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Q6KCD5

- NIPBL_MOUSE

UniProt

Q6KCD5 - NIPBL_MOUSE

Protein

Nipped-B-like protein

Gene

Nipbl

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Probably plays a structural role in chromatin. Involved in sister chromatid cohesion, possibly by interacting with the cohesin complex By similarity.By similarity

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. mediator complex binding Source: MGI

    GO - Biological processi

    1. brain development Source: Ensembl
    2. cellular protein localization Source: Ensembl
    3. cellular response to DNA damage stimulus Source: Ensembl
    4. cellular response to X-ray Source: Ensembl
    5. cognition Source: Ensembl
    6. developmental growth Source: Ensembl
    7. ear morphogenesis Source: Ensembl
    8. embryonic cranial skeleton morphogenesis Source: MGI
    9. embryonic digestive tract morphogenesis Source: Ensembl
    10. embryonic forelimb morphogenesis Source: Ensembl
    11. embryonic viscerocranium morphogenesis Source: MGI
    12. external genitalia morphogenesis Source: Ensembl
    13. eye morphogenesis Source: Ensembl
    14. face morphogenesis Source: Ensembl
    15. fat cell differentiation Source: MGI
    16. gall bladder development Source: Ensembl
    17. heart development Source: MGI
    18. maintenance of mitotic sister chromatid cohesion Source: UniProtKB
    19. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    20. outflow tract morphogenesis Source: Ensembl
    21. positive regulation of histone deacetylation Source: Ensembl
    22. positive regulation of multicellular organism growth Source: MGI
    23. positive regulation of ossification Source: MGI
    24. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    25. regulation of developmental growth Source: Ensembl
    26. regulation of embryonic development Source: Ensembl
    27. regulation of hair cycle Source: Ensembl
    28. sensory perception of sound Source: Ensembl
    29. stem cell maintenance Source: MGI
    30. uterus morphogenesis Source: Ensembl

    Keywords - Biological processi

    Cell cycle

    Enzyme and pathway databases

    ReactomeiREACT_196634. Cohesin Loading onto Chromatin.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nipped-B-like protein
    Alternative name(s):
    Delangin homolog
    SCC2 homolog
    Gene namesi
    Name:Nipbl
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:1913976. Nipbl.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. chromatin Source: MGI
    2. SMC loading complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 27982798Nipped-B-like proteinPRO_0000218597Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei150 – 1501PhosphoserineBy similarity
    Modified residuei162 – 1621PhosphoserineBy similarity
    Modified residuei256 – 2561PhosphoserineBy similarity
    Modified residuei280 – 2801Phosphoserine1 Publication
    Modified residuei306 – 3061PhosphoserineBy similarity
    Modified residuei318 – 3181PhosphoserineBy similarity
    Modified residuei350 – 3501PhosphoserineBy similarity
    Modified residuei713 – 7131PhosphothreonineBy similarity
    Modified residuei746 – 7461PhosphothreonineBy similarity
    Modified residuei906 – 9061PhosphoserineBy similarity
    Modified residuei1076 – 10761N6-acetyllysine1 Publication
    Modified residuei1083 – 10831PhosphoserineBy similarity
    Modified residuei1084 – 10841PhosphoserineBy similarity
    Modified residuei1090 – 10901PhosphoserineBy similarity
    Modified residuei1144 – 11441PhosphoserineBy similarity
    Modified residuei1146 – 11461PhosphoserineBy similarity
    Modified residuei1148 – 11481PhosphoserineBy similarity
    Modified residuei1154 – 11541PhosphoserineBy similarity
    Modified residuei2503 – 25031PhosphoserineBy similarity
    Modified residuei2505 – 25051PhosphoserineBy similarity
    Modified residuei2507 – 25071PhosphoserineBy similarity
    Modified residuei2509 – 25091PhosphoserineBy similarity
    Modified residuei2652 – 26521Phosphoserine2 Publications
    Modified residuei2661 – 26611Phosphothreonine1 Publication
    Modified residuei2666 – 26661Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ6KCD5.
    PaxDbiQ6KCD5.
    PRIDEiQ6KCD5.

