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Q6KCD5

- NIPBL_MOUSE

UniProt

Q6KCD5 - NIPBL_MOUSE

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Protein

Nipped-B-like protein

Gene

Nipbl

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Probably plays a structural role in chromatin. Involved in sister chromatid cohesion, possibly by interacting with the cohesin complex (By similarity).By similarity

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. mediator complex binding Source: MGI

GO - Biological processi

  1. brain development Source: Ensembl
  2. cellular protein localization Source: Ensembl
  3. cellular response to DNA damage stimulus Source: Ensembl
  4. cellular response to X-ray Source: Ensembl
  5. cognition Source: Ensembl
  6. developmental growth Source: Ensembl
  7. ear morphogenesis Source: Ensembl
  8. embryonic cranial skeleton morphogenesis Source: MGI
  9. embryonic digestive tract morphogenesis Source: Ensembl
  10. embryonic forelimb morphogenesis Source: Ensembl
  11. embryonic viscerocranium morphogenesis Source: MGI
  12. external genitalia morphogenesis Source: Ensembl
  13. eye morphogenesis Source: Ensembl
  14. face morphogenesis Source: Ensembl
  15. fat cell differentiation Source: MGI
  16. gall bladder development Source: Ensembl
  17. heart development Source: MGI
  18. maintenance of mitotic sister chromatid cohesion Source: UniProtKB
  19. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  20. outflow tract morphogenesis Source: Ensembl
  21. positive regulation of histone deacetylation Source: Ensembl
  22. positive regulation of multicellular organism growth Source: MGI
  23. positive regulation of ossification Source: MGI
  24. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  25. regulation of developmental growth Source: Ensembl
  26. regulation of embryonic development Source: Ensembl
  27. regulation of hair cycle Source: Ensembl
  28. sensory perception of sound Source: Ensembl
  29. stem cell maintenance Source: MGI
  30. uterus morphogenesis Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell cycle

Enzyme and pathway databases

ReactomeiREACT_196634. Cohesin Loading onto Chromatin.

Names & Taxonomyi

Protein namesi
Recommended name:
Nipped-B-like protein
Alternative name(s):
Delangin homolog
SCC2 homolog
Gene namesi
Name:Nipbl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:1913976. Nipbl.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. chromatin Source: MGI
  2. extracellular vesicular exosome Source: Ensembl
  3. SMC loading complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 27982798Nipped-B-like proteinPRO_0000218597Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei150 – 1501PhosphoserineBy similarity
Modified residuei162 – 1621PhosphoserineBy similarity
Modified residuei256 – 2561PhosphoserineBy similarity
Modified residuei280 – 2801Phosphoserine1 Publication
Modified residuei306 – 3061PhosphoserineBy similarity
Modified residuei318 – 3181PhosphoserineBy similarity
Modified residuei350 – 3501PhosphoserineBy similarity
Modified residuei713 – 7131PhosphothreonineBy similarity
Modified residuei746 – 7461PhosphothreonineBy similarity
Modified residuei906 – 9061PhosphoserineBy similarity
Modified residuei1076 – 10761N6-acetyllysine1 Publication
Modified residuei1083 – 10831PhosphoserineBy similarity
Modified residuei1084 – 10841PhosphoserineBy similarity
Modified residuei1090 – 10901PhosphoserineBy similarity
Modified residuei1144 – 11441PhosphoserineBy similarity
Modified residuei1146 – 11461PhosphoserineBy similarity
Modified residuei1148 – 11481PhosphoserineBy similarity
Modified residuei1154 – 11541PhosphoserineBy similarity
Modified residuei2503 – 25031PhosphoserineBy similarity
Modified residuei2505 – 25051PhosphoserineBy similarity
Modified residuei2507 – 25071PhosphoserineBy similarity
Modified residuei2509 – 25091PhosphoserineBy similarity
Modified residuei2652 – 26521Phosphoserine2 Publications
Modified residuei2661 – 26611Phosphothreonine1 Publication
Modified residuei2666 – 26661Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ6KCD5.
PaxDbiQ6KCD5.
PRIDEiQ6KCD5.

PTM databases

PhosphoSiteiQ6KCD5.

