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Q6KCD5

- NIPBL_MOUSE

UniProt

Q6KCD5 - NIPBL_MOUSE

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Protein
Nipped-B-like protein
Gene
Nipbl
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Probably plays a structural role in chromatin. Involved in sister chromatid cohesion, possibly by interacting with the cohesin complex By similarity.

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. mediator complex binding Source: MGI
Complete GO annotation...

GO - Biological processi

  1. brain development Source: Ensembl
  2. cellular protein localization Source: Ensembl
  3. cellular response to DNA damage stimulus Source: Ensembl
  4. cellular response to X-ray Source: Ensembl
  5. cognition Source: Ensembl
  6. developmental growth Source: Ensembl
  7. ear morphogenesis Source: Ensembl
  8. embryonic cranial skeleton morphogenesis Source: MGI
  9. embryonic digestive tract morphogenesis Source: Ensembl
  10. embryonic forelimb morphogenesis Source: Ensembl
  11. embryonic viscerocranium morphogenesis Source: MGI
  12. external genitalia morphogenesis Source: Ensembl
  13. eye morphogenesis Source: Ensembl
  14. face morphogenesis Source: Ensembl
  15. fat cell differentiation Source: MGI
  16. gall bladder development Source: Ensembl
  17. heart development Source: MGI
  18. maintenance of mitotic sister chromatid cohesion Source: UniProtKB
  19. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  20. outflow tract morphogenesis Source: Ensembl
  21. positive regulation of histone deacetylation Source: Ensembl
  22. positive regulation of multicellular organism growth Source: MGI
  23. positive regulation of ossification Source: MGI
  24. regulation of developmental growth Source: Ensembl
  25. regulation of embryonic development Source: Ensembl
  26. regulation of hair cycle Source: Ensembl
  27. sensory perception of sound Source: Ensembl
  28. stem cell maintenance Source: MGI
  29. uterus morphogenesis Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell cycle

Enzyme and pathway databases

ReactomeiREACT_196634. Cohesin Loading onto Chromatin.

Names & Taxonomyi

Protein namesi
Recommended name:
Nipped-B-like protein
Alternative name(s):
Delangin homolog
SCC2 homolog
Gene namesi
Name:Nipbl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:1913976. Nipbl.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. SMC loading complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 27982798Nipped-B-like protein
PRO_0000218597Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei150 – 1501Phosphoserine By similarity
Modified residuei162 – 1621Phosphoserine By similarity
Modified residuei256 – 2561Phosphoserine By similarity
Modified residuei280 – 2801Phosphoserine1 Publication
Modified residuei306 – 3061Phosphoserine By similarity
Modified residuei318 – 3181Phosphoserine By similarity
Modified residuei350 – 3501Phosphoserine By similarity
Modified residuei713 – 7131Phosphothreonine By similarity
Modified residuei746 – 7461Phosphothreonine By similarity
Modified residuei906 – 9061Phosphoserine By similarity
Modified residuei1076 – 10761N6-acetyllysine1 Publication
Modified residuei1083 – 10831Phosphoserine By similarity
Modified residuei1084 – 10841Phosphoserine By similarity
Modified residuei1090 – 10901Phosphoserine By similarity
Modified residuei1144 – 11441Phosphoserine By similarity
Modified residuei1146 – 11461Phosphoserine By similarity
Modified residuei1148 – 11481Phosphoserine By similarity
Modified residuei1154 – 11541Phosphoserine By similarity
Modified residuei2503 – 25031Phosphoserine By similarity
Modified residuei2505 – 25051Phosphoserine By similarity
Modified residuei2507 – 25071Phosphoserine By similarity
Modified residuei2509 – 25091Phosphoserine By similarity
Modified residuei2652 – 26521Phosphoserine2 Publications
Modified residuei2661 – 26611Phosphothreonine1 Publication
Modified residuei2666 – 26661Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ6KCD5.
PaxDbiQ6KCD5.
PRIDEiQ6KCD5.

