene expression databases

BgeeiQ6KCM7.
ExpressionAtlasiQ6KCM7. baseline and differential.
GenevisibleiQ6KCM7. HS.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.50.40.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR002167. Graves_DC.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
PF13833. EF-hand_8. 1 hit.
PF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00928. GRAVESDC.
PR00926. MITOCARRIER.
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
SSF47473. SSF47473. 1 hit.
PROSITEiPS50222. EF_HAND_2. 3 hits.
PS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel human subfamily of mitochondrial carriers with calcium-binding domains."
    del Arco A., Satrustegui J.
    J. Biol. Chem. 279:24701-24713(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 4 AND 6), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "Identification of the mitochondrial ATP-Mg/Pi transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution."
    Fiermonte G., De Leonardis F., Todisco S., Palmieri L., Lasorsa F.M., Palmieri F.
    J. Biol. Chem. 279:30722-30730(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Brain.
  3. "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins."
    Nagase T., Kikuno R., Ohara O.
    DNA Res. 8:179-187(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Lung and Teratocarcinoma.
  6. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Chondrosarcoma and Muscle.

Entry informationi

Entry nameiSCMC2_HUMAN
AccessioniPrimary (citable) accession number: Q6KCM7
Secondary accession number(s): Q5SYW7
, Q5SYW8, Q5SYX3, Q5VWU2, Q5VWU3, Q5VWU4, Q6KCM4, Q6KCM6, Q6UX48, Q705K2, Q96PZ1, Q9BSA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.