Expressioni

Developmental stagei

Widely expressed at E9.5 and E10.5, with notable accumulations in limb bud, branchial arch and craniofacial mesenchyme. These regions are involved in patterning of the skeleton and soft tissues of the limbs, jaw and face.1 Publication

Gene expression databases

BgeeiQ6KCD5.
CleanExiMM_NIPBL.
GenevestigatoriQ6KCD5.

Interactioni

Protein-protein interaction databases

BioGridi214531. 4 interactions.
DIPiDIP-56622N.
IntActiQ6KCD5. 4 interactions.
MINTiMINT-4104022.

Structurei

3D structure databases

ProteinModelPortaliQ6KCD5.
SMRiQ6KCD5. Positions 1767-1833.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati1761 – 179939HEAT 1Add
BLAST
Repeati1837 – 187539HEAT 2Add
BLAST
Repeati1939 – 197840HEAT 3Add
BLAST
Repeati2221 – 226141HEAT 4Add
BLAST
Repeati2307 – 234539HEAT 5Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi418 – 46245Gln-richAdd
BLAST

Sequence similaritiesi

Belongs to the SCC2/Nipped-B family.Curated
Contains 5 HEAT repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG128278.
GeneTreeiENSGT00390000010427.
HOGENOMiHOG000113787.
HOVERGENiHBG052626.
InParanoidiQ6KCD5.
KOiK06672.
OMAiRDICIEQ.
OrthoDBiEOG7CZK4Q.
PhylomeDBiQ6KCD5.
TreeFamiTF313121.