PTM databases

PhosphoSiteiQ6KCD5.

Expressioni

Developmental stagei

Widely expressed at E9.5 and E10.5, with notable accumulations in limb bud, branchial arch and craniofacial mesenchyme. These regions are involved in patterning of the skeleton and soft tissues of the limbs, jaw and face.1 Publication

Gene expression databases

BgeeiQ6KCD5.
CleanExiMM_NIPBL.
GenevestigatoriQ6KCD5.

Interactioni

Protein-protein interaction databases

BioGridi214531. 4 interactions.
DIPiDIP-56622N.
IntActiQ6KCD5. 4 interactions.
MINTiMINT-4104022.

Structurei

3D structure databases

ProteinModelPortaliQ6KCD5.
SMRiQ6KCD5. Positions 1762-1870, 2167-2192, 2276-2339.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati1761 – 179939HEAT 1
Add
BLAST
Repeati1837 – 187539HEAT 2
Add
BLAST
Repeati1939 – 197840HEAT 3
Add
BLAST
Repeati2221 – 226141HEAT 4
Add
BLAST
Repeati2307 – 234539HEAT 5
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi418 – 46245Gln-rich
Add
BLAST

Sequence similaritiesi

Belongs to the SCC2/Nipped-B family.
Contains 5 HEAT repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG128278.
GeneTreeiENSGT00390000010427.
HOGENOMiHOG000113787.
HOVERGENiHBG052626.
InParanoidiQ6KCD5.
KOiK06672.
OMAiRDICIEQ.
OrthoDBiEOG7CZK4Q.
PhylomeDBiQ6KCD5.
TreeFamiTF313121.