    PTM databases

    PhosphoSiteiQ6KCD5.

    Expressioni

    Developmental stagei

    Widely expressed at E9.5 and E10.5, with notable accumulations in limb bud, branchial arch and craniofacial mesenchyme. These regions are involved in patterning of the skeleton and soft tissues of the limbs, jaw and face.1 Publication

    Gene expression databases

    BgeeiQ6KCD5.
    CleanExiMM_NIPBL.
    GenevestigatoriQ6KCD5.

    Interactioni

    Protein-protein interaction databases

    BioGridi214531. 4 interactions.
    DIPiDIP-56622N.
    IntActiQ6KCD5. 4 interactions.
    MINTiMINT-4104022.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6KCD5.
    SMRiQ6KCD5. Positions 1762-1870, 2167-2192, 2276-2339.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati1761 – 179939HEAT 1Add
    BLAST
    Repeati1837 – 187539HEAT 2Add
    BLAST
    Repeati1939 – 197840HEAT 3Add
    BLAST
    Repeati2221 – 226141HEAT 4Add
    BLAST
    Repeati2307 – 234539HEAT 5Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi418 – 46245Gln-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SCC2/Nipped-B family.Curated
    Contains 5 HEAT repeats.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG128278.
    GeneTreeiENSGT00390000010427.
    HOGENOMiHOG000113787.
    HOVERGENiHBG052626.
    InParanoidiQ6KCD5.
    KOiK06672.
    OMAiRDICIEQ.
    OrthoDBiEOG7CZK4Q.
    PhylomeDBiQ6KCD5.
    TreeFamiTF313121.

    Family and domain databases

    Gene3Di1.25.10.10. 4 hits.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR026003. Cohesin_HEAT.
    IPR024986. Nipped-B_C.
    [Graphical view]
    PfamiPF12765. Cohesin_HEAT. 1 hit.
    PF12830. Nipped-B_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 2 hits.

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6KCD5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNGDMPHVPI TTLAGIASLT DLLNQLPLPS PLPATTTKSL LFNSRIAEEV     50
    NCLLACRDDN LVSQLVHSLN QVSTDHIELK DNLGSDDPEG DIPVLLQAVL 100
    ARSPNVFREK SMQNRYVQSG MMMSQYKLSQ NSMHSSPASS NYQQTTISHS 150
    PSSRFVPPQT SSGNRFMPQQ NSPVPSPYAP QSPAGYMPYS HPSSYTTHPQ 200
    MQQASVSSPI VAGGLRNIHD NKVSGPLSGN SANHHADNPR HGSSDDYLHM 250
    VHRLSSDDGD SSTMRNAASF PLRSPQPVCS PAGSDGTPKG SRPPLILQSQ 300
    SLPCSSPRDV PPDILLDSPE RKQKKQKKIK LGKDEKDQNE KAAMYDIISS 350
    PTKDSTKLTL RLSRVRSSDM DQQDDMLSGM ENSNVSENDI PFNVQYPGQT 400
    SKTPITPQDV NRPLNAAQCL SQQEQTAFLP ANQVPVLQQN TSVATKQPQT 450
    SVVQNQQQVS QQGPIYDEVE LDALAEIERI ERESAIERER FSKEVQDKDK 500
    PLKKRKQDSY PQEAGGATGG NRPASQETGS TGNGSRPALM VSIDLHQAGR 550
    VDSQASITQD SDSIKKPEET KQCNDAPISV LQEDIVGSLK SIPENHPETP 600
    KKKSDPELSK SEMKQNESRL SESKPNENQL GESKSNESKL ETKTETPTEE 650
    LKQNENKTTE SKQSESAVVE PKQNENRPCD TKPNDNKQNN TRSENTKARP 700
    ETPKQKAESR PETPKQKSEG RPETPKQKGD GRPETPKQKS EGRPETPKQK 750
    GEGRPETPKH RHENRRDSGK PSTEKKPDVS KHKQDIKSDS PRLKSERAEA 800
    LKQRPDGRWE SLRRDHDSKQ KSDDRGESER HRGDQSRVRR PETLRSSSRN 850
    DHSTKSDGSK TEKLERKHRH ESGDSRDRPS GEQKSRPDSP RVKQGDTNKS 900
    RPGFKSPNSK DDKRTEGNRS KVDSNKAHTD NKAEFPSYLL GGRSGALKNF 950
    VIPKIKRDKD GNITQETKKM DMKGEQKDKV EKMGLVEDLN KGAKPVVVLQ 1000
    KLSLDDVQKL IKDREEKSRS SLKSIKNKPS KSNKGSIDQS VLKELPPELL 1050
    AEIESTMPLC ERVKMNKRKR STVNEKPKYA EISSDEDNDS DEAFESSRKR 1100
    HKKDDDKAWE YEERDRRSSG DHRRSGHSHD GRRSSGGGRY RNRSPSDSDM 1150
    EDYSPPPSLS EVARKMKKKE KQKKRKAYEP KLTPEEMMDS STFKRFTASI 1200
    ENILDNLEDM DFTAFGDDDE IPQELLLGKH QLNELGSESA KIKAMGIMDK 1250
    LSTDKTVKVL NILEKNIQDG SKLSTLLNHN NDTEEEERLW RDLIMERVTK 1300
    SADACLTTIN IMTSPNMPKA VYIEDVIERV IQYTKFHLQN TLYPQYDPVY 1350
    RVDPHGGGLL SSKAKRAKCS THKQRVIVML YNKVCDIVSS LSELLEIQLL 1400
    TDTTILQVSS MGITPFFVEN VSELQLCAIK LVTAVFSRYE KHRQLILEEI 1450
    FTSLARLPTS KRSLRNFRLN SSDVDGEPMY IQMVTALVLQ LIQCVVHLPS 1500
    SEKDPNSEED SNKKVDQDVV ITNSYETAMR TAQNFLSIFL KKCGSKQGEE 1550
    DYRPLFENFV QDLLSTVNKP EWPAAELLLS LLGRLLVHQF SNKSTEMALR 1600
    VASLDYLGTV AARLRKDAVT SKMDQGSIER ILKQVSGGED EIQQLQKALL 1650
    DYLDENTETD PSLVFSRKFY IAQWFRDTTL ETEKAMKSQK DEESSDATHH 1700
    AKELETTGQI MHRAENRKKF LRSIIKTTPS QFSTLKMNSD TVDYDDACLI 1750
    VRYLASMRPF AQSFDIYLTQ ILRVLGENAI AVRTKAMKCL SEVVAVDPSI 1800
    LARLDMQRGV HGRLMDNSTS VREAAVELLG RFVLCRPQLA EQYYDMLIER 1850
    ILDTGISVRK RVIKILRDIC IEQPTFPKIT EMCVKMIRRV NDEEGIKKLV 1900
    NETFQKLWFT PTPHNDKEAM TRKILNITDV VAACRDTGYD WFEQLLQNLL 1950
    KSEEDSSYKP VKKACTQLVD NLVEHILKYE ESLADSDNKG VNSGRLVACI 2000
    TTLFLFSKIR PQLMVKHAMT MQPYLTTKCS TQNDFMVICN VAKILELVVP 2050
    LMEHPSETFL ATIEEDLMKL IIKYGMTVVQ HCVSCLGAVV NKVTQNFKFV 2100
    WACFNRYYGA ISKLKSQHQE DPNNTSLLTN KPALLRSLFT VGALCRHFDF 2150
    DLEDFKGNSK VNIKDKVLEL LMYFTKHSDE EVQTKAIIGL GFAFIQHPSL 2200
    MFEQEVKNLY NSILSDKNSS VNLKIQVLKN LQTYLQEEDT RMQQADRDWK 2250
    KVAKQEDLKE MGDVSSGMSS SIMQLYLKQV LEAFFHTQSS VRHFALNVIA 2300
    LTLNQGLIHP VQCVPYLIAM GTDPEPAMRN KADQQLVEID KKYAGFIHMK 2350
    AVAGMKMSYQ VQQAINTCLK DPVRGFRQDE SSSALCSHLY SMIRGNRQHR 2400
    RAFLISLLNL FDDTAKTEVT MLLYIADNLA CFPYQTQEEP LFIMHHIDIT 2450
    LSVSGSNLLQ SFKESMVKDK RKERKTSPAK ENESSESEEE VSRPRKSRKR 2500
    VDSESDSDSE DDINSVMKCL PENSAPLIEF ANVSQGILLL LMLKQHLKNL 2550
    CGFSDSKIQK YSPSESAKVY DKAINRKTGV HFHPKQTLDF LRSDMANSKL 2600
    TEDVKRSIVR QYLDFKLLME HLDPDEEEEE GEVSASTNAR NKAITSLLGG 2650
    GSPKNNTAAD TEDEESDGED RGGGTSGSLR RSKRNSDSTE LAAQMNESVD 2700
    VMDVIAICCP KYKDRPQIAR VVQRTSSGVS VQWMAGSYSG SWTEAKRRDG 2750
    RKLVPWVDTI KESDIIYKKI ALTSANKLTN KVVQTLRSLY AAKDGTSS 2798
    Length:2,798
    Mass (Da):315,450
    Last modified:July 5, 2004 - v1
    Checksum:iBC23B6E2C949C9B3
    GO
    Isoform 2 (identifier: Q6KCD5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         2678-2691: SLRRSKRNSDSTEL → VRRRRSQRISQRIT
         2692-2798: Missing.

    Show »
    Length:2,691
    Mass (Da):303,763
    Checksum:i15871B1EF11857A7
    GO
    Isoform 3 (identifier: Q6KCD5-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-2694: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:104
    Mass (Da):11,598
    Checksum:i48CCA6BE60A266F2
    GO
    Isoform 4 (identifier: Q6KCD5-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-263: Missing.
         499-556: DKPLKKRKQD...QAGRVDSQAS → GKGPLSLLLQ...NYITLFELLY
         557-2798: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:293
    Mass (Da):32,742
    Checksum:i946EB9CB53827AE3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti2577 – 25771K → I in BAC25453. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 26942694Missing in isoform 3. 1 PublicationVSP_011094Add
    BLAST
    Alternative sequencei1 – 263263Missing in isoform 4. 1 PublicationVSP_011095Add
    BLAST
    Alternative sequencei499 – 55658DKPLK…DSQAS → GKGPLSLLLQHLATCVLIPT SLLRYEFHSLAEASISDLII QYHRLSNLNYITLFELLY in isoform 4. 1 PublicationVSP_011096Add
    BLAST
    Alternative sequencei557 – 27982242Missing in isoform 4. 1 PublicationVSP_011097Add
    BLAST
    Alternative sequencei2678 – 269114SLRRS…DSTEL → VRRRRSQRISQRIT in isoform 2. 2 PublicationsVSP_011098Add
    BLAST
    Alternative sequencei2692 – 2798107Missing in isoform 2. 2 PublicationsVSP_011099Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ627033 mRNA. Translation: CAF25291.1.
    AJ640138 mRNA. Translation: CAG26692.1.
    AK014915 mRNA. Translation: BAC25453.1.
    AK016861 mRNA. Translation: BAB30471.1.
    AK049588 mRNA. Translation: BAC33829.1.
    BC055787 mRNA. Translation: AAH55787.1.
    CCDSiCCDS37035.1. [Q6KCD5-1]
    RefSeqiNP_081983.2. NM_027707.3. [Q6KCD5-1]
    NP_957684.1. NM_201232.2. [Q6KCD5-2]
    XP_006520057.1. XM_006519994.1. [Q6KCD5-1]
    XP_006520058.1. XM_006519995.1. [Q6KCD5-1]
    UniGeneiMm.240329.
    Mm.440537.

    Genome annotation databases

    EnsembliENSMUST00000052965; ENSMUSP00000059385; ENSMUSG00000022141. [Q6KCD5-1]
    GeneIDi71175.
    KEGGimmu:71175.
    UCSCiuc007veq.1. mouse. [Q6KCD5-1]
    uc007ver.1. mouse. [Q6KCD5-2]
    uc007vev.1. mouse. [Q6KCD5-4]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ627033 mRNA. Translation: CAF25291.1 .
    AJ640138 mRNA. Translation: CAG26692.1 .
    AK014915 mRNA. Translation: BAC25453.1 .
    AK016861 mRNA. Translation: BAB30471.1 .
    AK049588 mRNA. Translation: BAC33829.1 .
    BC055787 mRNA. Translation: AAH55787.1 .
    CCDSi CCDS37035.1. [Q6KCD5-1 ]
    RefSeqi NP_081983.2. NM_027707.3. [Q6KCD5-1 ]
    NP_957684.1. NM_201232.2. [Q6KCD5-2 ]
    XP_006520057.1. XM_006519994.1. [Q6KCD5-1 ]
    XP_006520058.1. XM_006519995.1. [Q6KCD5-1 ]
    UniGenei Mm.240329.
    Mm.440537.

    3D structure databases

    ProteinModelPortali Q6KCD5.
    SMRi Q6KCD5. Positions 1762-1870, 2167-2192, 2276-2339.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 214531. 4 interactions.
    DIPi DIP-56622N.
    IntActi Q6KCD5. 4 interactions.
    MINTi MINT-4104022.

    PTM databases

    PhosphoSitei Q6KCD5.

    Proteomic databases

    MaxQBi Q6KCD5.
    PaxDbi Q6KCD5.
    PRIDEi Q6KCD5.

    Protocols and materials databases

    DNASUi 71175.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000052965 ; ENSMUSP00000059385 ; ENSMUSG00000022141 . [Q6KCD5-1 ]
    GeneIDi 71175.
    KEGGi mmu:71175.
    UCSCi uc007veq.1. mouse. [Q6KCD5-1 ]
    uc007ver.1. mouse. [Q6KCD5-2 ]
    uc007vev.1. mouse. [Q6KCD5-4 ]

    Organism-specific databases

    CTDi 25836.
    MGIi MGI:1913976. Nipbl.

    Phylogenomic databases

    eggNOGi NOG128278.
    GeneTreei ENSGT00390000010427.
    HOGENOMi HOG000113787.
    HOVERGENi HBG052626.
    InParanoidi Q6KCD5.
    KOi K06672.
    OMAi RDICIEQ.
    OrthoDBi EOG7CZK4Q.
    PhylomeDBi Q6KCD5.
    TreeFami TF313121.

    Enzyme and pathway databases

    Reactomei REACT_196634. Cohesin Loading onto Chromatin.

    Miscellaneous databases

    NextBioi 333221.
    PROi Q6KCD5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6KCD5.
    CleanExi MM_NIPBL.
    Genevestigatori Q6KCD5.

    Family and domain databases

    Gene3Di 1.25.10.10. 4 hits.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR026003. Cohesin_HEAT.
    IPR024986. Nipped-B_C.
    [Graphical view ]
    Pfami PF12765. Cohesin_HEAT. 1 hit.
    PF12830. Nipped-B_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "NIPBL, encoding a homolog of fungal Scc2-type sister chromatid cohesion proteins and fly Nipped-B, is mutated in Cornelia de Lange syndrome."
      Tonkin E.T., Wang T.-J., Lisgo S., Bamshad M.J., Strachan T.
      Nat. Genet. 36:636-641(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-325, NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2575-2798 (ISOFORM 2).
      Strain: C57BL/6J.
      Tissue: Testis.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Strain: C57BL/6.
      Tissue: Brain.
    4. Cited for: DEVELOPMENTAL STAGE.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-280; SER-2652; THR-2661 AND SER-2666, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    6. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2652, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1076, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiNIPBL_MOUSE
    AccessioniPrimary (citable) accession number: Q6KCD5
    Secondary accession number(s): Q6KC78
    , Q7TNS4, Q8BKV4, Q8CES9, Q9CUC6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3