Family and domain databases

Gene3Di1.25.10.10. 4 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR026003. Cohesin_HEAT.
IPR024986. Nipped-B_C.
[Graphical view]
PfamiPF12765. Cohesin_HEAT. 1 hit.
PF12830. Nipped-B_C. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6KCD5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNGDMPHVPI TTLAGIASLT DLLNQLPLPS PLPATTTKSL LFNSRIAEEV
60 70 80 90 100
NCLLACRDDN LVSQLVHSLN QVSTDHIELK DNLGSDDPEG DIPVLLQAVL
110 120 130 140 150
ARSPNVFREK SMQNRYVQSG MMMSQYKLSQ NSMHSSPASS NYQQTTISHS
160 170 180 190 200
PSSRFVPPQT SSGNRFMPQQ NSPVPSPYAP QSPAGYMPYS HPSSYTTHPQ
210 220 230 240 250
MQQASVSSPI VAGGLRNIHD NKVSGPLSGN SANHHADNPR HGSSDDYLHM
260 270 280 290 300
VHRLSSDDGD SSTMRNAASF PLRSPQPVCS PAGSDGTPKG SRPPLILQSQ
310 320 330 340 350
SLPCSSPRDV PPDILLDSPE RKQKKQKKIK LGKDEKDQNE KAAMYDIISS
360 370 380 390 400
PTKDSTKLTL RLSRVRSSDM DQQDDMLSGM ENSNVSENDI PFNVQYPGQT
410 420 430 440 450
SKTPITPQDV NRPLNAAQCL SQQEQTAFLP ANQVPVLQQN TSVATKQPQT
460 470 480 490 500
SVVQNQQQVS QQGPIYDEVE LDALAEIERI ERESAIERER FSKEVQDKDK
510 520 530 540 550
PLKKRKQDSY PQEAGGATGG NRPASQETGS TGNGSRPALM VSIDLHQAGR
560 570 580 590 600
VDSQASITQD SDSIKKPEET KQCNDAPISV LQEDIVGSLK SIPENHPETP
610 620 630 640 650
KKKSDPELSK SEMKQNESRL SESKPNENQL GESKSNESKL ETKTETPTEE
660 670 680 690 700
LKQNENKTTE SKQSESAVVE PKQNENRPCD TKPNDNKQNN TRSENTKARP
710 720 730 740 750
ETPKQKAESR PETPKQKSEG RPETPKQKGD GRPETPKQKS EGRPETPKQK
760 770 780 790 800
GEGRPETPKH RHENRRDSGK PSTEKKPDVS KHKQDIKSDS PRLKSERAEA
810 820 830 840 850
LKQRPDGRWE SLRRDHDSKQ KSDDRGESER HRGDQSRVRR PETLRSSSRN
860 870 880 890 900
DHSTKSDGSK TEKLERKHRH ESGDSRDRPS GEQKSRPDSP RVKQGDTNKS
910 920 930 940 950
RPGFKSPNSK DDKRTEGNRS KVDSNKAHTD NKAEFPSYLL GGRSGALKNF
960 970 980 990 1000
VIPKIKRDKD GNITQETKKM DMKGEQKDKV EKMGLVEDLN KGAKPVVVLQ
1010 1020 1030 1040 1050
KLSLDDVQKL IKDREEKSRS SLKSIKNKPS KSNKGSIDQS VLKELPPELL
1060 1070 1080 1090 1100
AEIESTMPLC ERVKMNKRKR STVNEKPKYA EISSDEDNDS DEAFESSRKR
1110 1120 1130 1140 1150
HKKDDDKAWE YEERDRRSSG DHRRSGHSHD GRRSSGGGRY RNRSPSDSDM
1160 1170 1180 1190 1200
EDYSPPPSLS EVARKMKKKE KQKKRKAYEP KLTPEEMMDS STFKRFTASI
1210 1220 1230 1240 1250
ENILDNLEDM DFTAFGDDDE IPQELLLGKH QLNELGSESA KIKAMGIMDK
1260 1270 1280 1290 1300
LSTDKTVKVL NILEKNIQDG SKLSTLLNHN NDTEEEERLW RDLIMERVTK
1310 1320 1330 1340 1350
SADACLTTIN IMTSPNMPKA VYIEDVIERV IQYTKFHLQN TLYPQYDPVY
1360 1370 1380 1390 1400
RVDPHGGGLL SSKAKRAKCS THKQRVIVML YNKVCDIVSS LSELLEIQLL
1410 1420 1430 1440 1450
TDTTILQVSS MGITPFFVEN VSELQLCAIK LVTAVFSRYE KHRQLILEEI
1460 1470 1480 1490 1500
FTSLARLPTS KRSLRNFRLN SSDVDGEPMY IQMVTALVLQ LIQCVVHLPS
1510 1520 1530 1540 1550
SEKDPNSEED SNKKVDQDVV ITNSYETAMR TAQNFLSIFL KKCGSKQGEE
1560 1570 1580 1590 1600
DYRPLFENFV QDLLSTVNKP EWPAAELLLS LLGRLLVHQF SNKSTEMALR
1610 1620 1630 1640 1650
VASLDYLGTV AARLRKDAVT SKMDQGSIER ILKQVSGGED EIQQLQKALL
1660 1670 1680 1690 1700
DYLDENTETD PSLVFSRKFY IAQWFRDTTL ETEKAMKSQK DEESSDATHH
1710 1720 1730 1740 1750
AKELETTGQI MHRAENRKKF LRSIIKTTPS QFSTLKMNSD TVDYDDACLI
1760 1770 1780 1790 1800
VRYLASMRPF AQSFDIYLTQ ILRVLGENAI AVRTKAMKCL SEVVAVDPSI
1810 1820 1830 1840 1850
LARLDMQRGV HGRLMDNSTS VREAAVELLG RFVLCRPQLA EQYYDMLIER
1860 1870 1880 1890 1900
ILDTGISVRK RVIKILRDIC IEQPTFPKIT EMCVKMIRRV NDEEGIKKLV
1910 1920 1930 1940 1950
NETFQKLWFT PTPHNDKEAM TRKILNITDV VAACRDTGYD WFEQLLQNLL
1960 1970 1980 1990 2000
KSEEDSSYKP VKKACTQLVD NLVEHILKYE ESLADSDNKG VNSGRLVACI
2010 2020 2030 2040 2050
TTLFLFSKIR PQLMVKHAMT MQPYLTTKCS TQNDFMVICN VAKILELVVP
2060 2070 2080 2090 2100
LMEHPSETFL ATIEEDLMKL IIKYGMTVVQ HCVSCLGAVV NKVTQNFKFV
2110 2120 2130 2140 2150
WACFNRYYGA ISKLKSQHQE DPNNTSLLTN KPALLRSLFT VGALCRHFDF
2160 2170 2180 2190 2200
DLEDFKGNSK VNIKDKVLEL LMYFTKHSDE EVQTKAIIGL GFAFIQHPSL
2210 2220 2230 2240 2250
MFEQEVKNLY NSILSDKNSS VNLKIQVLKN LQTYLQEEDT RMQQADRDWK
2260 2270 2280 2290 2300
KVAKQEDLKE MGDVSSGMSS SIMQLYLKQV LEAFFHTQSS VRHFALNVIA
2310 2320 2330 2340 2350
LTLNQGLIHP VQCVPYLIAM GTDPEPAMRN KADQQLVEID KKYAGFIHMK
2360 2370 2380 2390 2400
AVAGMKMSYQ VQQAINTCLK DPVRGFRQDE SSSALCSHLY SMIRGNRQHR
2410 2420 2430 2440 2450
RAFLISLLNL FDDTAKTEVT MLLYIADNLA CFPYQTQEEP LFIMHHIDIT
2460 2470 2480 2490 2500
LSVSGSNLLQ SFKESMVKDK RKERKTSPAK ENESSESEEE VSRPRKSRKR
2510 2520 2530 2540 2550
VDSESDSDSE DDINSVMKCL PENSAPLIEF ANVSQGILLL LMLKQHLKNL
2560 2570 2580 2590 2600
CGFSDSKIQK YSPSESAKVY DKAINRKTGV HFHPKQTLDF LRSDMANSKL
2610 2620 2630 2640 2650
TEDVKRSIVR QYLDFKLLME HLDPDEEEEE GEVSASTNAR NKAITSLLGG
2660 2670 2680 2690 2700
GSPKNNTAAD TEDEESDGED RGGGTSGSLR RSKRNSDSTE LAAQMNESVD
2710 2720 2730 2740 2750
VMDVIAICCP KYKDRPQIAR VVQRTSSGVS VQWMAGSYSG SWTEAKRRDG
2760 2770 2780 2790
RKLVPWVDTI KESDIIYKKI ALTSANKLTN KVVQTLRSLY AAKDGTSS
Length:2,798
Mass (Da):315,450
Last modified:July 5, 2004 - v1
Checksum:iBC23B6E2C949C9B3
GO
Isoform 2 (identifier: Q6KCD5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     2678-2691: SLRRSKRNSDSTEL → VRRRRSQRISQRIT
     2692-2798: Missing.

Show »
Length:2,691
Mass (Da):303,763
Checksum:i15871B1EF11857A7
GO
Isoform 3 (identifier: Q6KCD5-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2694: Missing.

Note: No experimental confirmation available.

Show »
Length:104
Mass (Da):11,598
Checksum:i48CCA6BE60A266F2
GO
Isoform 4 (identifier: Q6KCD5-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-263: Missing.
     499-556: DKPLKKRKQD...QAGRVDSQAS → GKGPLSLLLQ...NYITLFELLY
     557-2798: Missing.

Note: No experimental confirmation available.

Show »
Length:293
Mass (Da):32,742
Checksum:i946EB9CB53827AE3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2577 – 25771K → I in BAC25453. (PubMed:16141072)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 26942694Missing in isoform 3. 1 PublicationVSP_011094Add
BLAST
Alternative sequencei1 – 263263Missing in isoform 4. 1 PublicationVSP_011095Add
BLAST
Alternative sequencei499 – 55658DKPLK…DSQAS → GKGPLSLLLQHLATCVLIPT SLLRYEFHSLAEASISDLII QYHRLSNLNYITLFELLY in isoform 4. 1 PublicationVSP_011096Add
BLAST
Alternative sequencei557 – 27982242Missing in isoform 4. 1 PublicationVSP_011097Add
BLAST
Alternative sequencei2678 – 269114SLRRS…DSTEL → VRRRRSQRISQRIT in isoform 2. 2 PublicationsVSP_011098Add
BLAST
Alternative sequencei2692 – 2798107Missing in isoform 2. 2 PublicationsVSP_011099Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ627033 mRNA. Translation: CAF25291.1.
AJ640138 mRNA. Translation: CAG26692.1.
AK014915 mRNA. Translation: BAC25453.1.
AK016861 mRNA. Translation: BAB30471.1.
AK049588 mRNA. Translation: BAC33829.1.
BC055787 mRNA. Translation: AAH55787.1.
CCDSiCCDS37035.1. [Q6KCD5-1]
RefSeqiNP_081983.2. NM_027707.3. [Q6KCD5-1]
NP_957684.1. NM_201232.2. [Q6KCD5-2]
XP_006520057.1. XM_006519994.1. [Q6KCD5-1]
XP_006520058.1. XM_006519995.1. [Q6KCD5-1]
UniGeneiMm.240329.
Mm.440537.

Genome annotation databases

EnsembliENSMUST00000052965; ENSMUSP00000059385; ENSMUSG00000022141. [Q6KCD5-1]
GeneIDi71175.
KEGGimmu:71175.
UCSCiuc007veq.1. mouse. [Q6KCD5-1]
uc007ver.1. mouse. [Q6KCD5-2]
uc007vev.1. mouse. [Q6KCD5-4]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ627033 mRNA. Translation: CAF25291.1 .
AJ640138 mRNA. Translation: CAG26692.1 .
AK014915 mRNA. Translation: BAC25453.1 .
AK016861 mRNA. Translation: BAB30471.1 .
AK049588 mRNA. Translation: BAC33829.1 .
BC055787 mRNA. Translation: AAH55787.1 .
CCDSi CCDS37035.1. [Q6KCD5-1 ]
RefSeqi NP_081983.2. NM_027707.3. [Q6KCD5-1 ]
NP_957684.1. NM_201232.2. [Q6KCD5-2 ]
XP_006520057.1. XM_006519994.1. [Q6KCD5-1 ]
XP_006520058.1. XM_006519995.1. [Q6KCD5-1 ]
UniGenei Mm.240329.
Mm.440537.

3D structure databases

ProteinModelPortali Q6KCD5.
SMRi Q6KCD5. Positions 1767-1833.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 214531. 4 interactions.
DIPi DIP-56622N.
IntActi Q6KCD5. 4 interactions.
MINTi MINT-4104022.

PTM databases

PhosphoSitei Q6KCD5.

Proteomic databases

MaxQBi Q6KCD5.
PaxDbi Q6KCD5.
PRIDEi Q6KCD5.

Protocols and materials databases

DNASUi 71175.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000052965 ; ENSMUSP00000059385 ; ENSMUSG00000022141 . [Q6KCD5-1 ]
GeneIDi 71175.
KEGGi mmu:71175.
UCSCi uc007veq.1. mouse. [Q6KCD5-1 ]
uc007ver.1. mouse. [Q6KCD5-2 ]
uc007vev.1. mouse. [Q6KCD5-4 ]

Organism-specific databases

CTDi 25836.
MGIi MGI:1913976. Nipbl.

Phylogenomic databases

eggNOGi NOG128278.
GeneTreei ENSGT00390000010427.
HOGENOMi HOG000113787.
HOVERGENi HBG052626.
InParanoidi Q6KCD5.
KOi K06672.
OMAi RDICIEQ.
OrthoDBi EOG7CZK4Q.
PhylomeDBi Q6KCD5.
TreeFami TF313121.

Enzyme and pathway databases

Reactomei REACT_196634. Cohesin Loading onto Chromatin.

Miscellaneous databases

NextBioi 333221.
PROi Q6KCD5.
SOURCEi Search...

Gene expression databases

Bgeei Q6KCD5.
CleanExi MM_NIPBL.
Genevestigatori Q6KCD5.

Family and domain databases

Gene3Di 1.25.10.10. 4 hits.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR026003. Cohesin_HEAT.
IPR024986. Nipped-B_C.
[Graphical view ]
Pfami PF12765. Cohesin_HEAT. 1 hit.
PF12830. Nipped-B_C. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "NIPBL, encoding a homolog of fungal Scc2-type sister chromatid cohesion proteins and fly Nipped-B, is mutated in Cornelia de Lange syndrome."
    Tonkin E.T., Wang T.-J., Lisgo S., Bamshad M.J., Strachan T.
    Nat. Genet. 36:636-641(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-325, NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2575-2798 (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Strain: C57BL/6.
    Tissue: Brain.
  4. Cited for: DEVELOPMENTAL STAGE.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-280; SER-2652; THR-2661 AND SER-2666, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2652, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1076, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiNIPBL_MOUSE
AccessioniPrimary (citable) accession number: Q6KCD5
Secondary accession number(s): Q6KC78
, Q7TNS4, Q8BKV4, Q8CES9, Q9CUC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 5, 2004
Last modified: November 26, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3