Family and domain databases

Gene3Di1.25.10.10. 4 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR026003. Cohesin_HEAT.
IPR024986. Nipped-B_C.
[Graphical view]
PfamiPF12765. Cohesin_HEAT. 1 hit.
PF12830. Nipped-B_C. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6KCD5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MNGDMPHVPI TTLAGIASLT DLLNQLPLPS PLPATTTKSL LFNSRIAEEV     50
NCLLACRDDN LVSQLVHSLN QVSTDHIELK DNLGSDDPEG DIPVLLQAVL 100
ARSPNVFREK SMQNRYVQSG MMMSQYKLSQ NSMHSSPASS NYQQTTISHS 150
PSSRFVPPQT SSGNRFMPQQ NSPVPSPYAP QSPAGYMPYS HPSSYTTHPQ 200
MQQASVSSPI VAGGLRNIHD NKVSGPLSGN SANHHADNPR HGSSDDYLHM 250
VHRLSSDDGD SSTMRNAASF PLRSPQPVCS PAGSDGTPKG SRPPLILQSQ 300
SLPCSSPRDV PPDILLDSPE RKQKKQKKIK LGKDEKDQNE KAAMYDIISS 350
PTKDSTKLTL RLSRVRSSDM DQQDDMLSGM ENSNVSENDI PFNVQYPGQT 400
SKTPITPQDV NRPLNAAQCL SQQEQTAFLP ANQVPVLQQN TSVATKQPQT 450
SVVQNQQQVS QQGPIYDEVE LDALAEIERI ERESAIERER FSKEVQDKDK 500
PLKKRKQDSY PQEAGGATGG NRPASQETGS TGNGSRPALM VSIDLHQAGR 550
VDSQASITQD SDSIKKPEET KQCNDAPISV LQEDIVGSLK SIPENHPETP 600
KKKSDPELSK SEMKQNESRL SESKPNENQL GESKSNESKL ETKTETPTEE 650
LKQNENKTTE SKQSESAVVE PKQNENRPCD TKPNDNKQNN TRSENTKARP 700
ETPKQKAESR PETPKQKSEG RPETPKQKGD GRPETPKQKS EGRPETPKQK 750
GEGRPETPKH RHENRRDSGK PSTEKKPDVS KHKQDIKSDS PRLKSERAEA 800
LKQRPDGRWE SLRRDHDSKQ KSDDRGESER HRGDQSRVRR PETLRSSSRN 850
DHSTKSDGSK TEKLERKHRH ESGDSRDRPS GEQKSRPDSP RVKQGDTNKS 900
RPGFKSPNSK DDKRTEGNRS KVDSNKAHTD NKAEFPSYLL GGRSGALKNF 950
VIPKIKRDKD GNITQETKKM DMKGEQKDKV EKMGLVEDLN KGAKPVVVLQ 1000
KLSLDDVQKL IKDREEKSRS SLKSIKNKPS KSNKGSIDQS VLKELPPELL 1050
AEIESTMPLC ERVKMNKRKR STVNEKPKYA EISSDEDNDS DEAFESSRKR 1100
HKKDDDKAWE YEERDRRSSG DHRRSGHSHD GRRSSGGGRY RNRSPSDSDM 1150
EDYSPPPSLS EVARKMKKKE KQKKRKAYEP KLTPEEMMDS STFKRFTASI 1200
ENILDNLEDM DFTAFGDDDE IPQELLLGKH QLNELGSESA KIKAMGIMDK 1250
LSTDKTVKVL NILEKNIQDG SKLSTLLNHN NDTEEEERLW RDLIMERVTK 1300
SADACLTTIN IMTSPNMPKA VYIEDVIERV IQYTKFHLQN TLYPQYDPVY 1350
RVDPHGGGLL SSKAKRAKCS THKQRVIVML YNKVCDIVSS LSELLEIQLL 1400
TDTTILQVSS MGITPFFVEN VSELQLCAIK LVTAVFSRYE KHRQLILEEI 1450
FTSLARLPTS KRSLRNFRLN SSDVDGEPMY IQMVTALVLQ LIQCVVHLPS 1500
SEKDPNSEED SNKKVDQDVV ITNSYETAMR TAQNFLSIFL KKCGSKQGEE 1550
DYRPLFENFV QDLLSTVNKP EWPAAELLLS LLGRLLVHQF SNKSTEMALR 1600
VASLDYLGTV AARLRKDAVT SKMDQGSIER ILKQVSGGED EIQQLQKALL 1650
DYLDENTETD PSLVFSRKFY IAQWFRDTTL ETEKAMKSQK DEESSDATHH 1700
AKELETTGQI MHRAENRKKF LRSIIKTTPS QFSTLKMNSD TVDYDDACLI 1750
VRYLASMRPF AQSFDIYLTQ ILRVLGENAI AVRTKAMKCL SEVVAVDPSI 1800
LARLDMQRGV HGRLMDNSTS VREAAVELLG RFVLCRPQLA EQYYDMLIER 1850
ILDTGISVRK RVIKILRDIC IEQPTFPKIT EMCVKMIRRV NDEEGIKKLV 1900
NETFQKLWFT PTPHNDKEAM TRKILNITDV VAACRDTGYD WFEQLLQNLL 1950
KSEEDSSYKP VKKACTQLVD NLVEHILKYE ESLADSDNKG VNSGRLVACI 2000
TTLFLFSKIR PQLMVKHAMT MQPYLTTKCS TQNDFMVICN VAKILELVVP 2050
LMEHPSETFL ATIEEDLMKL IIKYGMTVVQ HCVSCLGAVV NKVTQNFKFV 2100
WACFNRYYGA ISKLKSQHQE DPNNTSLLTN KPALLRSLFT VGALCRHFDF 2150
DLEDFKGNSK VNIKDKVLEL LMYFTKHSDE EVQTKAIIGL GFAFIQHPSL 2200
MFEQEVKNLY NSILSDKNSS VNLKIQVLKN LQTYLQEEDT RMQQADRDWK 2250
KVAKQEDLKE MGDVSSGMSS SIMQLYLKQV LEAFFHTQSS VRHFALNVIA 2300
LTLNQGLIHP VQCVPYLIAM GTDPEPAMRN KADQQLVEID KKYAGFIHMK 2350
AVAGMKMSYQ VQQAINTCLK DPVRGFRQDE SSSALCSHLY SMIRGNRQHR 2400
RAFLISLLNL FDDTAKTEVT MLLYIADNLA CFPYQTQEEP LFIMHHIDIT 2450
LSVSGSNLLQ SFKESMVKDK RKERKTSPAK ENESSESEEE VSRPRKSRKR 2500
VDSESDSDSE DDINSVMKCL PENSAPLIEF ANVSQGILLL LMLKQHLKNL 2550
CGFSDSKIQK YSPSESAKVY DKAINRKTGV HFHPKQTLDF LRSDMANSKL 2600
TEDVKRSIVR QYLDFKLLME HLDPDEEEEE GEVSASTNAR NKAITSLLGG 2650
GSPKNNTAAD TEDEESDGED RGGGTSGSLR RSKRNSDSTE LAAQMNESVD 2700
VMDVIAICCP KYKDRPQIAR VVQRTSSGVS VQWMAGSYSG SWTEAKRRDG 2750
RKLVPWVDTI KESDIIYKKI ALTSANKLTN KVVQTLRSLY AAKDGTSS 2798
Length:2,798
Mass (Da):315,450
Last modified:July 5, 2004 - v1
Checksum:iBC23B6E2C949C9B3
GO
Isoform 2 (identifier: Q6KCD5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     2678-2691: SLRRSKRNSDSTEL → VRRRRSQRISQRIT
     2692-2798: Missing.

Show »
Length:2,691
Mass (Da):303,763
Checksum:i15871B1EF11857A7
GO
Isoform 3 (identifier: Q6KCD5-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2694: Missing.

Note: No experimental confirmation available.

Show »
Length:104
Mass (Da):11,598
Checksum:i48CCA6BE60A266F2
GO
Isoform 4 (identifier: Q6KCD5-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-263: Missing.
     499-556: DKPLKKRKQD...QAGRVDSQAS → GKGPLSLLLQ...NYITLFELLY
     557-2798: Missing.

Note: No experimental confirmation available.

Show »
Length:293
Mass (Da):32,742
Checksum:i946EB9CB53827AE3
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 26942694Missing in isoform 3.
VSP_011094Add
BLAST
Alternative sequencei1 – 263263Missing in isoform 4.
VSP_011095Add
BLAST
Alternative sequencei499 – 55658DKPLK…DSQAS → GKGPLSLLLQHLATCVLIPT SLLRYEFHSLAEASISDLII QYHRLSNLNYITLFELLY in isoform 4.
VSP_011096Add
BLAST
Alternative sequencei557 – 27982242Missing in isoform 4.
VSP_011097Add
BLAST
Alternative sequencei2678 – 269114SLRRS…DSTEL → VRRRRSQRISQRIT in isoform 2.
VSP_011098Add
BLAST
Alternative sequencei2692 – 2798107Missing in isoform 2.
VSP_011099Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2577 – 25771K → I in BAC25453. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ627033 mRNA. Translation: CAF25291.1.
AJ640138 mRNA. Translation: CAG26692.1.
AK014915 mRNA. Translation: BAC25453.1.
AK016861 mRNA. Translation: BAB30471.1.
AK049588 mRNA. Translation: BAC33829.1.
BC055787 mRNA. Translation: AAH55787.1.
CCDSiCCDS37035.1. [Q6KCD5-1]
RefSeqiNP_081983.2. NM_027707.3. [Q6KCD5-1]
NP_957684.1. NM_201232.2. [Q6KCD5-2]
XP_006520057.1. XM_006519994.1. [Q6KCD5-1]
XP_006520058.1. XM_006519995.1. [Q6KCD5-1]
UniGeneiMm.240329.
Mm.440537.

Genome annotation databases

EnsembliENSMUST00000052965; ENSMUSP00000059385; ENSMUSG00000022141. [Q6KCD5-1]
GeneIDi71175.
KEGGimmu:71175.
UCSCiuc007veq.1. mouse. [Q6KCD5-1]
uc007ver.1. mouse. [Q6KCD5-2]
uc007vev.1. mouse. [Q6KCD5-4]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ627033 mRNA. Translation: CAF25291.1 .
AJ640138 mRNA. Translation: CAG26692.1 .
AK014915 mRNA. Translation: BAC25453.1 .
AK016861 mRNA. Translation: BAB30471.1 .
AK049588 mRNA. Translation: BAC33829.1 .
BC055787 mRNA. Translation: AAH55787.1 .
CCDSi CCDS37035.1. [Q6KCD5-1 ]
RefSeqi NP_081983.2. NM_027707.3. [Q6KCD5-1 ]
NP_957684.1. NM_201232.2. [Q6KCD5-2 ]
XP_006520057.1. XM_006519994.1. [Q6KCD5-1 ]
XP_006520058.1. XM_006519995.1. [Q6KCD5-1 ]
UniGenei Mm.240329.
Mm.440537.

3D structure databases

ProteinModelPortali Q6KCD5.
SMRi Q6KCD5. Positions 1762-1870, 2167-2192, 2276-2339.
ModBasei Search...

Protein-protein interaction databases

BioGridi 214531. 4 interactions.
DIPi DIP-56622N.
IntActi Q6KCD5. 4 interactions.
MINTi MINT-4104022.

PTM databases

PhosphoSitei Q6KCD5.

Proteomic databases

MaxQBi Q6KCD5.
PaxDbi Q6KCD5.
PRIDEi Q6KCD5.

Protocols and materials databases

DNASUi 71175.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000052965 ; ENSMUSP00000059385 ; ENSMUSG00000022141 . [Q6KCD5-1 ]
GeneIDi 71175.
KEGGi mmu:71175.
UCSCi uc007veq.1. mouse. [Q6KCD5-1 ]
uc007ver.1. mouse. [Q6KCD5-2 ]
uc007vev.1. mouse. [Q6KCD5-4 ]

Organism-specific databases

CTDi 25836.
MGIi MGI:1913976. Nipbl.

Phylogenomic databases

eggNOGi NOG128278.
GeneTreei ENSGT00390000010427.
HOGENOMi HOG000113787.
HOVERGENi HBG052626.
InParanoidi Q6KCD5.
KOi K06672.
OMAi RDICIEQ.
OrthoDBi EOG7CZK4Q.
PhylomeDBi Q6KCD5.
TreeFami TF313121.

Enzyme and pathway databases

Reactomei REACT_196634. Cohesin Loading onto Chromatin.

Miscellaneous databases

NextBioi 333221.
PROi Q6KCD5.
SOURCEi Search...

Gene expression databases

Bgeei Q6KCD5.
CleanExi MM_NIPBL.
Genevestigatori Q6KCD5.

Family and domain databases

Gene3Di 1.25.10.10. 4 hits.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR026003. Cohesin_HEAT.
IPR024986. Nipped-B_C.
[Graphical view ]
Pfami PF12765. Cohesin_HEAT. 1 hit.
PF12830. Nipped-B_C. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "NIPBL, encoding a homolog of fungal Scc2-type sister chromatid cohesion proteins and fly Nipped-B, is mutated in Cornelia de Lange syndrome."
    Tonkin E.T., Wang T.-J., Lisgo S., Bamshad M.J., Strachan T.
    Nat. Genet. 36:636-641(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-325, NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2575-2798 (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Strain: C57BL/6.
    Tissue: Brain.
  4. Cited for: DEVELOPMENTAL STAGE.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-280; SER-2652; THR-2661 AND SER-2666, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2652, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1076, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiNIPBL_MOUSE
AccessioniPrimary (citable) accession number: Q6KCD5
Secondary accession number(s): Q6KC78
, Q7TNS4, Q8BKV4, Q8CES9, Q9CUC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi