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Q6KCD5 (NIPBL_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nipped-B-like protein
Alternative name(s):
Delangin homolog
SCC2 homolog
Gene names
Name:Nipbl
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length2798 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probably plays a structural role in chromatin. Involved in sister chromatid cohesion, possibly by interacting with the cohesin complex By similarity.

Subcellular location

Nucleus By similarity.

Developmental stage

Widely expressed at E9.5 and E10.5, with notable accumulations in limb bud, branchial arch and craniofacial mesenchyme. These regions are involved in patterning of the skeleton and soft tissues of the limbs, jaw and face. Ref.4

Sequence similarities

Belongs to the SCC2/Nipped-B family.

Contains 5 HEAT repeats.

Ontologies

Keywords
   Biological processCell cycle
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   DomainRepeat
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processbrain development

Inferred from electronic annotation. Source: Ensembl

cellular protein localization

Inferred from electronic annotation. Source: Ensembl

cellular response to DNA damage stimulus

Inferred from electronic annotation. Source: Ensembl

cellular response to X-ray

Inferred from electronic annotation. Source: Ensembl

cognition

Inferred from electronic annotation. Source: Ensembl

developmental growth

Inferred from electronic annotation. Source: Ensembl

ear morphogenesis

Inferred from electronic annotation. Source: Ensembl

embryonic cranial skeleton morphogenesis

Inferred from mutant phenotype PubMed 19763162. Source: MGI

embryonic digestive tract morphogenesis

Inferred from electronic annotation. Source: Ensembl

embryonic forelimb morphogenesis

Inferred from electronic annotation. Source: Ensembl

embryonic viscerocranium morphogenesis

Inferred from mutant phenotype PubMed 19763162. Source: MGI

external genitalia morphogenesis

Inferred from electronic annotation. Source: Ensembl

eye morphogenesis

Inferred from electronic annotation. Source: Ensembl

face morphogenesis

Inferred from electronic annotation. Source: Ensembl

fat cell differentiation

Inferred from mutant phenotype PubMed 19763162. Source: MGI

gall bladder development

Inferred from electronic annotation. Source: Ensembl

heart development

Inferred from mutant phenotype PubMed 19763162. Source: MGI

maintenance of mitotic sister chromatid cohesion

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

outflow tract morphogenesis

Inferred from electronic annotation. Source: Ensembl

positive regulation of histone deacetylation

Inferred from electronic annotation. Source: Ensembl

positive regulation of multicellular organism growth

Inferred from mutant phenotype PubMed 19763162. Source: MGI

positive regulation of ossification

Inferred from mutant phenotype PubMed 19763162. Source: MGI

regulation of developmental growth

Inferred from electronic annotation. Source: Ensembl

regulation of embryonic development

Inferred from electronic annotation. Source: Ensembl

regulation of hair cycle

Inferred from electronic annotation. Source: Ensembl

sensory perception of sound

Inferred from electronic annotation. Source: Ensembl

stem cell maintenance

Inferred from mutant phenotype PubMed 20720539. Source: MGI

uterus morphogenesis

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentSMC loading complex

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionchromatin binding

Inferred from direct assay PubMed 20720539. Source: MGI

mediator complex binding

Inferred from direct assay PubMed 20720539. Source: MGI

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6KCD5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6KCD5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     2678-2691: SLRRSKRNSDSTEL → VRRRRSQRISQRIT
     2692-2798: Missing.
Note: Contains a phosphothreonine at position 2661. Contains a phosphoserine at position 2666.
Isoform 3 (identifier: Q6KCD5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-2694: Missing.
Note: No experimental confirmation available.
Isoform 4 (identifier: Q6KCD5-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-263: Missing.
     499-556: DKPLKKRKQD...QAGRVDSQAS → GKGPLSLLLQ...NYITLFELLY
     557-2798: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 27982798Nipped-B-like protein
PRO_0000218597

Regions

Repeat1761 – 179939HEAT 1
Repeat1837 – 187539HEAT 2
Repeat1939 – 197840HEAT 3
Repeat2221 – 226141HEAT 4
Repeat2307 – 234539HEAT 5
Compositional bias418 – 46245Gln-rich

Amino acid modifications

Modified residue1501Phosphoserine By similarity
Modified residue1621Phosphoserine By similarity
Modified residue2561Phosphoserine By similarity
Modified residue2801Phosphoserine Ref.5
Modified residue3061Phosphoserine By similarity
Modified residue3181Phosphoserine By similarity
Modified residue3501Phosphoserine By similarity
Modified residue7131Phosphothreonine By similarity
Modified residue7461Phosphothreonine By similarity
Modified residue9061Phosphoserine By similarity
Modified residue10761N6-acetyllysine Ref.7
Modified residue10831Phosphoserine By similarity
Modified residue10841Phosphoserine By similarity
Modified residue10901Phosphoserine By similarity
Modified residue11441Phosphoserine By similarity
Modified residue11461Phosphoserine By similarity
Modified residue11481Phosphoserine By similarity
Modified residue11541Phosphoserine By similarity
Modified residue25031Phosphoserine By similarity
Modified residue25051Phosphoserine By similarity
Modified residue25071Phosphoserine By similarity
Modified residue25091Phosphoserine By similarity
Modified residue26521Phosphoserine Ref.5 Ref.6
Modified residue26611Phosphothreonine Ref.5
Modified residue26661Phosphoserine Ref.5

Natural variations

Alternative sequence1 – 26942694Missing in isoform 3.
VSP_011094
Alternative sequence1 – 263263Missing in isoform 4.
VSP_011095
Alternative sequence499 – 55658DKPLK…DSQAS → GKGPLSLLLQHLATCVLIPT SLLRYEFHSLAEASISDLII QYHRLSNLNYITLFELLY in isoform 4.
VSP_011096
Alternative sequence557 – 27982242Missing in isoform 4.
VSP_011097
Alternative sequence2678 – 269114SLRRS…DSTEL → VRRRRSQRISQRIT in isoform 2.
VSP_011098
Alternative sequence2692 – 2798107Missing in isoform 2.
VSP_011099

Experimental info

Sequence conflict25771K → I in BAC25453. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: BC23B6E2C949C9B3

FASTA2,798315,450
        10         20         30         40         50         60 
MNGDMPHVPI TTLAGIASLT DLLNQLPLPS PLPATTTKSL LFNSRIAEEV NCLLACRDDN 

        70         80         90        100        110        120 
LVSQLVHSLN QVSTDHIELK DNLGSDDPEG DIPVLLQAVL ARSPNVFREK SMQNRYVQSG 

       130        140        150        160        170        180 
MMMSQYKLSQ NSMHSSPASS NYQQTTISHS PSSRFVPPQT SSGNRFMPQQ NSPVPSPYAP 

       190        200        210        220        230        240 
QSPAGYMPYS HPSSYTTHPQ MQQASVSSPI VAGGLRNIHD NKVSGPLSGN SANHHADNPR 

       250        260        270        280        290        300 
HGSSDDYLHM VHRLSSDDGD SSTMRNAASF PLRSPQPVCS PAGSDGTPKG SRPPLILQSQ 

       310        320        330        340        350        360 
SLPCSSPRDV PPDILLDSPE RKQKKQKKIK LGKDEKDQNE KAAMYDIISS PTKDSTKLTL 

       370        380        390        400        410        420 
RLSRVRSSDM DQQDDMLSGM ENSNVSENDI PFNVQYPGQT SKTPITPQDV NRPLNAAQCL 

       430        440        450        460        470        480 
SQQEQTAFLP ANQVPVLQQN TSVATKQPQT SVVQNQQQVS QQGPIYDEVE LDALAEIERI 

       490        500        510        520        530        540 
ERESAIERER FSKEVQDKDK PLKKRKQDSY PQEAGGATGG NRPASQETGS TGNGSRPALM 

       550        560        570        580        590        600 
VSIDLHQAGR VDSQASITQD SDSIKKPEET KQCNDAPISV LQEDIVGSLK SIPENHPETP 

       610        620        630        640        650        660 
KKKSDPELSK SEMKQNESRL SESKPNENQL GESKSNESKL ETKTETPTEE LKQNENKTTE 

       670        680        690        700        710        720 
SKQSESAVVE PKQNENRPCD TKPNDNKQNN TRSENTKARP ETPKQKAESR PETPKQKSEG 

       730        740        750        760        770        780 
RPETPKQKGD GRPETPKQKS EGRPETPKQK GEGRPETPKH RHENRRDSGK PSTEKKPDVS 

       790        800        810        820        830        840 
KHKQDIKSDS PRLKSERAEA LKQRPDGRWE SLRRDHDSKQ KSDDRGESER HRGDQSRVRR 

       850        860        870        880        890        900 
PETLRSSSRN DHSTKSDGSK TEKLERKHRH ESGDSRDRPS GEQKSRPDSP RVKQGDTNKS 

       910        920        930        940        950        960 
RPGFKSPNSK DDKRTEGNRS KVDSNKAHTD NKAEFPSYLL GGRSGALKNF VIPKIKRDKD 

       970        980        990       1000       1010       1020 
GNITQETKKM DMKGEQKDKV EKMGLVEDLN KGAKPVVVLQ KLSLDDVQKL IKDREEKSRS 

      1030       1040       1050       1060       1070       1080 
SLKSIKNKPS KSNKGSIDQS VLKELPPELL AEIESTMPLC ERVKMNKRKR STVNEKPKYA 

      1090       1100       1110       1120       1130       1140 
EISSDEDNDS DEAFESSRKR HKKDDDKAWE YEERDRRSSG DHRRSGHSHD GRRSSGGGRY 

      1150       1160       1170       1180       1190       1200 
RNRSPSDSDM EDYSPPPSLS EVARKMKKKE KQKKRKAYEP KLTPEEMMDS STFKRFTASI 

      1210       1220       1230       1240       1250       1260 
ENILDNLEDM DFTAFGDDDE IPQELLLGKH QLNELGSESA KIKAMGIMDK LSTDKTVKVL 

      1270       1280       1290       1300       1310       1320 
NILEKNIQDG SKLSTLLNHN NDTEEEERLW RDLIMERVTK SADACLTTIN IMTSPNMPKA 

      1330       1340       1350       1360       1370       1380 
VYIEDVIERV IQYTKFHLQN TLYPQYDPVY RVDPHGGGLL SSKAKRAKCS THKQRVIVML 

      1390       1400       1410       1420       1430       1440 
YNKVCDIVSS LSELLEIQLL TDTTILQVSS MGITPFFVEN VSELQLCAIK LVTAVFSRYE 

      1450       1460       1470       1480       1490       1500 
KHRQLILEEI FTSLARLPTS KRSLRNFRLN SSDVDGEPMY IQMVTALVLQ LIQCVVHLPS 

      1510       1520       1530       1540       1550       1560 
SEKDPNSEED SNKKVDQDVV ITNSYETAMR TAQNFLSIFL KKCGSKQGEE DYRPLFENFV 

      1570       1580       1590       1600       1610       1620 
QDLLSTVNKP EWPAAELLLS LLGRLLVHQF SNKSTEMALR VASLDYLGTV AARLRKDAVT 

      1630       1640       1650       1660       1670       1680 
SKMDQGSIER ILKQVSGGED EIQQLQKALL DYLDENTETD PSLVFSRKFY IAQWFRDTTL 

      1690       1700       1710       1720       1730       1740 
ETEKAMKSQK DEESSDATHH AKELETTGQI MHRAENRKKF LRSIIKTTPS QFSTLKMNSD 

      1750       1760       1770       1780       1790       1800 
TVDYDDACLI VRYLASMRPF AQSFDIYLTQ ILRVLGENAI AVRTKAMKCL SEVVAVDPSI 

      1810       1820       1830       1840       1850       1860 
LARLDMQRGV HGRLMDNSTS VREAAVELLG RFVLCRPQLA EQYYDMLIER ILDTGISVRK 

      1870       1880       1890       1900       1910       1920 
RVIKILRDIC IEQPTFPKIT EMCVKMIRRV NDEEGIKKLV NETFQKLWFT PTPHNDKEAM 

      1930       1940       1950       1960       1970       1980 
TRKILNITDV VAACRDTGYD WFEQLLQNLL KSEEDSSYKP VKKACTQLVD NLVEHILKYE 

      1990       2000       2010       2020       2030       2040 
ESLADSDNKG VNSGRLVACI TTLFLFSKIR PQLMVKHAMT MQPYLTTKCS TQNDFMVICN 

      2050       2060       2070       2080       2090       2100 
VAKILELVVP LMEHPSETFL ATIEEDLMKL IIKYGMTVVQ HCVSCLGAVV NKVTQNFKFV 

      2110       2120       2130       2140       2150       2160 
WACFNRYYGA ISKLKSQHQE DPNNTSLLTN KPALLRSLFT VGALCRHFDF DLEDFKGNSK 

      2170       2180       2190       2200       2210       2220 
VNIKDKVLEL LMYFTKHSDE EVQTKAIIGL GFAFIQHPSL MFEQEVKNLY NSILSDKNSS 

      2230       2240       2250       2260       2270       2280 
VNLKIQVLKN LQTYLQEEDT RMQQADRDWK KVAKQEDLKE MGDVSSGMSS SIMQLYLKQV 

      2290       2300       2310       2320       2330       2340 
LEAFFHTQSS VRHFALNVIA LTLNQGLIHP VQCVPYLIAM GTDPEPAMRN KADQQLVEID 

      2350       2360       2370       2380       2390       2400 
KKYAGFIHMK AVAGMKMSYQ VQQAINTCLK DPVRGFRQDE SSSALCSHLY SMIRGNRQHR 

      2410       2420       2430       2440       2450       2460 
RAFLISLLNL FDDTAKTEVT MLLYIADNLA CFPYQTQEEP LFIMHHIDIT LSVSGSNLLQ 

      2470       2480       2490       2500       2510       2520 
SFKESMVKDK RKERKTSPAK ENESSESEEE VSRPRKSRKR VDSESDSDSE DDINSVMKCL 

      2530       2540       2550       2560       2570       2580 
PENSAPLIEF ANVSQGILLL LMLKQHLKNL CGFSDSKIQK YSPSESAKVY DKAINRKTGV 

      2590       2600       2610       2620       2630       2640 
HFHPKQTLDF LRSDMANSKL TEDVKRSIVR QYLDFKLLME HLDPDEEEEE GEVSASTNAR 

      2650       2660       2670       2680       2690       2700 
NKAITSLLGG GSPKNNTAAD TEDEESDGED RGGGTSGSLR RSKRNSDSTE LAAQMNESVD 

      2710       2720       2730       2740       2750       2760 
VMDVIAICCP KYKDRPQIAR VVQRTSSGVS VQWMAGSYSG SWTEAKRRDG RKLVPWVDTI 

      2770       2780       2790 
KESDIIYKKI ALTSANKLTN KVVQTLRSLY AAKDGTSS 

« Hide

Isoform 2 [UniParc].

Checksum: 15871B1EF11857A7
Show »

FASTA2,691303,763
Isoform 3 [UniParc].

Checksum: 48CCA6BE60A266F2
Show »

FASTA10411,598
Isoform 4 [UniParc].

Checksum: 946EB9CB53827AE3
Show »

FASTA29332,742

References

« Hide 'large scale' references
[1]"NIPBL, encoding a homolog of fungal Scc2-type sister chromatid cohesion proteins and fly Nipped-B, is mutated in Cornelia de Lange syndrome."
Tonkin E.T., Wang T.-J., Lisgo S., Bamshad M.J., Strachan T.
Nat. Genet. 36:636-641(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6J.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-325, NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2575-2798 (ISOFORM 2).
Strain: C57BL/6J.
Tissue: Testis.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Strain: C57BL/6.
Tissue: Brain.
[4]"Cornelia de Lange syndrome is caused by mutations in NIPBL, the human homolog of Drosophila melanogaster Nipped-B."
Krantz I.D., McCallum J., DeScipio C., Kaur M., Gillis L.A., Yaeger D., Jukofsky L., Wasserman N., Bottani A., Morris C.A., Nowaczyk M.J.M., Toriello H., Bamshad M.J., Carey J.C., Rappaport E., Kawauchi S., Lander A.D., Calof A.L. expand/collapse author list , Li H.-H., Devoto M., Jackson L.G.
Nat. Genet. 36:631-635(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: DEVELOPMENTAL STAGE.
[5]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-280; SER-2652; THR-2661 AND SER-2666, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
[6]"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2652, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1076, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ627033 mRNA. Translation: CAF25291.1.
AJ640138 mRNA. Translation: CAG26692.1.
AK014915 mRNA. Translation: BAC25453.1.
AK016861 mRNA. Translation: BAB30471.1.
AK049588 mRNA. Translation: BAC33829.1.
BC055787 mRNA. Translation: AAH55787.1.
RefSeqNP_081983.2. NM_027707.3.
NP_957684.1. NM_201232.2.
XP_006520057.1. XM_006519994.1.
XP_006520058.1. XM_006519995.1.
UniGeneMm.240329.
Mm.440537.

3D structure databases

ProteinModelPortalQ6KCD5.
SMRQ6KCD5. Positions 1762-1870, 2167-2192, 2276-2339.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid214531. 3 interactions.
DIPDIP-56622N.
IntActQ6KCD5. 4 interactions.
MINTMINT-4104022.

PTM databases

PhosphoSiteQ6KCD5.

Proteomic databases

PaxDbQ6KCD5.
PRIDEQ6KCD5.

Protocols and materials databases

DNASU71175.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000052965; ENSMUSP00000059385; ENSMUSG00000022141. [Q6KCD5-1]
GeneID71175.
KEGGmmu:71175.
UCSCuc007veq.1. mouse. [Q6KCD5-1]
uc007ver.1. mouse. [Q6KCD5-2]
uc007vev.1. mouse. [Q6KCD5-4]

Organism-specific databases

CTD25836.
MGIMGI:1913976. Nipbl.

Phylogenomic databases

eggNOGNOG128278.
GeneTreeENSGT00390000010427.
HOGENOMHOG000113787.
HOVERGENHBG052626.
InParanoidQ6KCD5.
KOK06672.
OMARDICIEQ.
OrthoDBEOG7CZK4Q.
PhylomeDBQ6KCD5.
TreeFamTF313121.

Gene expression databases

BgeeQ6KCD5.
CleanExMM_NIPBL.
GenevestigatorQ6KCD5.

Family and domain databases

Gene3D1.25.10.10. 4 hits.
InterProIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR026003. Cohesin_HEAT.
IPR024986. Nipped-B_C.
[Graphical view]
PfamPF12765. Cohesin_HEAT. 1 hit.
PF12830. Nipped-B_C. 1 hit.
[Graphical view]
SUPFAMSSF48371. SSF48371. 2 hits.
ProtoNetSearch...

Other

NextBio333221.
PROQ6KCD5.
SOURCESearch...

Entry information

Entry nameNIPBL_MOUSE
AccessionPrimary (citable) accession number: Q6KCD5
Secondary accession number(s): Q6KC78 expand/collapse secondary AC list , Q7TNS4, Q8BKV4, Q8CES9, Q9CUC6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot